{"id":"https://openalex.org/W4317438751","doi":"https://doi.org/10.1038/s41583-022-00673-7","title":"Gene therapy for chronic pain: emerging opportunities in target-rich peripheral nociceptors","display_name":"Gene therapy for chronic pain: emerging opportunities in target-rich peripheral nociceptors","publication_year":2023,"publication_date":"2023-01-19","ids":{"openalex":"https://openalex.org/W4317438751","doi":"https://doi.org/10.1038/s41583-022-00673-7","pmid":"https://pubmed.ncbi.nlm.nih.gov/36658346"},"language":"en","primary_location":{"id":"doi:10.1038/s41583-022-00673-7","doi":"https://doi.org/10.1038/s41583-022-00673-7","is_oa":false,"landing_page_url":"https://doi.org/10.1038/s41583-022-00673-7","pdf_url":null,"source":{"id":"https://openalex.org/S26843219","display_name":"Nature reviews. Neuroscience","issn_l":"1471-003X","issn":["1471-003X","1471-0048"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Reviews Neuroscience","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://gala.gre.ac.uk/id/eprint/41638/7/41638_OVSEPIAN_%20Gene_therapy_for_chronic_pain_emerging_opportunities_in_target_rich_peripheral_nociceptors.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036467116","display_name":"Saak Victor Ovsepian","orcid":"https://orcid.org/0000-0002-9522-4159","observed_orcids":["https://orcid.org/0000-0002-9522-4159"]},"institutions":[{"id":"https://openalex.org/I55060895","display_name":"University of Greenwich","ror":"https://ror.org/00bmj0a71","country_code":"GB","type":"education","lineage":["https://openalex.org/I55060895"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Saak V. Ovsepian","raw_affiliation_strings":["School of Science, Faculty of Engineering and Science, University of Greenwich London, Chatham Maritime, UK. s.v.ovsepian@gre.ac.uk","School of Science, Faculty of Engineering and Science, University of Greenwich London, Chatham Maritime, UK"],"raw_orcid":"https://orcid.org/0000-0002-9522-4159","affiliations":[{"raw_affiliation_string":"School of Science, Faculty of Engineering and Science, University of Greenwich London, Chatham Maritime, UK. s.v.ovsepian@gre.ac.uk","institution_ids":["https://openalex.org/I55060895"]},{"raw_affiliation_string":"School of Science, Faculty of Engineering and Science, University of Greenwich London, Chatham Maritime, UK","institution_ids":["https://openalex.org/I55060895"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002957653","display_name":"Stephen G. Waxman","orcid":"https://orcid.org/0000-0001-5718-7177","observed_orcids":["https://orcid.org/0000-0001-5718-7177"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Stephen G. Waxman","raw_affiliation_strings":["Department of Neurology, Yale University School of Medicine, New Haven, CT, USA. stephen.waxman@yale.edu","Department of Neuroscience, Yale University School of Medicine, New Haven, CT, USA. stephen.waxman@yale.edu","Department of Pharmacology, Yale University School of Medicine, New Haven, CT, USA. stephen.waxman@yale.edu","Department of Neurology, Yale University School of Medicine, New Haven, CT, USA"],"raw_orcid":"https://orcid.org/0000-0001-5718-7177","affiliations":[{"raw_affiliation_string":"Department of Neurology, Yale University School of Medicine, New Haven, CT, USA. stephen.waxman@yale.edu","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Department of Neuroscience, Yale University School of Medicine, New Haven, CT, USA. stephen.waxman@yale.edu","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Department of Pharmacology, Yale University School of Medicine, New Haven, CT, USA. stephen.waxman@yale.edu","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Department of Neurology, Yale University School of Medicine, New Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5002957653","https://openalex.org/A5036467116"],"corresponding_institution_ids":["https://openalex.org/I32971472","https://openalex.org/I55060895"],"apc_list":null,"apc_paid":null,"fwci":1.3693,"has_fulltext":true,"cited_by_count":45,"citation_normalized_percentile":{"value":0.81087662,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"24","issue":"4","first_page":"252","last_page":"265"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9735999703407288,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9735999703407288,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.011599999852478504,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gene-therapy","display_name":"gene therapy","score":0.9959999918937683},{"id":"https://openalex.org/keywords/chronic-pain","display_name":"chronic pain","score":1.0},{"id":"https://openalex.org/keywords/peripheral-nociceptors","display_name":"peripheral nociceptors","score":0.9120000004768372},{"id":"https://openalex.org/keywords/primary-sensory-neurons","display_name":"primary sensory neurons","score":0.9950000047683716},{"id":"https://openalex.org/keywords/ion-channels","display_name":"ion channels","score":0.968999981880188},{"id":"https://openalex.org/keywords/pain-therapeutics","display_name":"pain therapeutics","score":0.492000013589859},{"id":"https://openalex.org/keywords/translational-potential","display_name":"translational potential","score":0.42800000309944153}],"concepts":[{"id":"https://openalex.org/C2781118164","wikidata":"https://www.wikidata.org/wiki/Q1088113","display_name":"Chronic pain","level":2,"score":0.7033693790435791},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6298321485519409},{"id":"https://openalex.org/C172659308","wikidata":"https://www.wikidata.org/wiki/Q412542","display_name":"Nociceptor","level":4,"score":0.5999699831008911},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.4699782431125641},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4405618906021118},{"id":"https://openalex.org/C94487597","wikidata":"https://www.wikidata.org/wiki/Q11101","display_name":"Sensory system","level":2,"score":0.4255581498146057},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4236384928226471},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3510347008705139},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3420676589012146},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3250827193260193},{"id":"https://openalex.org/C15490471","wikidata":"https://www.wikidata.org/wiki/Q2734305","display_name":"Nociception","level":3,"score":0.23233312368392944},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12878093123435974},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.09532544016838074}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009619","descriptor_name":"Nociceptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D059350","descriptor_name":"Chronic Pain","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D059350","descriptor_name":"Chronic Pain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D059350","descriptor_name":"Chronic Pain","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1038/s41583-022-00673-7","doi":"https://doi.org/10.1038/s41583-022-00673-7","is_oa":false,"landing_page_url":"https://doi.org/10.1038/s41583-022-00673-7","pdf_url":null,"source":{"id":"https://openalex.org/S26843219","display_name":"Nature reviews. Neuroscience","issn_l":"1471-003X","issn":["1471-003X","1471-0048"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Reviews Neuroscience","raw_type":"journal-article"},{"id":"pmid:36658346","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36658346","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature reviews. Neuroscience","raw_type":"Journal Article"},{"id":"pmh:oai:gala.gre.ac.uk:41638","doi":null,"is_oa":true,"landing_page_url":"http://gala.gre.ac.uk/id/eprint/41638/7/41638_OVSEPIAN_%20Gene_therapy_for_chronic_pain_emerging_opportunities_in_target_rich_peripheral_nociceptors.pdf","pdf_url":"http://gala.gre.ac.uk/id/eprint/41638/7/41638_OVSEPIAN_%20Gene_therapy_for_chronic_pain_emerging_opportunities_in_target_rich_peripheral_nociceptors.pdf","source":{"id":"https://openalex.org/S4306401244","display_name":"Greenwich Academic Literature Archive (University of Greenwich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I55060895","host_organization_name":"University of Greenwich","host_organization_lineage":["https://openalex.org/I55060895"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"pmh:oai:gala.gre.ac.uk:41638","doi":null,"is_oa":true,"landing_page_url":"http://gala.gre.ac.uk/id/eprint/41638/7/41638_OVSEPIAN_%20Gene_therapy_for_chronic_pain_emerging_opportunities_in_target_rich_peripheral_nociceptors.pdf","pdf_url":"http://gala.gre.ac.uk/id/eprint/41638/7/41638_OVSEPIAN_%20Gene_therapy_for_chronic_pain_emerging_opportunities_in_target_rich_peripheral_nociceptors.pdf","source":{"id":"https://openalex.org/S4306401244","display_name":"Greenwich Academic Literature Archive (University of Greenwich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I55060895","host_organization_name":"University of Greenwich","host_organization_lineage":["https://openalex.org/I55060895"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320311712","display_name":"University of Greenwich","ror":"https://ror.org/00bmj0a71"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4317438751.pdf","grobid_xml":"https://content.openalex.org/works/W4317438751.grobid-xml"},"referenced_works_count":218,"referenced_works":["https://openalex.org/W40340874","https://openalex.org/W1509844096","https://openalex.org/W1511198581","https://openalex.org/W1528778201","https://openalex.org/W1534770629","https://openalex.org/W1549160512","https://openalex.org/W1583371287","https://openalex.org/W1583710296","https://openalex.org/W1604428153","https://openalex.org/W1616824889","https://openalex.org/W1797134060","https://openalex.org/W1816134939","https://openalex.org/W1836647274","https://openalex.org/W1844967107","https://openalex.org/W1868960647","https://openalex.org/W1879998039","https://openalex.org/W1904847790","https://openalex.org/W1910213480","https://openalex.org/W1921440755","https://openalex.org/W1963768700","https://openalex.org/W1965547314","https://openalex.org/W1967441802","https://openalex.org/W1969166765","https://openalex.org/W1970227170","https://openalex.org/W1973073711","https://openalex.org/W1974360350","https://openalex.org/W1974642350","https://openalex.org/W1974801463","https://openalex.org/W1976488219","https://openalex.org/W1978008111","https://openalex.org/W1978354972","https://openalex.org/W1987456883","https://openalex.org/W1991705866","https://openalex.org/W1996906033","https://openalex.org/W1997333327","https://openalex.org/W1998308912","https://openalex.org/W1999720993","https://openalex.org/W2001358071","https://openalex.org/W2005054700","https://openalex.org/W2007337144","https://openalex.org/W2011674088","https://openalex.org/W2013514756","https://openalex.org/W2013711061","https://openalex.org/W2014299900","https://openalex.org/W2014619474","https://openalex.org/W2015249233","https://openalex.org/W2016905574","https://openalex.org/W2017299181","https://openalex.org/W2017732628","https://openalex.org/W2021565244","https://openalex.org/W2025118264","https://openalex.org/W2026551512","https://openalex.org/W2026842778","https://openalex.org/W2027063112","https://openalex.org/W2029342741","https://openalex.org/W2031572683","https://openalex.org/W2033072655","https://openalex.org/W2033770456","https://openalex.org/W2034085814","https://openalex.org/W2034147772","https://openalex.org/W2038693417","https://openalex.org/W2047833662","https://openalex.org/W2050480410","https://openalex.org/W2050910050","https://openalex.org/W2051997075","https://openalex.org/W2058713207","https://openalex.org/W2060424507","https://openalex.org/W2060972591","https://openalex.org/W2062761332","https://openalex.org/W2063338540","https://openalex.org/W2075766783","https://openalex.org/W2076805831","https://openalex.org/W2085805107","https://openalex.org/W2086690624","https://openalex.org/W2090913462","https://openalex.org/W2091991357","https://openalex.org/W2092112296","https://openalex.org/W2093457776","https://openalex.org/W2096195080","https://openalex.org/W2096701787","https://openalex.org/W2097354554","https://openalex.org/W2097697084","https://openalex.org/W2102671024","https://openalex.org/W2104124554","https://openalex.org/W2104818454","https://openalex.org/W2106922931","https://openalex.org/W2108114952","https://openalex.org/W2109008155","https://openalex.org/W2110195051","https://openalex.org/W2111569821","https://openalex.org/W2117266710","https://openalex.org/W2117380044","https://openalex.org/W2118590048","https://openalex.org/W2118621245","https://openalex.org/W2119336577","https://openalex.org/W2120411432","https://openalex.org/W2121644981","https://openalex.org/W2128490398","https://openalex.org/W2128865950","https://openalex.org/W2130496291","https://openalex.org/W2136814558","https://openalex.org/W2136987230","https://openalex.org/W2137746009","https://openalex.org/W2140983593","https://openalex.org/W2142362544","https://openalex.org/W2142844399","https://openalex.org/W2145201896","https://openalex.org/W2146530776","https://openalex.org/W2147268397","https://openalex.org/W2149756965","https://openalex.org/W2151515134","https://openalex.org/W2151975160","https://openalex.org/W2154646032","https://openalex.org/W2155419660","https://openalex.org/W2155765257","https://openalex.org/W2156289861","https://openalex.org/W2157282220","https://openalex.org/W2157952220","https://openalex.org/W2159470318","https://openalex.org/W2163573618","https://openalex.org/W2171439776","https://openalex.org/W2171785121","https://openalex.org/W2172067396","https://openalex.org/W2175896472","https://openalex.org/W2181527086","https://openalex.org/W2191880573","https://openalex.org/W2257961953","https://openalex.org/W2275773157","https://openalex.org/W2280099523","https://openalex.org/W2284441384","https://openalex.org/W2301368457","https://openalex.org/W2331570632","https://openalex.org/W2336914726","https://openalex.org/W2398204858","https://openalex.org/W2464448281","https://openalex.org/W2549105334","https://openalex.org/W2615918897","https://openalex.org/W2625603971","https://openalex.org/W2725297560","https://openalex.org/W2750899255","https://openalex.org/W2757842300","https://openalex.org/W2763205332","https://openalex.org/W2770070688","https://openalex.org/W2771247031","https://openalex.org/W2775004242","https://openalex.org/W2782917400","https://openalex.org/W2786888986","https://openalex.org/W2788934158","https://openalex.org/W2789607365","https://openalex.org/W2794595791","https://openalex.org/W2794975044","https://openalex.org/W2802054347","https://openalex.org/W2896504526","https://openalex.org/W2901895724","https://openalex.org/W2902502548","https://openalex.org/W2911570848","https://openalex.org/W2912743928","https://openalex.org/W2913267552","https://openalex.org/W2922255622","https://openalex.org/W2940989186","https://openalex.org/W2944013917","https://openalex.org/W2947777875","https://openalex.org/W2961510098","https://openalex.org/W2967302504","https://openalex.org/W2969783143","https://openalex.org/W2971807284","https://openalex.org/W2983603509","https://openalex.org/W3000561035","https://openalex.org/W3003918934","https://openalex.org/W3005107756","https://openalex.org/W3013942217","https://openalex.org/W3014461065","https://openalex.org/W3024255267","https://openalex.org/W3035623431","https://openalex.org/W3036450571","https://openalex.org/W3037975981","https://openalex.org/W3038108456","https://openalex.org/W3039709460","https://openalex.org/W3044522922","https://openalex.org/W3046165584","https://openalex.org/W3087553933","https://openalex.org/W3091008282","https://openalex.org/W3092924046","https://openalex.org/W3095897671","https://openalex.org/W3102899245","https://openalex.org/W3112179900","https://openalex.org/W3113914281","https://openalex.org/W3119504935","https://openalex.org/W3119693934","https://openalex.org/W3121560287","https://openalex.org/W3126032609","https://openalex.org/W3135015492","https://openalex.org/W3135213168","https://openalex.org/W3138032810","https://openalex.org/W3164222028","https://openalex.org/W3164967630","https://openalex.org/W3168094505","https://openalex.org/W3183138488","https://openalex.org/W3193935362","https://openalex.org/W3196353890","https://openalex.org/W3199382522","https://openalex.org/W3200584304","https://openalex.org/W3201079407","https://openalex.org/W3203432551","https://openalex.org/W4200227978","https://openalex.org/W4200556008","https://openalex.org/W4205824800","https://openalex.org/W4210311723","https://openalex.org/W4213339007","https://openalex.org/W4225287980","https://openalex.org/W4233595534","https://openalex.org/W4245660285","https://openalex.org/W4280506261","https://openalex.org/W4283388084","https://openalex.org/W4285248179","https://openalex.org/W4308369850","https://openalex.org/W6643806265","https://openalex.org/W6644851602"],"related_works":["https://openalex.org/W4403085282","https://openalex.org/W4385794436","https://openalex.org/W4231566691","https://openalex.org/W2613532744","https://openalex.org/W2466463425","https://openalex.org/W2123873410","https://openalex.org/W2415071258","https://openalex.org/W2050294231","https://openalex.org/W2037752814","https://openalex.org/W2783622331"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":12},{"year":2025,"cited_by_count":17},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":8}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2023-01-19T00:00:00"}