{"id":"https://openalex.org/W4316079574","doi":"https://doi.org/10.14309/01.ajg.0000869620.63869.d8","title":"S3245 \u201cHard-to-Treat HCV\u201d\u2014An Approach to Retreatment With Extended Duration: A Case Report","display_name":"S3245 \u201cHard-to-Treat HCV\u201d\u2014An Approach to Retreatment With Extended Duration: A Case Report","publication_year":2022,"publication_date":"2022-10-01","ids":{"openalex":"https://openalex.org/W4316079574","doi":"https://doi.org/10.14309/01.ajg.0000869620.63869.d8"},"language":"en","primary_location":{"id":"doi:10.14309/01.ajg.0000869620.63869.d8","doi":"https://doi.org/10.14309/01.ajg.0000869620.63869.d8","is_oa":false,"landing_page_url":"http://dx.doi.org/10.14309/01.ajg.0000869620.63869.d8","pdf_url":null,"source":{"id":"https://openalex.org/S66441642","display_name":"The American Journal of Gastroenterology","issn_l":"0002-9270","issn":["0002-9270","1572-0241"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Gastroenterology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028495519","display_name":"Yara Dababneh","orcid":"https://orcid.org/0000-0002-9149-1671","observed_orcids":["https://orcid.org/0000-0002-9149-1671"]},"institutions":[{"id":"https://openalex.org/I2803043754","display_name":"Henry Ford Hospital","ror":"https://ror.org/0193sb042","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I154057602","https://openalex.org/I2803043754"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yara Dababneh","raw_affiliation_strings":["Henry Ford Hospital, Detroit, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Henry Ford Hospital, Detroit, MI","institution_ids":["https://openalex.org/I2803043754"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111059358","display_name":"Tabassum F. Chowdhury","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tabassum Chowdhury","raw_affiliation_strings":["Wayne State University, Detroit, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wayne State University, Detroit, MI","institution_ids":["https://openalex.org/I185443292"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055496740","display_name":"Shiva Bongu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shiva Bongu","raw_affiliation_strings":["Wayne State University, Detroit, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wayne State University, Detroit, MI","institution_ids":["https://openalex.org/I185443292"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070592653","display_name":"Vivek Mendiratta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2803043754","display_name":"Henry Ford Hospital","ror":"https://ror.org/0193sb042","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I154057602","https://openalex.org/I2803043754"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vivek Mendiratta","raw_affiliation_strings":["Henry Ford Hospital, Detroit, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Henry Ford Hospital, Detroit, MI","institution_ids":["https://openalex.org/I2803043754"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087348988","display_name":"Syed\u2010Mohammed Jafri","orcid":"https://orcid.org/0000-0001-8108-7408","observed_orcids":["https://orcid.org/0000-0001-8108-7408"]},"institutions":[{"id":"https://openalex.org/I2803043754","display_name":"Henry Ford Hospital","ror":"https://ror.org/0193sb042","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I154057602","https://openalex.org/I2803043754"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Syed-Mohammed Jafri","raw_affiliation_strings":["Henry Ford Hospital, Detroit, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Henry Ford Hospital, Detroit, MI","institution_ids":["https://openalex.org/I2803043754"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046835105","display_name":"Stuart C. Gordon","orcid":"https://orcid.org/0000-0001-8666-3849","observed_orcids":["https://orcid.org/0000-0001-8666-3849"]},"institutions":[{"id":"https://openalex.org/I2803043754","display_name":"Henry Ford Hospital","ror":"https://ror.org/0193sb042","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I154057602","https://openalex.org/I2803043754"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stuart Gordon","raw_affiliation_strings":["Henry Ford Hospital, Detroit, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Henry Ford Hospital, Detroit, MI","institution_ids":["https://openalex.org/I2803043754"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"117","issue":"10S","first_page":"e2071","last_page":"e2071"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11495","display_name":"Animal Virus Infections Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-hepatitis-c","display_name":"chronic hepatitis C","score":0.8569999933242798},{"id":"https://openalex.org/keywords/hcv-genotype-1a","display_name":"HCV genotype 1a","score":0.8100000023841858},{"id":"https://openalex.org/keywords/liver-cirrhosis","display_name":"liver cirrhosis","score":0.7760000228881836},{"id":"https://openalex.org/keywords/salvage-therapy","display_name":"salvage therapy","score":0.6200000047683716},{"id":"https://openalex.org/keywords/pegylated-interferon","display_name":"pegylated interferon","score":0.8209999799728394},{"id":"https://openalex.org/keywords/ribavirin","display_name":"ribavirin","score":0.906000018119812},{"id":"https://openalex.org/keywords/sustained-virologic-response","display_name":"sustained virological response","score":0.8489999771118164},{"id":"https://openalex.org/keywords/hcv-relapse","display_name":"HCV relapse","score":0.5040000081062317},{"id":"https://openalex.org/keywords/daclatasvir","display_name":"daclatasvir","score":0.6589999794960022}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.926887035369873},{"id":"https://openalex.org/C2780040827","wikidata":"https://www.wikidata.org/wiki/Q421862","display_name":"Ribavirin","level":4,"score":0.8997049331665039},{"id":"https://openalex.org/C2778390639","wikidata":"https://www.wikidata.org/wiki/Q2502747","display_name":"Sofosbuvir","level":5,"score":0.8787670135498047},{"id":"https://openalex.org/C2776979040","wikidata":"https://www.wikidata.org/wiki/Q5207712","display_name":"Daclatasvir","level":5,"score":0.8248288631439209},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.7793943285942078},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5727477073669434},{"id":"https://openalex.org/C2776461080","wikidata":"https://www.wikidata.org/wiki/Q7160835","display_name":"Pegylated interferon","level":5,"score":0.5317690968513489},{"id":"https://openalex.org/C2776408679","wikidata":"https://www.wikidata.org/wiki/Q708693","display_name":"Hepatitis C virus","level":3,"score":0.4803427457809448},{"id":"https://openalex.org/C2776455275","wikidata":"https://www.wikidata.org/wiki/Q154869","display_name":"Hepatitis C","level":2,"score":0.4763484299182892},{"id":"https://openalex.org/C2780775027","wikidata":"https://www.wikidata.org/wiki/Q17141389","display_name":"Salvage therapy","level":3,"score":0.4655765891075134},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.345161110162735},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.23738697171211243},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.15747284889221191},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.12963390350341797}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.14309/01.ajg.0000869620.63869.d8","doi":"https://doi.org/10.14309/01.ajg.0000869620.63869.d8","is_oa":false,"landing_page_url":"http://dx.doi.org/10.14309/01.ajg.0000869620.63869.d8","pdf_url":null,"source":{"id":"https://openalex.org/S66441642","display_name":"The American Journal of Gastroenterology","issn_l":"0002-9270","issn":["0002-9270","1572-0241"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Gastroenterology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4288068139","https://openalex.org/W4413993824","https://openalex.org/W2790487941","https://openalex.org/W2884728681","https://openalex.org/W3022290796","https://openalex.org/W3163278809","https://openalex.org/W3133598554","https://openalex.org/W2892900463","https://openalex.org/W3011965764","https://openalex.org/W2942541802"],"abstract_inverted_index":{"Introduction:":[0],"Treatment":[1],"of":[2,25,39,59,90,106,121,126,135,143,149,180,184,208,221,260,272,285,300,309,321,336],"patients":[3,151,166,367],"with":[4,47,61,171,340,368],"chronic":[5,29],"hepatitis":[6],"C":[7],"virus":[8],"(HCV)":[9],"who":[10,31],"fail":[11],"to":[12,14,33,54,56,101,174,224,234,311,323,329,360],"respond":[13,55],"Direct":[15],"Acting":[16],"Antivirals":[17],"(DAA)":[18],"remains":[19],"challenging.":[20],"We":[21,98],"present":[22],"a":[23,34,103,118,162,192,305,319,363],"case":[24],"DAA":[26,154,215,278],"treatment":[27,155,246,279,310,352,373],"resistant":[28,69],"HCV":[30,48,150,301],"responded":[32],"prolonged":[35],"1-year":[36],"long":[37],"course":[38,105,142],"antiviral":[40,107],"therapy.":[41,144],"Case":[42],"Description/Methods:":[43],"A":[44,146],"71-year-old":[45],"man":[46],"genotype":[49],"1a":[50],"and":[51,67,115,132,186,253,342,371],"cirrhosis":[52],"failed":[53,205],"multiple":[57,206,369],"courses":[58,77,207],"DAAs":[60,338],"subsequent":[62],"complex":[63],"NS3":[64],"protease":[65],"domain":[66],"NS5B":[68],"associated":[70],"substitutions":[71],"(RAS).":[72],"Among":[73],"his":[74],"previous":[75,372],"salvage":[76,194],"included":[78],"glecaprevir-pibrentasivir-sofosbuvir-ribavirin":[79],"(SOF/G/P)":[80],"for":[81,93,117,188,212,256],"24":[82,88,94,189],"weeks":[83,89,95,190],"(with":[84,96],"relapse)":[85],"followed":[86,110],"by":[87,111],"sofosbuvir-velpatasvir-voxilaprevir-ribavirin":[91],"(SOF/VEL/VOX)":[92],"relapse).":[97],"then":[99],"elected":[100],"initiate":[102],"protracted":[104],"therapy":[108],"SOF/daclatasvir":[109],"SOF/velpatasvir":[112],"(SOF/VEL),":[113],"SOF/G/P,":[114],"SOF/VEL":[116],"total":[119],"duration":[120,259],"56":[122],"weeks.":[123],"Low":[124],"doses":[125,134],"pegylated":[127],"interferon":[128],"(IFN)":[129],"were":[130],"added":[131],"low":[133],"ribavirin":[136,187],"(RBV)":[137],"as":[138,164,344],"tolerated":[139],"throughout":[140],"the":[141,175,178,181,257,270,281,314],"Discussion:":[145],"small":[147],"number":[148],"still":[152],"have":[153],"failures":[156],"or":[157],"breakthroughs,":[158],"which":[159,196],"is":[160,191,264,293,347],"considered":[161],"dilemma":[163],"these":[165],"can":[167,287],"remain":[168],"chronically":[169],"infected":[170],"HCV.":[172],"According":[173],"AASLD":[176],"guidelines":[177],"use":[179],"quad":[182],"regimen":[183],"SOF/G/P":[185],"successful":[193],"regimen,":[195],"our":[197,202],"patient":[198,203,244,249,317],"failed.":[199],"Given":[200],"that":[201,266,296,350],"had":[204],"currently":[209],"recommended":[210],"therapies":[211],"re-treatment":[213],"after":[214,277,332],"failure,":[216,280],"there":[217,263],"was":[218,233,326],"an":[219],"absence":[220],"evidence-based":[222],"options":[223],"guide":[225],"treatment.":[226,261],"Our":[227,316],"goal,":[228],"based":[229],"on":[230,245],"clinical":[231],"judgment,":[232],"achieve":[235,324,330],"long-term":[236],"viral":[237],"suppression":[238],"even":[239],"if":[240],"this":[241],"required":[242],"maintaining":[243],"indefinitely.":[247],"The":[248],"also":[250,294],"took":[251],"IFN":[252,286,343],"RBV":[254,268,341],"intermittently":[255],"entire":[258],"Although":[262],"evidence":[265],"adjuvant":[267],"increases":[269],"rate":[271],"Sustained":[273],"Virologic":[274],"Response":[275],"(SVR)":[276],"potential":[282],"beneficial":[283],"role":[284],"only":[288],"be":[289,358],"speculated":[290],"upon.":[291],"It":[292,346],"possible":[295],"some":[297],"refractory":[298],"cases":[299],"may":[302,357],"simply":[303],"require":[304],"considerably":[306],"longer":[307],"span":[308],"successfully":[312,361],"eliminate":[313],"virus.":[315],"despite":[318],"history":[320],"failing":[322],"SVR,":[325],"finally":[327],"able":[328],"SVR12":[331],"roughly":[333],"13":[334],"months":[335],"continuous":[337],"coupled":[339],"tolerated.":[345],"possible,":[348],"therefore,":[349],"extending":[351],"length":[353],"beyond":[354],"current":[355],"recommendations":[356],"necessary":[359],"induce":[362],"durable":[364],"response":[365],"among":[366],"RASs":[370],"failures.":[374]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2023-01-14T00:00:00"}
