{"id":"https://openalex.org/W4316022650","doi":"https://doi.org/10.1021/acs.nanolett.2c03682","title":"Iron Oxide Nanoparticle-Incorporated Mesenchymal Stem Cells for Alzheimer\u2019s Disease Treatment","display_name":"Iron Oxide Nanoparticle-Incorporated Mesenchymal Stem Cells for Alzheimer\u2019s Disease Treatment","publication_year":2023,"publication_date":"2023-01-13","ids":{"openalex":"https://openalex.org/W4316022650","doi":"https://doi.org/10.1021/acs.nanolett.2c03682","pmid":"https://pubmed.ncbi.nlm.nih.gov/36638236"},"language":"en","primary_location":{"id":"doi:10.1021/acs.nanolett.2c03682","doi":"https://doi.org/10.1021/acs.nanolett.2c03682","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.nanolett.2c03682","pdf_url":null,"source":{"id":"https://openalex.org/S143846845","display_name":"Nano Letters","issn_l":"1530-6984","issn":["1530-6984","1530-6992"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nano Letters","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041548362","display_name":"Mungyo Jung","orcid":"https://orcid.org/0000-0001-9366-9026","observed_orcids":["https://orcid.org/0000-0001-9366-9026"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Mungyo Jung","raw_affiliation_strings":["School of Chemical and Biological Engineering, Seoul National University, Seoul08826, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0001-9366-9026","affiliations":[{"raw_affiliation_string":"School of Chemical and Biological Engineering, Seoul National University, Seoul08826, Republic of Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008662786","display_name":"Hyeongseop Kim","orcid":"https://orcid.org/0000-0001-8546-6472","observed_orcids":["https://orcid.org/0000-0001-8546-6472"]},"institutions":[{"id":"https://openalex.org/I2802194831","display_name":"Samsung Medical Center","ror":"https://ror.org/05a15z872","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2250650973","https://openalex.org/I2802194831"]},{"id":"https://openalex.org/I4405257398","display_name":"ENCell Co., Ltd. (South Korea)","ror":"https://ror.org/057ch1y38","country_code":"KR","type":"company","lineage":["https://openalex.org/I4405257398"]},{"id":"https://openalex.org/I4405260731","display_name":"Research Institute for Future Medicine","ror":"https://ror.org/046j9cm62","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2250650973","https://openalex.org/I2802194831","https://openalex.org/I4405258492","https://openalex.org/I4405260731"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hyeongseop Kim","raw_affiliation_strings":["Cell and Gene Therapy Institute (CGTI), Research Institute for Future Medicine, Samsung Medical Center, Seoul06351, Republic of Korea","Cell and Gene Therapy Institute, ENCell Co., Ltd., Seoul06072, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell and Gene Therapy Institute (CGTI), Research Institute for Future Medicine, Samsung Medical Center, Seoul06351, Republic of Korea","institution_ids":["https://openalex.org/I2802194831","https://openalex.org/I4405260731"]},{"raw_affiliation_string":"Cell and Gene Therapy Institute, ENCell Co., Ltd., Seoul06072, Republic of Korea","institution_ids":["https://openalex.org/I4405257398"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112522329","display_name":"Jung Won Hwang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I848706","display_name":"Sungkyunkwan University","ror":"https://ror.org/04q78tk20","country_code":"KR","type":"education","lineage":["https://openalex.org/I848706"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jung Won Hwang","raw_affiliation_strings":["Department of Health Sciences and Technology, Samsung Advanced Institute for Health Sciences & Technology, Sungkyunkwan University, Seoul06351, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Sciences and Technology, Samsung Advanced Institute for Health Sciences & Technology, Sungkyunkwan University, Seoul06351, Republic of Korea","institution_ids":["https://openalex.org/I848706"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102437616","display_name":"Yejoo Choi","orcid":"https://orcid.org/0000-0001-7580-1089","observed_orcids":["https://orcid.org/0000-0001-7580-1089"]},"institutions":[{"id":"https://openalex.org/I2802194831","display_name":"Samsung Medical Center","ror":"https://ror.org/05a15z872","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2250650973","https://openalex.org/I2802194831"]},{"id":"https://openalex.org/I4405260731","display_name":"Research Institute for Future Medicine","ror":"https://ror.org/046j9cm62","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2250650973","https://openalex.org/I2802194831","https://openalex.org/I4405258492","https://openalex.org/I4405260731"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yejoo Choi","raw_affiliation_strings":["Cell and Gene Therapy Institute (CGTI), Research Institute for Future Medicine, Samsung Medical Center, Seoul06351, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell and Gene Therapy Institute (CGTI), Research Institute for Future Medicine, Samsung Medical Center, Seoul06351, Republic of Korea","institution_ids":["https://openalex.org/I2802194831","https://openalex.org/I4405260731"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044550389","display_name":"Mikyung Kang","orcid":"https://orcid.org/0000-0002-0592-1648","observed_orcids":["https://orcid.org/0000-0002-0592-1648"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Mikyung Kang","raw_affiliation_strings":["Interdisciplinary Program for Bioengineering, Seoul National University, Seoul08826, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Interdisciplinary Program for Bioengineering, Seoul National University, Seoul08826, Republic of Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010311435","display_name":"Cheesue Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Cheesue Kim","raw_affiliation_strings":["School of Chemical and Biological Engineering, Seoul National University, Seoul08826, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemical and Biological Engineering, Seoul National University, Seoul08826, Republic of Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109599649","display_name":"Jihye Hong","orcid":"https://orcid.org/0000-0003-3789-7176","observed_orcids":["https://orcid.org/0000-0003-3789-7176"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jihye Hong","raw_affiliation_strings":["Interdisciplinary Program for Bioengineering, Seoul National University, Seoul08826, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Interdisciplinary Program for Bioengineering, Seoul National University, Seoul08826, Republic of Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013612599","display_name":"Na Kyung Lee","orcid":"https://orcid.org/0000-0001-6116-2562","observed_orcids":["https://orcid.org/0000-0001-6116-2562"]},"institutions":[{"id":"https://openalex.org/I2802194831","display_name":"Samsung Medical Center","ror":"https://ror.org/05a15z872","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2250650973","https://openalex.org/I2802194831"]},{"id":"https://openalex.org/I4405260731","display_name":"Research Institute for Future Medicine","ror":"https://ror.org/046j9cm62","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2250650973","https://openalex.org/I2802194831","https://openalex.org/I4405258492","https://openalex.org/I4405260731"]},{"id":"https://openalex.org/I848706","display_name":"Sungkyunkwan University","ror":"https://ror.org/04q78tk20","country_code":"KR","type":"education","lineage":["https://openalex.org/I848706"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Na Kyung Lee","raw_affiliation_strings":["Alzheimer\u2019s Disease Convergence Research Center, Samsung Medical Center, Seoul06351, Republic of Korea","Cell and Gene Therapy Institute (CGTI), Research Institute for Future Medicine, Samsung Medical Center, Seoul06351, Republic of Korea","School of Medicine, Sungkyunkwan University, Suwon16419, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alzheimer\u2019s Disease Convergence Research Center, Samsung Medical Center, Seoul06351, Republic of Korea","institution_ids":["https://openalex.org/I2802194831"]},{"raw_affiliation_string":"Cell and Gene Therapy Institute (CGTI), Research Institute for Future Medicine, Samsung Medical Center, Seoul06351, Republic of Korea","institution_ids":["https://openalex.org/I2802194831","https://openalex.org/I4405260731"]},{"raw_affiliation_string":"School of Medicine, Sungkyunkwan University, Suwon16419, Republic of Korea","institution_ids":["https://openalex.org/I848706"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089409725","display_name":"Sangjun Moon","orcid":"https://orcid.org/0000-0003-2002-3640","observed_orcids":["https://orcid.org/0000-0003-2002-3640"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sangjun Moon","raw_affiliation_strings":["School of Chemical and Biological Engineering, Seoul National University, Seoul08826, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemical and Biological Engineering, Seoul National University, Seoul08826, Republic of Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048602410","display_name":"Jong Wook Chang","orcid":"https://orcid.org/0000-0001-9335-5510","observed_orcids":["https://orcid.org/0000-0001-9335-5510"]},"institutions":[{"id":"https://openalex.org/I2802194831","display_name":"Samsung Medical Center","ror":"https://ror.org/05a15z872","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2250650973","https://openalex.org/I2802194831"]},{"id":"https://openalex.org/I4405257398","display_name":"ENCell Co., Ltd. (South Korea)","ror":"https://ror.org/057ch1y38","country_code":"KR","type":"company","lineage":["https://openalex.org/I4405257398"]},{"id":"https://openalex.org/I4405260731","display_name":"Research Institute for Future Medicine","ror":"https://ror.org/046j9cm62","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2250650973","https://openalex.org/I2802194831","https://openalex.org/I4405258492","https://openalex.org/I4405260731"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jong Wook Chang","raw_affiliation_strings":["Cell and Gene Therapy Institute (CGTI), Research Institute for Future Medicine, Samsung Medical Center, Seoul06351, Republic of Korea","Cell and Gene Therapy Institute, ENCell Co., Ltd., Seoul06072, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell and Gene Therapy Institute (CGTI), Research Institute for Future Medicine, Samsung Medical Center, Seoul06351, Republic of Korea","institution_ids":["https://openalex.org/I2802194831","https://openalex.org/I4405260731"]},{"raw_affiliation_string":"Cell and Gene Therapy Institute, ENCell Co., Ltd., Seoul06072, Republic of Korea","institution_ids":["https://openalex.org/I4405257398"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010885552","display_name":"Suk\u2010Joo Choi","orcid":"https://orcid.org/0000-0002-8946-4789","observed_orcids":["https://orcid.org/0000-0002-8946-4789"]},"institutions":[{"id":"https://openalex.org/I2802194831","display_name":"Samsung Medical Center","ror":"https://ror.org/05a15z872","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2250650973","https://openalex.org/I2802194831"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Suk-joo Choi","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Samsung Medical Center, Seoul06351, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Samsung Medical Center, Seoul06351, Republic of Korea","institution_ids":["https://openalex.org/I2802194831"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084612463","display_name":"Soo\u2010Young Oh","orcid":"https://orcid.org/0000-0003-3002-0048","observed_orcids":["https://orcid.org/0000-0003-3002-0048"]},"institutions":[{"id":"https://openalex.org/I2802194831","display_name":"Samsung Medical Center","ror":"https://ror.org/05a15z872","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2250650973","https://openalex.org/I2802194831"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Soo-young Oh","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Samsung Medical Center, Seoul06351, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Samsung Medical Center, Seoul06351, Republic of Korea","institution_ids":["https://openalex.org/I2802194831"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072413175","display_name":"Hyemin Jang","orcid":"https://orcid.org/0000-0003-3152-1274","observed_orcids":["https://orcid.org/0000-0003-3152-1274","https://orcid.org/0000-0002-8551-3336"]},"institutions":[{"id":"https://openalex.org/I2802194831","display_name":"Samsung Medical Center","ror":"https://ror.org/05a15z872","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2250650973","https://openalex.org/I2802194831"]},{"id":"https://openalex.org/I848706","display_name":"Sungkyunkwan University","ror":"https://ror.org/04q78tk20","country_code":"KR","type":"education","lineage":["https://openalex.org/I848706"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Hyemin Jang","raw_affiliation_strings":["Alzheimer\u2019s Disease Convergence Research Center, Samsung Medical Center, Seoul06351, Republic of Korea","Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul06351, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alzheimer\u2019s Disease Convergence Research Center, Samsung Medical Center, Seoul06351, Republic of Korea","institution_ids":["https://openalex.org/I2802194831"]},{"raw_affiliation_string":"Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul06351, Republic of Korea","institution_ids":["https://openalex.org/I2802194831","https://openalex.org/I848706"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022350068","display_name":"Duk Lyul Na","orcid":"https://orcid.org/0000-0002-0098-7592","observed_orcids":["https://orcid.org/0000-0002-0098-7592","https://orcid.org/0000-0003-1572-7862"]},"institutions":[{"id":"https://openalex.org/I2802194831","display_name":"Samsung Medical Center","ror":"https://ror.org/05a15z872","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2250650973","https://openalex.org/I2802194831"]},{"id":"https://openalex.org/I4405260731","display_name":"Research Institute for Future Medicine","ror":"https://ror.org/046j9cm62","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2250650973","https://openalex.org/I2802194831","https://openalex.org/I4405258492","https://openalex.org/I4405260731"]},{"id":"https://openalex.org/I848706","display_name":"Sungkyunkwan University","ror":"https://ror.org/04q78tk20","country_code":"KR","type":"education","lineage":["https://openalex.org/I848706"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Duk L. Na","raw_affiliation_strings":["Alzheimer\u2019s Disease Convergence Research Center, Samsung Medical Center, Seoul06351, Republic of Korea","Cell and Gene Therapy Institute (CGTI), Research Institute for Future Medicine, Samsung Medical Center, Seoul06351, Republic of Korea","Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul06351, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alzheimer\u2019s Disease Convergence Research Center, Samsung Medical Center, Seoul06351, Republic of Korea","institution_ids":["https://openalex.org/I2802194831"]},{"raw_affiliation_string":"Cell and Gene Therapy Institute (CGTI), Research Institute for Future Medicine, Samsung Medical Center, Seoul06351, Republic of Korea","institution_ids":["https://openalex.org/I2802194831","https://openalex.org/I4405260731"]},{"raw_affiliation_string":"Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul06351, Republic of Korea","institution_ids":["https://openalex.org/I2802194831","https://openalex.org/I848706"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100642851","display_name":"Byung\u2010Soo Kim","orcid":"https://orcid.org/0000-0001-5210-7430","observed_orcids":["https://orcid.org/0000-0001-5210-7430"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I4405269631","display_name":"Institute of Engineering Research","ror":"https://ror.org/04scsat82","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4405269631"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Byung-Soo Kim","raw_affiliation_strings":["Institute of Chemical Processes, Institute of Engineering Research, and BioMAX, Seoul National\u202fUniversity, Seoul08826, Republic of Korea","Interdisciplinary Program for Bioengineering, Seoul National University, Seoul08826, Republic of Korea","School of Chemical and Biological Engineering, Seoul National University, Seoul08826, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0001-5210-7430","affiliations":[{"raw_affiliation_string":"Institute of Chemical Processes, Institute of Engineering Research, and BioMAX, Seoul National\u202fUniversity, Seoul08826, Republic of Korea","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I4405269631"]},{"raw_affiliation_string":"Interdisciplinary Program for Bioengineering, Seoul National University, Seoul08826, Republic of Korea","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"School of Chemical and Biological Engineering, Seoul National University, Seoul08826, Republic of Korea","institution_ids":["https://openalex.org/I139264467"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5022350068","https://openalex.org/A5072413175","https://openalex.org/A5100642851"],"corresponding_institution_ids":["https://openalex.org/I139264467","https://openalex.org/I2802194831","https://openalex.org/I4405260731","https://openalex.org/I4405269631","https://openalex.org/I848706"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":3.4469,"has_fulltext":false,"cited_by_count":36,"citation_normalized_percentile":{"value":0.94154903,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"23","issue":"2","first_page":"476","last_page":"490"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.007600000128149986,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9959999918937683},{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.9950000047683716},{"id":"https://openalex.org/keywords/iron-oxide-nanoparticles","display_name":"iron oxide nanoparticles","score":1.0},{"id":"https://openalex.org/keywords/magnetic-targeting","display_name":"magnetic targeting","score":0.5180000066757202},{"id":"https://openalex.org/keywords/brain-retention","display_name":"brain retention","score":0.8610000014305115},{"id":"https://openalex.org/keywords/intracerebroventricular-injection","display_name":"intracerebroventricular administration","score":0.9319999814033508},{"id":"https://openalex.org/keywords/neurodegeneration-therapy","display_name":"neurodegeneration therapy","score":0.597000002861023}],"concepts":[{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.8976095914840698},{"id":"https://openalex.org/C102652120","wikidata":"https://www.wikidata.org/wiki/Q2419430","display_name":"Therapeutic effect","level":2,"score":0.6715313196182251},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5703014135360718},{"id":"https://openalex.org/C2778889443","wikidata":"https://www.wikidata.org/wiki/Q6073014","display_name":"Iron oxide nanoparticles","level":3,"score":0.549023449420929},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5191665887832642},{"id":"https://openalex.org/C2778384578","wikidata":"https://www.wikidata.org/wiki/Q16930687","display_name":"Therapeutic approach","level":3,"score":0.4858796000480652},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.46716248989105225},{"id":"https://openalex.org/C2779389132","wikidata":"https://www.wikidata.org/wiki/Q1533033","display_name":"Stem-cell therapy","level":3,"score":0.41036534309387207},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3977956175804138},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3214417099952698},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.21873095631599426},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2055342197418213},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17712774872779846},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.16519001126289368},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.14821085333824158},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.11652177572250366},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.11154711246490479}],"mesh":[{"descriptor_ui":"D000082662","descriptor_name":"Magnetic Iron Oxide Nanoparticles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019636","descriptor_name":"Neurodegenerative Diseases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059631","descriptor_name":"Wharton Jelly","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1021/acs.nanolett.2c03682","doi":"https://doi.org/10.1021/acs.nanolett.2c03682","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.nanolett.2c03682","pdf_url":null,"source":{"id":"https://openalex.org/S143846845","display_name":"Nano Letters","issn_l":"1530-6984","issn":["1530-6984","1530-6992"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nano Letters","raw_type":"journal-article"},{"id":"pmid:36638236","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36638236","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nano letters","raw_type":"Journal Article"},{"id":"pmh:oai:s-space.snu.ac.kr:10371/204224","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/10371/204224","pdf_url":null,"source":{"id":"https://openalex.org/S4306401345","display_name":"Seoul National University Open Repository (Seoul National University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139264467","host_organization_name":"Seoul National University","host_organization_lineage":["https://openalex.org/I139264467"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9922999739646912,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5159547475","display_name":null,"funder_award_id":"2019M3A9H1103651","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"}],"funders":[{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W200270092","https://openalex.org/W945277090","https://openalex.org/W1555936968","https://openalex.org/W2031977308","https://openalex.org/W2035176325","https://openalex.org/W2044987522","https://openalex.org/W2053288363","https://openalex.org/W2069893872","https://openalex.org/W2070991505","https://openalex.org/W2080415606","https://openalex.org/W2087353148","https://openalex.org/W2094330253","https://openalex.org/W2095066614","https://openalex.org/W2147180300","https://openalex.org/W2162070793","https://openalex.org/W2286229663","https://openalex.org/W2473005831","https://openalex.org/W2510806376","https://openalex.org/W2514727659","https://openalex.org/W2569051176","https://openalex.org/W2633207270","https://openalex.org/W2753285917","https://openalex.org/W2767913857","https://openalex.org/W2784733460","https://openalex.org/W2825453881","https://openalex.org/W2891312833","https://openalex.org/W2897996477","https://openalex.org/W2907547898","https://openalex.org/W2941661312","https://openalex.org/W2954290075","https://openalex.org/W2981027275","https://openalex.org/W2992558303","https://openalex.org/W3001124525","https://openalex.org/W3005481968","https://openalex.org/W3008251217","https://openalex.org/W3022592110","https://openalex.org/W3023935082","https://openalex.org/W3046677722","https://openalex.org/W3097527510","https://openalex.org/W3149181054","https://openalex.org/W3185034576","https://openalex.org/W3191692701","https://openalex.org/W3197035705","https://openalex.org/W4200169630","https://openalex.org/W4211016192","https://openalex.org/W4211036635","https://openalex.org/W4213065543","https://openalex.org/W4214625520","https://openalex.org/W4308188368"],"related_works":["https://openalex.org/W4200426327","https://openalex.org/W3008251217","https://openalex.org/W4402253379","https://openalex.org/W4297323816","https://openalex.org/W2532587591","https://openalex.org/W4302291043","https://openalex.org/W2515283883","https://openalex.org/W2360077602","https://openalex.org/W3046677722","https://openalex.org/W3038122116"],"abstract_inverted_index":{"Alzheimer's":[0],"disease":[1,6],"(AD)":[2],"is":[3],"a":[4,18,45,101],"neurodegenerative":[5],"with":[7],"multifactorial":[8],"pathogenesis.":[9],"However,":[10,48],"most":[11],"current":[12],"therapeutic":[13,26,59,71,91,112,130],"approaches":[14],"for":[15,147,151],"AD":[16,66,139],"target":[17],"single":[19],"pathophysiological":[20],"mechanism,":[21],"generally":[22],"resulting":[23],"in":[24,94,116,137],"unsatisfactory":[25],"outcomes.":[27],"Recently,":[28],"mesenchymal":[29],"stem":[30],"cell":[31],"(MSC)":[32],"therapy,":[33],"which":[34],"targets":[35],"multiple":[36],"pathological":[37],"mechanisms":[38],"of":[39,54,114,119,134],"AD,":[40],"has":[41],"been":[42],"explored":[43],"as":[44],"novel":[46],"treatment.":[47],"the":[49,111,145],"low":[50],"brain":[51,103],"retention":[52,104],"efficiency":[53,105],"administered":[55],"MSCs":[56,64,87,115,126,136],"limits":[57],"their":[58],"efficacy.":[60],"In":[61],"addition,":[62],"autologous":[63,135],"from":[65],"patients":[67],"may":[68,127,143],"have":[69],"poor":[70],"abilities.":[72],"Here,":[73],"we":[74],"overcome":[75],"these":[76],"limitations":[77],"by":[78],"developing":[79,148],"iron":[80],"oxide":[81],"nanoparticle":[82],"(IONP)-incorporated":[83],"human":[84,122],"Wharton's":[85,123],"jelly-derived":[86,124],"(MSC-IONPs).":[88],"IONPs":[89],"promote":[90],"molecule":[92],"expression":[93],"MSCs.":[95],"Following":[96],"intracerebroventricular":[97],"injection,":[98],"MSC-IONPs":[99],"showed":[100],"higher":[102,129],"under":[106],"magnetic":[107],"guidance.":[108],"This":[109,141],"potentiates":[110],"efficacy":[113],"murine":[117],"models":[118],"AD.":[120,152],"Furthermore,":[121],"allogeneic":[125],"exhibit":[128],"abilities":[131],"than":[132],"those":[133],"aged":[138],"patients.":[140],"strategy":[142],"pave":[144],"way":[146],"MSC":[149],"therapies":[150]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":6}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2023-01-14T00:00:00"}