{"id":"https://openalex.org/W4315928366","doi":"https://doi.org/10.1016/j.ebiom.2022.104432","title":"Mitochondrial related genome-wide Mendelian randomization identifies putatively causal genes for multiple cancer types","display_name":"Mitochondrial related genome-wide Mendelian randomization identifies putatively causal genes for multiple cancer types","publication_year":2023,"publication_date":"2023-01-10","ids":{"openalex":"https://openalex.org/W4315928366","doi":"https://doi.org/10.1016/j.ebiom.2022.104432","pmid":"https://pubmed.ncbi.nlm.nih.gov/36634566","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9841346"},"language":"en","primary_location":{"id":"doi:10.1016/j.ebiom.2022.104432","doi":"https://doi.org/10.1016/j.ebiom.2022.104432","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ebiom.2022.104432","pdf_url":null,"source":{"id":"https://openalex.org/S2531685872","display_name":"EBioMedicine","issn_l":"2352-3964","issn":["2352-3964"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eBioMedicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.ebiom.2022.104432","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100747563","display_name":"Yanni Li","orcid":"https://orcid.org/0000-0003-4550-8935","observed_orcids":["https://orcid.org/0000-0003-4550-8935"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Yanni Li","raw_affiliation_strings":["Center for Primary Health Care Research, Lund University/Region Sk\u00e5ne, Malm\u00f6, Sweden. Electronic address: yanni.li@med.lu.se"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Primary Health Care Research, Lund University/Region Sk\u00e5ne, Malm\u00f6, Sweden. Electronic address: yanni.li@med.lu.se","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087981165","display_name":"Kristina Sundquist","orcid":"https://orcid.org/0000-0001-8031-279X","observed_orcids":["https://orcid.org/0000-0001-8031-279X","https://orcid.org/0000-0002-5923-0092"]},"institutions":[{"id":"https://openalex.org/I169016828","display_name":"Shimane University","ror":"https://ror.org/01jaaym28","country_code":"JP","type":"education","lineage":["https://openalex.org/I169016828"]},{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]},{"id":"https://openalex.org/I4210146096","display_name":"Region Sk\u00e5ne","ror":"https://ror.org/03sawy356","country_code":"SE","type":"government","lineage":["https://openalex.org/I4210146096"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["JP","SE","US"],"is_corresponding":false,"raw_author_name":"Kristina Sundquist","raw_affiliation_strings":["Center for Primary Health Care Research, Lund University/Region Sk\u00e5ne, Malm\u00f6, Sweden; Department of Family Medicine and Community Health, Icahn School of Medicine at Mount Sinai, New York, United States; Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, United States; Center for Community-Based Healthcare Research and Education (CoHRE), Department of Functional Pathology, School of Medicine, Shimane University, Matsue, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Primary Health Care Research, Lund University/Region Sk\u00e5ne, Malm\u00f6, Sweden; Department of Family Medicine and Community Health, Icahn School of Medicine at Mount Sinai, New York, United States; Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, United States; Center for Community-Based Healthcare Research and Education (CoHRE), Department of Functional Pathology, School of Medicine, Shimane University, Matsue, Japan","institution_ids":["https://openalex.org/I169016828","https://openalex.org/I187531555","https://openalex.org/I4210146096","https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008452554","display_name":"Naiqi Zhang","orcid":"https://orcid.org/0000-0002-0668-7822","observed_orcids":["https://orcid.org/0000-0002-0668-7822"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]},{"id":"https://openalex.org/I4210146096","display_name":"Region Sk\u00e5ne","ror":"https://ror.org/03sawy356","country_code":"SE","type":"government","lineage":["https://openalex.org/I4210146096"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Naiqi Zhang","raw_affiliation_strings":["Center for Primary Health Care Research, Lund University/Region Sk\u00e5ne, Malm\u00f6, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Primary Health Care Research, Lund University/Region Sk\u00e5ne, Malm\u00f6, Sweden","institution_ids":["https://openalex.org/I187531555","https://openalex.org/I4210146096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100411526","display_name":"Xiao Wang","orcid":"https://orcid.org/0000-0003-3285-226X","observed_orcids":["https://orcid.org/0000-0003-3285-226X"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]},{"id":"https://openalex.org/I4210146096","display_name":"Region Sk\u00e5ne","ror":"https://ror.org/03sawy356","country_code":"SE","type":"government","lineage":["https://openalex.org/I4210146096"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Xiao Wang","raw_affiliation_strings":["Center for Primary Health Care Research, Lund University/Region Sk\u00e5ne, Malm\u00f6, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Primary Health Care Research, Lund University/Region Sk\u00e5ne, Malm\u00f6, Sweden","institution_ids":["https://openalex.org/I187531555","https://openalex.org/I4210146096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084812194","display_name":"Jan Sundquist","orcid":"https://orcid.org/0000-0001-7228-5015","observed_orcids":["https://orcid.org/0000-0001-7228-5015"]},"institutions":[{"id":"https://openalex.org/I169016828","display_name":"Shimane University","ror":"https://ror.org/01jaaym28","country_code":"JP","type":"education","lineage":["https://openalex.org/I169016828"]},{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]},{"id":"https://openalex.org/I4210146096","display_name":"Region Sk\u00e5ne","ror":"https://ror.org/03sawy356","country_code":"SE","type":"government","lineage":["https://openalex.org/I4210146096"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["JP","SE","US"],"is_corresponding":false,"raw_author_name":"Jan Sundquist","raw_affiliation_strings":["Center for Primary Health Care Research, Lund University/Region Sk\u00e5ne, Malm\u00f6, Sweden; Department of Family Medicine and Community Health, Icahn School of Medicine at Mount Sinai, New York, United States; Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, United States; Center for Community-Based Healthcare Research and Education (CoHRE), Department of Functional Pathology, School of Medicine, Shimane University, Matsue, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Primary Health Care Research, Lund University/Region Sk\u00e5ne, Malm\u00f6, Sweden; Department of Family Medicine and Community Health, Icahn School of Medicine at Mount Sinai, New York, United States; Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, United States; Center for Community-Based Healthcare Research and Education (CoHRE), Department of Functional Pathology, School of Medicine, Shimane University, Matsue, Japan","institution_ids":["https://openalex.org/I169016828","https://openalex.org/I187531555","https://openalex.org/I4210146096","https://openalex.org/I98704320"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008079107","display_name":"Ashfaque Ahmed Memon","orcid":"https://orcid.org/0000-0002-1081-3553","observed_orcids":["https://orcid.org/0000-0002-1081-3553"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]},{"id":"https://openalex.org/I4210146096","display_name":"Region Sk\u00e5ne","ror":"https://ror.org/03sawy356","country_code":"SE","type":"government","lineage":["https://openalex.org/I4210146096"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Ashfaque A. Memon","raw_affiliation_strings":["Center for Primary Health Care Research, Lund University/Region Sk\u00e5ne, Malm\u00f6, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Primary Health Care Research, Lund University/Region Sk\u00e5ne, Malm\u00f6, Sweden","institution_ids":["https://openalex.org/I187531555","https://openalex.org/I4210146096"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5100747563"],"corresponding_institution_ids":["https://openalex.org/I187531555"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":{"value":5000,"currency":"USD","value_usd":5000},"fwci":14.8533,"has_fulltext":true,"cited_by_count":123,"citation_normalized_percentile":{"value":0.99590164,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"88","issue":null,"first_page":"104432","last_page":"104432"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cancer-etiology","display_name":"cancer etiology","score":0.6639999747276306},{"id":"https://openalex.org/keywords/mitochondrial-related-genes","display_name":"mitochondrial-related genes","score":0.7689999938011169},{"id":"https://openalex.org/keywords/cancer-risk-genes","display_name":"cancer risk genes","score":0.527999997138977},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8399999737739563},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.9990000128746033},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":1.0},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.890999972820282},{"id":"https://openalex.org/keywords/expression-quantitative-trait-loci","display_name":"expression quantitative trait loci","score":0.9380000233650208},{"id":"https://openalex.org/keywords/colocalization","display_name":"colocalization","score":0.7250000238418579}],"concepts":[{"id":"https://openalex.org/C2779901538","wikidata":"https://www.wikidata.org/wiki/Q6816584","display_name":"Mendelian randomization","level":5,"score":0.8611393570899963},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5983314514160156},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5836940407752991},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.5217741131782532},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5190354585647583},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.5018010139465332},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4950543940067291},{"id":"https://openalex.org/C168393362","wikidata":"https://www.wikidata.org/wiki/Q5421706","display_name":"Expression quantitative trait loci","level":5,"score":0.4934054911136627},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.34392595291137695},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3438261151313782},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.29998743534088135},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2556701898574829},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.2432851791381836},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.2403123676776886},{"id":"https://openalex.org/C2993967602","wikidata":"https://www.wikidata.org/wiki/Q5532932","display_name":"Genetic variants","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006680","descriptor_name":"HLA Antigens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008780","descriptor_name":"Methyltransferases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014637","descriptor_name":"Valine-tRNA Ligase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D057182","descriptor_name":"Mendelian Randomization Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1016/j.ebiom.2022.104432","doi":"https://doi.org/10.1016/j.ebiom.2022.104432","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ebiom.2022.104432","pdf_url":null,"source":{"id":"https://openalex.org/S2531685872","display_name":"EBioMedicine","issn_l":"2352-3964","issn":["2352-3964"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eBioMedicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9841346","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9841346","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9841346/pdf/main.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eBioMedicine","raw_type":"Text"},{"id":"pmid:36634566","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36634566","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EBioMedicine","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:4d91f962a85d47ca894e7de6cfe3357d","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/4d91f962a85d47ca894e7de6cfe3357d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"EBioMedicine, Vol 88, Iss , Pp 104432- (2023)","raw_type":"article"},{"id":"pmh:oai:lup.lub.lu.se:1bc85b10-9df0-4b9d-9456-16cd9fc30718","doi":null,"is_oa":false,"landing_page_url":"https://lup.lub.lu.se/record/1bc85b10-9df0-4b9d-9456-16cd9fc30718","pdf_url":null,"source":{"id":"https://openalex.org/S4306400536","display_name":"Lund University Publications (Lund University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187531555","host_organization_name":"Lund University","host_organization_lineage":["https://openalex.org/I187531555"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 2352-3964","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1016/j.ebiom.2022.104432","doi":"https://doi.org/10.1016/j.ebiom.2022.104432","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ebiom.2022.104432","pdf_url":null,"source":{"id":"https://openalex.org/S2531685872","display_name":"EBioMedicine","issn_l":"2352-3964","issn":["2352-3964"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eBioMedicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G5318913912","display_name":null,"funder_award_id":"20211025","funder_id":"https://openalex.org/F4320325969","funder_display_name":"Allm\u00e4nna Sjukhusets i Malm\u00f6 Stiftelse f\u00f6r Bek\u00e4mpande av Cancer"}],"funders":[{"id":"https://openalex.org/F4320325969","display_name":"Allm\u00e4nna Sjukhusets i Malm\u00f6 Stiftelse f\u00f6r Bek\u00e4mpande av Cancer","ror":"https://ror.org/013pz4p34"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4315928366.pdf","grobid_xml":"https://content.openalex.org/works/W4315928366.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W1970005961","https://openalex.org/W1976436265","https://openalex.org/W1995231897","https://openalex.org/W2002252224","https://openalex.org/W2043069015","https://openalex.org/W2071539626","https://openalex.org/W2072583347","https://openalex.org/W2073836327","https://openalex.org/W2076130356","https://openalex.org/W2089556958","https://openalex.org/W2095714633","https://openalex.org/W2124457156","https://openalex.org/W2328393125","https://openalex.org/W2490528887","https://openalex.org/W2504181072","https://openalex.org/W2566116513","https://openalex.org/W2755094575","https://openalex.org/W2781506163","https://openalex.org/W2818417770","https://openalex.org/W2885870007","https://openalex.org/W2886245587","https://openalex.org/W2915365125","https://openalex.org/W2923797470","https://openalex.org/W2949437525","https://openalex.org/W2955177623","https://openalex.org/W2969996045","https://openalex.org/W2972351576","https://openalex.org/W3011893120","https://openalex.org/W3014637928","https://openalex.org/W3093451235","https://openalex.org/W3106539179","https://openalex.org/W3132095850","https://openalex.org/W3196871669","https://openalex.org/W3197364483","https://openalex.org/W3199145762","https://openalex.org/W4224062295","https://openalex.org/W4283723802","https://openalex.org/W4297093005","https://openalex.org/W6841335303"],"related_works":["https://openalex.org/W4409870479","https://openalex.org/W4390342912","https://openalex.org/W4404111409","https://openalex.org/W4388741951","https://openalex.org/W7052350263","https://openalex.org/W2092367330","https://openalex.org/W4402029628","https://openalex.org/W4393197248","https://openalex.org/W7125698464","https://openalex.org/W4412615740"],"abstract_inverted_index":{"BACKGROUND:":[0],"Mitochondrial":[1],"dysfunction":[2,34,191],"is":[3,10,14],"a":[4,15],"hallmark":[5],"of":[6,17,32,73,155,189,206],"cancer.":[7,18],"However,":[8],"it":[9,13],"unclear":[11],"whether":[12],"cause":[16],"This":[19,181,214],"two-sample":[20],"Mendelian":[21],"randomization":[22],"(MR)":[23],"analyses,":[24],"uses":[25],"genetic":[26],"instruments":[27],"to":[28,84,127,147],"proxy":[29],"the":[30,85,95,129,151,186,204],"exposure":[31],"mitochondrial":[33,96,138,190],"and":[35,58,66,91,104,141,168,172],"cancer":[36,142,170,178,211,229],"summary":[37],"statistics":[38,47],"as":[39,101,124],"outcomes,":[40],"allowing":[41],"for":[42,135,210],"causal":[43,106,187],"inferences.":[44],"METHODS:":[45],"Summary":[46],"from":[48],"18":[49],"common":[50],"cancers":[51,109],"(2107-491,974":[52],"participants),":[53],"gene":[54],"expression,":[55],"DNA":[56],"methylation":[57,163,174],"protein":[59],"expression":[60],"quantitative":[61],"trait":[62],"loci":[63,144],"(eQTL,":[64],"mQTL":[65],"pQTL,":[67],"respectively,":[68],"1000-31,684":[69],"participants)":[70],"on":[71,158],"individuals":[72],"European":[74],"ancestry,":[75],"were":[76,99,110,122],"included.":[77],"Genetic":[78],"variants":[79,157],"located":[80],"within":[81],"or":[82],"close":[83],"1136":[86],"mitochondrial-related":[87],"genes":[88,200],"(in":[89],"cis)":[90],"robustly":[92],"associated":[93],"with":[94,108,165,176],"molecular":[97,139],"alterations":[98],"used":[100,123],"instrumental":[102],"variables,":[103],"their":[105],"associations":[107],"examined":[111],"using":[112],"summary-data-based":[113],"MR":[114,120,183],"(SMR)":[115],"analyses.":[116],"An":[117],"additional":[118],"five":[119],"methods":[121],"sensitivity":[125],"analyses":[126],"confirm":[128],"casual":[130],"associations.":[131],"A":[132],"Bayesian":[133],"test":[134],"colocalization":[136],"between":[137],"QTLs":[140],"risk":[143,156],"was":[145,216],"performed":[146],"provide":[148],"insights":[149],"into":[150],"potential":[152,207],"regulatory":[153],"mechanisms":[154],"cancers.":[159,194],"FINDINGS:":[160],"),":[161],"NSUN4":[162],"level":[164,175],"both":[166],"breast":[167],"prostate":[169],"risk,":[171],"VARS2":[173],"lung":[177],"risk.":[179],"INTERPRETATIONS:":[180],"data-driven":[182],"study":[184,197],"demonstrated":[185],"role":[188],"in":[192],"multiple":[193],"Furthermore,":[195],"this":[196],"identified":[198],"candidate":[199],"that":[201],"can":[202],"be":[203],"targets":[205],"pharmacological":[208],"agents":[209],"prevention.":[212],"FUNDING:":[213],"work":[215],"supported":[217],"by":[218],"Styrelsen":[219],"f\u00f6r":[220,226],"Allm\u00e4nna":[221],"Sjukhusets":[222],"i":[223],"Malm\u00f6":[224],"Stiftelse":[225],"bek\u00e4mpande":[227],"av":[228],"(20211025).":[230]},"counts_by_year":[{"year":2026,"cited_by_count":34},{"year":2025,"cited_by_count":49},{"year":2024,"cited_by_count":37},{"year":2023,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2023-01-14T00:00:00"}
