{"id":"https://openalex.org/W4315784643","doi":"https://doi.org/10.33667/2078-5631-2022-31-7-14","title":"Pharmacotherapy regimens for patients with hormone-receptor positive (HR+), human epidermal growth factor 2 negative (HER2\u2013) metastatic breast cancer in routine clinical practice (results of non-interventional retrospective study)","display_name":"Pharmacotherapy regimens for patients with hormone-receptor positive (HR+), human epidermal growth factor 2 negative (HER2\u2013) metastatic breast cancer in routine clinical practice (results of non-interventional retrospective study)","publication_year":2023,"publication_date":"2023-01-11","ids":{"openalex":"https://openalex.org/W4315784643","doi":"https://doi.org/10.33667/2078-5631-2022-31-7-14"},"language":"en","primary_location":{"id":"doi:10.33667/2078-5631-2022-31-7-14","doi":"https://doi.org/10.33667/2078-5631-2022-31-7-14","is_oa":true,"landing_page_url":"https://doi.org/10.33667/2078-5631-2022-31-7-14","pdf_url":"https://www.med-alphabet.com/jour/article/download/2927/2538","source":{"id":"https://openalex.org/S4210210161","display_name":"Medical alphabet","issn_l":"2078-5631","issn":["2078-5631","2949-2807"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["russia-white-list-2"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical alphabet","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.med-alphabet.com/jour/article/download/2927/2538","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080531855","display_name":"\u0410. \u0412. \u0421\u0443\u043b\u0442\u0430\u043d\u0431\u0430\u0435\u0432","orcid":"https://orcid.org/0000-0003-0996-5995","observed_orcids":["https://orcid.org/0000-0003-0996-5995"]},"institutions":[{"id":"https://openalex.org/I4210124327","display_name":"Republican Oncological Clinical Dispensary","ror":"https://ror.org/0244v0536","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I4210124327"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"A. V. Sultanbaev","raw_affiliation_strings":["Republican Clinical Oncological Dispensary"],"raw_orcid":"https://orcid.org/0000-0003-0996-5995","affiliations":[{"raw_affiliation_string":"Republican Clinical Oncological Dispensary","institution_ids":["https://openalex.org/I4210124327"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114040398","display_name":"R. I. Fatyhov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210112656","display_name":"N.V. Sklifosovsky Research Institute of Emergency Medicine","ror":"https://ror.org/024s37521","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I4210112656"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"R. I. Fatyhov","raw_affiliation_strings":["Scientific Research Institute of Emergency Medicine n.a. N.V. Sklifosovsky"],"raw_orcid":"https://orcid.org/0000-0002-7322-8853","affiliations":[{"raw_affiliation_string":"Scientific Research Institute of Emergency Medicine n.a. N.V. Sklifosovsky","institution_ids":["https://openalex.org/I4210112656"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079898795","display_name":"O. A. Gladkov","orcid":"https://orcid.org/0000-0003-1367-2079","observed_orcids":["https://orcid.org/0000-0003-1367-2079"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"O. A. Gladkov","raw_affiliation_strings":["Evimed Co"],"raw_orcid":"https://orcid.org/0000-0003-1367-2079","affiliations":[{"raw_affiliation_string":"Evimed Co","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062080308","display_name":"Mikhail Vladimirovich Dvorkin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. V. Dvorkin","raw_affiliation_strings":["Clinical Oncological Dispensary of the Omsk Region"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Oncological Dispensary of the Omsk Region","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022474386","display_name":"E. P. Solovieva","orcid":"https://orcid.org/0000-0002-1224-8105","observed_orcids":["https://orcid.org/0000-0002-1224-8105"]},"institutions":[{"id":"https://openalex.org/I4210141308","display_name":"Arkhangel'skiy Klinicheskiy Onkologicheskiy Dispanser","ror":"https://ror.org/04cmvex31","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I4210141308"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"E. P. Solovieva","raw_affiliation_strings":["Arkhangelsk Clinical Oncology Centre"],"raw_orcid":"https://orcid.org/0000-0002-1224-8105","affiliations":[{"raw_affiliation_string":"Arkhangelsk Clinical Oncology Centre","institution_ids":["https://openalex.org/I4210141308"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090599068","display_name":"\u0427\u0435\u043f\u043e\u0440\u043e\u0432 \u0421\u0435\u0440\u0433\u0435\u0439 \u0412\u0430\u043b\u0435\u043d\u0442\u0438\u043d\u043e\u0432\u0438\u0447","orcid":"https://orcid.org/0000-0003-2776-4994","observed_orcids":["https://orcid.org/0000-0003-2776-4994"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. V. Cheporov","raw_affiliation_strings":["Regional Clinical Oncology Hospital"],"raw_orcid":"https://orcid.org/0000-0003-2776-4994","affiliations":[{"raw_affiliation_string":"Regional Clinical Oncology Hospital","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082405419","display_name":"Alexey Loleit","orcid":"https://orcid.org/0000-0001-8328-9839","observed_orcids":["https://orcid.org/0000-0001-8328-9839"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. S. Loleit","raw_affiliation_strings":["Data Matrix Co"],"raw_orcid":"https://orcid.org/0000-0001-8328-9839","affiliations":[{"raw_affiliation_string":"Data Matrix Co","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079101955","display_name":"\u0420\u0443\u0437\u0430\u0432\u0438\u043d\u0430 \u0415\u043b\u0435\u043d\u0430 \u0418\u0433\u043e\u0440\u0435\u0432\u043d\u0430","orcid":"https://orcid.org/0000-0001-6265-0509","observed_orcids":["https://orcid.org/0000-0001-6265-0509"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E. I. Ruzavina","raw_affiliation_strings":["Novartis Pharma Co"],"raw_orcid":"https://orcid.org/0000-0001-6265-0509","affiliations":[{"raw_affiliation_string":"Novartis Pharma Co","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2406,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.47422543,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":95},"biblio":{"volume":null,"issue":"31","first_page":"7","last_page":"14"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12829","display_name":"Advanced Breast Cancer Therapies","score":0.6195999979972839,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12829","display_name":"Advanced Breast Cancer Therapies","score":0.6195999979972839,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.3677000105381012,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hormone-receptor-positive-breast-cancer","display_name":"hormone receptor-positive breast cancer","score":0.7670000195503235},{"id":"https://openalex.org/keywords/her2-negative-metastatic-breast-cancer","display_name":"HER2-negative metastatic breast cancer","score":0.9200000166893005},{"id":"https://openalex.org/keywords/endocrine-resistance","display_name":"endocrine therapy resistance","score":0.7829999923706055},{"id":"https://openalex.org/keywords/aromatase-inhibitors","display_name":"aromatase inhibitors","score":0.9480000138282776},{"id":"https://openalex.org/keywords/antiestrogens","display_name":"antiestrogens","score":0.7910000085830688},{"id":"https://openalex.org/keywords/taxanes","display_name":"taxanes","score":0.6769999861717224},{"id":"https://openalex.org/keywords/pyrimidine-analogs","display_name":"pyrimidine analogues","score":0.6610000133514404},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.7720000147819519},{"id":"https://openalex.org/keywords/pik3ca-mutation","display_name":"PIK3CA mutation","score":0.7559999823570251},{"id":"https://openalex.org/keywords/ki-67-proliferation-index","display_name":"Ki-67 proliferation index","score":0.8600000143051147},{"id":"https://openalex.org/keywords/visceral-crisis","display_name":"visceral crisis","score":0.9739999771118164},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"artificial intelligence","score":0.492000013589859},{"id":"https://openalex.org/keywords/routine-clinical-practice","display_name":"routine clinical practice","score":0.718999981880188},{"id":"https://openalex.org/keywords/russia","display_name":"Russia","score":0.7570000290870667}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8346179723739624},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.680072009563446},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6288386583328247},{"id":"https://openalex.org/C2775930923","wikidata":"https://www.wikidata.org/wiki/Q12859063","display_name":"Metastatic breast cancer","level":4,"score":0.5922946929931641},{"id":"https://openalex.org/C500440147","wikidata":"https://www.wikidata.org/wiki/Q701216","display_name":"Pharmacotherapy","level":2,"score":0.5860171914100647},{"id":"https://openalex.org/C185926286","wikidata":"https://www.wikidata.org/wiki/Q1929812","display_name":"Systemic therapy","level":4,"score":0.571376383304596},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5678586959838867},{"id":"https://openalex.org/C2780275930","wikidata":"https://www.wikidata.org/wiki/Q1628266","display_name":"Hormone therapy","level":4,"score":0.5625790357589722},{"id":"https://openalex.org/C195910791","wikidata":"https://www.wikidata.org/wiki/Q1324077","display_name":"Medical record","level":2,"score":0.561147153377533},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5328106880187988},{"id":"https://openalex.org/C2778311097","wikidata":"https://www.wikidata.org/wiki/Q5903784","display_name":"Hormonal therapy","level":4,"score":0.5155677795410156},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.47461143136024475},{"id":"https://openalex.org/C2776999253","wikidata":"https://www.wikidata.org/wiki/Q1304270","display_name":"Combination therapy","level":2,"score":0.4226210117340088},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.41016319394111633}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.33667/2078-5631-2022-31-7-14","doi":"https://doi.org/10.33667/2078-5631-2022-31-7-14","is_oa":true,"landing_page_url":"https://doi.org/10.33667/2078-5631-2022-31-7-14","pdf_url":"https://www.med-alphabet.com/jour/article/download/2927/2538","source":{"id":"https://openalex.org/S4210210161","display_name":"Medical alphabet","issn_l":"2078-5631","issn":["2078-5631","2949-2807"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["russia-white-list-2"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical alphabet","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.33667/2078-5631-2022-31-7-14","doi":"https://doi.org/10.33667/2078-5631-2022-31-7-14","is_oa":true,"landing_page_url":"https://doi.org/10.33667/2078-5631-2022-31-7-14","pdf_url":"https://www.med-alphabet.com/jour/article/download/2927/2538","source":{"id":"https://openalex.org/S4210210161","display_name":"Medical alphabet","issn_l":"2078-5631","issn":["2078-5631","2949-2807"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["russia-white-list-2"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical alphabet","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320332736","display_name":"Novartis Pharma","ror":"https://ror.org/0013shd50"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4315784643.pdf","grobid_xml":"https://content.openalex.org/works/W4315784643.grobid-xml"},"referenced_works_count":8,"referenced_works":["https://openalex.org/W2988134040","https://openalex.org/W3088509668","https://openalex.org/W3120809037","https://openalex.org/W3207557929","https://openalex.org/W4211005384","https://openalex.org/W4220673086","https://openalex.org/W4225161593","https://openalex.org/W4225914759"],"related_works":["https://openalex.org/W2246553394","https://openalex.org/W2023769778","https://openalex.org/W4408207197","https://openalex.org/W3165252948","https://openalex.org/W2594807981","https://openalex.org/W4411286966","https://openalex.org/W2765167427","https://openalex.org/W2944603650","https://openalex.org/W2131106781","https://openalex.org/W4396586984"],"abstract_inverted_index":{"Background":[0],".":[1,54,78],"Analysis":[2],"of":[3,6,21,26,31,50,56,82,96,113,134,140,152,157,170,187,230,244,256,294,353,375,386,394,396,419],"the":[4,17,24,74,97,111,132,150,155,168,181,185,226,231,314,317,341,345,350,376,383,391,427,439,452,463],"sequence":[5],"HR+":[7,66,201],"HER2\u2013":[8,67,202],"mBC":[9,68,86],"therapy":[10,58,87,118,145,148,267,287,336,421,442],"in":[11,62,69,73,88,92,180,219,239,401,408,412,422,426,433,438],"routine":[12,70,89,402,409],"practice":[13,72,91,411],"is":[14],"important":[15],"for":[16,390],"assessment":[18],"and":[19,45,60,161,184,254,281,328,349,365,424,436,456],"optimization":[20],"approaches":[22],"to":[23,43,123,130,163,248],"treatment":[25,291],"breast":[27,215,399],"cancer.":[28],"Automatic":[29],"analysis":[30,193,393],"electronic":[32],"medical":[33],"records":[34],"(EMR)":[35],"using":[36,102,387,465],"artificial":[37,466],"intelligence":[38],"technology":[39,389],"makes":[40],"it":[41],"possible":[42,457],"collect":[44],"analyze":[46],"a":[47,188],"large":[48],"array":[49],"patient":[51,206],"data.":[52],"Purpose":[53],"Study":[55],"drug":[57,117],"regimens":[59],"schemes":[61],"female":[63],"patients":[64,83,114,135,158,198,245,257,264,271,277,284,397],"with":[65,159,200,323,356,362,398,451],"clinical":[71,90,410],"Russian":[75,98],"Federation.":[76],"Methods":[77],"The":[79,106,192,204,223,261,289,359,380,404,445],"retrospective":[80,392,453],"data":[81,107,195,395,461],"who":[84,115,136],"received":[85,116,137,265,272,278,285],"eight":[93],"healthcare":[94],"facilities":[95],"Federation":[99],"was":[100,208,217,237,382],"extracted":[101],"machine":[103],"learning":[104],"methods.":[105],"were":[108,225,246,251,320,369,431],"obtained":[109],"from":[110,119,196,462],"EMRs":[112],"February":[120],"1,":[121],"2018":[122],"May":[124],"31,":[125],"2021.":[126],"Main":[127],"study":[128,381,405,454],"objectives:":[129],"determine":[131],"proportion":[133,156],"various":[138],"types":[139],"pharmacotherapies":[141],"(chemotherapy":[142],"[CT],":[143],"hormone":[144,420],"[HT],":[146],"targeted":[147,335],"[TT]);":[149],"number":[151],"pharmacotherapy":[153],"lines,":[154,274,280,340,443],"resistance":[160],"sensitivity":[162],"HT.":[164],"Additional":[165],"objectives":[166],"included":[167,194,292],"determination":[169],"demographic":[171],"characteristics,":[172],"TNM":[173],"stages.":[174],"Ki\u201167":[175],"proliferative":[176],"activity":[177],"index,":[178],"mutations":[179],"PIK3CA":[182],"gene,":[183],"presence":[186],"visceral":[189],"crisis.":[190],"Results.":[191],"932":[197],"diagnosed":[199,218],"mBC.":[203],"average":[205],"age":[207],"58.9":[209],"\u00b1":[210],"11.3":[211],"years.":[212],"Primary":[213],"metastatic":[214],"cancer":[216,400],"172":[220],"(18.4%)":[221],"patients.":[222,242],"bones":[224],"most":[227,318,346,370],"common":[228,319],"localization":[229],"first":[232,384,440],"metastases":[233],"(32.6%).":[234],"Visceral":[235],"crisis":[236],"reported":[238],"29":[240],"(3.1%)":[241],"21%":[243],"sensitive":[247],"HT,":[249],"11.1%":[250],"primarily":[252],"resistant,":[253],"31.9%":[255],"had":[258],"secondary":[259],"resistance.":[260],"353":[262],"(37.9%)":[263],"one":[266],"line,":[268],"269":[269],"(28.9%)":[270],"two":[273],"139":[275],"(14.9%)":[276],"three":[279,441],"81":[282],"(8.7%)":[283],"four":[286],"lines.":[288,429],"first-line":[290],"mono-regimens":[293,305],"HT":[295,329,342],"(antiestrogens":[296],"\u2013":[297,302,307,311],"22.8%,":[298],"aromatase":[299,332,366],"inhibitors":[300,333,361,367],"[AI]":[301],"20.9%),":[303],"chemotherapy":[304,322,425],"(taxanes":[306],"11.7%,":[308],"pyrimidine":[309],"analogs":[310],"4.4%).":[312],"Among":[313],"combined":[315,321,377],"regimens,":[316],"cyclophosphamide":[324],"+":[325,330,334],"anthracyclines":[326],"(14.3%)":[327],"TT:":[331],"(5.2%).":[337],"In":[338],"subsequent":[339],"monotherapy":[343],"remained":[344],"frequently":[347],"prescribed,":[348],"specific":[351],"gravity":[352],"CT":[354],"increased":[355],"each":[357],"line.":[358],"CDK4/6":[360],"Fulvestrant":[363],"(8.6%)":[364],"(5.1%)":[368],"often":[371],"prescribed":[372],"as":[373],"part":[374],"regimens.":[378],"Conclusions.":[379],"experience":[385],"AI":[388],"practice.":[403],"shows":[406],"that":[407],"Russia":[413],"there":[414],"are":[415],"still":[416],"high":[417],"frequency":[418],"mono-regime":[423],"early":[428],"iCDK4/6":[430],"used":[432],"9.0%,":[434],"14.8%,":[435],"10.8%":[437],"respectively.":[444],"methodology":[446],"limitations":[447],"may":[448],"be":[449],"associated":[450],"design":[455],"errors":[458],"when":[459],"extracting":[460],"EMR":[464],"intelligence.":[467]},"counts_by_year":[{"year":2025,"cited_by_count":2}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2023-01-13T00:00:00"}