{"id":"https://openalex.org/W4315475352","doi":"https://doi.org/10.1016/j.ejps.2023.106378","title":"Mass spectrometry-based metabolomics approach and in vitro assays revealed promising role of 2,3-dihydroquinazolin-4(1H)-one derivatives against colorectal cancer cell lines","display_name":"Mass spectrometry-based metabolomics approach and in vitro assays revealed promising role of 2,3-dihydroquinazolin-4(1H)-one derivatives against colorectal cancer cell lines","publication_year":2023,"publication_date":"2023-01-10","ids":{"openalex":"https://openalex.org/W4315475352","doi":"https://doi.org/10.1016/j.ejps.2023.106378","pmid":"https://pubmed.ncbi.nlm.nih.gov/36638899"},"language":"en","primary_location":{"id":"doi:10.1016/j.ejps.2023.106378","doi":"https://doi.org/10.1016/j.ejps.2023.106378","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ejps.2023.106378","pdf_url":null,"source":{"id":"https://openalex.org/S119477091","display_name":"European Journal of Pharmaceutical Sciences","issn_l":"0928-0987","issn":["0928-0987","1879-0720"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Pharmaceutical Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.ejps.2023.106378","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021756364","display_name":"Lina A. Dahabiyeh","orcid":"https://orcid.org/0000-0002-4688-7052","observed_orcids":["https://orcid.org/0000-0002-4688-7052"]},"institutions":[{"id":"https://openalex.org/I114972647","display_name":"University of Jordan","ror":"https://ror.org/05k89ew48","country_code":"JO","type":"education","lineage":["https://openalex.org/I114972647"]}],"countries":["JO"],"is_corresponding":true,"raw_author_name":"Lina A. Dahabiyeh","raw_affiliation_strings":["Department of Pharmaceutical Sciences, School of Pharmacy, The University of Jordan, Amman 11942, Jordan. Electronic address: l.dahabiyeh@ju.edu.jo"],"raw_orcid":"https://orcid.org/0000-0002-4688-7052","affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, School of Pharmacy, The University of Jordan, Amman 11942, Jordan. Electronic address: l.dahabiyeh@ju.edu.jo","institution_ids":["https://openalex.org/I114972647"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027065809","display_name":"Farah Hudaib","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157392197","display_name":"Hashemite University","ror":"https://ror.org/04a1r5z94","country_code":"JO","type":"education","lineage":["https://openalex.org/I157392197"]}],"countries":["JO"],"is_corresponding":false,"raw_author_name":"Farah Hudaib","raw_affiliation_strings":["Depatment of Pharmaceutical Chemistry, School of Pharmaceutical Sciences, the Hashemite University, Zarqa, 13133, Jordan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Depatment of Pharmaceutical Chemistry, School of Pharmaceutical Sciences, the Hashemite University, Zarqa, 13133, Jordan","institution_ids":["https://openalex.org/I157392197"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077186087","display_name":"Wafa Hourani","orcid":"https://orcid.org/0000-0002-2809-741X","observed_orcids":["https://orcid.org/0000-0002-2809-741X"]},"institutions":[{"id":"https://openalex.org/I142263535","display_name":"University of Nottingham","ror":"https://ror.org/01ee9ar58","country_code":"GB","type":"education","lineage":["https://openalex.org/I142263535"]},{"id":"https://openalex.org/I153921779","display_name":"Philadelphia University","ror":"https://ror.org/05mqvn149","country_code":"JO","type":"education","lineage":["https://openalex.org/I153921779"]}],"countries":["GB","JO"],"is_corresponding":false,"raw_author_name":"Wafa Hourani","raw_affiliation_strings":["Department of Pharmaceutical Sciences, Faculty of Pharmacy, Philadelphia University, Amman 19392, Jordan; School of Life Sciences, Medical School, University of Nottingham, Nottingham NG7 2UH, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, Faculty of Pharmacy, Philadelphia University, Amman 19392, Jordan; School of Life Sciences, Medical School, University of Nottingham, Nottingham NG7 2UH, UK","institution_ids":["https://openalex.org/I142263535","https://openalex.org/I153921779"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083028286","display_name":"Wesam Darwish","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114972647","display_name":"University of Jordan","ror":"https://ror.org/05k89ew48","country_code":"JO","type":"education","lineage":["https://openalex.org/I114972647"]}],"countries":["JO"],"is_corresponding":false,"raw_author_name":"Wesam Darwish","raw_affiliation_strings":["Department of Pharmaceutical Sciences, School of Pharmacy, The University of Jordan, Amman 11942, Jordan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, School of Pharmacy, The University of Jordan, Amman 11942, Jordan","institution_ids":["https://openalex.org/I114972647"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036662735","display_name":"Bashaer Abu\u2010Irmaileh","orcid":"https://orcid.org/0000-0003-1040-3156","observed_orcids":["https://orcid.org/0000-0003-1040-3156"]},"institutions":[{"id":"https://openalex.org/I114972647","display_name":"University of Jordan","ror":"https://ror.org/05k89ew48","country_code":"JO","type":"education","lineage":["https://openalex.org/I114972647"]}],"countries":["JO"],"is_corresponding":false,"raw_author_name":"Bashaer Abu-Irmaileh","raw_affiliation_strings":["Hamdi Mango Center for Scientific Research, The University of Jordan, 11942 Amman, Jordan"],"raw_orcid":"https://orcid.org/0000-0003-1040-3156","affiliations":[{"raw_affiliation_string":"Hamdi Mango Center for Scientific Research, The University of Jordan, 11942 Amman, Jordan","institution_ids":["https://openalex.org/I114972647"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029780869","display_name":"Pran Kishore Deb","orcid":"https://orcid.org/0000-0002-8650-2874","observed_orcids":["https://orcid.org/0000-0002-8650-2874"]},"institutions":[{"id":"https://openalex.org/I153921779","display_name":"Philadelphia University","ror":"https://ror.org/05mqvn149","country_code":"JO","type":"education","lineage":["https://openalex.org/I153921779"]}],"countries":["JO"],"is_corresponding":false,"raw_author_name":"Pran Kishore Deb","raw_affiliation_strings":["Department of Pharmaceutical Sciences, Faculty of Pharmacy, Philadelphia University, Amman 19392, Jordan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, Faculty of Pharmacy, Philadelphia University, Amman 19392, Jordan","institution_ids":["https://openalex.org/I153921779"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011098931","display_name":"Katharigatta Narayanaswamy Venugopala","orcid":"https://orcid.org/0000-0003-0680-1549","observed_orcids":["https://orcid.org/0000-0003-0680-1549"]},"institutions":[{"id":"https://openalex.org/I177181097","display_name":"Durban University of Technology","ror":"https://ror.org/0303y7a51","country_code":"ZA","type":"education","lineage":["https://openalex.org/I177181097"]},{"id":"https://openalex.org/I4626487","display_name":"King Faisal University","ror":"https://ror.org/00dn43547","country_code":"SA","type":"education","lineage":["https://openalex.org/I4626487"]}],"countries":["SA","ZA"],"is_corresponding":false,"raw_author_name":"Katharigatta N. Venugopala","raw_affiliation_strings":["Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, Saudi Arabia; Department of Biotechnology and Food Science, Faculty of Applied Sciences, Durban University of Technology, Durban 4000, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, Saudi Arabia; Department of Biotechnology and Food Science, Faculty of Applied Sciences, Durban University of Technology, Durban 4000, South Africa","institution_ids":["https://openalex.org/I177181097","https://openalex.org/I4626487"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048041444","display_name":"Viresh Mohanlall","orcid":"https://orcid.org/0000-0002-0103-7089","observed_orcids":["https://orcid.org/0000-0002-0103-7089"]},"institutions":[{"id":"https://openalex.org/I177181097","display_name":"Durban University of Technology","ror":"https://ror.org/0303y7a51","country_code":"ZA","type":"education","lineage":["https://openalex.org/I177181097"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Viresh Mohanlall","raw_affiliation_strings":["Department of Biotechnology and Food Science, Faculty of Applied Sciences, Durban University of Technology, Durban 4000, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology and Food Science, Faculty of Applied Sciences, Durban University of Technology, Durban 4000, South Africa","institution_ids":["https://openalex.org/I177181097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029875096","display_name":"Sandeep Chandrashekharappa","orcid":"https://orcid.org/0000-0003-2475-7270","observed_orcids":["https://orcid.org/0000-0003-2475-7270"]},"institutions":[{"id":"https://openalex.org/I4210103783","display_name":"National Institute of Pharmaceutical Education and Research","ror":"https://ror.org/025qtp564","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210103783"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sandeep Chandrashekharappa","raw_affiliation_strings":["Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER-R) Raebareli, Lucknow 226002, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER-R) Raebareli, Lucknow 226002, India","institution_ids":["https://openalex.org/I4210103783"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021007368","display_name":"Rana Abu\u2010Dahab","orcid":"https://orcid.org/0000-0003-0857-7616","observed_orcids":["https://orcid.org/0000-0003-0857-7616"]},"institutions":[{"id":"https://openalex.org/I114972647","display_name":"University of Jordan","ror":"https://ror.org/05k89ew48","country_code":"JO","type":"education","lineage":["https://openalex.org/I114972647"]}],"countries":["JO"],"is_corresponding":false,"raw_author_name":"Rana Abu-Dahab","raw_affiliation_strings":["Department of Biopharmaceutics and Clinical Pharmacy, School of Pharmacy, The University of Jordan, Amman 11942, Jordan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biopharmaceutics and Clinical Pharmacy, School of Pharmacy, The University of Jordan, Amman 11942, Jordan","institution_ids":["https://openalex.org/I114972647"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009166125","display_name":"Mohammad Harb Semreen","orcid":"https://orcid.org/0000-0002-0169-7538","observed_orcids":["https://orcid.org/0000-0002-0169-7538"]},"institutions":[{"id":"https://openalex.org/I29891158","display_name":"University of Sharjah","ror":"https://ror.org/00engpz63","country_code":"AE","type":"education","lineage":["https://openalex.org/I29891158"]}],"countries":["AE"],"is_corresponding":false,"raw_author_name":"Mohammad H. Semreen","raw_affiliation_strings":["Department of Medicinal Chemistry, College of Pharmacy, University of Sharjah, Sharjah 27272, UAE"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, College of Pharmacy, University of Sharjah, Sharjah 27272, UAE","institution_ids":["https://openalex.org/I29891158"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044880368","display_name":"Yasser Khalil Bustanji","orcid":"https://orcid.org/0000-0003-1315-0609","observed_orcids":["https://orcid.org/0000-0003-1315-0609"]},"institutions":[{"id":"https://openalex.org/I29891158","display_name":"University of Sharjah","ror":"https://ror.org/00engpz63","country_code":"AE","type":"education","lineage":["https://openalex.org/I29891158"]}],"countries":["AE"],"is_corresponding":false,"raw_author_name":"Yasser Bustanji","raw_affiliation_strings":["Department of Basic Medical Sciences, College of Medicine, University of Sharjah, Sharjah 27272, UAE"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Basic Medical Sciences, College of Medicine, University of Sharjah, Sharjah 27272, UAE","institution_ids":["https://openalex.org/I29891158"]}]}],"institutions":[],"countries_distinct_count":6,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5021756364"],"corresponding_institution_ids":["https://openalex.org/I114972647"],"apc_list":{"value":2300,"currency":"USD","value_usd":2300},"apc_paid":{"value":2300,"currency":"USD","value_usd":2300},"fwci":2.7247,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.91462392,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"182","issue":null,"first_page":"106378","last_page":"106378"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12318","display_name":"Quinazolinone synthesis and applications","score":0.9550999999046326,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12318","display_name":"Quinazolinone synthesis and applications","score":0.9550999999046326,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.03750000149011612,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.8529999852180481},{"id":"https://openalex.org/keywords/anticancer-agents","display_name":"anticancer agents","score":0.9670000076293945},{"id":"https://openalex.org/keywords/hct116-cells","display_name":"HCT116 cells","score":0.9459999799728394},{"id":"https://openalex.org/keywords/sw480-cells","display_name":"SW480 cells","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cell-viability","display_name":"cell viability","score":0.6110000014305115},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.7329999804496765},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"cell adhesion","score":0.9160000085830688},{"id":"https://openalex.org/keywords/cell-invasion","display_name":"cell invasion","score":0.9480000138282776},{"id":"https://openalex.org/keywords/metabolomics","display_name":"metabolomics","score":0.7490000128746033},{"id":"https://openalex.org/keywords/polyamines","display_name":"polyamines","score":0.722000002861023},{"id":"https://openalex.org/keywords/spermine","display_name":"spermine","score":0.7990000247955322},{"id":"https://openalex.org/keywords/glutamine","display_name":"glutamine","score":0.7509999871253967},{"id":"https://openalex.org/keywords/creatine","display_name":"creatine","score":0.8600000143051147},{"id":"https://openalex.org/keywords/l-carnitine","display_name":"L-carnitine","score":0.9959999918937683},{"id":"https://openalex.org/keywords/amino-acid-metabolism","display_name":"amino acid metabolism","score":0.8799999952316284},{"id":"https://openalex.org/keywords/redox-homeostasis","display_name":"redox homeostasis","score":0.9750000238418579},{"id":"https://openalex.org/keywords/fatty-acid-oxidation","display_name":"fatty acid oxidation","score":0.8859999775886536},{"id":"https://openalex.org/keywords/warburg-effect","display_name":"Warburg effect","score":0.824999988079071},{"id":"https://openalex.org/keywords/one-carbon-metabolism","display_name":"one-carbon metabolism","score":0.925000011920929},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.8109999895095825}],"concepts":[{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.6384175419807434},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.603533923625946},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6003730297088623},{"id":"https://openalex.org/C109156525","wikidata":"https://www.wikidata.org/wiki/Q56770304","display_name":"Warburg effect","level":4,"score":0.5514270067214966},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.5508754253387451},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.5150858759880066},{"id":"https://openalex.org/C2779349466","wikidata":"https://www.wikidata.org/wiki/Q181619","display_name":"Glutamine","level":3,"score":0.48806989192962646},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4815150201320648},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.4710283875465393},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4709283709526062},{"id":"https://openalex.org/C2778866207","wikidata":"https://www.wikidata.org/wiki/Q426278","display_name":"Quinazoline","level":2,"score":0.4695494771003723},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3911955952644348},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3859562873840332},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3461943566799164},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.32948315143585205},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.2955566644668579},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2618183493614197},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.21882599592208862},{"id":"https://openalex.org/C20251656","wikidata":"https://www.wikidata.org/wiki/Q162643","display_name":"Glycolysis","level":3,"score":0.21812695264816284},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.11410930752754211},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002853","descriptor_name":"Chromatography, Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D045325","descriptor_name":"HCT116 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053719","descriptor_name":"Tandem Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.ejps.2023.106378","doi":"https://doi.org/10.1016/j.ejps.2023.106378","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ejps.2023.106378","pdf_url":null,"source":{"id":"https://openalex.org/S119477091","display_name":"European Journal of Pharmaceutical Sciences","issn_l":"0928-0987","issn":["0928-0987","1879-0720"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Pharmaceutical Sciences","raw_type":"journal-article"},{"id":"pmid:36638899","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36638899","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.ejps.2023.106378","doi":"https://doi.org/10.1016/j.ejps.2023.106378","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ejps.2023.106378","pdf_url":null,"source":{"id":"https://openalex.org/S119477091","display_name":"European Journal of Pharmaceutical Sciences","issn_l":"0928-0987","issn":["0928-0987","1879-0720"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Pharmaceutical Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G849707861","display_name":null,"funder_award_id":"125-34/100","funder_id":"https://openalex.org/F4320337174","funder_display_name":"Deanship of Scientific Research, University of Jordan"}],"funders":[{"id":"https://openalex.org/F4320319148","display_name":"Philadelphia University","ror":"https://ror.org/05mqvn149"},{"id":"https://openalex.org/F4320337174","display_name":"Deanship of Scientific Research, University of Jordan","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":83,"referenced_works":["https://openalex.org/W1967530242","https://openalex.org/W1979901296","https://openalex.org/W1980990431","https://openalex.org/W1983961550","https://openalex.org/W1994292828","https://openalex.org/W2015027939","https://openalex.org/W2025701648","https://openalex.org/W2026198465","https://openalex.org/W2029569943","https://openalex.org/W2033881351","https://openalex.org/W2041023139","https://openalex.org/W2053242176","https://openalex.org/W2058461395","https://openalex.org/W2060592426","https://openalex.org/W2066411725","https://openalex.org/W2073133083","https://openalex.org/W2078062693","https://openalex.org/W2084015464","https://openalex.org/W2089594231","https://openalex.org/W2097259163","https://openalex.org/W2102438936","https://openalex.org/W2110900526","https://openalex.org/W2124097453","https://openalex.org/W2139629432","https://openalex.org/W2146881937","https://openalex.org/W2154575874","https://openalex.org/W2158604971","https://openalex.org/W2161056396","https://openalex.org/W2162234541","https://openalex.org/W2165292984","https://openalex.org/W2176297535","https://openalex.org/W2277570265","https://openalex.org/W2476068333","https://openalex.org/W2566944468","https://openalex.org/W2588541827","https://openalex.org/W2598478141","https://openalex.org/W2604415318","https://openalex.org/W2607990832","https://openalex.org/W2746422205","https://openalex.org/W2771345740","https://openalex.org/W2791549657","https://openalex.org/W2799897236","https://openalex.org/W2805512669","https://openalex.org/W2807686328","https://openalex.org/W2810232209","https://openalex.org/W2885303230","https://openalex.org/W2885427810","https://openalex.org/W2886868067","https://openalex.org/W2896136838","https://openalex.org/W2902894605","https://openalex.org/W2931103462","https://openalex.org/W2945731602","https://openalex.org/W2955982897","https://openalex.org/W2981868700","https://openalex.org/W2990173246","https://openalex.org/W3001258059","https://openalex.org/W3010195317","https://openalex.org/W3011019824","https://openalex.org/W3012135596","https://openalex.org/W3037584172","https://openalex.org/W3099909722","https://openalex.org/W3102288871","https://openalex.org/W3104079531","https://openalex.org/W3118575215","https://openalex.org/W3130513416","https://openalex.org/W3134810965","https://openalex.org/W3155387234","https://openalex.org/W3159995035","https://openalex.org/W3164822920","https://openalex.org/W3178723556","https://openalex.org/W3184685530","https://openalex.org/W3210571978","https://openalex.org/W4200190705","https://openalex.org/W4200599080","https://openalex.org/W4210438925","https://openalex.org/W4211168195","https://openalex.org/W4214564815","https://openalex.org/W4226340906","https://openalex.org/W4232039486","https://openalex.org/W4281608386","https://openalex.org/W4283277417","https://openalex.org/W4310243855","https://openalex.org/W6678838943"],"related_works":["https://openalex.org/W4225598921","https://openalex.org/W4282973556","https://openalex.org/W7130846834","https://openalex.org/W4282976652","https://openalex.org/W7133905620","https://openalex.org/W4415224441","https://openalex.org/W4323841133","https://openalex.org/W3042916153","https://openalex.org/W2142099002","https://openalex.org/W4387616994"],"abstract_inverted_index":{"Colorectal":[0],"cancer":[1,10,263],"(CRC)":[2],"is":[3],"the":[4,14,23,53,96,126,143,160,179,244,258],"most":[5,127],"frequent":[6],"form":[7],"of":[8,13,17,22,47,55,147,162,181,246,257],"gastrointestinal":[9],"and":[11,72,82,115,134,139,153,156,165,189,191,199,206,223,240,253],"one":[12],"major":[15],"causes":[16],"human":[18],"mortality":[19],"worldwide.":[20],"Many":[21],"current":[24],"CRC":[25,68],"therapies":[26],"have":[27,236],"limitations":[28],"due":[29],"to":[30,94],"multidrug":[31],"resistance":[32],"and/or":[33],"severe":[34],"side":[35],"effects.":[36],"Quinazoline":[37],"derivatives":[38],"are":[39],"promising":[40,237],"lead":[41],"compounds":[42,111,144],"with":[43,123],"a":[44],"wide":[45],"range":[46],"pharmacological":[48],"actions.":[49],"In":[50],"this":[51],"study,":[52],"effect":[54,130],"seven":[56],"synthesized":[57],"2,3-dihydroquinazolin-4(1":[58,230],"H":[59,231],")-one":[60,232],"analogues":[61],"as":[62,202],"potential":[63],"anticancer":[64,238],"agents":[65],"against":[66,137],"two":[67],"cell":[69,77,197],"lines":[70],"(HCT116":[71],"SW480)":[73],"was":[74,92],"investigated":[75],"using":[76],"viability":[78,105],"proliferation,":[79],"migration,":[80],"adhesion":[81],"invasion":[83],"assays.":[84],"A":[85],"liquid":[86],"chromatography-mass":[87],"spectrometry":[88],"(LC-MS/MS)":[89],"metabolomics":[90,247],"approach":[91],"used":[93],"identify":[95],"underlying":[97],"biochemical":[98,193],"pathways":[99,259],"disturbed":[100],"in":[101,178,248,261],"treated-HCT116":[102],"cells.":[103,264],"Cell":[104],"proliferation":[106,198],"assay":[107],"revealed":[108,172],"that":[109,173,229],"four":[110],"(C2,":[112],"C3,":[113],"C5,":[114,235],"C7)":[116],"had":[117],"IC":[118],"50":[119,132],"<":[120],"10":[121],"\u00b5M":[122,136],"C5":[124,157,174],"displaying":[125],"potent":[128],"cytotoxic":[129],"(IC":[131],"1.4":[133],"0.3":[135],"HCT116":[138,167],"SW480,":[140],"respectively).":[141],"Additionally,":[142],"showed":[145],"suppression":[146],"wound":[148],"closure":[149],"after":[150],"72":[151],"h,":[152],"both":[154],"C2":[155],"significantly":[158],"decreased":[159],"number":[161],"adherent":[163],"cells":[164,168],"suppressed":[166],"invasion.":[169],"Metabolomics":[170],"study":[171],"induced":[175],"significant":[176],"perturbations":[177],"level":[180],"several":[182],"metabolites":[183],"including":[184],"spermine,":[185],"polyamines,":[186],"glutamine,":[187],"creatine":[188],"carnitine,":[190],"altered":[192,260],"processes":[194,212],"essential":[195],"for":[196],"progression":[200],"such":[201],"amino":[203],"acids":[204],"biosynthesis":[205],"metabolism,":[207],"redox":[208],"homeostasis,":[209],"energy":[210],"related":[211],"(":[213],"e.g.":[214],",":[215],"fatty":[216],"acid":[217],"oxidation,":[218],"second":[219],"Warburg":[220],"like":[221],"effect)":[222],"one-carbon":[224],"metabolism.":[225],"Our":[226],"findings":[227],"indicate":[228],"analogues,":[233],"particularly":[234],"properties,":[239],"shed":[241],"light":[242],"on":[243],"role":[245],"identifying":[249],"new":[250],"therapeutic":[251],"targets":[252],"providing":[254],"better":[255],"understanding":[256],"treated":[262]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2023-01-11T00:00:00"}
