{"id":"https://openalex.org/W4315436592","doi":"https://doi.org/10.1021/acsinfecdis.2c00492","title":"Development of Host-Cleavable Antibody\u2013Bactericide Conjugates against Extracellular Pathogens","display_name":"Development of Host-Cleavable Antibody\u2013Bactericide Conjugates against Extracellular Pathogens","publication_year":2023,"publication_date":"2023-01-10","ids":{"openalex":"https://openalex.org/W4315436592","doi":"https://doi.org/10.1021/acsinfecdis.2c00492","pmid":"https://pubmed.ncbi.nlm.nih.gov/36626184"},"language":"en","primary_location":{"id":"doi:10.1021/acsinfecdis.2c00492","doi":"https://doi.org/10.1021/acsinfecdis.2c00492","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsinfecdis.2c00492","pdf_url":null,"source":{"id":"https://openalex.org/S2764646616","display_name":"ACS Infectious Diseases","issn_l":"2373-8227","issn":["2373-8227"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Infectious Diseases","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038278914","display_name":"Meghan K. O\u2019Leary","orcid":"https://orcid.org/0000-0002-6689-2529","observed_orcids":["https://orcid.org/0000-0002-6689-2529"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Meghan K. O\u2019Leary","raw_affiliation_strings":["Robert Frederick Smith School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, New York 14853, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Robert Frederick Smith School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, New York 14853, United States","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066476213","display_name":"Asraa Ahmed","orcid":"https://orcid.org/0000-0001-7222-268X","observed_orcids":["https://orcid.org/0000-0001-7222-268X"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Asraa Ahmed","raw_affiliation_strings":["Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, United States"],"raw_orcid":"https://orcid.org/0000-0001-7222-268X","affiliations":[{"raw_affiliation_string":"Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, United States","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046388197","display_name":"Christopher A. Alabi","orcid":"https://orcid.org/0000-0003-2654-018X","observed_orcids":["https://orcid.org/0000-0003-2654-018X"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Christopher A. Alabi","raw_affiliation_strings":["Robert Frederick Smith School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, New York 14853, United States"],"raw_orcid":"https://orcid.org/0000-0003-2654-018X","affiliations":[{"raw_affiliation_string":"Robert Frederick Smith School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, New York 14853, United States","institution_ids":["https://openalex.org/I205783295"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5046388197"],"corresponding_institution_ids":["https://openalex.org/I205783295"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":1.821,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.82238783,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"9","issue":"2","first_page":"322","last_page":"329"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.8560000061988831,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.8560000061988831,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12526","display_name":"Antimicrobial agents and applications","score":0.120899997651577,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antibody-drug-conjugates","display_name":"antibody-drug conjugates","score":0.9279999732971191},{"id":"https://openalex.org/keywords/antimicrobial-peptides","display_name":"antimicrobial peptides","score":0.7919999957084656},{"id":"https://openalex.org/keywords/pseudomonas-aeruginosa","display_name":"Pseudomonas aeruginosa","score":0.972000002861023},{"id":"https://openalex.org/keywords/multidrug-resistant-bacteria","display_name":"multidrug-resistant bacteria","score":0.753000020980835},{"id":"https://openalex.org/keywords/polymyxin-b-resistance","display_name":"polymyxin B resistance","score":0.7369999885559082},{"id":"https://openalex.org/keywords/antibacterial-activity","display_name":"antibacterial activity","score":0.460999995470047},{"id":"https://openalex.org/keywords/extracellular-pathogens","display_name":"extracellular pathogens","score":0.5559999942779541},{"id":"https://openalex.org/keywords/targeted-drug-delivery","display_name":"targeted drug delivery","score":0.4189999997615814}],"concepts":[{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.6990710496902466},{"id":"https://openalex.org/C2777637488","wikidata":"https://www.wikidata.org/wiki/Q31856","display_name":"Pseudomonas aeruginosa","level":3,"score":0.624738335609436},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.6139175891876221},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.5924029350280762},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5695391297340393},{"id":"https://openalex.org/C2780557392","wikidata":"https://www.wikidata.org/wiki/Q523796","display_name":"Linker","level":2,"score":0.5275062322616577},{"id":"https://openalex.org/C540938839","wikidata":"https://www.wikidata.org/wiki/Q1201508","display_name":"Antimicrobial peptides","level":3,"score":0.5074915289878845},{"id":"https://openalex.org/C2780675486","wikidata":"https://www.wikidata.org/wiki/Q423765","display_name":"Polymyxin","level":3,"score":0.46366244554519653},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4480484127998352},{"id":"https://openalex.org/C133936738","wikidata":"https://www.wikidata.org/wiki/Q643839","display_name":"Multiple drug resistance","level":3,"score":0.44570672512054443},{"id":"https://openalex.org/C197336794","wikidata":"https://www.wikidata.org/wiki/Q5161150","display_name":"Conjugate","level":2,"score":0.44253063201904297},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.43108171224594116},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34613215923309326},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.2890852689743042},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1825205385684967},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14779558777809143},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.13864979147911072},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000890","descriptor_name":"Anti-Infective Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011112","descriptor_name":"Polymyxin B","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/acsinfecdis.2c00492","doi":"https://doi.org/10.1021/acsinfecdis.2c00492","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsinfecdis.2c00492","pdf_url":null,"source":{"id":"https://openalex.org/S2764646616","display_name":"ACS Infectious Diseases","issn_l":"2373-8227","issn":["2373-8227"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Infectious Diseases","raw_type":"journal-article"},{"id":"pmid:36626184","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36626184","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS infectious diseases","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8681914295","display_name":"Targeted Macromolecular Antimicrobial Prodrugs Against Pseudomonas Aeruginosa","funder_award_id":"R21AI154102","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000899167","display_name":"Development of Targeted Antipseudomonal Bactericidal Prodrugs","funder_award_id":"R01AI174461","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320309624","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1482291463","https://openalex.org/W1497725591","https://openalex.org/W1531651933","https://openalex.org/W1915856409","https://openalex.org/W1991210310","https://openalex.org/W1997152791","https://openalex.org/W2003029464","https://openalex.org/W2004373761","https://openalex.org/W2031424136","https://openalex.org/W2073371480","https://openalex.org/W2079228339","https://openalex.org/W2097099115","https://openalex.org/W2098375088","https://openalex.org/W2334848959","https://openalex.org/W2340083595","https://openalex.org/W2342937250","https://openalex.org/W2531611585","https://openalex.org/W2574369735","https://openalex.org/W2683261339","https://openalex.org/W2769959541","https://openalex.org/W2803239426","https://openalex.org/W2806527490","https://openalex.org/W2883244120","https://openalex.org/W2938893965","https://openalex.org/W3012472334","https://openalex.org/W3044673166","https://openalex.org/W3110696757","https://openalex.org/W4213263546"],"related_works":["https://openalex.org/W4386494902","https://openalex.org/W3119998089","https://openalex.org/W7130522371","https://openalex.org/W7139919552","https://openalex.org/W4307432153","https://openalex.org/W4213263546","https://openalex.org/W4399648443","https://openalex.org/W3164807433","https://openalex.org/W4417454721","https://openalex.org/W4221015714"],"abstract_inverted_index":{"Novel":[0],"antimicrobial":[1,137],"agents":[2],"with":[3],"potent":[4],"bactericidal":[5],"activity":[6],"are":[7,28],"needed":[8],"to":[9,31,41,67,84,90,95,109,124,134,139,162,191,196,208],"treat":[10],"infections":[11],"caused":[12],"by":[13,63],"multidrug-resistant":[14],"(MDR)":[15],"extracellular":[16],"pathogens,":[17],"such":[18],"as":[19,80],"Pseudomonas":[20],"aeruginosa":[21,166,186],".":[22],"Antimicrobial":[23],"peptides":[24],"(AMPs)":[25],"and":[26,46,188,213,225],"peptidomimetics":[27],"promising":[29],"alternatives":[30],"traditional":[32],"antibiotics,":[33],"but":[34],"their":[35],"therapeutic":[36,117],"use":[37],"is":[38,132,160,223],"limited":[39],"due":[40,83],"the":[42,56,65,68,85,88,92,96,102,110,125,140,146,155,197,205,209,217,220],"lack":[43],"of":[44,52,87,105,127,148,184,216],"specificity":[45],"resulting":[47],"off-target":[48],"effects.":[49],"The":[50,172],"incorporation":[51],"an":[53,130,136,149,163],"antibody":[54,89,131,167],"into":[55],"drug":[57,173],"design":[58],"would":[59],"alleviate":[60],"these":[61],"challenges":[62],"localizing":[64],"AMP":[66],"target":[69,111],"bacterial":[70,141,210],"cells.":[71,98],"Antibody\u2013drug":[72],"conjugates":[73],"(ADCs)":[74],"have":[75],"already":[76],"achieved":[77],"clinical":[78],"success":[79],"anticancer":[81],"therapeutics,":[82],"ability":[86,190],"deliver":[91,135],"payload":[93,222],"directly":[94],"cancer":[97],"This":[99,119],"strategy":[100],"involves":[101],"selective":[103],"delivery":[104],"highly":[106],"cytotoxic":[107],"drugs":[108],"cells,":[112],"which":[113,154],"enables":[114],"a":[115,169,182],"broad":[116],"window.":[118],"platform":[120],"can":[121],"be":[122],"translated":[123],"treatment":[126],"infections,":[128],"whereby":[129],"used":[133],"agent":[138,199],"antigen.":[142],"Herein,":[143],"we":[144],"propose":[145],"development":[147],"antibody\u2013bactericide":[150],"conjugate":[151],"(ABC)":[152],"in":[153],"antibacterial":[156],"oligothioetheramide":[157],"(oligoTEA),":[158],"BDT-4G,":[159],"coupled":[161],"anti-":[164],"P.":[165,185],"via":[168],"cleavable":[170],"linker.":[171],"BDT-4G":[174],"was":[175],"chosen":[176],"based":[177],"on":[178],"its":[179,189],"efficacy":[180],"against":[181],"range":[183],"isolates":[187],"evade":[192],"mechanisms":[193],"conferring":[194],"resistance":[195],"last-resort":[198],"polymyxin":[200],"B.":[201],"We":[202],"demonstrate":[203],"that":[204],"ABC":[206],"binds":[207],"cell":[211],"surface,":[212],"following":[214],"cleavage":[215],"peptide":[218],"linker,":[219],"oligoTEA":[221],"released":[224],"exhibits":[226],"antipseudomonal":[227],"activity.":[228]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-01-11T00:00:00"}
