{"id":"https://openalex.org/W43152002","doi":null,"title":"Influence of organomercurials on the induction chromosome alterations in CHO cells","display_name":"Influence of organomercurials on the induction chromosome alterations in CHO cells","publication_year":1994,"publication_date":"1994-12-31","ids":{"openalex":"https://openalex.org/W43152002","mag":"43152002"},"language":"en","primary_location":{"id":"mag:43152002","doi":null,"is_oa":false,"landing_page_url":"http://www.osti.gov/scitech/biblio/88888-influence-organomercurials-induction-chromosome-alterations-cho-cells","pdf_url":null,"source":{"id":"https://openalex.org/S204663187","display_name":"Environmental and Molecular Mutagenesis","issn_l":"0893-6692","issn":["0893-6692","1098-2280"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Environmental and Molecular Mutagenesis","raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044925899","display_name":"Tejinder S. Kochhar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T. S. Kochhar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Aaron Wilson","orcid":"https://orcid.org/0000-0003-4321-8897","observed_orcids":["https://orcid.org/0000-0003-4321-8897"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aaron Wilson","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4321-8897","affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"Ana C. Anderson","orcid":"https://orcid.org/0000-0002-0877-2932","observed_orcids":["https://orcid.org/0000-0002-0877-2932"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ana C. Anderson","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0877-2932","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00171902,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"23","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/organomercury-compounds","display_name":"organomercury compounds","score":0.9919999837875366},{"id":"https://openalex.org/keywords/phenylmercuric-chloride","display_name":"phenylmercuric chloride","score":0.9369999766349792},{"id":"https://openalex.org/keywords/mercury-poisoning","display_name":"mercury toxicity","score":0.9430000185966492},{"id":"https://openalex.org/keywords/chromosomal-abnormalities","display_name":"chromosomal abnormalities","score":0.9610000252723694},{"id":"https://openalex.org/keywords/sister-chromatid-exchange","display_name":"sister chromatid exchange","score":0.9940000176429749},{"id":"https://openalex.org/keywords/cho-cells","display_name":"CHO cells","score":0.9470000267028809},{"id":"https://openalex.org/keywords/endoreduplication","display_name":"endoreduplication","score":0.9819999933242798},{"id":"https://openalex.org/keywords/mitotic-spindle","display_name":"mitotic spindle","score":0.5950000286102295},{"id":"https://openalex.org/keywords/thiol-binding","display_name":"thiol binding","score":0.7749999761581421},{"id":"https://openalex.org/keywords/genotoxicity","display_name":"genotoxicity","score":0.8519999980926514}],"concepts":[{"id":"https://openalex.org/C175656101","wikidata":"https://www.wikidata.org/wiki/Q56646","display_name":"Chinese hamster ovary cell","level":3,"score":0.848280668258667},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6773377656936646},{"id":"https://openalex.org/C2778695967","wikidata":"https://www.wikidata.org/wiki/Q44791900","display_name":"Chloride","level":2,"score":0.6162689328193665},{"id":"https://openalex.org/C2779071816","wikidata":"https://www.wikidata.org/wiki/Q21095324","display_name":"Sister chromatid exchange","level":3,"score":0.5638684034347534},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4850310683250427},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3789282739162445},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3662516474723816},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23774805665016174},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.22391155362129211},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.07708817720413208},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:43152002","doi":null,"is_oa":false,"landing_page_url":"http://www.osti.gov/scitech/biblio/88888-influence-organomercurials-induction-chromosome-alterations-cho-cells","pdf_url":null,"source":{"id":"https://openalex.org/S204663187","display_name":"Environmental and Molecular Mutagenesis","issn_l":"0893-6692","issn":["0893-6692","1098-2280"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":"Environmental and Molecular Mutagenesis","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.43070000410079956,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.5299999713897705,"display_name":"Clean water and sanitation","id":"https://metadata.un.org/sdg/6"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1985071480","https://openalex.org/W2094529017","https://openalex.org/W2018301200","https://openalex.org/W2009599788","https://openalex.org/W2091007734","https://openalex.org/W2006577992","https://openalex.org/W2060670293","https://openalex.org/W2154877555","https://openalex.org/W1970558865","https://openalex.org/W1976434896","https://openalex.org/W2038971626","https://openalex.org/W2006149374","https://openalex.org/W2046095509","https://openalex.org/W2077612047","https://openalex.org/W2005409902","https://openalex.org/W2030945074","https://openalex.org/W2406392171","https://openalex.org/W2004637059","https://openalex.org/W1524340159","https://openalex.org/W2065127608"],"abstract_inverted_index":{"Mercury":[0,164],"is":[1],"well":[2],"known":[3,167],"as":[4],"a":[5],"toxic":[6],"heavy":[7],"metal":[8],"and":[9,29,36,61,66,77],"protoplasmic":[10],"poison.":[11],"In":[12,100],"order":[13],"to":[14,90,96,126,131,146,157,168],"further":[15],"assess":[16],"its":[17],"effect":[18,122,150],"on":[19,32,41],"cell`s":[20,172],"genetic":[21],"material,":[22],"the":[23,85,91,116,121,140,147,158,162,171],"influence":[24],"of":[25,64,80,87,110,118,142,176],"organomercurials,":[26],"phenylmercuric":[27,81,105],"chloride":[28,31,82,106,134],"ethylmercuric":[30,67,133],"chromosome":[33],"aberrations":[34],"(CA)":[35],"sister":[37],"chromatid":[38],"exchanges":[39],"(SCE)":[40],"Chinese":[42],"hamster":[43],"ovary":[44],"(CHO)":[45],"cells":[46],"was":[47,70,135],"investigated.":[48],"The":[49,93,112,149],"cell":[50],"cultures":[51],"were":[52],"treated":[53],"with":[54,170],"10{sup":[55,57,59,62,78,101],"-8},":[56],"-7},":[58],"-6},":[60],"-5}":[63,102],"phenyl":[65],"chloride.":[68],"It":[69],"observed":[71],"that":[72],"higher":[73],"concentrations":[74],"(10{sup":[75],"-6}":[76],"-5}M)":[79],"substantially":[83],"elevated":[84],"frequency":[86],"CA":[88],"compared":[89,145],"controls.":[92,148],"increase":[94],"appeared":[95],"be":[97,127,155],"dose":[98,128],"dependent.":[99,129],"M":[103],"level,":[104],"produced":[107,151],"excessive":[108],"endoreduplication":[109],"chromosomes.":[111],"compound":[113],"also":[114],"raised":[115],"rates":[117,141],"SCE":[119],"but":[120],"did":[123],"not":[124],"appear":[125],"Compared":[130],"this,":[132],"less":[136],"effective":[137],"in":[138,161],"increasing":[139],"above":[143],"parameters":[144],"by":[152],"organomercurials":[153],"may":[154],"related":[156],"binding":[159],"sites":[160],"cell.":[163],"compounds":[165],"are":[166],"interact":[169],"spindle":[173],"apparatus":[174],"because":[175],"their":[177],"affinity":[178],"for":[179],"thiol":[180],"groups.":[181]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2025-10-10T00:00:00"}