{"id":"https://openalex.org/W4313825762","doi":"https://doi.org/10.3390/biomedicines11010160","title":"Bioinformatical Design and Performance Evaluation of a Nucleocapsid- and an RBD-Based Particle Enhanced Turbidimetric Immunoassay (PETIA) to Quantify the Wild Type and Variants of Concern-Derived Immunoreactivity of SARS-CoV-2","display_name":"Bioinformatical Design and Performance Evaluation of a Nucleocapsid- and an RBD-Based Particle Enhanced Turbidimetric Immunoassay (PETIA) to Quantify the Wild Type and Variants of Concern-Derived Immunoreactivity of SARS-CoV-2","publication_year":2023,"publication_date":"2023-01-08","ids":{"openalex":"https://openalex.org/W4313825762","doi":"https://doi.org/10.3390/biomedicines11010160","pmid":"https://pubmed.ncbi.nlm.nih.gov/36672668","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9855841"},"language":"en","primary_location":{"id":"doi:10.3390/biomedicines11010160","doi":"https://doi.org/10.3390/biomedicines11010160","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biomedicines11010160","pdf_url":"https://www.mdpi.com/2227-9059/11/1/160/pdf?version=1674004797","source":{"id":"https://openalex.org/S2737005842","display_name":"Biomedicines","issn_l":"2227-9059","issn":["2227-9059"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2227-9059/11/1/160/pdf?version=1674004797","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075978299","display_name":"Leoni Wey","orcid":"https://orcid.org/0000-0002-2172-250X","observed_orcids":["https://orcid.org/0000-0002-2172-250X"]},"institutions":[{"id":"https://openalex.org/I4210135900","display_name":"Hochschule Fresenius","ror":"https://ror.org/03hj50651","country_code":"DE","type":"education","lineage":["https://openalex.org/I4210135900"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Leoni Wey","raw_affiliation_strings":["DiaSys Diagnostic Systems GmbH, Alte Str. 9, 65558 Holzheim, Germany","Hochschule Fresenius Gem. Tr\u00e4gergesellschaft mbH, University of Applied Sciences, Limburger Str. 2, 65510 Idstein, Germany"],"raw_orcid":"https://orcid.org/0000-0002-2172-250X","affiliations":[{"raw_affiliation_string":"DiaSys Diagnostic Systems GmbH, Alte Str. 9, 65558 Holzheim, Germany","institution_ids":[]},{"raw_affiliation_string":"Hochschule Fresenius Gem. Tr\u00e4gergesellschaft mbH, University of Applied Sciences, Limburger Str. 2, 65510 Idstein, Germany","institution_ids":["https://openalex.org/I4210135900"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089512024","display_name":"Thomas Masetto","orcid":"https://orcid.org/0000-0001-9609-3405","observed_orcids":["https://orcid.org/0000-0001-9609-3405"]},"institutions":[{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thomas Masetto","raw_affiliation_strings":["DiaSys Diagnostic Systems GmbH, Alte Str. 9, 65558 Holzheim, Germany","Institut f\u00fcr Molekulare Medizin I, Heinrich-Heine-Universit\u00e4t, Universit\u00e4tsstr. 1, 40225 D\u00fcsseldorf, Germany"],"raw_orcid":"https://orcid.org/0000-0001-9609-3405","affiliations":[{"raw_affiliation_string":"DiaSys Diagnostic Systems GmbH, Alte Str. 9, 65558 Holzheim, Germany","institution_ids":[]},{"raw_affiliation_string":"Institut f\u00fcr Molekulare Medizin I, Heinrich-Heine-Universit\u00e4t, Universit\u00e4tsstr. 1, 40225 D\u00fcsseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109512082","display_name":"Alexander Spaeth","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alexander Spaeth","raw_affiliation_strings":["MVZ Medizinische Labore Dessau Kassel GmbH, Bauh\u00fcttenstr. 6, 06847 Dessau-Ro\u00dflau, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MVZ Medizinische Labore Dessau Kassel GmbH, Bauh\u00fcttenstr. 6, 06847 Dessau-Ro\u00dflau, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jessica Brehm","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jessica Brehm","raw_affiliation_strings":["MVZ Medizinische Labore Dessau Kassel GmbH, Bauh\u00fcttenstr. 6, 06847 Dessau-Ro\u00dflau, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MVZ Medizinische Labore Dessau Kassel GmbH, Bauh\u00fcttenstr. 6, 06847 Dessau-Ro\u00dflau, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039889419","display_name":"Christian Kochem","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christian Kochem","raw_affiliation_strings":["DiaSys Diagnostic Systems GmbH, Alte Str. 9, 65558 Holzheim, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DiaSys Diagnostic Systems GmbH, Alte Str. 9, 65558 Holzheim, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058171040","display_name":"Marco Reinhart","orcid":"https://orcid.org/0000-0001-6745-9500","observed_orcids":["https://orcid.org/0000-0001-6745-9500"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marco Reinhart","raw_affiliation_strings":["GfA GmbH, Allg\u00e4uer Str. 1, 87459 Pfronten, Germany"],"raw_orcid":"https://orcid.org/0000-0001-6745-9500","affiliations":[{"raw_affiliation_string":"GfA GmbH, Allg\u00e4uer Str. 1, 87459 Pfronten, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Holger M\u00fcller","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Holger M\u00fcller","raw_affiliation_strings":["DiaSys Diagnostic Systems GmbH, Alte Str. 9, 65558 Holzheim, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DiaSys Diagnostic Systems GmbH, Alte Str. 9, 65558 Holzheim, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051137977","display_name":"Uwe Kempin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Uwe Kempin","raw_affiliation_strings":["pes Medizinische Diagnosesysteme GmbH, Hauptstr. 103, 04416 Markkleeberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"pes Medizinische Diagnosesysteme GmbH, Hauptstr. 103, 04416 Markkleeberg, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060857359","display_name":"Franziska Lorenz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Franziska Lorenz","raw_affiliation_strings":["MVZ Medizinische Labore Dessau Kassel GmbH, Bauh\u00fcttenstr. 6, 06847 Dessau-Ro\u00dflau, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MVZ Medizinische Labore Dessau Kassel GmbH, Bauh\u00fcttenstr. 6, 06847 Dessau-Ro\u00dflau, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Christoph Peter","orcid":"https://orcid.org/0000-0002-0048-2279","observed_orcids":["https://orcid.org/0000-0002-0048-2279"]},"institutions":[{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christoph Peter","raw_affiliation_strings":["Institut f\u00fcr Molekulare Medizin I, Heinrich-Heine-Universit\u00e4t, Universit\u00e4tsstr. 1, 40225 D\u00fcsseldorf, Germany"],"raw_orcid":"https://orcid.org/0000-0002-0048-2279","affiliations":[{"raw_affiliation_string":"Institut f\u00fcr Molekulare Medizin I, Heinrich-Heine-Universit\u00e4t, Universit\u00e4tsstr. 1, 40225 D\u00fcsseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069541914","display_name":"Matthias Grimmler","orcid":"https://orcid.org/0000-0003-2860-3391","observed_orcids":["https://orcid.org/0000-0003-2860-3391"]},"institutions":[{"id":"https://openalex.org/I4210135900","display_name":"Hochschule Fresenius","ror":"https://ror.org/03hj50651","country_code":"DE","type":"education","lineage":["https://openalex.org/I4210135900"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Matthias Grimmler","raw_affiliation_strings":["DiaSys Diagnostic Systems GmbH, Alte Str. 9, 65558 Holzheim, Germany","Hochschule Fresenius Gem. Tr\u00e4gergesellschaft mbH, University of Applied Sciences, Limburger Str. 2, 65510 Idstein, Germany"],"raw_orcid":"https://orcid.org/0000-0003-2860-3391","affiliations":[{"raw_affiliation_string":"DiaSys Diagnostic Systems GmbH, Alte Str. 9, 65558 Holzheim, Germany","institution_ids":[]},{"raw_affiliation_string":"Hochschule Fresenius Gem. Tr\u00e4gergesellschaft mbH, University of Applied Sciences, Limburger Str. 2, 65510 Idstein, Germany","institution_ids":["https://openalex.org/I4210135900"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5069541914"],"corresponding_institution_ids":["https://openalex.org/I4210135900"],"apc_list":{"value":2200,"currency":"CHF","value_usd":2447},"apc_paid":{"value":2200,"currency":"CHF","value_usd":2447},"fwci":0.5758,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.60375575,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"11","issue":"1","first_page":"160","last_page":"160"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11754","display_name":"SARS-CoV-2 detection and testing","score":0.9164999723434448,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11754","display_name":"SARS-CoV-2 detection and testing","score":0.9164999723434448,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.08209999650716782,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12867","display_name":"Advanced Biosensing Techniques and Applications","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sars-cov-2","display_name":"SARS-CoV-2","score":0.9789999723434448},{"id":"https://openalex.org/keywords/spike-rbd","display_name":"spike RBD","score":0.6729999780654907},{"id":"https://openalex.org/keywords/nucleocapsid-protein","display_name":"nucleocapsid protein","score":0.9879999756813049},{"id":"https://openalex.org/keywords/variants-of-concern","display_name":"variants of concern","score":0.7900000214576721},{"id":"https://openalex.org/keywords/omicron-variant","display_name":"Omicron variant","score":0.875},{"id":"https://openalex.org/keywords/serological-diagnosis","display_name":"serological diagnosis","score":0.49399998784065247},{"id":"https://openalex.org/keywords/antibody-cross-reactivity","display_name":"antibody cross-reactivity","score":0.8289999961853027},{"id":"https://openalex.org/keywords/sensitivity-and-specificity","display_name":"sensitivity and specificity","score":0.4869999885559082}],"concepts":[{"id":"https://openalex.org/C2780420688","wikidata":"https://www.wikidata.org/wiki/Q759183","display_name":"Immunoassay","level":3,"score":0.5737728476524353},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.5604810118675232},{"id":"https://openalex.org/C3007834351","wikidata":"https://www.wikidata.org/wiki/Q82069695","display_name":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","level":5,"score":0.5120354294776917},{"id":"https://openalex.org/C45189115","wikidata":"https://www.wikidata.org/wiki/Q502159","display_name":"Serology","level":3,"score":0.49454161524772644},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.47391948103904724},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4056618809700012},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38293978571891785},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3458958864212036},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.3430401384830475},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.333139568567276},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.33178967237472534},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.25140050053596497},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.20838260650634766},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.13519993424415588},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/biomedicines11010160","doi":"https://doi.org/10.3390/biomedicines11010160","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biomedicines11010160","pdf_url":"https://www.mdpi.com/2227-9059/11/1/160/pdf?version=1674004797","source":{"id":"https://openalex.org/S2737005842","display_name":"Biomedicines","issn_l":"2227-9059","issn":["2227-9059"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9855841","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9855841","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9855841/pdf/biomedicines-11-00160.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"Text"},{"id":"pmid:36672668","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36672668","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:f8ffceb571894c39a02f44749328c74c","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/f8ffceb571894c39a02f44749328c74c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biomedicines, Vol 11, Iss 1, p 160 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/biomedicines11010160","doi":"https://doi.org/10.3390/biomedicines11010160","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biomedicines11010160","pdf_url":"https://www.mdpi.com/2227-9059/11/1/160/pdf?version=1674004797","source":{"id":"https://openalex.org/S2737005842","display_name":"Biomedicines","issn_l":"2227-9059","issn":["2227-9059"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4313825762.pdf","grobid_xml":"https://content.openalex.org/works/W4313825762.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W184103592","https://openalex.org/W1922262644","https://openalex.org/W2025060492","https://openalex.org/W2034767282","https://openalex.org/W2129265645","https://openalex.org/W2903899730","https://openalex.org/W3001897055","https://openalex.org/W3003217347","https://openalex.org/W3004280078","https://openalex.org/W3005409321","https://openalex.org/W3009335299","https://openalex.org/W3011978530","https://openalex.org/W3015369767","https://openalex.org/W3016655948","https://openalex.org/W3017023889","https://openalex.org/W3024006735","https://openalex.org/W3024072922","https://openalex.org/W3025631553","https://openalex.org/W3030495690","https://openalex.org/W3033661606","https://openalex.org/W3034680516","https://openalex.org/W3038707046","https://openalex.org/W3038836337","https://openalex.org/W3041821205","https://openalex.org/W3045079087","https://openalex.org/W3080921111","https://openalex.org/W3081491793","https://openalex.org/W3092455678","https://openalex.org/W3112213940","https://openalex.org/W3118528158","https://openalex.org/W3123989488","https://openalex.org/W3126729284","https://openalex.org/W3157625523","https://openalex.org/W3158002510","https://openalex.org/W3165479483","https://openalex.org/W3177828909","https://openalex.org/W3179119084","https://openalex.org/W3183374808","https://openalex.org/W3186226593","https://openalex.org/W3211172645","https://openalex.org/W4200438336","https://openalex.org/W4210988539","https://openalex.org/W4220928249","https://openalex.org/W4221105274","https://openalex.org/W4226284222","https://openalex.org/W4281291961","https://openalex.org/W4283361551","https://openalex.org/W4289786409","https://openalex.org/W4292324195","https://openalex.org/W4303415485","https://openalex.org/W6776208904","https://openalex.org/W6782481958"],"related_works":["https://openalex.org/W3186226593","https://openalex.org/W4321326355","https://openalex.org/W4389225203","https://openalex.org/W4364355476","https://openalex.org/W4366290439","https://openalex.org/W4390145939","https://openalex.org/W4384037040","https://openalex.org/W4200438336","https://openalex.org/W4407882154","https://openalex.org/W3202419431"],"abstract_inverted_index":{"Since":[0],"SARS-CoV-2":[1,67,122],"emerged":[2],"in":[3,6],"December":[4],"2019":[5],"Wuhan,":[7],"the":[8,13,19,41,50,66,104,110,115,134,165,189,192],"resulting":[9],"pandemic":[10],"has":[11],"paralyzed":[12],"economic":[14],"and":[15,34,52,75,82,112,142,152,160],"cultural":[16],"life":[17],"of":[18,22,55,114,121,133,164,168,191],"world.":[20],"Variants":[21],"concern":[23],"(VOC)":[24],"strongly":[25],"increase":[26],"pressure":[27],"on":[28],"public":[29],"health":[30],"systems.":[31],"Rapid,":[32],"easy-to-use,":[33],"cost-effective":[35],"assays":[36],"are":[37],"essential":[38],"to":[39,64,171,198],"manage":[40],"pandemic.":[42],"Here":[43],"we":[44,148],"present":[45],"a":[46,76,91,126],"bioinformatical":[47,71],"approach":[48],"for":[49,86],"fast":[51],"efficient":[53],"design":[54],"two":[56],"innovative":[57],"serological":[58],"Particle":[59],"Enhanced":[60],"Turbidimetric":[61],"Immunoassays":[62],"(PETIA)":[63],"quantify":[65],"immunoresponse.":[68],"To":[69,187],"confirm":[70],"assumptions,":[72],"an":[73],"S-RBD-":[74],"Nucleocapsid-based":[77],"PETIA":[78,98,107,117,154],"were":[79,84,123,144],"produced.":[80],"Sensitivity":[81],"specificity":[83,101],"compared":[85],"95":[87],"patient":[88],"samples":[89],"using":[90,175],"BioMajesty\u2122":[92],"fully":[93],"automated":[94],"analyzer.":[95],"The":[96,130,162],"S-RBD-based":[97],"showed":[99,149],"necessary":[100],"(98%)":[102],"over":[103],"N":[105],"protein-based":[106],"(21%).":[108],"Further,":[109],"reactivity":[111],"cross-reactivity":[113,184],"RBD-based":[116],"towards":[118],"variant-derived":[119],"antibodies":[120],"assessed":[124],"by":[125],"quenching":[127],"inhibition":[128,131],"test.":[129],"kinetics":[132],"S-RBD":[135],"variants":[136,169],"Alpha,":[137],"Beta,":[138],"Delta,":[139],"Gamma,":[140],"Kappa,":[141],"Omicron":[143,181,193],"evaluated.":[145],"In":[146,179],"summary,":[147],"that":[150],"specific":[151,176],"robust":[153],"immunoassays":[155,196],"can":[156],"be":[157,199],"rapidly":[158],"designed":[159],"developed.":[161],"quantification":[163,190],"SARS-CoV-2-related":[166],"immunoresponse":[167],"(Alpha":[170],"Kappa)":[172],"is":[173],"possible":[174],"RBD":[177],"assays.":[178],"contrast,":[180],"revealed":[182],"lower":[183],"(approx.":[185],"50%).":[186],"ensure":[188],"variant,":[194],"modified":[195],"appear":[197],"necessary.":[200]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2023-01-09T00:00:00"}