{"id":"https://openalex.org/W4313656136","doi":"https://doi.org/10.29011/2574-7754.101102","title":"Macrophage-Regulating Drug Treatment Promotes Tissue Proliferation in a Diabetic Foot Ulcer Patient with Exposed Anterior Tibialis Tendon - A Case Report","display_name":"Macrophage-Regulating Drug Treatment Promotes Tissue Proliferation in a Diabetic Foot Ulcer Patient with Exposed Anterior Tibialis Tendon - A Case Report","publication_year":2022,"publication_date":"2022-12-28","ids":{"openalex":"https://openalex.org/W4313656136","doi":"https://doi.org/10.29011/2574-7754.101102"},"language":"en","primary_location":{"id":"doi:10.29011/2574-7754.101102","doi":"https://doi.org/10.29011/2574-7754.101102","is_oa":true,"landing_page_url":"http://dx.doi.org/10.29011/2574-7754.101102","pdf_url":"https://www.gavinpublishers.com/assets/articles_pdf/Macrophage-Regulating-Drug-Treatment-Promotes-Tissue-Proliferation-in-a-Diabetic-Foot-Ulcer-Patient-with-Exposed-Anterior-Tibialis-Tendon---A-Case-Report.pdf","source":{"id":"https://openalex.org/S4210209106","display_name":"Annals of Case Reports","issn_l":"2574-7754","issn":["2574-7754"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Case Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.gavinpublishers.com/assets/articles_pdf/Macrophage-Regulating-Drug-Treatment-Promotes-Tissue-Proliferation-in-a-Diabetic-Foot-Ulcer-Patient-with-Exposed-Anterior-Tibialis-Tendon---A-Case-Report.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100768191","display_name":"Yun-Nan Lin","orcid":"https://orcid.org/0000-0002-7286-7928","observed_orcids":["https://orcid.org/0000-0002-7286-7928"]},"institutions":[{"id":"https://openalex.org/I152743029","display_name":"Kaohsiung Medical University","ror":"https://ror.org/03gk81f96","country_code":"TW","type":"education","lineage":["https://openalex.org/I152743029"]},{"id":"https://openalex.org/I2802587341","display_name":"Kaohsiung Medical University Chung-Ho Memorial Hospital","ror":"https://ror.org/02xmkec90","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I2802587341"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yun-Nan Lin","raw_affiliation_strings":["Division of Plastic Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Plastic Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan","institution_ids":["https://openalex.org/I152743029","https://openalex.org/I2802587341"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072761707","display_name":"Jui-Ching Chen","orcid":"https://orcid.org/0000-0002-5474-2371","observed_orcids":["https://orcid.org/0000-0002-5474-2371"]},"institutions":[{"id":"https://openalex.org/I4405267120","display_name":"Oneness Biotech Co., Ltd. (Taiwan)","ror":"https://ror.org/019z49298","country_code":"TW","type":"company","lineage":["https://openalex.org/I4405267120"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Jui-Ching Chen","raw_affiliation_strings":["Department of Medical Science, Oneness Biotech Co., Ltd., Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Science, Oneness Biotech Co., Ltd., Taiwan","institution_ids":["https://openalex.org/I4405267120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030490345","display_name":"Kuan\u2010I Lee","orcid":"https://orcid.org/0000-0001-8248-7761","observed_orcids":["https://orcid.org/0000-0001-8248-7761"]},"institutions":[{"id":"https://openalex.org/I152743029","display_name":"Kaohsiung Medical University","ror":"https://ror.org/03gk81f96","country_code":"TW","type":"education","lineage":["https://openalex.org/I152743029"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Kuan-I Lee","raw_affiliation_strings":["School of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan","institution_ids":["https://openalex.org/I152743029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109376469","display_name":"Shyi-Gen Chen","orcid":"https://orcid.org/0000-0001-6796-8188","observed_orcids":["https://orcid.org/0000-0001-6796-8188"]},"institutions":[{"id":"https://openalex.org/I4405267120","display_name":"Oneness Biotech Co., Ltd. (Taiwan)","ror":"https://ror.org/019z49298","country_code":"TW","type":"company","lineage":["https://openalex.org/I4405267120"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Shyi-Gen Chen","raw_affiliation_strings":["Department of Medical Science, Oneness Biotech Co., Ltd., Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Science, Oneness Biotech Co., Ltd., Taiwan","institution_ids":["https://openalex.org/I4405267120"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113572280","display_name":"Yur Ren Kuo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I152743029","display_name":"Kaohsiung Medical University","ror":"https://ror.org/03gk81f96","country_code":"TW","type":"education","lineage":["https://openalex.org/I152743029"]},{"id":"https://openalex.org/I2802587341","display_name":"Kaohsiung Medical University Chung-Ho Memorial Hospital","ror":"https://ror.org/02xmkec90","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I2802587341"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Yur-Ren Kuo","raw_affiliation_strings":["Division of Plastic Surgery , Department of Surgery , Kaohsiung Medical University Hospital , Kaohsiung Medical University , Kaohsiung , No.100 , Tzyou 1st Rd , Sanmin Dist. , Kaohsiung City 80756 , Taiwan, R.O","Division of Plastic Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Plastic Surgery , Department of Surgery , Kaohsiung Medical University Hospital , Kaohsiung Medical University , Kaohsiung , No.100 , Tzyou 1st Rd , Sanmin Dist. , Kaohsiung City 80756 , Taiwan, R.O","institution_ids":["https://openalex.org/I152743029","https://openalex.org/I2802587341"]},{"raw_affiliation_string":"Division of Plastic Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan","institution_ids":["https://openalex.org/I152743029","https://openalex.org/I2802587341"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5113572280"],"corresponding_institution_ids":["https://openalex.org/I152743029","https://openalex.org/I2802587341"],"apc_list":null,"apc_paid":null,"fwci":0.2081,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.41227014,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"7","issue":"6","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.8525000214576721,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.8525000214576721,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11227","display_name":"Diabetic Foot Ulcer Assessment and Management","score":0.14669999480247498,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12433","display_name":"Skin Diseases and Diabetes","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diabetic-foot-ulcer","display_name":"diabetic foot ulcer","score":0.9860000014305115},{"id":"https://openalex.org/keywords/macrophage-modulation","display_name":"macrophage modulation","score":0.890999972820282},{"id":"https://openalex.org/keywords/soft-tissue-necrosis","display_name":"soft tissue necrosis","score":0.8450000286102295},{"id":"https://openalex.org/keywords/wound-healing","display_name":"wound healing","score":0.7289999723434448},{"id":"https://openalex.org/keywords/chronic-inflammation","display_name":"chronic inflammation","score":0.7129999995231628},{"id":"https://openalex.org/keywords/peripheral-arterial-disease","display_name":"peripheral arterial disease","score":0.7850000262260437},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.906000018119812}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.66142737865448},{"id":"https://openalex.org/C2780105995","wikidata":"https://www.wikidata.org/wiki/Q232358","display_name":"Tendon","level":2,"score":0.5411623120307922},{"id":"https://openalex.org/C2778144972","wikidata":"https://www.wikidata.org/wiki/Q52859","display_name":"Diabetic foot ulcer","level":4,"score":0.5198181867599487},{"id":"https://openalex.org/C115076146","wikidata":"https://www.wikidata.org/wiki/Q1651051","display_name":"Foot (prosody)","level":2,"score":0.5042484998703003},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4246233105659485},{"id":"https://openalex.org/C2777858829","wikidata":"https://www.wikidata.org/wiki/Q52856","display_name":"Diabetic foot","level":3,"score":0.37573936581611633},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.3470379710197449},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.1882430613040924},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.09440037608146667},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.29011/2574-7754.101102","doi":"https://doi.org/10.29011/2574-7754.101102","is_oa":true,"landing_page_url":"http://dx.doi.org/10.29011/2574-7754.101102","pdf_url":"https://www.gavinpublishers.com/assets/articles_pdf/Macrophage-Regulating-Drug-Treatment-Promotes-Tissue-Proliferation-in-a-Diabetic-Foot-Ulcer-Patient-with-Exposed-Anterior-Tibialis-Tendon---A-Case-Report.pdf","source":{"id":"https://openalex.org/S4210209106","display_name":"Annals of Case Reports","issn_l":"2574-7754","issn":["2574-7754"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Case Reports","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.29011/2574-7754.101102","doi":"https://doi.org/10.29011/2574-7754.101102","is_oa":true,"landing_page_url":"http://dx.doi.org/10.29011/2574-7754.101102","pdf_url":"https://www.gavinpublishers.com/assets/articles_pdf/Macrophage-Regulating-Drug-Treatment-Promotes-Tissue-Proliferation-in-a-Diabetic-Foot-Ulcer-Patient-with-Exposed-Anterior-Tibialis-Tendon---A-Case-Report.pdf","source":{"id":"https://openalex.org/S4210209106","display_name":"Annals of Case Reports","issn_l":"2574-7754","issn":["2574-7754"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Case Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4313656136.pdf","grobid_xml":"https://content.openalex.org/works/W4313656136.grobid-xml"},"referenced_works_count":9,"referenced_works":["https://openalex.org/W1535244513","https://openalex.org/W2041394651","https://openalex.org/W2145824881","https://openalex.org/W2772277960","https://openalex.org/W3009329836","https://openalex.org/W3012353290","https://openalex.org/W3217567683","https://openalex.org/W4200026682","https://openalex.org/W4281683528"],"related_works":["https://openalex.org/W4282009454","https://openalex.org/W4309481154","https://openalex.org/W7212146633","https://openalex.org/W4297547935","https://openalex.org/W3196804933","https://openalex.org/W4381377343","https://openalex.org/W3173952956","https://openalex.org/W4413141242","https://openalex.org/W4281683528","https://openalex.org/W4399050547"],"abstract_inverted_index":{"A":[0],"53-year-old":[1],"woman":[2],"with":[3,22,39],"type":[4],"2":[5],"diabetes":[6],"mellitus":[7],"(DM),":[8],"peripheral":[9],"arterial":[10],"disease":[11],"(PAD),":[12],"hypertension,":[13],"and":[14,25,42,89],"hyperlipidemia":[15],"was":[16,46,64],"sent":[17],"to":[18,85],"the":[19,54,59],"emergency":[20],"department":[21],"exposed":[23],"tendon":[24],"soft":[26],"tissue":[27,44,87],"necrosis":[28],"from":[29],"a":[30,82],"diabetic":[31],"foot":[32],"ulcer":[33,68],"(DFU).After":[34],"10":[35],"days":[36],"of":[37],"treatment":[38],"broad-spectrum":[40],"antibiotics":[41],"angioplasty,":[43],"proliferation":[45],"still":[47],"halted":[48],"by":[49],"persistent":[50],"inflammation.Despite":[51],"multiple":[52],"interventions,":[53],"wound":[55],"did":[56],"not":[57],"heal.Therefore,":[58],"topical":[60],"macrophage-modulating":[61],"drug,":[62],"ON101,":[63],"used":[65],"twice":[66],"daily.The":[67],"area":[69],"then":[70],"completely":[71],"closed":[72],"after":[73],"16":[74],"weeks.In":[75],"our":[76],"study,":[77],"macrophage":[78],"modulation":[79],"can":[80],"be":[81],"new":[83],"approach":[84],"promote":[86],"repair":[88],"rescue":[90],"difficult":[91],"wounds.":[92]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2023-01-07T00:00:00"}