{"id":"https://openalex.org/W4313650905","doi":"https://doi.org/10.1002/cnr2.1764","title":"Technological advancements in cancer diagnostics: Improvements and limitations","display_name":"Technological advancements in cancer diagnostics: Improvements and limitations","publication_year":2023,"publication_date":"2023-01-06","ids":{"openalex":"https://openalex.org/W4313650905","doi":"https://doi.org/10.1002/cnr2.1764","pmid":"https://pubmed.ncbi.nlm.nih.gov/36607830","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9940009"},"language":"en","primary_location":{"id":"doi:10.1002/cnr2.1764","doi":"https://doi.org/10.1002/cnr2.1764","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cnr2.1764","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cnr2.1764","source":{"id":"https://openalex.org/S4210241191","display_name":"Cancer Reports","issn_l":"2573-8348","issn":["2573-8348"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Reports","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cnr2.1764","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087562009","display_name":"Akhil Pulumati","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I75421653","display_name":"University of Missouri\u2013Kansas City","ror":"https://ror.org/01w0d5g70","country_code":"US","type":"education","lineage":["https://openalex.org/I75421653"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Akhil Pulumati","raw_affiliation_strings":["University of Missouri-Kansas City, Kansas City, Missouri, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Missouri-Kansas City, Kansas City, Missouri, USA","institution_ids":["https://openalex.org/I75421653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044937699","display_name":"Anika Pulumati","orcid":"https://orcid.org/0000-0002-4613-8430","observed_orcids":["https://orcid.org/0000-0002-4613-8430"]},"institutions":[{"id":"https://openalex.org/I75421653","display_name":"University of Missouri\u2013Kansas City","ror":"https://ror.org/01w0d5g70","country_code":"US","type":"education","lineage":["https://openalex.org/I75421653"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anika Pulumati","raw_affiliation_strings":["University of Missouri-Kansas City, Kansas City, Missouri, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Missouri-Kansas City, Kansas City, Missouri, USA","institution_ids":["https://openalex.org/I75421653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010785248","display_name":"Bilikere Srinivasa Rao Dwarakanath","orcid":"https://orcid.org/0000-0001-6988-2601","observed_orcids":["https://orcid.org/0000-0001-6988-2601"]},"institutions":[{"id":"https://openalex.org/I20107917","display_name":"Sri Ramachandra Institute of Higher Education and Research","ror":"https://ror.org/0108gdg43","country_code":"IN","type":"education","lineage":["https://openalex.org/I20107917"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Bilikere S. Dwarakanath","raw_affiliation_strings":["Central Research Facility, Sri Ramachandra Institute of Higher Education and Research Porur, Chennai, India","Department of Biotechnology, Indian Academy Degree College, Bangalore, India"],"raw_orcid":"https://orcid.org/0000-0001-6988-2601","affiliations":[{"raw_affiliation_string":"Central Research Facility, Sri Ramachandra Institute of Higher Education and Research Porur, Chennai, India","institution_ids":["https://openalex.org/I20107917"]},{"raw_affiliation_string":"Department of Biotechnology, Indian Academy Degree College, Bangalore, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074016586","display_name":"Amit Verma","orcid":"https://orcid.org/0000-0002-9138-0330","observed_orcids":["https://orcid.org/0000-0002-9138-0330"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Amit Verma","raw_affiliation_strings":["PACT & Health LLC Branford Connecticut USA"],"raw_orcid":"https://orcid.org/0000-0002-9138-0330","affiliations":[{"raw_affiliation_string":"PACT & Health LLC Branford Connecticut USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050909852","display_name":"Rao V. L. Papineni","orcid":"https://orcid.org/0000-0002-1263-4292","observed_orcids":["https://orcid.org/0000-0002-1263-4292"]},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Rao V. L. Papineni","raw_affiliation_strings":["Department of Surgery, University of Kansas Medical Center, Kansas City, Kansas, USA","PACT & Health LLC Branford Connecticut USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Kansas Medical Center, Kansas City, Kansas, USA","institution_ids":["https://openalex.org/I4210128618"]},{"raw_affiliation_string":"PACT & Health LLC Branford Connecticut USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5050909852","https://openalex.org/A5074016586"],"corresponding_institution_ids":["https://openalex.org/I4210128618"],"apc_list":{"value":2970,"currency":"USD","value_usd":2970},"apc_paid":{"value":2970,"currency":"USD","value_usd":2970},"fwci":14.3225,"has_fulltext":true,"cited_by_count":345,"citation_normalized_percentile":{"value":0.99851559,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"6","issue":"2","first_page":"e1764","last_page":"e1764"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.7583000063896179,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.7583000063896179,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12379","display_name":"Cancer Diagnosis and Treatment","score":0.08579999953508377,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.029999999329447746,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cancer-diagnosis","display_name":"cancer diagnosis","score":0.9739999771118164},{"id":"https://openalex.org/keywords/tumor-imaging","display_name":"tumor imaging","score":0.9010000228881836},{"id":"https://openalex.org/keywords/molecular-diagnosis","display_name":"molecular diagnosis","score":0.6710000038146973},{"id":"https://openalex.org/keywords/positron-emission-tomography","display_name":"positron emission tomography","score":0.8289999961853027},{"id":"https://openalex.org/keywords/computed-tomography","display_name":"computed tomography","score":0.8629999756813049},{"id":"https://openalex.org/keywords/magnetic-resonance-spectroscopy","display_name":"magnetic resonance spectroscopy","score":0.9959999918937683},{"id":"https://openalex.org/keywords/tumor-screening","display_name":"cancer screening","score":0.5070000290870667},{"id":"https://openalex.org/keywords/early-cancer-detection","display_name":"early cancer detection","score":0.7070000171661377},{"id":"https://openalex.org/keywords/low-cost-diagnostic-device","display_name":"low-cost diagnostic device","score":0.6439999938011169},{"id":"https://openalex.org/keywords/artificial-intelligence-in-cancer-diagnosis","display_name":"artificial intelligence in cancer diagnosis","score":0.7609999775886536},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.7680000066757202},{"id":"https://openalex.org/keywords/picture-archiving-and-communication-systems","display_name":"PACS","score":0.8970000147819519},{"id":"https://openalex.org/keywords/low-and-middle-income-countries","display_name":"low- and middle-income countries","score":0.8259999752044678},{"id":"https://openalex.org/keywords/deep-seated-tumors","display_name":"deep-seated tumors","score":0.6579999923706055},{"id":"https://openalex.org/keywords/tumor-margin-assessment","display_name":"tumor margin assessment","score":0.3580000102519989}],"concepts":[{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6541340947151184},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6246140003204346},{"id":"https://openalex.org/C534262118","wikidata":"https://www.wikidata.org/wiki/Q177719","display_name":"Medical diagnosis","level":2,"score":0.6203734874725342},{"id":"https://openalex.org/C2775842073","wikidata":"https://www.wikidata.org/wiki/Q208376","display_name":"Positron emission tomography","level":2,"score":0.5826046466827393},{"id":"https://openalex.org/C2985322473","wikidata":"https://www.wikidata.org/wiki/Q3044843","display_name":"Cancer detection","level":3,"score":0.5640951991081238},{"id":"https://openalex.org/C19527891","wikidata":"https://www.wikidata.org/wiki/Q1120908","display_name":"Medical physics","level":1,"score":0.4493475556373596},{"id":"https://openalex.org/C3019816032","wikidata":"https://www.wikidata.org/wiki/Q2575340","display_name":"Cancer treatment","level":3,"score":0.4125324785709381},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.4105573296546936},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.40234532952308655},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.27063003182411194},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.2549206614494324},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17949852347373962}],"mesh":[{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014057","descriptor_name":"Tomography, X-Ray Computed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049268","descriptor_name":"Positron-Emission Tomography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1002/cnr2.1764","doi":"https://doi.org/10.1002/cnr2.1764","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cnr2.1764","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cnr2.1764","source":{"id":"https://openalex.org/S4210241191","display_name":"Cancer Reports","issn_l":"2573-8348","issn":["2573-8348"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Reports","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9940009","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9940009","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9940009/pdf/CNR2-6-e1764.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Rep (Hoboken)","raw_type":"Text"},{"id":"pmid:36607830","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36607830","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer reports (Hoboken, N.J.)","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:c62c86ef33fa4c6f899d0cfc45640a81","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/c62c86ef33fa4c6f899d0cfc45640a81","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancer Reports, Vol 6, Iss 2, Pp n/a-n/a (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1002/cnr2.1764","doi":"https://doi.org/10.1002/cnr2.1764","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cnr2.1764","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cnr2.1764","source":{"id":"https://openalex.org/S4210241191","display_name":"Cancer Reports","issn_l":"2573-8348","issn":["2573-8348"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2820943924","display_name":null,"funder_award_id":"75N91019C00043","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6926534951","display_name":null,"funder_award_id":"75N91019C00016","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4313650905.pdf","grobid_xml":"https://content.openalex.org/works/W4313650905.grobid-xml"},"referenced_works_count":111,"referenced_works":["https://openalex.org/W41104782","https://openalex.org/W179239159","https://openalex.org/W1505591375","https://openalex.org/W1568793698","https://openalex.org/W1586312274","https://openalex.org/W1908118656","https://openalex.org/W1924463094","https://openalex.org/W1972042372","https://openalex.org/W1974755730","https://openalex.org/W1983217073","https://openalex.org/W1983613967","https://openalex.org/W1984043016","https://openalex.org/W1984079023","https://openalex.org/W2017566801","https://openalex.org/W2021911949","https://openalex.org/W2022892077","https://openalex.org/W2025919969","https://openalex.org/W2027034274","https://openalex.org/W2037479635","https://openalex.org/W2043680485","https://openalex.org/W2050612949","https://openalex.org/W2050813096","https://openalex.org/W2060538136","https://openalex.org/W2061985730","https://openalex.org/W2062991711","https://openalex.org/W2063110593","https://openalex.org/W2075206831","https://openalex.org/W2090610995","https://openalex.org/W2101676003","https://openalex.org/W2101907056","https://openalex.org/W2108595830","https://openalex.org/W2110081171","https://openalex.org/W2110417418","https://openalex.org/W2116830183","https://openalex.org/W2119846994","https://openalex.org/W2130738775","https://openalex.org/W2137682223","https://openalex.org/W2139501554","https://openalex.org/W2145342077","https://openalex.org/W2146045158","https://openalex.org/W2149603455","https://openalex.org/W2152615936","https://openalex.org/W2155698506","https://openalex.org/W2158609758","https://openalex.org/W2161328137","https://openalex.org/W2162547088","https://openalex.org/W2190593755","https://openalex.org/W2216675461","https://openalex.org/W2287398810","https://openalex.org/W2321724522","https://openalex.org/W2337391992","https://openalex.org/W2340143378","https://openalex.org/W2410481269","https://openalex.org/W2499016125","https://openalex.org/W2509183844","https://openalex.org/W2510751458","https://openalex.org/W2557256009","https://openalex.org/W2574456047","https://openalex.org/W2585769337","https://openalex.org/W2620180145","https://openalex.org/W2635927576","https://openalex.org/W2737983007","https://openalex.org/W2744780828","https://openalex.org/W2748499912","https://openalex.org/W2763827426","https://openalex.org/W2767348571","https://openalex.org/W2783092519","https://openalex.org/W2789250124","https://openalex.org/W2806372829","https://openalex.org/W2906050093","https://openalex.org/W2911605224","https://openalex.org/W2914020168","https://openalex.org/W2921909073","https://openalex.org/W2922876669","https://openalex.org/W2939548416","https://openalex.org/W2944318130","https://openalex.org/W2970803599","https://openalex.org/W2983621264","https://openalex.org/W3010672459","https://openalex.org/W3016871628","https://openalex.org/W3026704535","https://openalex.org/W3030172556","https://openalex.org/W3033659573","https://openalex.org/W3036318564","https://openalex.org/W3040892857","https://openalex.org/W3082828614","https://openalex.org/W3095000040","https://openalex.org/W3100840294","https://openalex.org/W3103359657","https://openalex.org/W3105911569","https://openalex.org/W3109708434","https://openalex.org/W3120287578","https://openalex.org/W3126033692","https://openalex.org/W3128646645","https://openalex.org/W3135090575","https://openalex.org/W3154599582","https://openalex.org/W3155976854","https://openalex.org/W3159713567","https://openalex.org/W3160954197","https://openalex.org/W3161020215","https://openalex.org/W3208056280","https://openalex.org/W4200085248","https://openalex.org/W4200177091","https://openalex.org/W4200343503","https://openalex.org/W4206161442","https://openalex.org/W4220770604","https://openalex.org/W4229007096","https://openalex.org/W4281289502","https://openalex.org/W4281644757","https://openalex.org/W4298137411","https://openalex.org/W6683773101"],"related_works":["https://openalex.org/W4403106807","https://openalex.org/W4401656589","https://openalex.org/W4403253479","https://openalex.org/W4409923472","https://openalex.org/W4411112511","https://openalex.org/W4236929656","https://openalex.org/W4404029482","https://openalex.org/W2415908051","https://openalex.org/W4410058861","https://openalex.org/W2885280648"],"abstract_inverted_index":{"BACKGROUND:":[0],"Cancer":[1],"is":[2,24,58],"characterized":[3],"by":[4],"the":[5,25,46,50,102,114,128,147,153,157,175,194,288,314,344],"rampant":[6],"proliferation,":[7],"growth,":[8],"and":[9,38,56,61,82,87,96,155,171,190,215,219,242,275,285,306,309,322,337,347],"infiltration":[10],"of":[11,28,53,66,105,113,119,130,138,149,169,197,200,228,237,262,287,296,349],"malignantly":[12],"transformed":[13],"cancer":[14,69,106,115,121,151,229,300,328,335],"cells":[15],"past":[16],"their":[17],"normal":[18],"boundaries":[19],"into":[20],"adjacent":[21],"tissues.":[22],"It":[23],"leading":[26],"cause":[27],"death":[29],"worldwide,":[30],"responsible":[31],"for":[32,101,110,141,234,316,326,343],"approximately":[33],"19.3":[34],"million":[35,40,60],"new":[36,54,232,263],"diagnoses":[37,55],"10":[39],"deaths":[41,57],"globally":[42],"in":[43,152,240,334],"2020.":[44],"In":[45,207],"United":[47],"States":[48],"alone,":[49],"estimated":[51],"number":[52],"1.9":[59],"609":[62],"360,":[63],"respectively.":[64],"Implementation":[65],"currently":[67],"existing":[68],"diagnostic":[70,89,162,217,264],"techniques":[71,163,265,340],"such":[72,180],"as":[73,181],"positron":[74],"emission":[75],"tomography":[76,80],"(PET),":[77],"X-ray":[78],"computed":[79],"(CT),":[81],"magnetic":[83],"resonance":[84],"spectroscopy":[85],"(MRS),":[86],"molecular":[88,338],"techniques,":[90],"have":[91],"enabled":[92],"early":[93,111],"detection":[94,112],"rates":[95],"are":[97,124,164,255,341],"instrumental":[98],"not":[99],"only":[100],"therapeutic":[103],"management":[104,236],"patients,":[107],"but":[108],"also":[109],"itself.":[116],"The":[117],"effectiveness":[118],"these":[120,161],"screening":[122],"programs":[123],"heavily":[125],"dependent":[126],"on":[127],"rate":[129,137],"accurate":[131,195,345],"precursor":[132],"lesion":[133],"identification;":[134],"an":[135,260],"increased":[136],"identification":[139],"allows":[140],"earlier":[142],"onset":[143],"treatment,":[144],"thus":[145],"decreasing":[146],"incidence":[148],"invasive":[150],"long-term,":[154],"improving":[156,327],"overall":[158],"prognosis.":[159],"Although":[160],"advantageous":[165],"due":[166],"to":[167,187,223,258],"lack":[168],"invasiveness":[170],"easier":[172],"accessibility":[173],"within":[174],"clinical":[176],"setting,":[177],"several":[178],"limitations":[179],"optimal":[182],"target":[183],"definition,":[184],"high":[185,205],"signal":[186],"background":[188],"ratio":[189],"associated":[191,204],"artifacts":[192],"hinder":[193],"diagnosis":[196,284,346],"specific":[198],"types":[199],"deep-seated":[201],"tumors,":[202],"besides":[203],"cost.":[206],"this":[208],"review":[209],"we":[210,249,291],"discuss":[211,250],"various":[212,251],"imaging,":[213],"molecular,":[214],"low-cost":[216],"tools":[218],"related":[220],"technological":[221,252,332],"advancements,":[222],"provide":[224,292],"a":[225,282,293],"better":[226],"understanding":[227],"diagnostics,":[230],"unraveling":[231],"opportunities":[233],"effective":[235],"cancer,":[238],"particularly":[239],"low-":[241],"middle-income":[243],"countries":[244],"(LMICs).":[245],"RECENT":[246],"FINDINGS:":[247],"Herein":[248],"advancements":[253,333],"that":[254,266],"being":[256],"utilized":[257],"construct":[259],"assortment":[261],"incorporate":[267],"hardware,":[268],"image":[269],"reconstruction":[270],"software,":[271],"imaging":[272,336],"devices,":[273],"biomarkers,":[274],"even":[276],"artificial":[277],"intelligence":[278],"algorithms,":[279],"thereby":[280],"providing":[281],"reliable":[283],"analysis":[286],"tumor.":[289],"Also,":[290],"brief":[294],"account":[295],"alternative":[297],"low":[298],"cost-effective":[299],"therapy":[301],"devices":[302],"(CryoPop\u00ae,":[303],"LumaGEM\u00ae,":[304],"MarginProbe\u00ae)":[305],"picture":[307],"archiving":[308],"communication":[310],"systems":[311],"(PACS),":[312],"emphasizing":[313],"need":[315],"multi-disciplinary":[317],"collaboration":[318],"among":[319],"radiologists,":[320],"pathologists,":[321],"other":[323],"involved":[324],"specialties":[325],"diagnostics.":[329],"CONCLUSION:":[330],"Revolutionary":[331],"biology":[339],"indispensable":[342],"prognosis":[348],"cancer.":[350]},"counts_by_year":[{"year":2026,"cited_by_count":54},{"year":2025,"cited_by_count":160},{"year":2024,"cited_by_count":99},{"year":2023,"cited_by_count":32}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-01-07T00:00:00"}