{"id":"https://openalex.org/W4313643449","doi":"https://doi.org/10.1002/ptr.7627","title":"Tenuifolin ameliorates the sleep deprivation\u2010induced cognitive deficits","display_name":"Tenuifolin ameliorates the sleep deprivation\u2010induced cognitive deficits","publication_year":2023,"publication_date":"2023-01-06","ids":{"openalex":"https://openalex.org/W4313643449","doi":"https://doi.org/10.1002/ptr.7627","pmid":"https://pubmed.ncbi.nlm.nih.gov/36608695"},"language":"en","primary_location":{"id":"doi:10.1002/ptr.7627","doi":"https://doi.org/10.1002/ptr.7627","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ptr.7627","pdf_url":null,"source":{"id":"https://openalex.org/S206789554","display_name":"Phytotherapy Research","issn_l":"0951-418X","issn":["0951-418X","1099-1573"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Phytotherapy Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101913001","display_name":"Ning Jiang","orcid":"https://orcid.org/0000-0002-1534-0177","observed_orcids":["https://orcid.org/0000-0002-1534-0177"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210147708","display_name":"Institute of Medicinal Plant Development","ror":"https://ror.org/052nj8f19","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210141683","https://openalex.org/I4210147708"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ning Jiang","raw_affiliation_strings":["Research Center for Pharmacology and Toxicology, Institute of Medicinal Plant Development (IMPLAD), Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Center for Pharmacology and Toxicology, Institute of Medicinal Plant Development (IMPLAD), Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210147708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100430649","display_name":"Yiwen Zhang","orcid":"https://orcid.org/0000-0001-7894-9556","observed_orcids":["https://orcid.org/0000-0001-7894-9556"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210147708","display_name":"Institute of Medicinal Plant Development","ror":"https://ror.org/052nj8f19","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210141683","https://openalex.org/I4210147708"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yiwen Zhang","raw_affiliation_strings":["Research Center for Pharmacology and Toxicology, Institute of Medicinal Plant Development (IMPLAD), Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Center for Pharmacology and Toxicology, Institute of Medicinal Plant Development (IMPLAD), Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210147708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073780627","display_name":"Caihong Yao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210147708","display_name":"Institute of Medicinal Plant Development","ror":"https://ror.org/052nj8f19","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210141683","https://openalex.org/I4210147708"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Caihong Yao","raw_affiliation_strings":["Research Center for Pharmacology and Toxicology, Institute of Medicinal Plant Development (IMPLAD), Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Center for Pharmacology and Toxicology, Institute of Medicinal Plant Development (IMPLAD), Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210147708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041585602","display_name":"Yupei Liu","orcid":"https://orcid.org/0000-0002-9636-0099","observed_orcids":["https://orcid.org/0000-0002-9636-0099"]},"institutions":[{"id":"https://openalex.org/I14992734","display_name":"Hunan University of Traditional Chinese Medicine","ror":"https://ror.org/05qfq0x09","country_code":"CN","type":"education","lineage":["https://openalex.org/I14992734"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yupei Liu","raw_affiliation_strings":["Key Laboratory of TCM Heart and Lung Syndrome Differentiation & Medicated Diet and Dietotherapy, Hunan University of Chinese Medicine Changsha China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of TCM Heart and Lung Syndrome Differentiation & Medicated Diet and Dietotherapy, Hunan University of Chinese Medicine Changsha China","institution_ids":["https://openalex.org/I14992734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101413306","display_name":"Yuzhen Chen","orcid":"https://orcid.org/0000-0002-1951-8470","observed_orcids":["https://orcid.org/0000-0002-1951-8470"]},"institutions":[{"id":"https://openalex.org/I14992734","display_name":"Hunan University of Traditional Chinese Medicine","ror":"https://ror.org/05qfq0x09","country_code":"CN","type":"education","lineage":["https://openalex.org/I14992734"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuzhen Chen","raw_affiliation_strings":["Key Laboratory of TCM Heart and Lung Syndrome Differentiation & Medicated Diet and Dietotherapy, Hunan University of Chinese Medicine Changsha China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of TCM Heart and Lung Syndrome Differentiation & Medicated Diet and Dietotherapy, Hunan University of Chinese Medicine Changsha China","institution_ids":["https://openalex.org/I14992734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100400044","display_name":"Fang Chen","orcid":"https://orcid.org/0009-0008-6594-8026","observed_orcids":["https://orcid.org/0009-0008-6594-8026"]},"institutions":[{"id":"https://openalex.org/I14992734","display_name":"Hunan University of Traditional Chinese Medicine","ror":"https://ror.org/05qfq0x09","country_code":"CN","type":"education","lineage":["https://openalex.org/I14992734"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fang Chen","raw_affiliation_strings":["Key Laboratory of TCM Heart and Lung Syndrome Differentiation & Medicated Diet and Dietotherapy, Hunan University of Chinese Medicine Changsha China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of TCM Heart and Lung Syndrome Differentiation & Medicated Diet and Dietotherapy, Hunan University of Chinese Medicine Changsha China","institution_ids":["https://openalex.org/I14992734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100322574","display_name":"Yan Wang","orcid":"https://orcid.org/0000-0001-9786-7492","observed_orcids":["https://orcid.org/0000-0001-9786-7492"]},"institutions":[{"id":"https://openalex.org/I193670377","display_name":"University of Karachi","ror":"https://ror.org/05bbbc791","country_code":"PK","type":"education","lineage":["https://openalex.org/I193670377"]},{"id":"https://openalex.org/I4210121526","display_name":"International Center for Chemical and Biological Sciences","ror":"https://ror.org/024ghrf67","country_code":"PK","type":"facility","lineage":["https://openalex.org/I4210121526"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Yan Wang","raw_affiliation_strings":["H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan","institution_ids":["https://openalex.org/I193670377","https://openalex.org/I4210121526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040577138","display_name":"Muhammad Iqbal Choudhary","orcid":"https://orcid.org/0000-0001-5356-3585","observed_orcids":["https://orcid.org/0000-0001-5356-3585"]},"institutions":[{"id":"https://openalex.org/I193670377","display_name":"University of Karachi","ror":"https://ror.org/05bbbc791","country_code":"PK","type":"education","lineage":["https://openalex.org/I193670377"]},{"id":"https://openalex.org/I4210121526","display_name":"International Center for Chemical and Biological Sciences","ror":"https://ror.org/024ghrf67","country_code":"PK","type":"facility","lineage":["https://openalex.org/I4210121526"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Muhammad Iqbal Choudhary","raw_affiliation_strings":["H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan"],"raw_orcid":"https://orcid.org/0000-0001-5356-3585","affiliations":[{"raw_affiliation_string":"H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan","institution_ids":["https://openalex.org/I193670377","https://openalex.org/I4210121526"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100703342","display_name":"Xinmin Liu","orcid":"https://orcid.org/0000-0001-6452-4645","observed_orcids":["https://orcid.org/0000-0001-6452-4645"]},"institutions":[{"id":"https://openalex.org/I14992734","display_name":"Hunan University of Traditional Chinese Medicine","ror":"https://ror.org/05qfq0x09","country_code":"CN","type":"education","lineage":["https://openalex.org/I14992734"]},{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210147708","display_name":"Institute of Medicinal Plant Development","ror":"https://ror.org/052nj8f19","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210141683","https://openalex.org/I4210147708"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xinmin Liu","raw_affiliation_strings":["Key Laboratory of TCM Heart and Lung Syndrome Differentiation & Medicated Diet and Dietotherapy, Hunan University of Chinese Medicine Changsha China","Research Center for Pharmacology and Toxicology, Institute of Medicinal Plant Development (IMPLAD), Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"],"raw_orcid":"https://orcid.org/0000-0001-6452-4645","affiliations":[{"raw_affiliation_string":"Key Laboratory of TCM Heart and Lung Syndrome Differentiation & Medicated Diet and Dietotherapy, Hunan University of Chinese Medicine Changsha China","institution_ids":["https://openalex.org/I14992734"]},{"raw_affiliation_string":"Research Center for Pharmacology and Toxicology, Institute of Medicinal Plant Development (IMPLAD), Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210147708"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5100703342"],"corresponding_institution_ids":["https://openalex.org/I14992734","https://openalex.org/I200296433","https://openalex.org/I4210147708"],"apc_list":{"value":4430,"currency":"USD","value_usd":4430},"apc_paid":null,"fwci":6.0771,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.96533333,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"37","issue":"2","first_page":"464","last_page":"476"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12891","display_name":"Medicinal Plants and Neuroprotection","score":0.8080999851226807,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12891","display_name":"Medicinal Plants and Neuroprotection","score":0.8080999851226807,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14144","display_name":"Neurological Disease Mechanisms and Treatments","score":0.07240000367164612,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10985","display_name":"Sleep and Wakefulness Research","score":0.051100000739097595,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tenuifolin","display_name":"tenuifolin","score":0.8899999856948853},{"id":"https://openalex.org/keywords/polygala-tenuifolia","display_name":"Polygala tenuifolia","score":0.9350000023841858},{"id":"https://openalex.org/keywords/sleep-deprivation","display_name":"sleep deprivation","score":0.9959999918937683},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.7940000295639038},{"id":"https://openalex.org/keywords/memory-impairment","display_name":"memory impairment","score":0.8450000286102295},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.9869999885559082},{"id":"https://openalex.org/keywords/hippocampal-neurogenesis","display_name":"hippocampal neurogenesis","score":0.8199999928474426},{"id":"https://openalex.org/keywords/microglial-activation","display_name":"microglial activation","score":0.7319999933242798},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.8629999756813049},{"id":"https://openalex.org/keywords/nlrp3-inflammasome","display_name":"NLRP3 inflammasome","score":0.902999997138977},{"id":"https://openalex.org/keywords/caspase-1","display_name":"caspase-1","score":0.9089999794960022},{"id":"https://openalex.org/keywords/antioxidant-status","display_name":"antioxidant status","score":0.5640000104904175},{"id":"https://openalex.org/keywords/huperzine-a","display_name":"huperzine A","score":0.8399999737739563}],"concepts":[{"id":"https://openalex.org/C2778329153","wikidata":"https://www.wikidata.org/wiki/Q1364801","display_name":"Sleep deprivation","level":3,"score":0.8325027823448181},{"id":"https://openalex.org/C2775841894","wikidata":"https://www.wikidata.org/wiki/Q4683692","display_name":"Sleep (system call)","level":2,"score":0.606856644153595},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5598104000091553},{"id":"https://openalex.org/C185711340","wikidata":"https://www.wikidata.org/wiki/Q5347381","display_name":"Effects of sleep deprivation on cognitive performance","level":3,"score":0.5510679483413696},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.5139345526695251},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.38864025473594666},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3503187298774719},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.30747273564338684},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.07716497778892517},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003071","descriptor_name":"Cognition","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012503","descriptor_name":"Saponins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012892","descriptor_name":"Sleep Deprivation","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D012892","descriptor_name":"Sleep Deprivation","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018782","descriptor_name":"Maze Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045786","descriptor_name":"Diterpenes, Kaurane","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/ptr.7627","doi":"https://doi.org/10.1002/ptr.7627","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ptr.7627","pdf_url":null,"source":{"id":"https://openalex.org/S206789554","display_name":"Phytotherapy Research","issn_l":"0951-418X","issn":["0951-418X","1099-1573"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Phytotherapy Research","raw_type":"journal-article"},{"id":"pmid:36608695","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36608695","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Phytotherapy research : PTR","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8077154843","display_name":null,"funder_award_id":"81773930","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W646218571","https://openalex.org/W959095434","https://openalex.org/W1554223333","https://openalex.org/W1817666133","https://openalex.org/W1877118068","https://openalex.org/W1906422585","https://openalex.org/W1966265284","https://openalex.org/W1970819735","https://openalex.org/W1970836174","https://openalex.org/W1972717126","https://openalex.org/W1972729587","https://openalex.org/W1993100025","https://openalex.org/W1993976394","https://openalex.org/W2000742404","https://openalex.org/W2001484935","https://openalex.org/W2059330166","https://openalex.org/W2060968640","https://openalex.org/W2066548957","https://openalex.org/W2079237757","https://openalex.org/W2089394861","https://openalex.org/W2138789522","https://openalex.org/W2145796722","https://openalex.org/W2159364733","https://openalex.org/W2213408176","https://openalex.org/W2547552480","https://openalex.org/W2611471265","https://openalex.org/W2776269520","https://openalex.org/W2779446741","https://openalex.org/W2790286704","https://openalex.org/W2799328995","https://openalex.org/W2799985106","https://openalex.org/W2803900565","https://openalex.org/W2914421852","https://openalex.org/W2933452447","https://openalex.org/W2941020388","https://openalex.org/W2944504803","https://openalex.org/W2945692830","https://openalex.org/W2963476296","https://openalex.org/W2969505265","https://openalex.org/W2975833698","https://openalex.org/W2982109472","https://openalex.org/W2982420612","https://openalex.org/W3002656448","https://openalex.org/W3005158722","https://openalex.org/W3009657342","https://openalex.org/W3026913550","https://openalex.org/W3027126165","https://openalex.org/W3039280853","https://openalex.org/W3100761942","https://openalex.org/W3148314774","https://openalex.org/W3158878919","https://openalex.org/W3179093066","https://openalex.org/W3185256927","https://openalex.org/W4200380390","https://openalex.org/W4210886859"],"related_works":["https://openalex.org/W4210886859","https://openalex.org/W4307435126","https://openalex.org/W4361291436","https://openalex.org/W4379140969","https://openalex.org/W2800917659","https://openalex.org/W2982109472","https://openalex.org/W4400838085","https://openalex.org/W4402544597","https://openalex.org/W4224033411","https://openalex.org/W7220744727"],"abstract_inverted_index":{"Tenuifolin":[0],"(TEN),":[1],"a":[2,192],"natural":[3],"neuroprotective":[4,195],"compound":[5],"obtained":[6],"from":[7],"the":[8,18,33,41,44,76,95,105,112,128,134,149,166,169,176],"Polygala":[9],"tenuifolia":[10],"Willd":[11],"plant,":[12],"has":[13],"improved":[14],"cognitive":[15,50],"symptoms.":[16],"However,":[17],"impact":[19],"of":[20,35,47,107,114,136,151,168],"TEN":[21,48,55,83,103,130,164,190],"on":[22,49],"memory":[23,89],"impairments":[24,90],"caused":[25,52,91],"by":[26,53,92,181],"sleep":[27],"deprivation":[28],"(SD)":[29],"is":[30,191],"unclear.":[31],"Accordingly,":[32],"objective":[34],"this":[36],"study":[37],"was":[38],"to":[39,67],"investigate":[40],"mechanisms":[42],"behind":[43],"preventative":[45],"benefits":[46],"impairment":[51],"SD.":[54,182],"(10":[56],"and":[57,60,87,99,119,121,143,160,175],"20":[58],"mg/kg)":[59,64],"Huperzine":[61],"A":[62],"(0.1":[63],"were":[65],"given":[66],"mice":[68],"through":[69],"oral":[70],"gavage":[71],"for":[72,197],"28":[73],"days":[74],"during":[75],"SD":[77,93],"process.":[78],"The":[79],"results":[80],"indicate":[81],"that":[82,189],"administrations":[84],"improve":[85],"short-":[86],"long-term":[88],"in":[94,127],"Y-maze,":[96],"object":[97],"identification,":[98],"step-through":[100],"tests.":[101],"Moreover,":[102],"stimulated":[104],"generation":[106],"anti-inflammatory":[108],"cytokines":[109,116],"(interleukin-10),":[110],"lowered":[111],"production":[113],"pro-inflammatory":[115],"(interleukin-1\u03b2,":[117],"interleukin-6,":[118],"interleukin-18),":[120],"activated":[122],"microglia,":[123],"improving":[124],"antioxidant":[125],"status":[126],"hippocampus.":[129],"treatments":[131],"significantly":[132],"boosted":[133],"expression":[135,150],"nuclear":[137],"factor":[138,141,172],"erythroid":[139],"2-related":[140],"2":[142],"heme":[144],"oxygenase-1":[145],"while":[146],"considerably":[147],"decreasing":[148],"NOD-like":[152],"receptor":[153],"thermal":[154],"protein":[155,158],"domain":[156],"associated":[157],"3":[159],"caspase-1":[161],"p20.":[162],"Additionally,":[163],"restored":[165],"downregulation":[167],"brain-derived":[170],"neurotrophic":[171],"signaling":[173],"cascade":[174],"impaired":[177],"hippocampal":[178],"neurogenesis":[179],"induced":[180],"When":[183],"considered":[184],"collectively,":[185],"our":[186],"data":[187],"suggest":[188],"potentially":[193],"effective":[194],"agent":[196],"cognition":[198],"dysfunction.":[199]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-01-07T00:00:00"}