{"id":"https://openalex.org/W4313639121","doi":"https://doi.org/10.1200/cci.22.00140","title":"Target Trial Emulation: A Design Tool for Cancer Clinical Trials","display_name":"Target Trial Emulation: A Design Tool for Cancer Clinical Trials","publication_year":2023,"publication_date":"2023-01-01","ids":{"openalex":"https://openalex.org/W4313639121","doi":"https://doi.org/10.1200/cci.22.00140","pmid":"https://pubmed.ncbi.nlm.nih.gov/36608311","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10166475"},"language":"en","primary_location":{"id":"doi:10.1200/cci.22.00140","doi":"https://doi.org/10.1200/cci.22.00140","is_oa":true,"landing_page_url":"https://doi.org/10.1200/cci.22.00140","pdf_url":"https://ascopubs.org/doi/pdfdirect/10.1200/CCI.22.00140?role=tab","source":{"id":"https://openalex.org/S4210181501","display_name":"JCO Clinical Cancer Informatics","issn_l":"2473-4276","issn":["2473-4276"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCO Clinical Cancer Informatics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://ascopubs.org/doi/pdfdirect/10.1200/CCI.22.00140?role=tab","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028096127","display_name":"Sandi Alexander Kwee","orcid":"https://orcid.org/0000-0002-4624-8787","observed_orcids":["https://orcid.org/0000-0002-4624-8787"]},"institutions":[{"id":"https://openalex.org/I117965899","display_name":"University of Hawai\u02bbi at M\u0101noa","ror":"https://ror.org/01wspgy28","country_code":"US","type":"education","lineage":["https://openalex.org/I117965899"]},{"id":"https://openalex.org/I4210104115","display_name":"Queen's Medical Center","ror":"https://ror.org/016gbn942","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210104115"]},{"id":"https://openalex.org/I4390039246","display_name":"University of Hawaii Cancer Center","ror":"https://ror.org/00kt3nk56","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039246"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sandi A. Kwee","raw_affiliation_strings":["The Queen's Medical Center, Honolulu, HI","University of Hawai`i Cancer Center, Clinical and Translational Sciences Program, University of Hawaii at Manoa, Honolulu, HI"],"raw_orcid":"https://orcid.org/0000-0002-4624-8787","affiliations":[{"raw_affiliation_string":"The Queen's Medical Center, Honolulu, HI","institution_ids":["https://openalex.org/I4210104115"]},{"raw_affiliation_string":"University of Hawai`i Cancer Center, Clinical and Translational Sciences Program, University of Hawaii at Manoa, Honolulu, HI","institution_ids":["https://openalex.org/I117965899","https://openalex.org/I4390039246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069748932","display_name":"Linda L. Wong","orcid":"https://orcid.org/0000-0003-3143-5384","observed_orcids":["https://orcid.org/0000-0003-3143-5384"]},"institutions":[{"id":"https://openalex.org/I117965899","display_name":"University of Hawai\u02bbi at M\u0101noa","ror":"https://ror.org/01wspgy28","country_code":"US","type":"education","lineage":["https://openalex.org/I117965899"]},{"id":"https://openalex.org/I4390039246","display_name":"University of Hawaii Cancer Center","ror":"https://ror.org/00kt3nk56","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039246"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Linda L. Wong","raw_affiliation_strings":["Department of Surgery, The John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI","University of Hawai`i Cancer Center, Clinical and Translational Sciences Program, University of Hawaii at Manoa, Honolulu, HI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, The John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI","institution_ids":["https://openalex.org/I117965899"]},{"raw_affiliation_string":"University of Hawai`i Cancer Center, Clinical and Translational Sciences Program, University of Hawaii at Manoa, Honolulu, HI","institution_ids":["https://openalex.org/I117965899","https://openalex.org/I4390039246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063821258","display_name":"Christina Ludema","orcid":"https://orcid.org/0000-0003-0779-810X","observed_orcids":["https://orcid.org/0000-0003-0779-810X"]},"institutions":[{"id":"https://openalex.org/I4210119109","display_name":"Indiana University Bloomington","ror":"https://ror.org/02k40bc56","country_code":"US","type":"education","lineage":["https://openalex.org/I4210119109","https://openalex.org/I592451"]},{"id":"https://openalex.org/I592451","display_name":"Indiana University","ror":"https://ror.org/01kg8sb98","country_code":"US","type":"education","lineage":["https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christina Ludema","raw_affiliation_strings":["Indiana University School of Public Health, Bloomington, IN"],"raw_orcid":"https://orcid.org/0000-0003-0779-810X","affiliations":[{"raw_affiliation_string":"Indiana University School of Public Health, Bloomington, IN","institution_ids":["https://openalex.org/I4210119109","https://openalex.org/I592451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022502658","display_name":"Chris K. Deng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I117965899","display_name":"University of Hawai\u02bbi at M\u0101noa","ror":"https://ror.org/01wspgy28","country_code":"US","type":"education","lineage":["https://openalex.org/I117965899"]},{"id":"https://openalex.org/I4390039246","display_name":"University of Hawaii Cancer Center","ror":"https://ror.org/00kt3nk56","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039246"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chris K. Deng","raw_affiliation_strings":["University of Hawai`i Cancer Center, Clinical and Translational Sciences Program, University of Hawaii at Manoa, Honolulu, HI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Hawai`i Cancer Center, Clinical and Translational Sciences Program, University of Hawaii at Manoa, Honolulu, HI","institution_ids":["https://openalex.org/I117965899","https://openalex.org/I4390039246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046647220","display_name":"Deborah Ann Taira","orcid":"https://orcid.org/0000-0002-1989-0109","observed_orcids":["https://orcid.org/0000-0002-1989-0109"]},"institutions":[{"id":"https://openalex.org/I35722693","display_name":"University of Hawaii at Hilo","ror":"https://ror.org/02mp2av58","country_code":"US","type":"education","lineage":["https://openalex.org/I35722693"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deborah Taira","raw_affiliation_strings":["The Daniel K. Inouye College of Pharmacy, University of Hawaii at Hilo, Hilo, HI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Daniel K. Inouye College of Pharmacy, University of Hawaii at Hilo, Hilo, HI","institution_ids":["https://openalex.org/I35722693"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025198443","display_name":"Todd B. Seto","orcid":"https://orcid.org/0000-0001-9872-4290","observed_orcids":["https://orcid.org/0000-0001-9872-4290"]},"institutions":[{"id":"https://openalex.org/I4210104115","display_name":"Queen's Medical Center","ror":"https://ror.org/016gbn942","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210104115"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Todd Seto","raw_affiliation_strings":["The Queen's Medical Center, Honolulu, HI"],"raw_orcid":"https://orcid.org/0000-0001-9872-4290","affiliations":[{"raw_affiliation_string":"The Queen's Medical Center, Honolulu, HI","institution_ids":["https://openalex.org/I4210104115"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103123626","display_name":"Douglas P. Landsittel","orcid":"https://orcid.org/0000-0002-0452-304X","observed_orcids":["https://orcid.org/0000-0002-0452-304X","https://orcid.org/0009-0006-8980-1956"]},"institutions":[{"id":"https://openalex.org/I4210119109","display_name":"Indiana University Bloomington","ror":"https://ror.org/02k40bc56","country_code":"US","type":"education","lineage":["https://openalex.org/I4210119109","https://openalex.org/I592451"]},{"id":"https://openalex.org/I592451","display_name":"Indiana University","ror":"https://ror.org/01kg8sb98","country_code":"US","type":"education","lineage":["https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Douglas Landsittel","raw_affiliation_strings":["Indiana University School of Public Health, Bloomington, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University School of Public Health, Bloomington, IN","institution_ids":["https://openalex.org/I4210119109","https://openalex.org/I592451"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5028096127"],"corresponding_institution_ids":["https://openalex.org/I117965899","https://openalex.org/I4210104115","https://openalex.org/I4390039246"],"apc_list":null,"apc_paid":null,"fwci":3.126,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.9358203,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"7","issue":"7","first_page":"e2200140","last_page":"e2200140"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10845","display_name":"Advanced Causal Inference Techniques","score":0.8163999915122986,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10845","display_name":"Advanced Causal Inference Techniques","score":0.8163999915122986,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.1200999990105629,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.017000000923871994,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/target-trial-emulation","display_name":"target trial emulation","score":0.9990000128746033},{"id":"https://openalex.org/keywords/clinical-trial-design","display_name":"clinical trial design","score":0.7459999918937683},{"id":"https://openalex.org/keywords/eligibility-criteria","display_name":"eligibility criteria","score":0.9470000267028809},{"id":"https://openalex.org/keywords/radioembolization","display_name":"radioembolization","score":0.9240000247955322},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.8500000238418579},{"id":"https://openalex.org/keywords/portal-vein-invasion","display_name":"portal vein invasion","score":0.9940000176429749},{"id":"https://openalex.org/keywords/propensity-score-matching","display_name":"propensity score matching","score":0.8629999756813049},{"id":"https://openalex.org/keywords/exchangeability","display_name":"exchangeability","score":0.746999979019165},{"id":"https://openalex.org/keywords/real-world-data","display_name":"real-world data","score":0.6840000152587891},{"id":"https://openalex.org/keywords/sample-size","display_name":"sample size","score":0.46000000834465027},{"id":"https://openalex.org/keywords/survival-outcomes","display_name":"survival outcomes","score":0.8019999861717224},{"id":"https://openalex.org/keywords/national-cancer-database","display_name":"National Cancer Database","score":0.6069999933242798}],"concepts":[{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.6462291479110718},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.6049410104751587},{"id":"https://openalex.org/C17923572","wikidata":"https://www.wikidata.org/wiki/Q7250160","display_name":"Propensity score matching","level":2,"score":0.587969183921814},{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.5711967349052429},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5593767762184143},{"id":"https://openalex.org/C40423286","wikidata":"https://www.wikidata.org/wiki/Q284172","display_name":"Selection bias","level":2,"score":0.5324315428733826},{"id":"https://openalex.org/C129848803","wikidata":"https://www.wikidata.org/wiki/Q2564360","display_name":"Sample size determination","level":2,"score":0.5272347331047058},{"id":"https://openalex.org/C19527891","wikidata":"https://www.wikidata.org/wiki/Q1120908","display_name":"Medical physics","level":1,"score":0.5102005004882812},{"id":"https://openalex.org/C153083717","wikidata":"https://www.wikidata.org/wiki/Q6535263","display_name":"Leverage (statistics)","level":2,"score":0.5088872909545898},{"id":"https://openalex.org/C148482608","wikidata":"https://www.wikidata.org/wiki/Q17007018","display_name":"Clinical study design","level":3,"score":0.486769437789917},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.4851404130458832},{"id":"https://openalex.org/C149810388","wikidata":"https://www.wikidata.org/wiki/Q5374873","display_name":"Emulation","level":2,"score":0.47765886783599854},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.34427833557128906},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17422962188720703},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.15855863690376282},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.1548340618610382},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.12486711144447327},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.07655179500579834},{"id":"https://openalex.org/C77805123","wikidata":"https://www.wikidata.org/wiki/Q161272","display_name":"Social psychology","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D012107","descriptor_name":"Research Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015982","descriptor_name":"Bias","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018401","descriptor_name":"Sample Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1200/cci.22.00140","doi":"https://doi.org/10.1200/cci.22.00140","is_oa":true,"landing_page_url":"https://doi.org/10.1200/cci.22.00140","pdf_url":"https://ascopubs.org/doi/pdfdirect/10.1200/CCI.22.00140?role=tab","source":{"id":"https://openalex.org/S4210181501","display_name":"JCO Clinical Cancer Informatics","issn_l":"2473-4276","issn":["2473-4276"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCO Clinical Cancer Informatics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10166475","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10166475","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10166475/pdf/cci-7-e2200140.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCO Clin Cancer Inform","raw_type":"Text"},{"id":"pmid:36608311","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36608311","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCO clinical cancer informatics","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1200/cci.22.00140","doi":"https://doi.org/10.1200/cci.22.00140","is_oa":true,"landing_page_url":"https://doi.org/10.1200/cci.22.00140","pdf_url":"https://ascopubs.org/doi/pdfdirect/10.1200/CCI.22.00140?role=tab","source":{"id":"https://openalex.org/S4210181501","display_name":"JCO Clinical Cancer Informatics","issn_l":"2473-4276","issn":["2473-4276"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCO Clinical Cancer Informatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1606707585","display_name":"EXPANDING NATIONAL CAPACITY IN PCOR THROUGH TRAINING (ENACT)","funder_award_id":"R25HS023185","funder_id":"https://openalex.org/F4320332177","funder_display_name":"Agency for Healthcare Research and Quality"},{"id":"https://openalex.org/G9000870016","display_name":"University of Hawaii Cancer Center CCSG","funder_award_id":"P30CA071789","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332177","display_name":"Agency for Healthcare Research and Quality","ror":"https://ror.org/03jmfdf59"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4313639121.pdf","grobid_xml":"https://content.openalex.org/works/W4313639121.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W1982910299","https://openalex.org/W2048565444","https://openalex.org/W2058887247","https://openalex.org/W2062359643","https://openalex.org/W2110818436","https://openalex.org/W2110847259","https://openalex.org/W2120056474","https://openalex.org/W2120224267","https://openalex.org/W2128984831","https://openalex.org/W2129618217","https://openalex.org/W2132324013","https://openalex.org/W2144168223","https://openalex.org/W2161330753","https://openalex.org/W2168458505","https://openalex.org/W2298338128","https://openalex.org/W2404984931","https://openalex.org/W2582878252","https://openalex.org/W2737633790","https://openalex.org/W2745636525","https://openalex.org/W2748203354","https://openalex.org/W2763133656","https://openalex.org/W2772445760","https://openalex.org/W2809424106","https://openalex.org/W2885447570","https://openalex.org/W2899378451","https://openalex.org/W2904964912","https://openalex.org/W2914373213","https://openalex.org/W2939670107","https://openalex.org/W2965008065","https://openalex.org/W2967573282","https://openalex.org/W2976369321","https://openalex.org/W2978231265","https://openalex.org/W2981615951","https://openalex.org/W2990602950","https://openalex.org/W3025022288","https://openalex.org/W3029774995","https://openalex.org/W3088232525","https://openalex.org/W3112964578","https://openalex.org/W3127009504","https://openalex.org/W3127951105","https://openalex.org/W3131883061","https://openalex.org/W3140760072","https://openalex.org/W3178286948","https://openalex.org/W3196121261","https://openalex.org/W4399640967"],"related_works":["https://openalex.org/W7130521417","https://openalex.org/W7128089166","https://openalex.org/W2737633790","https://openalex.org/W7131436187","https://openalex.org/W2179765783","https://openalex.org/W4390339044","https://openalex.org/W7222842878","https://openalex.org/W6890005509","https://openalex.org/W4377694292","https://openalex.org/W7131872216"],"abstract_inverted_index":{"PURPOSE:":[0],"To":[1],"apply":[2],"target":[3,144,189,207],"trial":[4,29,65,94,145,190,208,244],"emulation":[5,95],"to":[6,44,112,216,221],"explore":[7],"the":[8,15,46,64,84,98,105,142,150,159,187,223],"potential":[9],"impact":[10,196],"of":[11,18,25,30,48,63,107,115,137,158,182,197,225],"eligibility":[12,71,166,183],"criteria":[13,167],"on":[14,51,67,200],"primary":[16],"outcome":[17],"a":[19,26,108,133,179,229,234],"randomized":[20,230],"controlled":[21,110,231],"trial.":[22],"METHODS:":[23],"Simulations":[24,58],"real-world":[27,124,219],"explanatory":[28],"transarterial":[31],"radioembolization":[32],"for":[33,77,101,156,228,238],"advanced":[34],"unresectable":[35],"hepatocellular":[36],"carcinoma":[37],"with":[38,177],"portal":[39],"vein":[40],"invasion":[41],"were":[42,81,146,175],"performed":[43],"examine":[45],"effects":[47],"cohort":[49,226],"specification":[50,227],"survival":[52],"outcomes":[53,202],"and":[54,74,88,168],"patient":[55,198],"sample":[56],"size.":[57],"comprised":[59],"24":[60],"different":[61],"permutations":[62],"varied":[66],"three":[68],"disease":[69],"nonspecific":[70],"parameters.":[72],"Treatment":[73],"control":[75],"arms":[76,155],"these":[78],"emulated":[79,160],"trials":[80,161],"drawn":[82],"from":[83],"National":[85,151],"Cancer":[86,152],"Database":[87],"matched":[89],"by":[90,141],"treatment":[91,173,201],"propensity.":[92],"Target":[93],"served":[96],"as":[97],"causal":[99],"framework":[100,212],"this":[102,239],"analysis,":[103],"allowing":[104],"architecture":[106],"true":[109],"experiment":[111],"address":[113],"forms":[114],"bias":[116],"routinely":[117],"encountered":[118],"in":[119,242],"comparative":[120],"effectiveness":[121],"studies":[122],"involving":[123],"observational":[125],"data.":[126],"RESULTS:":[127],"Twenty-four":[128],"propensity":[129],"score-matched":[130],"cohorts":[131],"comprising":[132],"wider":[134],"clinical":[135,170,243],"spectrum":[136],"patients":[138],"than":[139],"specified":[140],"original":[143,188],"successfully":[147],"generated":[148],"using":[149,206],"Database.":[153],"The":[154,195],"each":[157],"demonstrated":[162],"exchangeability":[163],"across":[164],"all":[165],"other":[169],"covariates.":[171],"Significant":[172],"benefits":[174],"associated":[176],"only":[178],"narrow":[180],"range":[181],"criteria,":[184],"indicating":[185],"that":[186],"was":[191],"well":[192],"specified.":[193],"CONCLUSION:":[194],"selection":[199],"can":[203,213],"be":[204],"studied":[205],"emulation.":[209],"This":[210],"analytical":[211],"furthermore":[214],"serve":[215],"leverage":[217],"existing":[218],"data":[220],"inform":[222],"task":[224],"trial,":[232],"facilitating":[233],"more":[235],"data-driven":[236],"approach":[237],"important":[240],"step":[241],"design.":[245]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-01-07T00:00:00"}