{"id":"https://openalex.org/W4313488706","doi":"https://doi.org/10.1021/acsbiomaterials.2c01038","title":"Delivery of Immobilized IFN-\u03b3 With PCN-333 and Its Effect on Human Mesenchymal Stem Cells","display_name":"Delivery of Immobilized IFN-\u03b3 With PCN-333 and Its Effect on Human Mesenchymal Stem Cells","publication_year":2023,"publication_date":"2023-01-04","ids":{"openalex":"https://openalex.org/W4313488706","doi":"https://doi.org/10.1021/acsbiomaterials.2c01038","pmid":"https://pubmed.ncbi.nlm.nih.gov/36598843"},"language":"en","primary_location":{"id":"doi:10.1021/acsbiomaterials.2c01038","doi":"https://doi.org/10.1021/acsbiomaterials.2c01038","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsbiomaterials.2c01038","pdf_url":null,"source":{"id":"https://openalex.org/S2764739176","display_name":"ACS Biomaterials Science & Engineering","issn_l":"2373-9878","issn":["2373-9878"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Biomaterials Science & Engineering","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://mdsoar.org/bitstreams/3c5c867f-8cee-487a-af48-36b067d066ac/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036515159","display_name":"Joshua Phipps","orcid":"https://orcid.org/0000-0002-2538-2290","observed_orcids":["https://orcid.org/0000-0002-2538-2290"]},"institutions":[{"id":"https://openalex.org/I78715868","display_name":"University of Arkansas at Fayetteville","ror":"https://ror.org/05jbt9m15","country_code":"US","type":"education","lineage":["https://openalex.org/I78715868"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Josh Phipps","raw_affiliation_strings":["Cell and Molecular Biology Graduate Program, University of Arkansas, Fayetteville, Arkansas 72701, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell and Molecular Biology Graduate Program, University of Arkansas, Fayetteville, Arkansas 72701, United States","institution_ids":["https://openalex.org/I78715868"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043589574","display_name":"Mahsa Haseli","orcid":"https://orcid.org/0000-0002-6593-6139","observed_orcids":["https://orcid.org/0000-0002-6593-6139"]},"institutions":[{"id":"https://openalex.org/I78715868","display_name":"University of Arkansas at Fayetteville","ror":"https://ror.org/05jbt9m15","country_code":"US","type":"education","lineage":["https://openalex.org/I78715868"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mahsa Haseli","raw_affiliation_strings":["Ralph E. Martin Department of Chemical Engineering, University of Arkansas, Fayetteville, Arkansas 72701, United States"],"raw_orcid":"https://orcid.org/0000-0002-6593-6139","affiliations":[{"raw_affiliation_string":"Ralph E. Martin Department of Chemical Engineering, University of Arkansas, Fayetteville, Arkansas 72701, United States","institution_ids":["https://openalex.org/I78715868"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080822968","display_name":"Luis Pinzon\u2010Herrera","orcid":"https://orcid.org/0000-0001-9726-1343","observed_orcids":["https://orcid.org/0000-0001-9726-1343"]},"institutions":[{"id":"https://openalex.org/I78715868","display_name":"University of Arkansas at Fayetteville","ror":"https://ror.org/05jbt9m15","country_code":"US","type":"education","lineage":["https://openalex.org/I78715868"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Luis Pinzon-Herrera","raw_affiliation_strings":["Ralph E. Martin Department of Chemical Engineering, University of Arkansas, Fayetteville, Arkansas 72701, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ralph E. Martin Department of Chemical Engineering, University of Arkansas, Fayetteville, Arkansas 72701, United States","institution_ids":["https://openalex.org/I78715868"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102062681","display_name":"Ben Wilson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78715868","display_name":"University of Arkansas at Fayetteville","ror":"https://ror.org/05jbt9m15","country_code":"US","type":"education","lineage":["https://openalex.org/I78715868"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ben Wilson","raw_affiliation_strings":["Ralph E. Martin Department of Chemical Engineering, University of Arkansas, Fayetteville, Arkansas 72701, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ralph E. Martin Department of Chemical Engineering, University of Arkansas, Fayetteville, Arkansas 72701, United States","institution_ids":["https://openalex.org/I78715868"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068939066","display_name":"Joshua Corbitt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78715868","display_name":"University of Arkansas at Fayetteville","ror":"https://ror.org/05jbt9m15","country_code":"US","type":"education","lineage":["https://openalex.org/I78715868"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua Corbitt","raw_affiliation_strings":["Ralph E. Martin Department of Chemical Engineering, University of Arkansas, Fayetteville, Arkansas 72701, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ralph E. Martin Department of Chemical Engineering, University of Arkansas, Fayetteville, Arkansas 72701, United States","institution_ids":["https://openalex.org/I78715868"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021272911","display_name":"Shannon L. Servoss","orcid":"https://orcid.org/0000-0003-3075-5423","observed_orcids":["https://orcid.org/0000-0003-3075-5423"]},"institutions":[{"id":"https://openalex.org/I78715868","display_name":"University of Arkansas at Fayetteville","ror":"https://ror.org/05jbt9m15","country_code":"US","type":"education","lineage":["https://openalex.org/I78715868"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shannon Servoss","raw_affiliation_strings":["Ralph E. Martin Department of Chemical Engineering, University of Arkansas, Fayetteville, Arkansas 72701, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ralph E. Martin Department of Chemical Engineering, University of Arkansas, Fayetteville, Arkansas 72701, United States","institution_ids":["https://openalex.org/I78715868"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036212011","display_name":"Jorge Almod\u00f3var","orcid":"https://orcid.org/0000-0002-1151-3878","observed_orcids":["https://orcid.org/0000-0002-1151-3878"]},"institutions":[{"id":"https://openalex.org/I78715868","display_name":"University of Arkansas at Fayetteville","ror":"https://ror.org/05jbt9m15","country_code":"US","type":"education","lineage":["https://openalex.org/I78715868"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jorge Almodovar","raw_affiliation_strings":["Cell and Molecular Biology Graduate Program, University of Arkansas, Fayetteville, Arkansas 72701, United States","Ralph E. Martin Department of Chemical Engineering, University of Arkansas, Fayetteville, Arkansas 72701, United States"],"raw_orcid":"https://orcid.org/0000-0002-1151-3878","affiliations":[{"raw_affiliation_string":"Cell and Molecular Biology Graduate Program, University of Arkansas, Fayetteville, Arkansas 72701, United States","institution_ids":["https://openalex.org/I78715868"]},{"raw_affiliation_string":"Ralph E. Martin Department of Chemical Engineering, University of Arkansas, Fayetteville, Arkansas 72701, United States","institution_ids":["https://openalex.org/I78715868"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5036212011"],"corresponding_institution_ids":["https://openalex.org/I78715868"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":0.4433,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.47697974,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"9","issue":"2","first_page":"671","last_page":"679"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10096","display_name":"Metal-Organic Frameworks: Synthesis and Applications","score":0.6567000150680542,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10096","display_name":"Metal-Organic Frameworks: Synthesis and Applications","score":0.6567000150680542,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.26339998841285706,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10735","display_name":"Mesoporous Materials and Catalysis","score":0.023800000548362732,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.9909999966621399},{"id":"https://openalex.org/keywords/metal-organic-frameworks","display_name":"metal-organic frameworks","score":0.9710000157356262},{"id":"https://openalex.org/keywords/protein-immobilization","display_name":"protein immobilization","score":0.9520000219345093},{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.847000002861023},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.6940000057220459},{"id":"https://openalex.org/keywords/indoleamine-2-3-dioxygenase","display_name":"indoleamine 2,3-dioxygenase","score":0.9599999785423279},{"id":"https://openalex.org/keywords/cell-therapy-manufacturing","display_name":"cell therapy manufacturing","score":0.5139999985694885},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.6549999713897705},{"id":"https://openalex.org/keywords/immune-response-proteins","display_name":"immune response proteins","score":0.5120000243186951},{"id":"https://openalex.org/keywords/stem-cell-proliferation-and-differentiation","display_name":"stem cell proliferation and differentiation","score":0.6110000014305115}],"concepts":[{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.8947421312332153},{"id":"https://openalex.org/C2777230088","wikidata":"https://www.wikidata.org/wiki/Q864426","display_name":"Biocompatibility","level":2,"score":0.608303427696228},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.5891862511634827},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5003347396850586},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.48778706789016724},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.46582266688346863},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4267319440841675},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.388461709022522},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.38154494762420654},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.2134673297405243},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2073538899421692},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16080105304718018},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1021/acsbiomaterials.2c01038","doi":"https://doi.org/10.1021/acsbiomaterials.2c01038","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsbiomaterials.2c01038","pdf_url":null,"source":{"id":"https://openalex.org/S2764739176","display_name":"ACS Biomaterials Science & Engineering","issn_l":"2373-9878","issn":["2373-9878"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Biomaterials Science & Engineering","raw_type":"journal-article"},{"id":"pmid:36598843","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36598843","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS biomaterials science & engineering","raw_type":"Journal Article"},{"id":"pmh:oai:mdsoar.org:11603/32606","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11603/32606","pdf_url":"https://mdsoar.org/bitstreams/3c5c867f-8cee-487a-af48-36b067d066ac/download","source":{"id":"https://openalex.org/S4306402556","display_name":"Maryland Shared Open Access Repository (USMAI Consortium)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"doi:10.13016/m2quyx-p8ak","doi":"https://doi.org/10.13016/m2quyx-p8ak","is_oa":true,"landing_page_url":"https://doi.org/10.13016/m2quyx-p8ak","pdf_url":null,"source":{"id":"https://openalex.org/S4306402644","display_name":"Digital Repository at the University of Maryland (University of Maryland College Park)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I66946132","host_organization_name":"University of Maryland, College Park","host_organization_lineage":["https://openalex.org/I66946132"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"pmh:oai:mdsoar.org:11603/32606","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11603/32606","pdf_url":"https://mdsoar.org/bitstreams/3c5c867f-8cee-487a-af48-36b067d066ac/download","source":{"id":"https://openalex.org/S4306402556","display_name":"Maryland Shared Open Access Repository (USMAI Consortium)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8108102875","display_name":"Identifying hMSC interaction pathways in soluble interferon-gamma and stratified collagen/heparin coatings for the manufacturing of therapeutic cells","funder_award_id":"2051582","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320310058","display_name":"University of Arkansas","ror":"https://ror.org/05jbt9m15"},{"id":"https://openalex.org/F4320310362","display_name":"Arkansas Biosciences Institute","ror":"https://ror.org/00xcryt71"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4313488706.pdf","grobid_xml":"https://content.openalex.org/works/W4313488706.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W1505072916","https://openalex.org/W1584346353","https://openalex.org/W1966897576","https://openalex.org/W1975501285","https://openalex.org/W1979681627","https://openalex.org/W1987632972","https://openalex.org/W2008623993","https://openalex.org/W2014054292","https://openalex.org/W2014909360","https://openalex.org/W2021371517","https://openalex.org/W2022085591","https://openalex.org/W2053984526","https://openalex.org/W2069527111","https://openalex.org/W2084063536","https://openalex.org/W2090815903","https://openalex.org/W2101376945","https://openalex.org/W2131631451","https://openalex.org/W2141939342","https://openalex.org/W2157405618","https://openalex.org/W2164043498","https://openalex.org/W2230149622","https://openalex.org/W2237376052","https://openalex.org/W2318475041","https://openalex.org/W2412679450","https://openalex.org/W2463941642","https://openalex.org/W2500409440","https://openalex.org/W2591028889","https://openalex.org/W2592858278","https://openalex.org/W2599866603","https://openalex.org/W2609455338","https://openalex.org/W2774855349","https://openalex.org/W2795132984","https://openalex.org/W2901216354","https://openalex.org/W2904505935","https://openalex.org/W2917632841","https://openalex.org/W2946745423","https://openalex.org/W2965262455","https://openalex.org/W2984557191","https://openalex.org/W2991416247","https://openalex.org/W3031000187","https://openalex.org/W3049770505","https://openalex.org/W3081052873","https://openalex.org/W3096449470","https://openalex.org/W3109672820","https://openalex.org/W3109804533","https://openalex.org/W3112069176","https://openalex.org/W3194911068","https://openalex.org/W4200133451"],"related_works":["https://openalex.org/W4388517907","https://openalex.org/W2500409440","https://openalex.org/W2965262455","https://openalex.org/W2412566089","https://openalex.org/W4309845682","https://openalex.org/W1966897576","https://openalex.org/W3194911068","https://openalex.org/W2319524499","https://openalex.org/W2783211174","https://openalex.org/W762158981"],"abstract_inverted_index":{"Interferon-gamma":[0],"(IFN-\u03b3)":[1],"plays":[2],"a":[3,32,130],"vital":[4],"role":[5,131],"in":[6,18,29,132,162,165],"modulating":[7],"the":[8,38,74,90,99,124,163,166],"immunosuppressive":[9],"properties":[10],"of":[11,40,94,126,138,147,168],"human":[12],"mesenchymal":[13],"stem/stromal":[14],"cells":[15,100],"(hMSCs)":[16],"used":[17],"cell":[19],"therapies.":[20],"However,":[21],"IFN-\u03b3":[22,36,88,116,149,158],"suffers":[23],"from":[24],"low":[25],"bioavailability":[26],"and":[27,53,77,86,102,135],"degrades":[28],"media,":[30],"creating":[31],"challenge":[33],"when":[34],"using":[35,154],"during":[37],"manufacturing":[39,167],"hMSCs.":[41,95,171],"Metal-organic":[42],"frameworks":[43],"(MOFs),":[44],"with":[45,105],"their":[46],"porous":[47],"interiors,":[48],"biocompatibility,":[49],"high":[50],"loading":[51],"capacity,":[52],"ability":[54],"to":[55,84,89,120,145,156],"be":[56,82,160],"functionalized":[57],"for":[58,66],"targeting,":[59],"have":[60],"become":[61],"an":[62],"increasingly":[63],"suitable":[64],"platform":[65],"protein":[67],"delivery.":[68],"In":[69,96],"this":[70],"work,":[71],"we":[72],"synthesize":[73],"MOF":[75],"PCN-333(Fe)":[76,113],"show":[78],"that":[79,112,128,146],"it":[80],"can":[81,122],"utilized":[83],"immobilize":[85],"deliver":[87,157],"local":[91],"extracellular":[92],"environment":[93],"doing":[97],"so,":[98],"proliferate":[101],"differentiate":[103],"appropriately":[104],"no":[106],"observed":[107],"side":[108],"effects.":[109],"We":[110],"demonstrate":[111],"MOFs":[114,155],"containing":[115],"are":[117,136],"not":[118],"cytotoxic":[119],"hMSCs,":[121],"promote":[123],"expression":[125],"proteins":[127],"play":[129],"immune":[133],"response,":[134],"capable":[137],"inducing":[139],"indoleamine":[140],"2,3-dioxygenase":[141],"(IDO)":[142],"production":[143],"similar":[144],"soluble":[148],"at":[150],"lower":[151],"concentrations.":[152],"Overall,":[153],"may":[159],"leveraged":[161],"future":[164],"therapeutically":[169],"relevant":[170]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-01-06T00:00:00"}