{"id":"https://openalex.org/W4313475111","doi":"https://doi.org/10.21873/invivo.13052","title":"Molecular Mechanisms Involved in Craniosynostosis","display_name":"Molecular Mechanisms Involved in Craniosynostosis","publication_year":2023,"publication_date":"2023-01-01","ids":{"openalex":"https://openalex.org/W4313475111","doi":"https://doi.org/10.21873/invivo.13052","pmid":"https://pubmed.ncbi.nlm.nih.gov/36593018","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9843758"},"language":"en","primary_location":{"id":"doi:10.21873/invivo.13052","doi":"https://doi.org/10.21873/invivo.13052","is_oa":true,"landing_page_url":"https://doi.org/10.21873/invivo.13052","pdf_url":"https://iv.iiarjournals.org/content/invivo/37/1/36.full.pdf","source":{"id":"https://openalex.org/S115443242","display_name":"In Vivo","issn_l":"0258-851X","issn":["0258-851X","1791-7549"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4322764940","host_organization_name":"Stanford University Highwire Press","host_organization_lineage":["https://openalex.org/P4322764940"],"host_organization_lineage_names":["Stanford University Highwire Press"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"In Vivo","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://iv.iiarjournals.org/content/invivo/37/1/36.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077407698","display_name":"Christos Yapijakis","orcid":"https://orcid.org/0000-0001-6695-186X","observed_orcids":["https://orcid.org/0000-0001-6695-186X"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]},{"id":"https://openalex.org/I4210120313","display_name":"Children's Hospital Agia Sophia","ror":"https://ror.org/0315ea826","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210120313"]},{"id":"https://openalex.org/I4210140282","display_name":"University General Hospital Attikon","ror":"https://ror.org/03gb7n667","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210140282"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"CHRISTOS YAPIJAKIS","raw_affiliation_strings":["Department of Molecular Genetics, \"Cephalogenetics\" Center, Athens, Greece","Department of Oral Maxillofacial Surgery, School of Medicine, National Kapodistrian University of Athens, Attikon Hospital, Athens, Greece","Unit of Orofacial Genetics, 1 Department of Pediatrics, School of Medicine, National Kapodistrian University of Athens, \"Agia Sophia\" Children's Hospital, Athens, Greece; cyapi@med.uoa.gr","Unit of Orofacial Genetics, 1st Department of Pediatrics, School of Medicine, National Kapodistrian University of Athens, \"Agia Sophia\" Children's Hospital, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Genetics, \"Cephalogenetics\" Center, Athens, Greece","institution_ids":[]},{"raw_affiliation_string":"Department of Oral Maxillofacial Surgery, School of Medicine, National Kapodistrian University of Athens, Attikon Hospital, Athens, Greece","institution_ids":["https://openalex.org/I200777214","https://openalex.org/I4210140282"]},{"raw_affiliation_string":"Unit of Orofacial Genetics, 1 Department of Pediatrics, School of Medicine, National Kapodistrian University of Athens, \"Agia Sophia\" Children's Hospital, Athens, Greece; cyapi@med.uoa.gr","institution_ids":["https://openalex.org/I200777214","https://openalex.org/I4210120313"]},{"raw_affiliation_string":"Unit of Orofacial Genetics, 1st Department of Pediatrics, School of Medicine, National Kapodistrian University of Athens, \"Agia Sophia\" Children's Hospital, Athens, Greece","institution_ids":["https://openalex.org/I200777214","https://openalex.org/I4210120313"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003569783","display_name":"NIKOLAOS PACHIS","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]},{"id":"https://openalex.org/I4210120313","display_name":"Children's Hospital Agia Sophia","ror":"https://ror.org/0315ea826","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210120313"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"NIKOLAOS PACHIS","raw_affiliation_strings":["Department of Molecular Genetics, \"Cephalogenetics\" Center, Athens, Greece","Unit of Orofacial Genetics, 1 Department of Pediatrics, School of Medicine, National Kapodistrian University of Athens, \"Agia Sophia\" Children's Hospital, Athens, Greece","Unit of Orofacial Genetics, 1st Department of Pediatrics, School of Medicine, National Kapodistrian University of Athens, \"Agia Sophia\" Children's Hospital, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Genetics, \"Cephalogenetics\" Center, Athens, Greece","institution_ids":[]},{"raw_affiliation_string":"Unit of Orofacial Genetics, 1 Department of Pediatrics, School of Medicine, National Kapodistrian University of Athens, \"Agia Sophia\" Children's Hospital, Athens, Greece","institution_ids":["https://openalex.org/I200777214","https://openalex.org/I4210120313"]},{"raw_affiliation_string":"Unit of Orofacial Genetics, 1st Department of Pediatrics, School of Medicine, National Kapodistrian University of Athens, \"Agia Sophia\" Children's Hospital, Athens, Greece","institution_ids":["https://openalex.org/I200777214","https://openalex.org/I4210120313"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089637885","display_name":"Triantafyllia Sotiriadou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]},{"id":"https://openalex.org/I4210120313","display_name":"Children's Hospital Agia Sophia","ror":"https://ror.org/0315ea826","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210120313"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"TRIANTAFYLLIA SOTIRIADOU","raw_affiliation_strings":["Unit of Orofacial Genetics, 1 Department of Pediatrics, School of Medicine, National Kapodistrian University of Athens, \"Agia Sophia\" Children's Hospital, Athens, Greece","Unit of Orofacial Genetics, 1st Department of Pediatrics, School of Medicine, National Kapodistrian University of Athens, \"Agia Sophia\" Children's Hospital, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit of Orofacial Genetics, 1 Department of Pediatrics, School of Medicine, National Kapodistrian University of Athens, \"Agia Sophia\" Children's Hospital, Athens, Greece","institution_ids":["https://openalex.org/I200777214","https://openalex.org/I4210120313"]},{"raw_affiliation_string":"Unit of Orofacial Genetics, 1st Department of Pediatrics, School of Medicine, National Kapodistrian University of Athens, \"Agia Sophia\" Children's Hospital, Athens, Greece","institution_ids":["https://openalex.org/I200777214","https://openalex.org/I4210120313"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050851314","display_name":"CHRISTINA VAILA","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"CHRISTINA VAILA","raw_affiliation_strings":["Department of Molecular Genetics, \"Cephalogenetics\" Center, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Genetics, \"Cephalogenetics\" Center, Athens, Greece","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064620698","display_name":"Vasiliki Michopoulou","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"VASILIKI MICHOPOULOU","raw_affiliation_strings":["Department of Molecular Genetics, \"Cephalogenetics\" Center, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Genetics, \"Cephalogenetics\" Center, Athens, Greece","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080356433","display_name":"Stavros Vassiliou","orcid":"https://orcid.org/0000-0001-6102-2551","observed_orcids":["https://orcid.org/0000-0001-6102-2551"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]},{"id":"https://openalex.org/I4210140282","display_name":"University General Hospital Attikon","ror":"https://ror.org/03gb7n667","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210140282"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"STAVROS VASSILIOU","raw_affiliation_strings":["Department of Oral Maxillofacial Surgery, School of Medicine, National Kapodistrian University of Athens, Attikon Hospital, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Maxillofacial Surgery, School of Medicine, National Kapodistrian University of Athens, Attikon Hospital, Athens, Greece","institution_ids":["https://openalex.org/I200777214","https://openalex.org/I4210140282"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.6396,"has_fulltext":true,"cited_by_count":30,"citation_normalized_percentile":{"value":0.84463509,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"37","issue":"1","first_page":"36","last_page":"46"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11679","display_name":"Craniofacial Disorders and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11679","display_name":"Craniofacial Disorders and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11919","display_name":"dental development and anomalies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13328","display_name":"Osteomyelitis and Bone Disorders Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/craniosynostosis","display_name":"craniosynostosis","score":1.0},{"id":"https://openalex.org/keywords/cranial-sutures","display_name":"cranial sutures","score":0.8880000114440918},{"id":"https://openalex.org/keywords/syndromic-craniosynostosis","display_name":"syndromic craniosynostosis","score":0.9850000143051147},{"id":"https://openalex.org/keywords/nonsyndromic-craniosynostosis","display_name":"nonsyndromic craniosynostosis","score":0.9750000238418579},{"id":"https://openalex.org/keywords/fgfr1","display_name":"FGFR1","score":0.7889999747276306},{"id":"https://openalex.org/keywords/fgfr2","display_name":"FGFR2","score":1.0},{"id":"https://openalex.org/keywords/fgfr3","display_name":"FGFR3","score":0.9990000128746033},{"id":"https://openalex.org/keywords/twist1","display_name":"TWIST1","score":0.996999979019165},{"id":"https://openalex.org/keywords/msx2","display_name":"Msx2","score":0.9819999933242798},{"id":"https://openalex.org/keywords/craniofacial-abnormalities","display_name":"craniofacial anomalies","score":0.7770000100135803},{"id":"https://openalex.org/keywords/craniosynostosis-surgery","display_name":"craniosynostosis surgery","score":0.7889999747276306},{"id":"https://openalex.org/keywords/pfeiffer-syndrome","display_name":"Pfeiffer syndrome","score":0.8830000162124634},{"id":"https://openalex.org/keywords/apert-syndrome","display_name":"Apert syndrome","score":0.9869999885559082},{"id":"https://openalex.org/keywords/crouzon-syndrome","display_name":"Crouzon syndrome","score":0.968999981880188},{"id":"https://openalex.org/keywords/muenke-syndrome","display_name":"Muenke syndrome","score":0.9800000190734863}],"concepts":[{"id":"https://openalex.org/C2779302956","wikidata":"https://www.wikidata.org/wiki/Q378183","display_name":"Craniosynostosis","level":2,"score":0.9876492023468018},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6805013418197632},{"id":"https://openalex.org/C2776673712","wikidata":"https://www.wikidata.org/wiki/Q2141048","display_name":"Synostosis","level":2,"score":0.6654931306838989},{"id":"https://openalex.org/C2781245598","wikidata":"https://www.wikidata.org/wiki/Q5182134","display_name":"Craniofacial","level":2,"score":0.6272876858711243},{"id":"https://openalex.org/C2911059045","wikidata":"https://www.wikidata.org/wiki/Q378183","display_name":"Craniosynostoses","level":3,"score":0.6236481666564941},{"id":"https://openalex.org/C2777327002","wikidata":"https://www.wikidata.org/wiki/Q2865760","display_name":"Fibrous joint","level":2,"score":0.5273939967155457},{"id":"https://openalex.org/C2780639360","wikidata":"https://www.wikidata.org/wiki/Q779250","display_name":"Crouzon syndrome","level":3,"score":0.49124377965927124},{"id":"https://openalex.org/C2778043341","wikidata":"https://www.wikidata.org/wiki/Q5182142","display_name":"Craniofacial surgery","level":3,"score":0.44981649518013},{"id":"https://openalex.org/C2777203189","wikidata":"https://www.wikidata.org/wiki/Q1269307","display_name":"Dysostosis","level":3,"score":0.4481389820575714},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.31237083673477173},{"id":"https://openalex.org/C2992981700","wikidata":"https://www.wikidata.org/wiki/Q727096","display_name":"Congenital disease","level":2,"score":0.0997212827205658},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003398","descriptor_name":"Craniosynostoses","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D003398","descriptor_name":"Craniosynostoses","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012886","descriptor_name":"Skull","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013577","descriptor_name":"Syndrome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.21873/invivo.13052","doi":"https://doi.org/10.21873/invivo.13052","is_oa":true,"landing_page_url":"https://doi.org/10.21873/invivo.13052","pdf_url":"https://iv.iiarjournals.org/content/invivo/37/1/36.full.pdf","source":{"id":"https://openalex.org/S115443242","display_name":"In Vivo","issn_l":"0258-851X","issn":["0258-851X","1791-7549"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4322764940","host_organization_name":"Stanford University Highwire Press","host_organization_lineage":["https://openalex.org/P4322764940"],"host_organization_lineage_names":["Stanford University Highwire Press"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"In Vivo","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9843758","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9843758","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9843758/pdf/in_vivo-37-36.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"In Vivo","raw_type":"Text"},{"id":"pmid:36593018","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36593018","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"In vivo (Athens, Greece)","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.21873/invivo.13052","doi":"https://doi.org/10.21873/invivo.13052","is_oa":true,"landing_page_url":"https://doi.org/10.21873/invivo.13052","pdf_url":"https://iv.iiarjournals.org/content/invivo/37/1/36.full.pdf","source":{"id":"https://openalex.org/S115443242","display_name":"In Vivo","issn_l":"0258-851X","issn":["0258-851X","1791-7549"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4322764940","host_organization_name":"Stanford University Highwire Press","host_organization_lineage":["https://openalex.org/P4322764940"],"host_organization_lineage_names":["Stanford University Highwire Press"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"In Vivo","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4313475111.pdf","grobid_xml":"https://content.openalex.org/works/W4313475111.grobid-xml"},"referenced_works_count":78,"referenced_works":["https://openalex.org/W1544694629","https://openalex.org/W1563996790","https://openalex.org/W1566187568","https://openalex.org/W1576976592","https://openalex.org/W1929611763","https://openalex.org/W1954138059","https://openalex.org/W1964395993","https://openalex.org/W1966345426","https://openalex.org/W1969353228","https://openalex.org/W1979490174","https://openalex.org/W1985648832","https://openalex.org/W1988067304","https://openalex.org/W1988824842","https://openalex.org/W1991423292","https://openalex.org/W1991732233","https://openalex.org/W1994575776","https://openalex.org/W2001410834","https://openalex.org/W2004893262","https://openalex.org/W2014199331","https://openalex.org/W2020999791","https://openalex.org/W2026201824","https://openalex.org/W2030157853","https://openalex.org/W2033030584","https://openalex.org/W2038532985","https://openalex.org/W2044280612","https://openalex.org/W2046162233","https://openalex.org/W2054121301","https://openalex.org/W2055458838","https://openalex.org/W2065409409","https://openalex.org/W2067964671","https://openalex.org/W2068208801","https://openalex.org/W2069181244","https://openalex.org/W2072288858","https://openalex.org/W2074166336","https://openalex.org/W2075328770","https://openalex.org/W2078555692","https://openalex.org/W2083428661","https://openalex.org/W2091808003","https://openalex.org/W2105601954","https://openalex.org/W2110341920","https://openalex.org/W2111689936","https://openalex.org/W2115224457","https://openalex.org/W2129223193","https://openalex.org/W2131587128","https://openalex.org/W2132893438","https://openalex.org/W2133097247","https://openalex.org/W2135269565","https://openalex.org/W2143858459","https://openalex.org/W2153429518","https://openalex.org/W2161613003","https://openalex.org/W2165149719","https://openalex.org/W2170516128","https://openalex.org/W2172171123","https://openalex.org/W2289346141","https://openalex.org/W2305024637","https://openalex.org/W2316827020","https://openalex.org/W2318539914","https://openalex.org/W2395316646","https://openalex.org/W2400983980","https://openalex.org/W2402216163","https://openalex.org/W2404260170","https://openalex.org/W2440922083","https://openalex.org/W2513953659","https://openalex.org/W2626233920","https://openalex.org/W2790463464","https://openalex.org/W2901283631","https://openalex.org/W2909598390","https://openalex.org/W2916537965","https://openalex.org/W3141225505","https://openalex.org/W4229933927","https://openalex.org/W4231119834","https://openalex.org/W4235520325","https://openalex.org/W4236062039","https://openalex.org/W4238727789","https://openalex.org/W4241312036","https://openalex.org/W4248808434","https://openalex.org/W4250636285","https://openalex.org/W4281793263"],"related_works":["https://openalex.org/W7135906984","https://openalex.org/W2404522065","https://openalex.org/W2111304268","https://openalex.org/W4254739191","https://openalex.org/W4255408774","https://openalex.org/W2769676409","https://openalex.org/W1571399449","https://openalex.org/W2055458838","https://openalex.org/W2062360202","https://openalex.org/W2412770049"],"abstract_inverted_index":{"Craniosynostosis":[0],"refers":[1],"to":[2,53],"the":[3,108,114,117],"early":[4],"fusion":[5],"of":[6,39,62,110,116],"one":[7],"or":[8],"many":[9],"cranial":[10,93],"sutures,":[11],"causing":[12],"craniofacial":[13],"abnormalities":[14],"observed":[15],"in":[16,33,79,104],"1:2,500":[17],"births":[18],"worldwide.":[19],"In":[20],"most":[21],"cases":[22,35],"(85%),":[23],"craniosynostosis":[24,63,80],"is":[25],"presented":[26],"as":[27,37,102],"sporadic":[28],"anomaly":[29],"(non-syndromic":[30],"craniosynostosis),":[31],"while":[32],"other":[34],"(15%)":[36],"part":[38],"syndromes":[40,61],"(syndromic":[41],"craniosynostosis).":[42],"Patients":[43],"with":[44,55],"syndromic":[45],"disorder":[46],"usually":[47],"have":[48],"more":[49],"severe":[50],"symptoms":[51],"compared":[52],"those":[54],"single":[56],"suture":[57],"synostosis.":[58],"Most":[59],"common":[60],"include":[64],"Pfeiffer,":[65],"Apert,":[66],"Crouzon,":[67],"Jackson-Weiss,":[68],"Muenke":[69],"and":[70,86,107],"Boston":[71],"type":[72,109],"MSX2-related":[73],"syndrome.":[74],"The":[75,96],"main":[76,97],"gene":[77],"mutations":[78],"involve":[81],"FGFR1,":[82],"FGFR2,":[83],"FGFR3,":[84],"TWIST1":[85],"MSX2,":[87],"which":[88],"encode":[89],"key":[90],"factors":[91],"influencing":[92],"bone":[94],"morphogenesis.":[95],"therapeutic":[98],"approaches":[99],"are":[100],"surgical":[101],"discussed":[103],"this":[105],"review,":[106],"therapy":[111],"depends":[112],"on":[113],"graveness":[115],"incident.":[118]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":15},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-01-06T00:00:00"}