{"id":"https://openalex.org/W4313429191","doi":"https://doi.org/10.4049/jimmunol.178.supp.45.2","title":"\u03b1B-crystallin protects the retina during S. aureus induced endophthalmitis (45.2)","display_name":"\u03b1B-crystallin protects the retina during S. aureus induced endophthalmitis (45.2)","publication_year":2007,"publication_date":"2007-04-01","ids":{"openalex":"https://openalex.org/W4313429191","doi":"https://doi.org/10.4049/jimmunol.178.supp.45.2"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.178.supp.45.2","doi":"https://doi.org/10.4049/jimmunol.178.supp.45.2","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.178.supp.45.2","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103467999","display_name":"Meredith S. Gregory","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Meredith Gregory","raw_affiliation_strings":["Ophthalmology, Harvard Medical School , 20 Staniford Street, Boston, MA, 02114","1Ophthalmology, Harvard Medical School, 20 Staniford Street, Boston, MA, 02114,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ophthalmology, Harvard Medical School , 20 Staniford Street, Boston, MA, 02114","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"1Ophthalmology, Harvard Medical School, 20 Staniford Street, Boston, MA, 02114,","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087149344","display_name":"Emily Whiston","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emily Whiston","raw_affiliation_strings":["Ophthalmology, Harvard Medical School , 20 Staniford Street, Boston, MA, 02114","1Ophthalmology, Harvard Medical School, 20 Staniford Street, Boston, MA, 02114,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ophthalmology, Harvard Medical School , 20 Staniford Street, Boston, MA, 02114","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"1Ophthalmology, Harvard Medical School, 20 Staniford Street, Boston, MA, 02114,","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068363191","display_name":"Norito Sugi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Norito Sugi","raw_affiliation_strings":["Ophthalmology, Harvard Medical School , 20 Staniford Street, Boston, MA, 02114","1Ophthalmology, Harvard Medical School, 20 Staniford Street, Boston, MA, 02114,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ophthalmology, Harvard Medical School , 20 Staniford Street, Boston, MA, 02114","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"1Ophthalmology, Harvard Medical School, 20 Staniford Street, Boston, MA, 02114,","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072748636","display_name":"Coralynn S. Sack","orcid":"https://orcid.org/0000-0003-1825-6066","observed_orcids":["https://orcid.org/0000-0003-1825-6066"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Coralynn Sack","raw_affiliation_strings":["Ophthalmology, Harvard Medical School , 20 Staniford Street, Boston, MA, 02114","1Ophthalmology, Harvard Medical School, 20 Staniford Street, Boston, MA, 02114,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ophthalmology, Harvard Medical School , 20 Staniford Street, Boston, MA, 02114","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"1Ophthalmology, Harvard Medical School, 20 Staniford Street, Boston, MA, 02114,","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048299806","display_name":"Merideth C. Kamradt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17856709","display_name":"Bridgewater State University","ror":"https://ror.org/02x3skf39","country_code":"US","type":"education","lineage":["https://openalex.org/I17856709"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Merideth C Kamradt","raw_affiliation_strings":["School of Arts and Sciences, Bridgewater State College , 24 Park Avenue, Bridgewater, MA, 02325","2School of Arts and Sciences, Bridgewater State College, 24 Park Avenue, Bridgewater, MA, 02325"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Arts and Sciences, Bridgewater State College , 24 Park Avenue, Bridgewater, MA, 02325","institution_ids":["https://openalex.org/I17856709"]},{"raw_affiliation_string":"2School of Arts and Sciences, Bridgewater State College, 24 Park Avenue, Bridgewater, MA, 02325","institution_ids":["https://openalex.org/I17856709"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113888108","display_name":"Susan R. Heimer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan Heimer","raw_affiliation_strings":["Ophthalmology, Harvard Medical School , 20 Staniford Street, Boston, MA, 02114","1Ophthalmology, Harvard Medical School, 20 Staniford Street, Boston, MA, 02114,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ophthalmology, Harvard Medical School , 20 Staniford Street, Boston, MA, 02114","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"1Ophthalmology, Harvard Medical School, 20 Staniford Street, Boston, MA, 02114,","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057107293","display_name":"Michael S. Gilmore","orcid":"https://orcid.org/0000-0001-6389-832X","observed_orcids":["https://orcid.org/0000-0001-6389-832X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael S Gilmore","raw_affiliation_strings":["Ophthalmology, Harvard Medical School , 20 Staniford Street, Boston, MA, 02114","1Ophthalmology, Harvard Medical School, 20 Staniford Street, Boston, MA, 02114,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ophthalmology, Harvard Medical School , 20 Staniford Street, Boston, MA, 02114","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"1Ophthalmology, Harvard Medical School, 20 Staniford Street, Boston, MA, 02114,","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086226110","display_name":"Bruce R. Ksander","orcid":"https://orcid.org/0000-0001-5546-0360","observed_orcids":["https://orcid.org/0000-0001-5546-0360"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bruce R Ksander","raw_affiliation_strings":["Ophthalmology, Harvard Medical School , 20 Staniford Street, Boston, MA, 02114","1Ophthalmology, Harvard Medical School, 20 Staniford Street, Boston, MA, 02114,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ophthalmology, Harvard Medical School , 20 Staniford Street, Boston, MA, 02114","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"1Ophthalmology, Harvard Medical School, 20 Staniford Street, Boston, MA, 02114,","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"178","issue":"1_Supplement","first_page":"S57","last_page":"S57"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11826","display_name":"Ocular Infections and Treatments","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11826","display_name":"Ocular Infections and Treatments","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alphab-crystallin","display_name":"alphaB-crystallin","score":0.9639999866485596},{"id":"https://openalex.org/keywords/endophthalmitis","display_name":"endophthalmitis","score":0.8450000286102295},{"id":"https://openalex.org/keywords/staphylococcus-aureus","display_name":"Staphylococcus aureus","score":0.9959999918937683},{"id":"https://openalex.org/keywords/retinal-apoptosis","display_name":"retinal apoptosis","score":0.8820000290870667},{"id":"https://openalex.org/keywords/small-heat-shock-proteins","display_name":"small heat shock proteins","score":0.8199999928474426},{"id":"https://openalex.org/keywords/retinal-protection","display_name":"retinal protection","score":0.7350000143051147},{"id":"https://openalex.org/keywords/bacterial-proteases","display_name":"bacterial proteases","score":0.9110000133514404},{"id":"https://openalex.org/keywords/retinal-ganglion-cells","display_name":"retinal ganglion cells","score":0.718999981880188},{"id":"https://openalex.org/keywords/inner-nuclear-layer","display_name":"inner nuclear layer","score":0.9399999976158142},{"id":"https://openalex.org/keywords/retinal-function","display_name":"retinal function","score":0.45100000500679016}],"concepts":[{"id":"https://openalex.org/C2777093970","wikidata":"https://www.wikidata.org/wiki/Q169342","display_name":"Retina","level":2,"score":0.8651976585388184},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7232911586761475},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.6735656261444092},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.557651937007904},{"id":"https://openalex.org/C2777506830","wikidata":"https://www.wikidata.org/wiki/Q4113799","display_name":"Inner nuclear layer","level":3,"score":0.5460342168807983},{"id":"https://openalex.org/C2778231335","wikidata":"https://www.wikidata.org/wiki/Q4113701","display_name":"Outer nuclear layer","level":3,"score":0.537341296672821},{"id":"https://openalex.org/C196795494","wikidata":"https://www.wikidata.org/wiki/Q1624817","display_name":"TUNEL assay","level":3,"score":0.5236639380455017},{"id":"https://openalex.org/C2777235844","wikidata":"https://www.wikidata.org/wiki/Q1294912","display_name":"Endophthalmitis","level":2,"score":0.5047858953475952},{"id":"https://openalex.org/C205260736","wikidata":"https://www.wikidata.org/wiki/Q418939","display_name":"Heat shock protein","level":3,"score":0.44388431310653687},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3737947940826416},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1311766803264618},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0612388551235199},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4049/jimmunol.178.supp.45.2","doi":"https://doi.org/10.4049/jimmunol.178.supp.45.2","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.178.supp.45.2","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2119332353","https://openalex.org/W9315233","https://openalex.org/W2993395946","https://openalex.org/W2992153951","https://openalex.org/W2065046881","https://openalex.org/W2518633607","https://openalex.org/W1992713548","https://openalex.org/W2045674060","https://openalex.org/W2763693026","https://openalex.org/W2572424104"],"abstract_inverted_index":{"Abstract":[0],"Purpose:":[1],"Bacterial":[2],"infections":[3],"in":[4,12,49,109,137,161,175,178,201],"the":[5,8,50,57,110,115,138,162,184,206],"posterior":[6],"of":[7,71,107,114,135,159,183],"eye":[9],"(endophthalmitis)":[10],"result":[11],"toxin-related":[13],"retinal":[14,33,125,128,146,194],"destruction.":[15],"However,":[16],"it":[17],"is":[18,40,190],"not":[19],"known":[20],"whether":[21,30],"apoptosis":[22,95,108,136,182],"contributes":[23],"to":[24,192,204],"infection":[25],"pathology.":[26],"We":[27,52],"are":[28,199],"investigating":[29],"\u03b1B-crystallin":[31,39,55,63,160,174,189],"protects":[32,56],"tissue":[34],"during":[35,187],"S.":[36,74,155,165],"aureus":[37,156,166],"endophthalmitis.":[38,188],"an":[41,202],"anti-apoptotic":[42],"small":[43],"heat":[44],"shock":[45],"protein":[46],"constitutively":[47],"expressed":[48],"retina.":[51,116,207],"hypothesize":[53],"that":[54,154,170],"retina":[58,163,185],"from":[59],"apoptosis.":[60],"Methods:":[61],"129S6/SvEv":[62],"KO":[64,120],"and":[65,78,87,132,143,164,172,177],"wild-type":[66],"mice":[67,102,121],"received":[68],"intravitreal":[69],"injections":[70],"500":[72],"CFU":[73],"aureus.":[75],"Clinical":[76],"examinations":[77],"ERGs":[79],"(electroretinalgram)":[80],"were":[81,91],"performed":[82],"at":[83,148],"24,":[84],"48,":[85],"72":[86],"96":[88],"hours.":[89,150],"Eyes":[90],"analyzed":[92],"histologically":[93],"for":[94],"via":[96,130],"TUNEL":[97],"staining.":[98],"Results:":[99],"Infected":[100],"WT":[101],"had":[103],"only":[104],"low":[105],"levels":[106,134],"inner":[111,141],"nuclear":[112,142,145],"layer":[113],"By":[117],"contrast,":[118],"infected":[119],"displayed:":[122],"decreased":[123],"ERG":[124],"function,":[126],"increased":[127,191],"destruction":[129],"histopathology,":[131],"higher":[133],"ganglion":[139],"cell,":[140],"outer":[144],"layers":[147],"48":[149],"Further":[151],"experiments":[152],"demonstrated":[153],"triggers":[157],"up-regulation":[158],"produces":[167],"a":[168],"protease":[169],"cleaves":[171],"inactivates":[173],"vitro":[176],"vivo.":[179],"Conclusions:":[180],"Bacterial-induced":[181],"occurs":[186],"prevent":[193],"apoptosis,":[195],"while":[196],"bacterial":[197],"proteases":[198],"released":[200],"attempt":[203],"invade":[205],"NIH-EY-016145":[208],"(M":[209],"Gregory)":[210]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2023-01-06T00:00:00"}