{"id":"https://openalex.org/W4313428150","doi":"https://doi.org/10.4049/jimmunol.208.supp.116.17","title":"Effects of sample storage using tumor and tissue preservation reagent on genomic data quality","display_name":"Effects of sample storage using tumor and tissue preservation reagent on genomic data quality","publication_year":2022,"publication_date":"2022-05-01","ids":{"openalex":"https://openalex.org/W4313428150","doi":"https://doi.org/10.4049/jimmunol.208.supp.116.17"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.208.supp.116.17","doi":"https://doi.org/10.4049/jimmunol.208.supp.116.17","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.208.supp.116.17","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101533177","display_name":"Xiaoshan Shi","orcid":"https://orcid.org/0000-0002-2442-8429","observed_orcids":["https://orcid.org/0000-0002-2442-8429"]},"institutions":[{"id":"https://openalex.org/I4210116987","display_name":"BD Biosciences (United States)","ror":"https://ror.org/02h9td068","country_code":"US","type":"company","lineage":["https://openalex.org/I146461966","https://openalex.org/I4210116987"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaoshan Shi","raw_affiliation_strings":["Applied Research & Technologies, bd biosciences","1Applied Research & Technologies, bd biosciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Applied Research & Technologies, bd biosciences","institution_ids":["https://openalex.org/I4210116987"]},{"raw_affiliation_string":"1Applied Research & Technologies, bd biosciences","institution_ids":["https://openalex.org/I4210116987"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075561399","display_name":"Aimee Tran","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116987","display_name":"BD Biosciences (United States)","ror":"https://ror.org/02h9td068","country_code":"US","type":"company","lineage":["https://openalex.org/I146461966","https://openalex.org/I4210116987"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aimee Tran","raw_affiliation_strings":["Clinical Reagent, bd biosciences","2Clinical Reagent, bd biosciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Reagent, bd biosciences","institution_ids":["https://openalex.org/I4210116987"]},{"raw_affiliation_string":"2Clinical Reagent, bd biosciences","institution_ids":["https://openalex.org/I4210116987"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070942966","display_name":"Stephanie Widmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116987","display_name":"BD Biosciences (United States)","ror":"https://ror.org/02h9td068","country_code":"US","type":"company","lineage":["https://openalex.org/I146461966","https://openalex.org/I4210116987"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephanie Widmann","raw_affiliation_strings":["Applied Research & Technologies, bd biosciences","1Applied Research & Technologies, bd biosciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Applied Research & Technologies, bd biosciences","institution_ids":["https://openalex.org/I4210116987"]},{"raw_affiliation_string":"1Applied Research & Technologies, bd biosciences","institution_ids":["https://openalex.org/I4210116987"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000121750","display_name":"Aaron J. Tyznik","orcid":"https://orcid.org/0000-0002-9120-8530","observed_orcids":["https://orcid.org/0000-0002-9120-8530"]},"institutions":[{"id":"https://openalex.org/I4210116987","display_name":"BD Biosciences (United States)","ror":"https://ror.org/02h9td068","country_code":"US","type":"company","lineage":["https://openalex.org/I146461966","https://openalex.org/I4210116987"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aaron J Tyznik","raw_affiliation_strings":["Applied Research & Technologies, bd biosciences","1Applied Research & Technologies, bd biosciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Applied Research & Technologies, bd biosciences","institution_ids":["https://openalex.org/I4210116987"]},{"raw_affiliation_string":"1Applied Research & Technologies, bd biosciences","institution_ids":["https://openalex.org/I4210116987"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210116987"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"208","issue":"Supplement_1","first_page":"116.17","last_page":"116.17"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.70169997215271,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.70169997215271,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11970","display_name":"Molecular Biology Techniques and Applications","score":0.19099999964237213,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.0794999971985817,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sample-storage","display_name":"sample storage","score":0.7590000033378601},{"id":"https://openalex.org/keywords/rna-quality","display_name":"RNA quality","score":0.9319999814033508},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.7870000004768372},{"id":"https://openalex.org/keywords/single-cell-rna-sequencing","display_name":"single-cell RNA sequencing","score":0.7630000114440918},{"id":"https://openalex.org/keywords/single-cell-capture","display_name":"single-cell capture","score":0.6859999895095825},{"id":"https://openalex.org/keywords/tumor-heterogeneity","display_name":"tumor heterogeneity","score":0.7630000114440918},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.42500001192092896}],"concepts":[{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5533226132392883},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.5199117064476013},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.5038148760795593},{"id":"https://openalex.org/C198531522","wikidata":"https://www.wikidata.org/wiki/Q485146","display_name":"Sample (material)","level":2,"score":0.4953242838382721},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4814576506614685},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47474557161331177},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.45912113785743713},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4583103358745575},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3966885805130005},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.3905816376209259},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3746783137321472},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.18963390588760376},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1424797773361206},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4049/jimmunol.208.supp.116.17","doi":"https://doi.org/10.4049/jimmunol.208.supp.116.17","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.208.supp.116.17","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.766700029373169,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2052024234","https://openalex.org/W2335649076","https://openalex.org/W2618833666","https://openalex.org/W7171531077","https://openalex.org/W4393084755","https://openalex.org/W7097576727","https://openalex.org/W4309235355","https://openalex.org/W2147763734","https://openalex.org/W2768373653","https://openalex.org/W4319593057"],"abstract_inverted_index":{"Abstract":[0],"In-depth":[1],"understanding":[2],"of":[3,9,30,35,67,151,162,198,244],"the":[4,10,75,110,148,169,190,237],"intrinsic":[5],"properties":[6],"and":[7,19,38,43,59,84,87,127,141,189,209,240,247],"complexity":[8],"tumor":[11,26,48,82,103],"microenvironment":[12,27],"is":[13,28,71,194,206],"crucial":[14],"to":[15,45,54,56,73,80,91,118,122,158,196,217],"develop":[16,85],"both":[17],"diagnostic":[18,232],"therapeutic":[20,89,234],"strategies":[21,90],"for":[22,212,229],"cancer":[23,41],"treatment.":[24],"The":[25],"composed":[29],"various":[31],"cell":[32,125,182],"types,":[33],"all":[34],"which":[36],"interact":[37],"collectively":[39],"determine":[40],"progression":[42],"response":[44],"therapy.":[46],"Additionally,":[47],"cells":[49,199],"have":[50],"a":[51,65,135,207],"strong":[52],"ability":[53],"adapt":[55],"environmental":[57],"stimuli":[58],"can":[60],"evade":[61],"treatment":[62],"modalities.":[63],"As":[64],"result":[66],"those":[68],"features,":[69],"it":[70],"essential":[72],"understand":[74],"dynamic":[76],"gene":[77,192],"expression":[78,193],"profile":[79],"decipher":[81],"heterogeneity":[83],"efficient":[86],"safe":[88],"fight":[92],"cancer.":[93],"Challenges":[94],"are":[95,242],"faced":[96],"by":[97,262],"downstream":[98,218],"genomic":[99,219],"assay":[100],"design":[101],"where":[102],"specimens":[104],"cannot":[105],"be":[106,119],"processed":[107],"immediately":[108],"in":[109,154,176,231],"clinical":[111],"site.":[112],"In":[113,130,203],"this":[114,131,155],"case,":[115],"samples":[116,174],"need":[117],"preserved":[120],"properly":[121],"maintain":[123],"good":[124],"quality":[126,150],"transcriptomic":[128],"profile.":[129],"work,":[132],"we":[133],"propose":[134],"storage":[136,153,170,215],"solution":[137,156,211],"named":[138],"BD\u00ae":[139],"Tumor":[140],"Tissue":[142],"Preservation":[143],"Reagent":[144],"(TTPR).":[145],"We":[146],"evaluated":[147],"RNA":[149],"sample":[152,214],"up":[157],"three":[159],"days.":[160],"Expression":[161],"cellular":[163],"stress-related":[164],"genes":[165],"were":[166],"assessed":[167],"over":[168],"time":[171],"course.":[172],"Importantly,":[173],"stored":[175],"TTPR":[177,205],"proved":[178],"compatible":[179],"with":[180],"single":[181],"capture":[183],"workflow":[184],"using":[185],"BD":[186,238],"RhapsodyTM":[187],"system":[188],"single-cell":[191,222],"comparable":[195],"that":[197],"from":[200],"fresh":[201],"sample.":[202],"conclusion,":[204],"useful":[208],"convenient":[210],"short-term":[213],"prior":[216],"assays":[220],"including":[221],"sequencing.":[223],"For":[224],"Research":[225],"Use":[226],"Only.":[227],"Not":[228],"use":[230],"or":[233,249],"procedures.":[235],"BD,":[236],"Logo":[239],"Rhapsody":[241],"trademarks":[243],"Becton,":[245],"Dickinson":[246],"Company":[248],"its":[250],"affiliates.":[251],"\u00a9":[252],"2021":[253],"BD.":[254],"All":[255],"rights":[256],"reserved.":[257],"MSA":[258],"Approved":[259],"1121":[260],"Supported":[261],"NA":[263]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2023-01-06T00:00:00"}
