{"id":"https://openalex.org/W4313419692","doi":"https://doi.org/10.1016/j.mbplus.2022.100127","title":"Fibrosis resolution in the mouse liver: Role of Mmp12 and potential role of calpain 1/2","display_name":"Fibrosis resolution in the mouse liver: Role of Mmp12 and potential role of calpain 1/2","publication_year":2022,"publication_date":"2022-12-28","ids":{"openalex":"https://openalex.org/W4313419692","doi":"https://doi.org/10.1016/j.mbplus.2022.100127","pmid":"https://pubmed.ncbi.nlm.nih.gov/36632559","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9826883"},"language":"en","primary_location":{"id":"doi:10.1016/j.mbplus.2022.100127","doi":"https://doi.org/10.1016/j.mbplus.2022.100127","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.mbplus.2022.100127","pdf_url":null,"source":{"id":"https://openalex.org/S4210173719","display_name":"Matrix Biology Plus","issn_l":"2590-0285","issn":["2590-0285"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","norway-1","oarl","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Matrix Biology Plus","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.mbplus.2022.100127","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102444265","display_name":"Toshifumi Sato","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Toshifumi Sato","raw_affiliation_strings":["Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003018444","display_name":"Kimberly Z. Head","orcid":"https://orcid.org/0000-0003-4856-0077","observed_orcids":["https://orcid.org/0000-0003-4856-0077"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kimberly Z. Head","raw_affiliation_strings":["Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15213, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15213, United States","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100392392","display_name":"Jiang Li","orcid":"https://orcid.org/0000-0003-4812-2501","observed_orcids":["https://orcid.org/0000-0003-4812-2501"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jiang Li","raw_affiliation_strings":["Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081642373","display_name":"Christine E. Dolin","orcid":"https://orcid.org/0000-0002-0700-6224","observed_orcids":["https://orcid.org/0000-0002-0700-6224"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christine E. Dolin","raw_affiliation_strings":["Department of Pharmacology and Toxicology, University of Louisville, Louisville, KY 40292, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology, University of Louisville, Louisville, KY 40292, United States","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017157522","display_name":"Daniel Wade Wilkey","orcid":"https://orcid.org/0000-0001-7491-7696","observed_orcids":["https://orcid.org/0000-0001-7491-7696"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel Wilkey","raw_affiliation_strings":["Department of Medicine, Division of Nephrology and Hypertension, University of Louisville, Louisville, KY 40292, United States","University of Louisville Alcohol Research Center, University of Louisville, Louisville, KY 40292, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Nephrology and Hypertension, University of Louisville, Louisville, KY 40292, United States","institution_ids":["https://openalex.org/I142740786"]},{"raw_affiliation_string":"University of Louisville Alcohol Research Center, University of Louisville, Louisville, KY 40292, United States","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112683324","display_name":"Nolan Skirtich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nolan Skirtich","raw_affiliation_strings":["Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, United States","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063730172","display_name":"Katelyn Smith","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katelyn Smith","raw_affiliation_strings":["Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15213, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15213, United States","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076734248","display_name":"Dylan D. McCreary","orcid":"https://orcid.org/0000-0003-3822-1338","observed_orcids":["https://orcid.org/0000-0003-3822-1338"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dylan D. McCreary","raw_affiliation_strings":["Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, United States","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Sylvia Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sylvia Liu","raw_affiliation_strings":["Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15213, United States","Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, PA 15213, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15213, United States","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, PA 15213, United States","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049669101","display_name":"Juliane I. Beier","orcid":"https://orcid.org/0000-0002-5395-5682","observed_orcids":["https://orcid.org/0000-0002-5395-5682"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Juliane I. Beier","raw_affiliation_strings":["Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15213, United States","Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, United States","Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, PA 15213, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15213, United States","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, United States","institution_ids":[]},{"raw_affiliation_string":"Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, PA 15213, United States","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023598971","display_name":"Aatur Dilip Singhi","orcid":"https://orcid.org/0000-0003-3930-7096","observed_orcids":["https://orcid.org/0000-0003-3930-7096"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aatur D. Singhi","raw_affiliation_strings":["Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15213, United States","Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, PA 15213, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15213, United States","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, PA 15213, United States","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078046474","display_name":"Ryan M McEnaney","orcid":"https://orcid.org/0000-0003-3040-0366","observed_orcids":["https://orcid.org/0000-0003-3040-0366"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryan M. McEnaney","raw_affiliation_strings":["Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, United States","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085061817","display_name":"Michael L. Merchant","orcid":"https://orcid.org/0000-0003-4128-4057","observed_orcids":["https://orcid.org/0000-0003-4128-4057"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael L. Merchant","raw_affiliation_strings":["Department of Medicine, Division of Nephrology and Hypertension, University of Louisville, Louisville, KY 40292, United States","University of Louisville Alcohol Research Center, University of Louisville, Louisville, KY 40292, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Nephrology and Hypertension, University of Louisville, Louisville, KY 40292, United States","institution_ids":["https://openalex.org/I142740786"]},{"raw_affiliation_string":"University of Louisville Alcohol Research Center, University of Louisville, Louisville, KY 40292, United States","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054025613","display_name":"Gavin E. Arteel","orcid":"https://orcid.org/0000-0002-2253-5984","observed_orcids":["https://orcid.org/0000-0002-2253-5984"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Gavin E. Arteel","raw_affiliation_strings":["Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, United States","Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, PA 15213, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, United States","institution_ids":[]},{"raw_affiliation_string":"Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, PA 15213, United States","institution_ids":["https://openalex.org/I170201317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5054025613"],"corresponding_institution_ids":["https://openalex.org/I170201317"],"apc_list":{"value":2200,"currency":"USD","value_usd":2200},"apc_paid":{"value":2200,"currency":"USD","value_usd":2200},"fwci":1.3417,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.80874565,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"17","issue":null,"first_page":"100127","last_page":"100127"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mmp-12","display_name":"MMP-12","score":0.9789999723434448},{"id":"https://openalex.org/keywords/elastin","display_name":"elastin","score":0.8040000200271606},{"id":"https://openalex.org/keywords/extracellular-matrix-degradation","display_name":"extracellular matrix degradation","score":0.8339999914169312},{"id":"https://openalex.org/keywords/degradome","display_name":"degradome","score":0.8410000205039978},{"id":"https://openalex.org/keywords/carbon-tetrachloride-induced-liver-injury","display_name":"carbon tetrachloride-induced liver injury","score":0.9150000214576721},{"id":"https://openalex.org/keywords/plasma-proteomics","display_name":"plasma proteomics","score":0.40299999713897705},{"id":"https://openalex.org/keywords/extracellular-matrix-remodeling","display_name":"extracellular matrix remodeling","score":0.5080000162124634}],"concepts":[{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.751495361328125},{"id":"https://openalex.org/C2993667909","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Hepatic fibrosis","level":3,"score":0.6351357698440552},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5464760065078735},{"id":"https://openalex.org/C2777359374","wikidata":"https://www.wikidata.org/wiki/Q225045","display_name":"Carbon tetrachloride","level":2,"score":0.5281103849411011},{"id":"https://openalex.org/C102124568","wikidata":"https://www.wikidata.org/wiki/Q5009626","display_name":"CCL4","level":3,"score":0.5143960118293762},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.45893216133117676},{"id":"https://openalex.org/C182220744","wikidata":"https://www.wikidata.org/wiki/Q7251226","display_name":"Proteases","level":3,"score":0.4517173767089844},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.36162692308425903},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.32704734802246094},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.27537932991981506},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2682465612888336},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.252878338098526},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.08259075880050659},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1016/j.mbplus.2022.100127","doi":"https://doi.org/10.1016/j.mbplus.2022.100127","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.mbplus.2022.100127","pdf_url":null,"source":{"id":"https://openalex.org/S4210173719","display_name":"Matrix Biology Plus","issn_l":"2590-0285","issn":["2590-0285"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","norway-1","oarl","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Matrix Biology Plus","raw_type":"journal-article"},{"id":"doi:10.1101/2022.02.15.480540","doi":"https://doi.org/10.1101/2022.02.15.480540","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2022.02.15.480540","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2022/05/25/2022.02.15.480540.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:9826883","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9826883","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Matrix Biol Plus","raw_type":"Text"},{"id":"pmid:36632559","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36632559","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Matrix biology plus","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:b4a3e19f54cd4396a9a5f48571ac9871","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/b4a3e19f54cd4396a9a5f48571ac9871","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Matrix Biology Plus, Vol 17, Iss , Pp 100127- (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.mbplus.2022.100127","doi":"https://doi.org/10.1016/j.mbplus.2022.100127","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.mbplus.2022.100127","pdf_url":null,"source":{"id":"https://openalex.org/S4210173719","display_name":"Matrix Biology Plus","issn_l":"2590-0285","issn":["2590-0285"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","norway-1","oarl","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Matrix Biology Plus","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1810286441","display_name":null,"funder_award_id":"IK2 BX003509","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G235718858","display_name":"Request for a Nikon A1 confocal microscope","funder_award_id":"1s10od019973-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3519000338","display_name":"Request for Confocal/multiphoton equipment","funder_award_id":"1s10rr025676-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5859945969","display_name":"Vinyl chloride-induced changes to the epitranscriptome: interaction with diet","funder_award_id":"R21ES031531","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G5995284066","display_name":"Biomarkers of Alcoholic Hepatitis","funder_award_id":"R01AA028436","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G7763918954","display_name":"Role of ECM and inflammatory remodeling in alcohol-induced ilver and lung damage","funder_award_id":"R01AA021978","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G9000032711","display_name":null,"funder_award_id":"DK120531","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000856395","display_name":"Pittsburgh Liver Research Center","funder_award_id":"P30DK120531","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000869741","display_name":"Novel Biomarkers for Post-Liver Transplant NASH Fibrosis","funder_award_id":"R01DK130294","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000873112","display_name":"The Role of Nutrition in the Development/Progression of Alcohol-Induced Organ Injury","funder_award_id":"P50AA024337","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G9000886852","display_name":"Hepatobiology and Toxicology COBRE","funder_award_id":"P20GM113226","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334411","display_name":"Pittsburgh Liver Research Center, University of Pittsburgh","ror":null},{"id":"https://openalex.org/F4320337330","display_name":"National Institute on Alcohol Abuse and Alcoholism","ror":"https://ror.org/02jzrsm59"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4313419692.pdf","grobid_xml":"https://content.openalex.org/works/W4313419692.grobid-xml"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W95301928","https://openalex.org/W797317773","https://openalex.org/W1772733387","https://openalex.org/W1965498876","https://openalex.org/W1971094896","https://openalex.org/W1975694876","https://openalex.org/W2004344918","https://openalex.org/W2022080991","https://openalex.org/W2023165472","https://openalex.org/W2058082238","https://openalex.org/W2066056583","https://openalex.org/W2066984664","https://openalex.org/W2076256952","https://openalex.org/W2080769597","https://openalex.org/W2092236356","https://openalex.org/W2094100492","https://openalex.org/W2094174828","https://openalex.org/W2113766156","https://openalex.org/W2120394416","https://openalex.org/W2137828665","https://openalex.org/W2146247809","https://openalex.org/W2148715809","https://openalex.org/W2149391365","https://openalex.org/W2153812810","https://openalex.org/W2155257926","https://openalex.org/W2163386417","https://openalex.org/W2167342453","https://openalex.org/W2179438025","https://openalex.org/W2315070794","https://openalex.org/W2414561002","https://openalex.org/W2524249329","https://openalex.org/W2556725207","https://openalex.org/W2588964480","https://openalex.org/W2604296804","https://openalex.org/W2618917571","https://openalex.org/W2743112891","https://openalex.org/W2747917382","https://openalex.org/W2749443843","https://openalex.org/W2750659292","https://openalex.org/W2755472272","https://openalex.org/W2762743485","https://openalex.org/W2768209141","https://openalex.org/W2773476769","https://openalex.org/W2792218137","https://openalex.org/W2895014743","https://openalex.org/W2945124778","https://openalex.org/W2987781276","https://openalex.org/W3017336344","https://openalex.org/W3035985570","https://openalex.org/W3095484986","https://openalex.org/W3107527779","https://openalex.org/W3109708108","https://openalex.org/W3138484572","https://openalex.org/W3191953214","https://openalex.org/W3195831281","https://openalex.org/W3199457602","https://openalex.org/W4200351549","https://openalex.org/W6804965753"],"related_works":["https://openalex.org/W2027328967","https://openalex.org/W7024359380","https://openalex.org/W2167342453","https://openalex.org/W1547216586","https://openalex.org/W2417478303","https://openalex.org/W2007001839","https://openalex.org/W7005513444","https://openalex.org/W2979793882","https://openalex.org/W2147270124","https://openalex.org/W4400698230"],"abstract_inverted_index":{"Abstract":[0],"Although":[1],"most":[2],"work":[3],"has":[4],"focused":[5],"on":[6],"resolution":[7,12,89,171],"of":[8,21,32,54,106,146,156,159,166,188,206,212,232,242,253,275],"collagen":[9,138,153],"ECM,":[10],"fibrosis":[11,55,94,126,160,170,189,201,218,254],"involves":[13],"changes":[14,41],"to":[15,28,38],"several":[16,179],"ECM":[17,108],"proteins.":[18],"The":[19,104,164,204],"purpose":[20],"the":[22,30,40,48,88,111,213,230,233,243,251,271],"current":[23],"study":[24,208],"was":[25,58,71,95,113,277],"two-fold:":[26],"1)":[27],"examine":[29],"role":[31,266],"MMP12":[33,84,167],"and":[34,36,69,93,101,127,222,256,273],"elastin;":[35],"2)":[37],"investigate":[39],"in":[42,45,50,110,132,200,270],"degraded":[43,107,183],"proteins":[44,180,276],"plasma":[46,112,244],"(i.e.,":[47],"\u201cdegradome\u201d)":[49],"a":[51,220,263],"preclinical":[52],"model":[53],"resolution.":[56,190,202],"Fibrosis":[57],"induced":[59],"by":[60,97,116,257],"4":[61,66,76,148],"weeks":[62],"carbon":[63],"tetrachloride":[64],"(CCl":[65],")":[67],"exposure,":[68],"recovery":[70,216],"monitored":[72,96],"for":[73,267],"an":[74],"additional":[75],"weeks.":[77],"Some":[78],"mice":[79],"were":[80,140,161,181,193],"treated":[81],"with":[82,119],"daily":[83],"inhibitor":[85],"(MMP408)":[86],"during":[87,215],"phase.":[90],"Liver":[91],"injury":[92,129],"clinical":[98],"chemistry,":[99],"histology":[100],"gene":[102],"expression.":[103],"release":[105],"peptides":[109],"analyzed":[114],"using":[115],"1D-LC-MS/MS,":[117],"coupled":[118],"PEAKS":[120],"Studio":[121],"(v10)":[122],"peptide":[123],"identification.":[124],"Hepatic":[125],"liver":[128,214],"rapidly":[130],"resolved":[131],"this":[133,151,207],"mouse":[134],"model.":[135],"However,":[136],"some":[137],"fibrils":[139],"still":[141],"present":[142],"28d":[143],"after":[144],"cessation":[145],"CCl":[147],".":[149],"Despite":[150],"persistent":[152],"presence,":[154],"expression":[155],"canonical":[157],"markers":[158],"also":[162,238],"normalized.":[163],"inhibition":[165],"dramatically":[168],"delayed":[169],"under":[172],"these":[173],"conditions.":[174],"LC-MS/MS":[175],"analysis":[176,241],"identified":[177,194],"that":[178,210,226,240],"being":[182],"even":[184],"at":[185],"late":[186],"stages":[187],"Calpains":[191],"1/2":[192],"as":[195],"potential":[196,265],"new":[197,248,259],"proteases":[198],"involved":[199],"CONCLUSION.":[203],"results":[205,237],"indicate":[209,239],"remodeling":[211],"from":[217],"is":[219],"complex":[221],"highly":[223],"coordinated":[224],"process":[225],"extends":[227],"well":[228],"beyond":[229],"degradation":[231,272],"collagenous":[234],"scar.":[235],"These":[236],"degradome":[245],"may":[246],"yield":[247],"insight":[249],"into":[250],"mechanisms":[252],"recovery,":[255],"extension,":[258],"\u201ctheragnostic\u201d":[260],"targets.":[261],"Lastly,":[262],"novel":[264],"calpain":[268],"activation":[269],"turnover":[274],"identified.":[278]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-01-06T00:00:00"}