{"id":"https://openalex.org/W4313409553","doi":"https://doi.org/10.3390/cancers15010208","title":"Remarkable Synergy When Combining EZH2 Inhibitors with YM155 Is H3K27me3-Independent","display_name":"Remarkable Synergy When Combining EZH2 Inhibitors with YM155 Is H3K27me3-Independent","publication_year":2022,"publication_date":"2022-12-29","ids":{"openalex":"https://openalex.org/W4313409553","doi":"https://doi.org/10.3390/cancers15010208","pmid":"https://pubmed.ncbi.nlm.nih.gov/36612203","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9818370"},"language":"en","primary_location":{"id":"doi:10.3390/cancers15010208","doi":"https://doi.org/10.3390/cancers15010208","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers15010208","pdf_url":"https://www.mdpi.com/2072-6694/15/1/208/pdf?version=1672311564","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2072-6694/15/1/208/pdf?version=1672311564","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061426227","display_name":"Jun Yang","orcid":"https://orcid.org/0000-0002-4233-3220","observed_orcids":["https://orcid.org/0000-0002-4233-3220"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]},{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jun Yang","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, College of Medicine, The University of Tennessee Health Science Center, Memphis, TN 38163, USA","Department of Surgery, St. Jude Children\u2019s Research Hospital, Memphis, TN 38105, USA","St. Jude Graduate School of Biomedical Sciences, St. Jude Children\u2019s Research Hospital, Memphis, TN 38105, USA"],"raw_orcid":"https://orcid.org/0000-0002-4233-3220","affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, College of Medicine, The University of Tennessee Health Science Center, Memphis, TN 38163, USA","institution_ids":["https://openalex.org/I160606119"]},{"raw_affiliation_string":"Department of Surgery, St. Jude Children\u2019s Research Hospital, Memphis, TN 38105, USA","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"St. Jude Graduate School of Biomedical Sciences, St. Jude Children\u2019s Research Hospital, Memphis, TN 38105, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063456712","display_name":"Andrew M. Davidoff","orcid":"https://orcid.org/0000-0001-7900-2794","observed_orcids":["https://orcid.org/0000-0001-7900-2794"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]},{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew M. Davidoff","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, College of Medicine, The University of Tennessee Health Science Center, Memphis, TN 38163, USA","Department of Surgery, St. Jude Children\u2019s Research Hospital, Memphis, TN 38105, USA","Division of Pediatric Surgery, Department of Surgery, University of Tennessee Health Science Center, Memphis, TN 38105, USA","St. Jude Graduate School of Biomedical Sciences, St. Jude Children\u2019s Research Hospital, Memphis, TN 38105, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, College of Medicine, The University of Tennessee Health Science Center, Memphis, TN 38163, USA","institution_ids":["https://openalex.org/I160606119"]},{"raw_affiliation_string":"Department of Surgery, St. Jude Children\u2019s Research Hospital, Memphis, TN 38105, USA","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"Division of Pediatric Surgery, Department of Surgery, University of Tennessee Health Science Center, Memphis, TN 38105, USA","institution_ids":["https://openalex.org/I160606119"]},{"raw_affiliation_string":"St. Jude Graduate School of Biomedical Sciences, St. Jude Children\u2019s Research Hospital, Memphis, TN 38105, USA","institution_ids":["https://openalex.org/I1313298211"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5061426227"],"corresponding_institution_ids":["https://openalex.org/I1313298211","https://openalex.org/I160606119"],"apc_list":{"value":2400,"currency":"CHF","value_usd":2513},"apc_paid":{"value":2400,"currency":"CHF","value_usd":2513},"fwci":0.1632,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.38266558,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"15","issue":"1","first_page":"208","last_page":"208"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9779999852180481,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9779999852180481,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13157","display_name":"Cancer-related gene regulation","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ezh2-inhibitors","display_name":"EZH2 inhibitors","score":0.9919999837875366},{"id":"https://openalex.org/keywords/ym155","display_name":"YM155","score":0.996999979019165},{"id":"https://openalex.org/keywords/survivin","display_name":"survivin","score":0.9470000267028809},{"id":"https://openalex.org/keywords/h3k27me3","display_name":"H3K27me3","score":0.8040000200271606},{"id":"https://openalex.org/keywords/polycomb-repressive-complex-2","display_name":"polycomb repressive complex 2","score":0.9309999942779541},{"id":"https://openalex.org/keywords/histone-methyltransferase-activity","display_name":"histone methyltransferase activity","score":0.8190000057220459},{"id":"https://openalex.org/keywords/drug-synergy","display_name":"drug synergy","score":0.7300000190734863},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.8190000057220459},{"id":"https://openalex.org/keywords/solid-tumors","display_name":"solid tumors","score":0.9470000267028809},{"id":"https://openalex.org/keywords/actionable-therapeutic-targets","display_name":"actionable targets","score":0.6499999761581421}],"concepts":[{"id":"https://openalex.org/C50171091","wikidata":"https://www.wikidata.org/wiki/Q17917770","display_name":"EZH2","level":4,"score":0.9580390453338623},{"id":"https://openalex.org/C91965660","wikidata":"https://www.wikidata.org/wiki/Q415875","display_name":"Methyltransferase","level":4,"score":0.5989294648170471},{"id":"https://openalex.org/C150425827","wikidata":"https://www.wikidata.org/wiki/Q2560317","display_name":"Histone methyltransferase","level":4,"score":0.555202066898346},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5150537490844727},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.5094831585884094},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5028824210166931},{"id":"https://openalex.org/C2776915012","wikidata":"https://www.wikidata.org/wiki/Q17125871","display_name":"PRC2","level":5,"score":0.5007069110870361},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.48689237236976624},{"id":"https://openalex.org/C161624437","wikidata":"https://www.wikidata.org/wiki/Q1988322","display_name":"Small molecule","level":2,"score":0.4586943984031677},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3914336562156677},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3474588394165039},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.32550549507141113},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.22079461812973022},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17862513661384583}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.3390/cancers15010208","doi":"https://doi.org/10.3390/cancers15010208","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers15010208","pdf_url":"https://www.mdpi.com/2072-6694/15/1/208/pdf?version=1672311564","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9818370","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9818370","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers (Basel)","raw_type":"Text"},{"id":"pmid:36612203","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36612203","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3390/cancers15010208","doi":"https://doi.org/10.3390/cancers15010208","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers15010208","pdf_url":"https://www.mdpi.com/2072-6694/15/1/208/pdf?version=1672311564","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2655265172","display_name":"Development of small molecules to target KDM4B","funder_award_id":"5r01ca229739-04","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3829743247","display_name":null,"funder_award_id":"1R01CA229739-01","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3990879038","display_name":null,"funder_award_id":"1R01CA266600-01A1","funder_id":"https://openalex.org/F4320306095","funder_display_name":"American Cancer Society"},{"id":"https://openalex.org/G5775726095","display_name":null,"funder_award_id":"R01 CA229739","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6203915187","display_name":null,"funder_award_id":"1R01CA229739-01","funder_id":"https://openalex.org/F4320306095","funder_display_name":"American Cancer Society"},{"id":"https://openalex.org/G6715120684","display_name":null,"funder_award_id":"130421-RSG-17-071-01-TBG","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7283801956","display_name":null,"funder_award_id":"1R01CA229739","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8578241615","display_name":"The functions of JMJD6 in MYC-mediated cancer","funder_award_id":"130421-RSG-17-071-01-TBG","funder_id":"https://openalex.org/F4320306095","funder_display_name":"American Cancer Society"},{"id":"https://openalex.org/G9000859177","display_name":"EXPLORE AND TARGET THE EPIGENETIC VULNERABILITY OF PAX3-FOXO1-DRIVEN RHABDOMYOSARCOMA","funder_award_id":"R01CA266600","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306095","display_name":"American Cancer Society","ror":"https://ror.org/02e463172"},{"id":"https://openalex.org/F4320306242","display_name":"Assisi Foundation of Memphis","ror":"https://ror.org/03b8ttp75"},{"id":"https://openalex.org/F4320310040","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967"},{"id":"https://openalex.org/F4320313598","display_name":"American Lebanese Syrian Associated Charities","ror":"https://ror.org/03rx10x31"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4313409553.pdf","grobid_xml":"https://content.openalex.org/works/W4313409553.grobid-xml"},"referenced_works_count":70,"referenced_works":["https://openalex.org/W1662899239","https://openalex.org/W1968631483","https://openalex.org/W1985003152","https://openalex.org/W1987742709","https://openalex.org/W2004380688","https://openalex.org/W2010111403","https://openalex.org/W2015284016","https://openalex.org/W2015346703","https://openalex.org/W2019926646","https://openalex.org/W2024373518","https://openalex.org/W2033478449","https://openalex.org/W2033554865","https://openalex.org/W2040182688","https://openalex.org/W2040581784","https://openalex.org/W2049942970","https://openalex.org/W2051704077","https://openalex.org/W2053116646","https://openalex.org/W2060605982","https://openalex.org/W2060608189","https://openalex.org/W2070604281","https://openalex.org/W2080863138","https://openalex.org/W2094824446","https://openalex.org/W2098282574","https://openalex.org/W2100630390","https://openalex.org/W2101006499","https://openalex.org/W2101139969","https://openalex.org/W2109155259","https://openalex.org/W2110345770","https://openalex.org/W2118071133","https://openalex.org/W2132546867","https://openalex.org/W2139558183","https://openalex.org/W2140146894","https://openalex.org/W2140477106","https://openalex.org/W2147370638","https://openalex.org/W2149821525","https://openalex.org/W2156683768","https://openalex.org/W2160689782","https://openalex.org/W2163841147","https://openalex.org/W2170846478","https://openalex.org/W2171439874","https://openalex.org/W2179237675","https://openalex.org/W2264682687","https://openalex.org/W2320983896","https://openalex.org/W2408741330","https://openalex.org/W2522895022","https://openalex.org/W2530170227","https://openalex.org/W2702680930","https://openalex.org/W2738563754","https://openalex.org/W2774087343","https://openalex.org/W2793601014","https://openalex.org/W2806522712","https://openalex.org/W3086206613","https://openalex.org/W3087297916","https://openalex.org/W3112137768","https://openalex.org/W3122155574","https://openalex.org/W3127547722","https://openalex.org/W3135831963","https://openalex.org/W3137366663","https://openalex.org/W3143387950","https://openalex.org/W3184057816","https://openalex.org/W3211359479","https://openalex.org/W3215085642","https://openalex.org/W4200349633","https://openalex.org/W4206403567","https://openalex.org/W4211147182","https://openalex.org/W4220788861","https://openalex.org/W4220928677","https://openalex.org/W4225525066","https://openalex.org/W6675519975","https://openalex.org/W6680967299"],"related_works":["https://openalex.org/W4313544886","https://openalex.org/W4225262625","https://openalex.org/W3139001557","https://openalex.org/W2892042921","https://openalex.org/W4372207304","https://openalex.org/W7221642848","https://openalex.org/W2936334155","https://openalex.org/W4320167877","https://openalex.org/W3204154164","https://openalex.org/W2621991070"],"abstract_inverted_index":{"Targeting":[0],"multiple":[1],"molecules":[2],"in":[3,24,45,55],"the":[4,61],"same":[5],"biological":[6],"network":[7],"may":[8],"maximize":[9],"therapeutic":[10,75],"efficacy.":[11],"In":[12],"this":[13,56],"study,":[14],"we":[15],"identified":[16],"a":[17,40,46,73],"27-gene":[18],"module":[19],"that":[20],"is":[21,58],"highly":[22],"expressed":[23],"solid":[25,79],"tumors,":[26],"encoding":[27],"actionable":[28],"targets":[29],"including":[30],"EZH2":[31,37,53,84],"and":[32,39,85],"BIRC5.":[33,86],"The":[34,50],"combination":[35],"of":[36,52,60,65],"inhibitors":[38,54],"BIRC5":[41],"inhibitor,":[42],"YM155,":[43],"results":[44],"remarkable":[47],"synergistic":[48],"effect.":[49],"action":[51],"process":[57],"independent":[59],"histone":[62],"methyltransferase":[63],"activity":[64],"polycomb":[66],"repressive":[67],"complex":[68],"2.":[69],"Our":[70],"study":[71],"reveals":[72],"potential":[74],"approach":[76],"for":[77],"treating":[78],"tumors":[80],"by":[81],"simultaneously":[82],"targeting":[83]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2023-01-06T00:00:00"}
