{"id":"https://openalex.org/W4313396397","doi":"https://doi.org/10.3389/fimmu.2022.1061394","title":"TGF-\u03b2: A novel predictor and target for anti-PD-1/PD-L1 therapy","display_name":"TGF-\u03b2: A novel predictor and target for anti-PD-1/PD-L1 therapy","publication_year":2022,"publication_date":"2022-12-19","ids":{"openalex":"https://openalex.org/W4313396397","doi":"https://doi.org/10.3389/fimmu.2022.1061394","pmid":"https://pubmed.ncbi.nlm.nih.gov/36601124","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9807229"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2022.1061394","doi":"https://doi.org/10.3389/fimmu.2022.1061394","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2022.1061394","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2022.1061394/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2022.1061394/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085143863","display_name":"Ming Yi","orcid":"https://orcid.org/0000-0001-5243-6613","observed_orcids":["https://orcid.org/0000-0001-5243-6613"]},"institutions":[{"id":"https://openalex.org/I4210160344","display_name":"Tongji Hospital","ror":"https://ror.org/04xy45965","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160344"]},{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ming Yi","raw_affiliation_strings":["Department of Breast Surgery, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China","Department of Oncology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Breast Surgery, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I76130692"]},{"raw_affiliation_string":"Department of Oncology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China","institution_ids":["https://openalex.org/I4210160344","https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006442099","display_name":"Tianye Li","orcid":"https://orcid.org/0000-0002-9422-5782","observed_orcids":["https://orcid.org/0000-0002-9422-5782","https://orcid.org/0000-0001-6120-4590"]},"institutions":[{"id":"https://openalex.org/I4210158318","display_name":"Second Affiliated Hospital of Zhejiang University","ror":"https://ror.org/059cjpv64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158318"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tianye Li","raw_affiliation_strings":["Department of Gynecology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China","institution_ids":["https://openalex.org/I4210158318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069964251","display_name":"Mengke Niu","orcid":"https://orcid.org/0009-0004-4029-8208","observed_orcids":["https://orcid.org/0009-0004-4029-8208"]},"institutions":[{"id":"https://openalex.org/I4210160344","display_name":"Tongji Hospital","ror":"https://ror.org/04xy45965","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160344"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mengke Niu","raw_affiliation_strings":["Department of Oncology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China","institution_ids":["https://openalex.org/I4210160344","https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101533565","display_name":"Yuze Wu","orcid":"https://orcid.org/0000-0002-7344-6623","observed_orcids":["https://orcid.org/0000-0002-7344-6623"]},"institutions":[{"id":"https://openalex.org/I4210160344","display_name":"Tongji Hospital","ror":"https://ror.org/04xy45965","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160344"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuze Wu","raw_affiliation_strings":["Department of Oncology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China","institution_ids":["https://openalex.org/I4210160344","https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060643969","display_name":"Zhenyu Zhao","orcid":"https://orcid.org/0000-0002-8697-1419","observed_orcids":["https://orcid.org/0000-0002-8697-1419","https://orcid.org/0000-0002-2355-6832","https://orcid.org/0009-0007-1113-5946"]},"institutions":[{"id":"https://openalex.org/I4210160344","display_name":"Tongji Hospital","ror":"https://ror.org/04xy45965","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160344"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhenyu Zhao","raw_affiliation_strings":["Department of Urology, Institute of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Institute of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China","institution_ids":["https://openalex.org/I4210160344","https://openalex.org/I47720641"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044031959","display_name":"Kongming Wu","orcid":"https://orcid.org/0000-0003-2499-1032","observed_orcids":["https://orcid.org/0000-0003-2499-1032"]},"institutions":[{"id":"https://openalex.org/I4210160344","display_name":"Tongji Hospital","ror":"https://ror.org/04xy45965","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160344"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Kongming Wu","raw_affiliation_strings":["Department of Oncology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China","institution_ids":["https://openalex.org/I4210160344","https://openalex.org/I47720641"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5044031959","https://openalex.org/A5060643969"],"corresponding_institution_ids":["https://openalex.org/I4210160344","https://openalex.org/I47720641"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":2.0164,"has_fulltext":true,"cited_by_count":97,"citation_normalized_percentile":{"value":0.90541672,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"13","issue":null,"first_page":"1061394","last_page":"1061394"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.5005000233650208,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.5005000233650208,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.4948999881744385,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tgf-beta-signaling","display_name":"TGF-beta signaling","score":0.9800000190734863},{"id":"https://openalex.org/keywords/pd-1-pd-l1-blockade","display_name":"PD-1/PD-L1 blockade","score":0.9160000085830688},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.9599999785423279},{"id":"https://openalex.org/keywords/immune-evasion","display_name":"immune evasion","score":0.6579999923706055},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.9789999723434448},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.6179999709129333},{"id":"https://openalex.org/keywords/tgf-beta-blockade","display_name":"TGF-beta blockade","score":0.6990000009536743},{"id":"https://openalex.org/keywords/bispecific-antibodies","display_name":"bispecific antibodies","score":0.9900000095367432},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.6489999890327454},{"id":"https://openalex.org/keywords/treatment-resistance","display_name":"treatment resistance","score":0.5820000171661377}],"concepts":[{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.7681269645690918},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6507213115692139},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.6325703263282776},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.6066498160362244},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5751422643661499},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5652012228965759},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.5448418259620667},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4928569793701172},{"id":"https://openalex.org/C2780851360","wikidata":"https://www.wikidata.org/wiki/Q21686041","display_name":"Immune checkpoint","level":4,"score":0.488329142332077},{"id":"https://openalex.org/C2781053074","wikidata":"https://www.wikidata.org/wiki/Q21100639","display_name":"PD-L1","level":4,"score":0.48529666662216187},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4827412962913513},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18177738785743713}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060890","descriptor_name":"B7-H1 Antigen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3389/fimmu.2022.1061394","doi":"https://doi.org/10.3389/fimmu.2022.1061394","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2022.1061394","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2022.1061394/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"pmid:36601124","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36601124","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in immunology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9807229","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9807229/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Immunol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:7bd4eb4875d14c9cb1a2d828db9c399f","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/7bd4eb4875d14c9cb1a2d828db9c399f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol 13 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2022.1061394","doi":"https://doi.org/10.3389/fimmu.2022.1061394","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2022.1061394","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2022.1061394/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2098758287","display_name":null,"funder_award_id":"82272794","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4588820041","display_name":null,"funder_award_id":"2022M722766","funder_id":"https://openalex.org/F4320321543","funder_display_name":"China Postdoctoral Science Foundation"},{"id":"https://openalex.org/G5237532140","display_name":null,"funder_award_id":"81874120","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5475569323","display_name":null,"funder_award_id":"82073370","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8125152111","display_name":null,"funder_award_id":"82073370, 82073370, 81874120","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321543","display_name":"China Postdoctoral Science Foundation","ror":"https://ror.org/0426zh255"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4313396397.pdf","grobid_xml":"https://content.openalex.org/works/W4313396397.grobid-xml"},"referenced_works_count":156,"referenced_works":["https://openalex.org/W1524314479","https://openalex.org/W1700691315","https://openalex.org/W1702502468","https://openalex.org/W1767363509","https://openalex.org/W1905104097","https://openalex.org/W1913780655","https://openalex.org/W1940241680","https://openalex.org/W1964847767","https://openalex.org/W1967582330","https://openalex.org/W1970302173","https://openalex.org/W1991235944","https://openalex.org/W1993615391","https://openalex.org/W1994993231","https://openalex.org/W2011243140","https://openalex.org/W2011827420","https://openalex.org/W2016983859","https://openalex.org/W2034899869","https://openalex.org/W2035653659","https://openalex.org/W2047914041","https://openalex.org/W2053333794","https://openalex.org/W2068718097","https://openalex.org/W2074604431","https://openalex.org/W2075873658","https://openalex.org/W2076271925","https://openalex.org/W2081419234","https://openalex.org/W2104347254","https://openalex.org/W2116583846","https://openalex.org/W2117225762","https://openalex.org/W2125061065","https://openalex.org/W2125616358","https://openalex.org/W2146839556","https://openalex.org/W2147622445","https://openalex.org/W2149607528","https://openalex.org/W2158580537","https://openalex.org/W2160834915","https://openalex.org/W2171544045","https://openalex.org/W2225532122","https://openalex.org/W2339890238","https://openalex.org/W2342679639","https://openalex.org/W2344682920","https://openalex.org/W2519292031","https://openalex.org/W2527634451","https://openalex.org/W2530516001","https://openalex.org/W2551413444","https://openalex.org/W2560367415","https://openalex.org/W2570763587","https://openalex.org/W2572174216","https://openalex.org/W2578528809","https://openalex.org/W2592339836","https://openalex.org/W2592369722","https://openalex.org/W2593598026","https://openalex.org/W2602612283","https://openalex.org/W2622499649","https://openalex.org/W2762777471","https://openalex.org/W2765314233","https://openalex.org/W2766903152","https://openalex.org/W2767373327","https://openalex.org/W2781947653","https://openalex.org/W2783370150","https://openalex.org/W2785374083","https://openalex.org/W2785803176","https://openalex.org/W2788975052","https://openalex.org/W2789720205","https://openalex.org/W2790574591","https://openalex.org/W2791527925","https://openalex.org/W2792793299","https://openalex.org/W2794616539","https://openalex.org/W2797675588","https://openalex.org/W2803397860","https://openalex.org/W2883703281","https://openalex.org/W2885431388","https://openalex.org/W2888408613","https://openalex.org/W2896652675","https://openalex.org/W2900657494","https://openalex.org/W2903686952","https://openalex.org/W2917714624","https://openalex.org/W2923110622","https://openalex.org/W2937823726","https://openalex.org/W2944860885","https://openalex.org/W2946527426","https://openalex.org/W2953805270","https://openalex.org/W2955008365","https://openalex.org/W2963671594","https://openalex.org/W2965332892","https://openalex.org/W2972280418","https://openalex.org/W2977648831","https://openalex.org/W2980682287","https://openalex.org/W2981114563","https://openalex.org/W2987225757","https://openalex.org/W2987385271","https://openalex.org/W2987436342","https://openalex.org/W2988686122","https://openalex.org/W2999989559","https://openalex.org/W3006876324","https://openalex.org/W3007004914","https://openalex.org/W3008326983","https://openalex.org/W3011497962","https://openalex.org/W3012080769","https://openalex.org/W3012963315","https://openalex.org/W3013319043","https://openalex.org/W3014005795","https://openalex.org/W3048618543","https://openalex.org/W3085152134","https://openalex.org/W3090617252","https://openalex.org/W3096878939","https://openalex.org/W3100433875","https://openalex.org/W3108804421","https://openalex.org/W3112064419","https://openalex.org/W3112223966","https://openalex.org/W3112741855","https://openalex.org/W3114743310","https://openalex.org/W3118950316","https://openalex.org/W3119561657","https://openalex.org/W3123099520","https://openalex.org/W3126965123","https://openalex.org/W3130927738","https://openalex.org/W3134477587","https://openalex.org/W3137678638","https://openalex.org/W3146786433","https://openalex.org/W3149714833","https://openalex.org/W3157710113","https://openalex.org/W3160405744","https://openalex.org/W3161062127","https://openalex.org/W3164132377","https://openalex.org/W3166264321","https://openalex.org/W3172297355","https://openalex.org/W3177546055","https://openalex.org/W3193119799","https://openalex.org/W3200648346","https://openalex.org/W3202901824","https://openalex.org/W3206061095","https://openalex.org/W3214871787","https://openalex.org/W3215678342","https://openalex.org/W4200156483","https://openalex.org/W4205454439","https://openalex.org/W4205941321","https://openalex.org/W4206633897","https://openalex.org/W4220913311","https://openalex.org/W4220915201","https://openalex.org/W4225898639","https://openalex.org/W4226318899","https://openalex.org/W4281732693","https://openalex.org/W4281799359","https://openalex.org/W4282926225","https://openalex.org/W4284962583","https://openalex.org/W4286254644","https://openalex.org/W4290000587","https://openalex.org/W4293860912","https://openalex.org/W4296139756","https://openalex.org/W4297324427","https://openalex.org/W4297497831","https://openalex.org/W4303673960","https://openalex.org/W6774559871","https://openalex.org/W6791430902","https://openalex.org/W6804028824","https://openalex.org/W7053203154"],"related_works":["https://openalex.org/W2988686122","https://openalex.org/W4200069709","https://openalex.org/W4315436970","https://openalex.org/W4289731410","https://openalex.org/W2954079966","https://openalex.org/W6995544653","https://openalex.org/W3012963315","https://openalex.org/W3119553910","https://openalex.org/W4210809687","https://openalex.org/W3206061095"],"abstract_inverted_index":{"Transforming":[0],"growth":[1],"factor-\u03b2":[2],"(TGF-\u03b2)":[3],"signaling":[4,84,129],"regulates":[5],"multiple":[6],"physiological":[7],"processes,":[8],"such":[9],"as":[10],"cell":[11],"proliferation,":[12],"differentiation,":[13],"immune":[14,40,57,60,70],"homeostasis,":[15],"and":[16,37,55,76,101,109,130],"wound":[17],"healing.":[18],"Besides,":[19],"TGF-\u03b2":[20,33,50,83,96,128],"plays":[21],"a":[22],"vital":[23],"role":[24],"in":[25,42],"diseases,":[26],"including":[27,107],"cancer.":[28],"Accumulating":[29],"evidence":[30],"indicates":[31],"that":[32,81,95],"controls":[34],"the":[35,43,53,124,131],"composition":[36],"behavior":[38],"of":[39,127,133],"components":[41],"tumor":[44],"microenvironment":[45],"(TME).":[46],"Advanced":[47],"cancers":[48],"leverage":[49],"to":[51],"reshape":[52],"TME":[54],"escape":[56],"surveillance.":[58],"TGF-\u03b2-mediated":[59],"evasion":[61],"is":[62,85],"an":[63],"unfavorable":[64],"factor":[65],"for":[66,116,136],"cancer":[67,117,137],"immunotherapy,":[68],"especially":[69],"checkpoint":[71],"inhibitors":[72],"(ICI).":[73],"Numerous":[74],"preclinical":[75],"clinical":[77],"studies":[78],"have":[79,112],"demonstrated":[80],"hyperactive":[82],"closely":[86],"associated":[87],"with":[88,99],"ICI":[89,100],"resistance.":[90,104],"It":[91],"has":[92],"been":[93],"validated":[94],"blockade":[97],"synergizes":[98],"overcomes":[102],"treatment":[103],"TGF-\u03b2-targeted":[105,134],"therapies,":[106],"trap":[108],"bispecific":[110],"antibodies,":[111],"shown":[113],"immense":[114],"potential":[115],"immunotherapy.":[118,138],"In":[119],"this":[120],"review,":[121],"we":[122],"summarized":[123],"predictive":[125],"value":[126],"prospects":[132],"therapies":[135]},"counts_by_year":[{"year":2026,"cited_by_count":17},{"year":2025,"cited_by_count":26},{"year":2024,"cited_by_count":41},{"year":2023,"cited_by_count":13}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2023-01-06T00:00:00"}
