{"id":"https://openalex.org/W4313386751","doi":"https://doi.org/10.4049/jimmunol.186.supp.104.14","title":"Determining the role of basal NF-\u03baB in the survival of quiescent naive T cells (104.14)","display_name":"Determining the role of basal NF-\u03baB in the survival of quiescent naive T cells (104.14)","publication_year":2011,"publication_date":"2011-04-01","ids":{"openalex":"https://openalex.org/W4313386751","doi":"https://doi.org/10.4049/jimmunol.186.supp.104.14"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.186.supp.104.14","doi":"https://doi.org/10.4049/jimmunol.186.supp.104.14","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.186.supp.104.14","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110456178","display_name":"Michelle L. Miller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michelle Miller","raw_affiliation_strings":["University of Chicago , Chicago, IL","1University of Chicago, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Chicago , Chicago, IL","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"1University of Chicago, Chicago, IL","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081637691","display_name":"Mona Mashayekhi","orcid":"https://orcid.org/0000-0003-0331-2395","observed_orcids":["https://orcid.org/0000-0003-0331-2395"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mona Mashayekhi","raw_affiliation_strings":["University of Chicago , Chicago, IL","1University of Chicago, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Chicago , Chicago, IL","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"1University of Chicago, Chicago, IL","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085681006","display_name":"Luqiu Chen","orcid":"https://orcid.org/0000-0003-0370-7848","observed_orcids":["https://orcid.org/0000-0003-0370-7848"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Luqiu Chen","raw_affiliation_strings":["University of Chicago , Chicago, IL","1University of Chicago, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Chicago , Chicago, IL","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"1University of Chicago, Chicago, IL","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087181844","display_name":"Xindong Liu","orcid":"https://orcid.org/0000-0002-2465-0337","observed_orcids":["https://orcid.org/0000-0002-2465-0337"]},"institutions":[{"id":"https://openalex.org/I39822340","display_name":"Virginia\u2013Maryland College of Veterinary Medicine","ror":"https://ror.org/010prmy50","country_code":"US","type":"education","lineage":["https://openalex.org/I39822340","https://openalex.org/I66946132","https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xindong Liu","raw_affiliation_strings":["Virgina-Maryland Regional Col. of Vet. Med. , College Park, MD","2Virgina-Maryland Regional Col. of Vet. Med., College Park, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Virgina-Maryland Regional Col. of Vet. Med. , College Park, MD","institution_ids":["https://openalex.org/I39822340"]},{"raw_affiliation_string":"2Virgina-Maryland Regional Col. of Vet. Med., College Park, MD","institution_ids":["https://openalex.org/I39822340"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059211578","display_name":"Monica M. Michelotti","orcid":"https://orcid.org/0000-0003-0888-2346","observed_orcids":["https://orcid.org/0000-0003-0888-2346"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Monica Michelotti","raw_affiliation_strings":["University of Chicago , Chicago, IL","1University of Chicago, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Chicago , Chicago, IL","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"1University of Chicago, Chicago, IL","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110133244","display_name":"Nicole L. Tramontini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicole Tramontini","raw_affiliation_strings":["University of Chicago , Chicago, IL","1University of Chicago, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Chicago , Chicago, IL","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"1University of Chicago, Chicago, IL","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103242944","display_name":"Sarah E. Powers","orcid":"https://orcid.org/0000-0002-6812-4312","observed_orcids":["https://orcid.org/0000-0002-6812-4312"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah Powers","raw_affiliation_strings":["University of Chicago , Chicago, IL","1University of Chicago, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Chicago , Chicago, IL","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"1University of Chicago, Chicago, IL","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036299368","display_name":"Xiaoping Zhu","orcid":"https://orcid.org/0000-0001-7515-2277","observed_orcids":["https://orcid.org/0000-0001-7515-2277"]},"institutions":[{"id":"https://openalex.org/I39822340","display_name":"Virginia\u2013Maryland College of Veterinary Medicine","ror":"https://ror.org/010prmy50","country_code":"US","type":"education","lineage":["https://openalex.org/I39822340","https://openalex.org/I66946132","https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaoping Zhu","raw_affiliation_strings":["Virgina-Maryland Regional Col. of Vet. Med. , College Park, MD","2Virgina-Maryland Regional Col. of Vet. Med., College Park, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Virgina-Maryland Regional Col. of Vet. Med. , College Park, MD","institution_ids":["https://openalex.org/I39822340"]},{"raw_affiliation_string":"2Virgina-Maryland Regional Col. of Vet. Med., College Park, MD","institution_ids":["https://openalex.org/I39822340"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023053917","display_name":"Maria\u2010Luisa Alegre","orcid":"https://orcid.org/0000-0001-5707-6194","observed_orcids":["https://orcid.org/0000-0001-5707-6194"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maria-Luisa Alegre","raw_affiliation_strings":["University of Chicago , Chicago, IL","1University of Chicago, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Chicago , Chicago, IL","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"1University of Chicago, Chicago, IL","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056037326","display_name":"Luciana Lorena Molinero","orcid":"https://orcid.org/0000-0001-5866-5214","observed_orcids":["https://orcid.org/0000-0001-5866-5214"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Luciana Molinero","raw_affiliation_strings":["University of Chicago , Chicago, IL","1University of Chicago, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Chicago , Chicago, IL","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"1University of Chicago, Chicago, IL","institution_ids":["https://openalex.org/I40347166"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"186","issue":"1_Supplement","first_page":"104.14","last_page":"104.14"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.9208999872207642,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.9208999872207642,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.07559999823570251,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12620","display_name":"Signaling Pathways in Disease","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.8880000114440918},{"id":"https://openalex.org/keywords/naive-t-cells","display_name":"naive T cells","score":0.8999999761581421},{"id":"https://openalex.org/keywords/il-7-signaling","display_name":"IL-7 signaling","score":0.7429999709129333},{"id":"https://openalex.org/keywords/il-7-receptor-alpha","display_name":"IL-7 receptor alpha","score":0.9290000200271606},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.7089999914169312},{"id":"https://openalex.org/keywords/nf-kappab-binding-site","display_name":"NF-kappaB binding site","score":0.796999990940094},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.8740000128746033},{"id":"https://openalex.org/keywords/t-cell-lifespan","display_name":"T cell lifespan","score":0.6340000033378601}],"concepts":[{"id":"https://openalex.org/C98270193","wikidata":"https://www.wikidata.org/wiki/Q3359522","display_name":"P50","level":4,"score":0.7784633636474609},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.6709913611412048},{"id":"https://openalex.org/C2777730290","wikidata":"https://www.wikidata.org/wiki/Q411114","display_name":"NF-\u03baB","level":3,"score":0.6222864985466003},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6221033334732056},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.591605007648468},{"id":"https://openalex.org/C2778024521","wikidata":"https://www.wikidata.org/wiki/Q55639806","display_name":"Basal (medicine)","level":3,"score":0.5356462001800537},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.48621049523353577},{"id":"https://openalex.org/C123982805","wikidata":"https://www.wikidata.org/wiki/Q6046964","display_name":"Interleukin-7 receptor","level":5,"score":0.4770578444004059},{"id":"https://openalex.org/C123298856","wikidata":"https://www.wikidata.org/wiki/Q15317427","display_name":"NFKB1","level":4,"score":0.4763512909412384},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.42632508277893066},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3820626437664032},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3059532642364502},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.1728629171848297},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14472395181655884},{"id":"https://openalex.org/C79484868","wikidata":"https://www.wikidata.org/wiki/Q5971673","display_name":"IL-2 receptor","level":4,"score":0.12996307015419006},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.11335170269012451},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10857120156288147},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4049/jimmunol.186.supp.104.14","doi":"https://doi.org/10.4049/jimmunol.186.supp.104.14","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.186.supp.104.14","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1992163987","https://openalex.org/W4313354932","https://openalex.org/W2292151277","https://openalex.org/W2161838780","https://openalex.org/W2074584468","https://openalex.org/W2060234891","https://openalex.org/W4382203484","https://openalex.org/W2099888440","https://openalex.org/W2111300838","https://openalex.org/W1894578834"],"abstract_inverted_index":{"Abstract":[0],"NF-\u03baB":[1,38,88,129,152,182,216],"is":[2,31,49],"an":[3,161],"essential":[4],"transcription":[5,231],"factor":[6],"for":[7,78],"the":[8,24,55,105,144,176,212,222,233],"survival":[9,25,53,82,223],"of":[10,26,57,108,143,159,181,198,224,232],"T":[11,29,43,58,64,80,100,115,124,155,194,227],"cells":[12,30,44,65,101,116,156,228],"following":[13],"antigen":[14],"stimulation,":[15],"but":[16,190],"whether":[17,47,86,128],"it":[18,48],"plays":[19,218],"a":[20,136,219],"role":[21,220],"in":[22,40,51,54,69,110,186,221],"maintaining":[23],"unstimulated":[27],"nai\u0308ve":[28,41,62,79,99,154,193,226],"not":[32,191],"known.":[33],"We":[34],"have":[35],"detected":[36],"basal":[37,87,215],"activity":[39,89,217],"quiescent":[42,225],"and":[45,112,178,206],"investigated":[46],"important":[50,77],"cell":[52,59,81],"absence":[56],"activation.":[60],"NF-\u03baB-impaired":[61,98,192],"CD4+":[63],"showed":[66],"decreased":[67],"lifespan":[68],"vivo.":[70],"IL-7":[71,109],"has":[72],"been":[73],"shown":[74],"to":[75,104],"be":[76],"prompting":[83],"investigation":[84],"into":[85],"could":[90,130],"regulate":[91,131],"IL-7/IL-7R":[92],"signaling.":[93],"Our":[94],"results":[95,210],"indicate":[96],"that":[97,113,175,214],"are":[102],"resistant":[103],"pro-survival":[106],"effects":[107],"vitro,":[111],"these":[114,209],"express":[117],"less":[118],"surface":[119],"IL-7R\u03b1":[120,132,199],"than":[121],"wild":[122,188],"type":[123,189],"cells.":[125,195],"To":[126],"determine":[127],"expression":[133],"by":[134,169,229],"transcription,":[135],"putative":[137],"NF-\u03baB-binding":[138],"site":[139,148],"3.5":[140],"kB":[141],"upstream":[142],"IL7r":[145,234],"translational":[146],"start":[147],"was":[149,157,203],"tested.":[150],"Nuclear":[151],"from":[153],"capable":[158],"binding":[160],"oligonucleotide":[162],"probe":[163],"containing":[164],"this":[165,184],"sequence,":[166],"as":[167],"determined":[168],"EMSA.":[170],"A":[171],"ChIP":[172],"assay":[173],"confirmed":[174],"p50":[177],"p65":[179],"subunits":[180],"bound":[183],"region":[185],"live":[187],"Finally,":[196],"re-expression":[197],"after":[200],"IL-7-mediated":[201],"degradation":[202],"RNA":[204],"polymerase-":[205],"NF-\u03baB-dependent.":[207],"Together,":[208],"support":[211],"idea":[213],"controlling":[230],"gene.":[235]},"counts_by_year":[],"updated_date":"2026-09-25T08:18:29.962427","created_date":"2023-01-06T00:00:00"}