{"id":"https://openalex.org/W4313386182","doi":"https://doi.org/10.4049/jimmunol.194.supp.140.16","title":"MHC class II-disparate heart but not skin allografts accelerate recipient cardiovascular disease (TRAN1P.934)","display_name":"MHC class II-disparate heart but not skin allografts accelerate recipient cardiovascular disease (TRAN1P.934)","publication_year":2015,"publication_date":"2015-05-01","ids":{"openalex":"https://openalex.org/W4313386182","doi":"https://doi.org/10.4049/jimmunol.194.supp.140.16"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.194.supp.140.16","doi":"https://doi.org/10.4049/jimmunol.194.supp.140.16","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.194.supp.140.16","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Jing Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jing Zhou","raw_affiliation_strings":["Surgery, Yale Sch. of Med. , New Haven, CT","1Surgery, Yale Sch. of Med., New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Surgery, Yale Sch. of Med. , New Haven, CT","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"1Surgery, Yale Sch. of Med., New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028806508","display_name":"Tai Yi","orcid":"https://orcid.org/0000-0003-0464-1043","observed_orcids":["https://orcid.org/0000-0003-0464-1043"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"tai yi","raw_affiliation_strings":["Immunobiology, Yale Sch. of Med. , New Haven, CT","2Immunobiology, Yale Sch. of Med., New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunobiology, Yale Sch. of Med. , New Haven, CT","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"2Immunobiology, Yale Sch. of Med., New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023705448","display_name":"Lingfeng Qin","orcid":"https://orcid.org/0000-0002-5381-6826","observed_orcids":["https://orcid.org/0000-0002-5381-6826"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lingfeng Qin","raw_affiliation_strings":["Surgery, Yale Sch. of Med. , New Haven, CT","1Surgery, Yale Sch. of Med., New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Surgery, Yale Sch. of Med. , New Haven, CT","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"1Surgery, Yale Sch. of Med., New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036991823","display_name":"Rahmat Ali","orcid":"https://orcid.org/0000-0003-1230-9868","observed_orcids":["https://orcid.org/0000-0003-1230-9868"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rahmat Ali","raw_affiliation_strings":["Surgery, Yale Sch. of Med. , New Haven, CT","1Surgery, Yale Sch. of Med., New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Surgery, Yale Sch. of Med. , New Haven, CT","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"1Surgery, Yale Sch. of Med., New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017247384","display_name":"Qingle Li","orcid":"https://orcid.org/0000-0001-9014-6721","observed_orcids":["https://orcid.org/0000-0001-9014-6721"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qingle Li","raw_affiliation_strings":["Surgery, Yale Sch. of Med. , New Haven, CT","1Surgery, Yale Sch. of Med., New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Surgery, Yale Sch. of Med. , New Haven, CT","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"1Surgery, Yale Sch. of Med., New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103106918","display_name":"Yang Jiao","orcid":"https://orcid.org/0000-0002-8388-0634","observed_orcids":["https://orcid.org/0000-0002-8388-0634"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yang Jiao","raw_affiliation_strings":["Surgery, Yale Sch. of Med. , New Haven, CT","1Surgery, Yale Sch. of Med., New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Surgery, Yale Sch. of Med. , New Haven, CT","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"1Surgery, Yale Sch. of Med., New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Guangxing Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guangxing Li","raw_affiliation_strings":["Surgery, Yale Sch. of Med. , New Haven, CT","1Surgery, Yale Sch. of Med., New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Surgery, Yale Sch. of Med. , New Haven, CT","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"1Surgery, Yale Sch. of Med., New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100743600","display_name":"Jiasheng Zhang","orcid":"https://orcid.org/0000-0002-4637-5655","observed_orcids":["https://orcid.org/0000-0002-4637-5655"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jiasheng Zhang","raw_affiliation_strings":["Medicine, Yale Sch. of Med. , New Haven, CT","3Medicine, Yale Sch. of Med., New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, Yale Sch. of Med. , New Haven, CT","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"3Medicine, Yale Sch. of Med., New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082859951","display_name":"Mehran M. Sadeghi","orcid":"https://orcid.org/0000-0002-5074-3510","observed_orcids":["https://orcid.org/0000-0002-5074-3510"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]},{"id":"https://openalex.org/I4210086971","display_name":"VA Connecticut Healthcare System","ror":"https://ror.org/000rgm762","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210086971","https://openalex.org/I4210095851"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mehran Sadeghi","raw_affiliation_strings":["Medicine, Yale Sch. of Med. , New Haven, CT","Veterans Affairs Connecticut Healthcare System , West Haven, CT","3Medicine, Yale Sch. of Med., New Haven, CT","4Veterans Affairs Connecticut Healthcare System, West Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, Yale Sch. of Med. , New Haven, CT","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Veterans Affairs Connecticut Healthcare System , West Haven, CT","institution_ids":["https://openalex.org/I4210086971"]},{"raw_affiliation_string":"3Medicine, Yale Sch. of Med., New Haven, CT","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"4Veterans Affairs Connecticut Healthcare System, West Haven, CT","institution_ids":["https://openalex.org/I4210086971"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022235365","display_name":"Jordan S. Pober","orcid":"https://orcid.org/0000-0001-5990-1071","observed_orcids":["https://orcid.org/0000-0001-5990-1071"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jordan Pober","raw_affiliation_strings":["Immunobiology, Yale Sch. of Med. , New Haven, CT","2Immunobiology, Yale Sch. of Med., New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunobiology, Yale Sch. of Med. , New Haven, CT","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"2Immunobiology, Yale Sch. of Med., New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036202065","display_name":"George Tellides","orcid":"https://orcid.org/0000-0001-7042-8190","observed_orcids":["https://orcid.org/0000-0001-7042-8190"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]},{"id":"https://openalex.org/I4210086971","display_name":"VA Connecticut Healthcare System","ror":"https://ror.org/000rgm762","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210086971","https://openalex.org/I4210095851"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George Tellides","raw_affiliation_strings":["Surgery, Yale Sch. of Med. , New Haven, CT","Veterans Affairs Connecticut Healthcare System , West Haven, CT","1Surgery, Yale Sch. of Med., New Haven, CT","4Veterans Affairs Connecticut Healthcare System, West Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Surgery, Yale Sch. of Med. , New Haven, CT","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Veterans Affairs Connecticut Healthcare System , West Haven, CT","institution_ids":["https://openalex.org/I4210086971"]},{"raw_affiliation_string":"1Surgery, Yale Sch. of Med., New Haven, CT","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"4Veterans Affairs Connecticut Healthcare System, West Haven, CT","institution_ids":["https://openalex.org/I4210086971"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"194","issue":"1_Supplement","first_page":"140.16","last_page":"140.16"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.01360000018030405,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12900","display_name":"Organ and Tissue Transplantation Research","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heart-transplantation","display_name":"heart transplantation","score":0.703000009059906},{"id":"https://openalex.org/keywords/skin-grafting","display_name":"skin grafting","score":0.8769999742507935},{"id":"https://openalex.org/keywords/allograft-rejection","display_name":"allograft rejection","score":0.9120000004768372},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.9679999947547913},{"id":"https://openalex.org/keywords/apoe-deficient-mice","display_name":"ApoE-deficient mice","score":0.8100000023841858},{"id":"https://openalex.org/keywords/allorecognition","display_name":"allorecognition","score":0.7250000238418579},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.9160000085830688},{"id":"https://openalex.org/keywords/cd69","display_name":"CD69","score":0.9210000038146973},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.8539999723434448},{"id":"https://openalex.org/keywords/il-12","display_name":"IL-12","score":0.9390000104904175},{"id":"https://openalex.org/keywords/chronic-inflammation","display_name":"chronic inflammation","score":0.675000011920929}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6456624865531921},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.6266109347343445},{"id":"https://openalex.org/C200315206","wikidata":"https://www.wikidata.org/wiki/Q4733146","display_name":"Allorecognition","level":4,"score":0.5440380573272705},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5164123177528381},{"id":"https://openalex.org/C2778849806","wikidata":"https://www.wikidata.org/wiki/Q643396","display_name":"Heart transplantation","level":3,"score":0.5128538608551025},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5111985802650452},{"id":"https://openalex.org/C207936829","wikidata":"https://www.wikidata.org/wiki/Q423163","display_name":"Major histocompatibility complex","level":3,"score":0.4274849593639374},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.39592310786247253},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27371734380722046},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.21636611223220825}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4049/jimmunol.194.supp.140.16","doi":"https://doi.org/10.4049/jimmunol.194.supp.140.16","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.194.supp.140.16","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2266384908","https://openalex.org/W2323768436","https://openalex.org/W2260070235","https://openalex.org/W2131056307","https://openalex.org/W4241291960","https://openalex.org/W2055874794","https://openalex.org/W2003354598","https://openalex.org/W4237357183","https://openalex.org/W2055421990","https://openalex.org/W2055323933"],"abstract_inverted_index":{"Abstract":[0],"Organ":[1],"transplantation":[2],"is":[3,15,27],"the":[4,31,39,86,94,105,118,166,186],"most":[5],"effective":[6],"therapy":[7],"for":[8,78,195],"patients":[9],"with":[10,107,117,146,188],"end-stage":[11],"organ":[12],"failure":[13],"but":[14,176],"limited":[16],"by":[17,47,209],"premature":[18],"deaths":[19],"from":[20,56,67,157],"cardiovascular":[21],"disease":[22],"(CVD).":[23],"The":[24,125],"underlying":[25],"mechanism":[26],"poorly":[28],"understood.":[29],"Using":[30],"ApoE-/-":[32,63],"mouse":[33],"model":[34],"of":[35,41,85,104,127,148,165,173,180],"atherosclerosis":[36],"we":[37],"investigated":[38],"effect":[40],"allograft":[42],"rejection":[43,84],"on":[44],"recipient":[45,64,224],"CVD":[46],"transplanting":[48],"MHC":[49],"class":[50],"II-disparate":[51],"cardiac":[52,108,132,149,189],"or":[53,121,151,182],"skin":[54,95,119,152,183],"allografts":[55,96,109,129,175,190],"BM12":[57,87],"donor":[58,69],"mice":[59,70,106,116,126,187],"into":[60],"C57BL/6":[61],"(B6)":[62],"mice.":[65],"Isografts":[66],"B6":[68],"were":[71,76,97],"used":[72],"as":[73],"controls.":[74],"Mice":[75],"observed":[77],"12":[79,112],"weeks":[80,113],"post":[81],"transplantation.":[82],"Allograft":[83],"hearts":[88],"occurred":[89],"around":[90],"60":[91],"days":[92],"whereas":[93],"rejected":[98],"within":[99],"15":[100],"days.":[101],"About":[102],"half":[103],"died":[110],"before":[111],"although":[114],"all":[115],"grafts":[120],"heart":[122,128,174],"isografts":[123,150,181],"survived.":[124],"exhibited":[130],"impaired":[131],"function":[133],"(decreased":[134],"fractional":[135],"shortening":[136],"and":[137,141,159,197,217],"enlarged":[138],"left":[139],"ventricles)":[140],"larger":[142],"atherosclerotic":[143,160],"lesions":[144,161],"compared":[145],"those":[147,179],"grafts.":[153],"CD4":[154,211],"T":[155,212],"cells":[156,213],"blood":[158],"expressed":[162],"higher":[163],"levels":[164,194],"early":[167],"activation":[168],"marker":[169],"CD69":[170],"in":[171,178,199,222],"hosts":[172],"not":[177],"allografts.":[184],"Only":[185],"showed":[191],"elevated":[192],"mRNA":[193],"IFN-\u03b3":[196],"IL-12a":[198],"their":[200],"native":[201],"hearts.":[202],"Our":[203],"data":[204],"indicate":[205],"that":[206],"chronic":[207],"allorecognition":[208],"alloreactive":[210],"elicits":[214],"sustained":[215],"inflammation":[216],"plays":[218],"a":[219],"key":[220],"role":[221],"promoting":[223],"CVD.":[225]},"counts_by_year":[],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2023-01-06T00:00:00"}