{"id":"https://openalex.org/W4313383178","doi":"https://doi.org/10.4049/jimmunol.204.supp.59.1","title":"Chemokine CCL28 treats oropharyngeal candidiasis through rapid membrane disruption","display_name":"Chemokine CCL28 treats oropharyngeal candidiasis through rapid membrane disruption","publication_year":2020,"publication_date":"2020-05-01","ids":{"openalex":"https://openalex.org/W4313383178","doi":"https://doi.org/10.4049/jimmunol.204.supp.59.1"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.204.supp.59.1","doi":"https://doi.org/10.4049/jimmunol.204.supp.59.1","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.204.supp.59.1","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062028300","display_name":"Ji\u00e9 He","orcid":"https://orcid.org/0000-0003-0327-8852","observed_orcids":["https://orcid.org/0000-0003-0327-8852"]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jie He","raw_affiliation_strings":["Medical College of Wisconsin","1Medical College of Wisconsin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical College of Wisconsin","institution_ids":["https://openalex.org/I204308271"]},{"raw_affiliation_string":"1Medical College of Wisconsin","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074712454","display_name":"Monica A. Thomas","orcid":"https://orcid.org/0000-0003-2513-3371","observed_orcids":["https://orcid.org/0000-0003-2513-3371"]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Monica A Thomas","raw_affiliation_strings":["Medical College of Wisconsin","1Medical College of Wisconsin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical College of Wisconsin","institution_ids":["https://openalex.org/I204308271"]},{"raw_affiliation_string":"1Medical College of Wisconsin","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054970732","display_name":"Emma Van Why","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emma Van Why","raw_affiliation_strings":["Medical College of Wisconsin","1Medical College of Wisconsin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical College of Wisconsin","institution_ids":["https://openalex.org/I204308271"]},{"raw_affiliation_string":"1Medical College of Wisconsin","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043556111","display_name":"Mitchell H. Grayson","orcid":"https://orcid.org/0000-0002-4673-2122","observed_orcids":["https://orcid.org/0000-0002-4673-2122"]},"institutions":[{"id":"https://openalex.org/I1314135232","display_name":"Nationwide Children's Hospital","ror":"https://ror.org/003rfsp33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1314135232"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mitchell H Grayson","raw_affiliation_strings":["Nationwide Children\u2019s Hospital","2Nationwide Children\u2019s Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nationwide Children\u2019s Hospital","institution_ids":["https://openalex.org/I1314135232"]},{"raw_affiliation_string":"2Nationwide Children\u2019s Hospital","institution_ids":["https://openalex.org/I1314135232"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088703972","display_name":"Brian F. Volkman","orcid":"https://orcid.org/0000-0002-6681-5179","observed_orcids":["https://orcid.org/0000-0002-6681-5179"]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian F Volkman","raw_affiliation_strings":["Medical College of Wisconsin","1Medical College of Wisconsin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical College of Wisconsin","institution_ids":["https://openalex.org/I204308271"]},{"raw_affiliation_string":"1Medical College of Wisconsin","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086035743","display_name":"Anna R. Huppler","orcid":"https://orcid.org/0000-0003-1263-6623","observed_orcids":["https://orcid.org/0000-0003-1263-6623"]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anna R Huppler","raw_affiliation_strings":["Medical College of Wisconsin","1Medical College of Wisconsin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical College of Wisconsin","institution_ids":["https://openalex.org/I204308271"]},{"raw_affiliation_string":"1Medical College of Wisconsin","institution_ids":["https://openalex.org/I204308271"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"204","issue":"1_Supplement","first_page":"59.1","last_page":"59.1"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.8866999745368958,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.8866999745368958,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.10610000044107437,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ccl28","display_name":"CCL28","score":0.9980000257492065},{"id":"https://openalex.org/keywords/oropharyngeal-candidiasis","display_name":"oropharyngeal candidiasis","score":0.9390000104904175},{"id":"https://openalex.org/keywords/candida-albicans","display_name":"Candida albicans","score":0.9990000128746033},{"id":"https://openalex.org/keywords/candida-glabrata","display_name":"Candida glabrata","score":0.921999990940094},{"id":"https://openalex.org/keywords/antimicrobial-peptides","display_name":"antimicrobial peptides","score":0.8550000190734863},{"id":"https://openalex.org/keywords/fungal-membrane-disruption","display_name":"fungal membrane disruption","score":0.7400000095367432},{"id":"https://openalex.org/keywords/cc-chemokines","display_name":"CC chemokines","score":0.7879999876022339},{"id":"https://openalex.org/keywords/immunodeficient-mice","display_name":"immunodeficient mice","score":0.6209999918937683},{"id":"https://openalex.org/keywords/c-terminal-tail","display_name":"C-terminal tail","score":0.7720000147819519},{"id":"https://openalex.org/keywords/polyamine-transporters","display_name":"polyamine transporters","score":0.781000018119812},{"id":"https://openalex.org/keywords/antifungal-therapy","display_name":"antifungal therapy","score":0.6660000085830688}],"concepts":[{"id":"https://openalex.org/C2780917455","wikidata":"https://www.wikidata.org/wiki/Q310443","display_name":"Candida albicans","level":2,"score":0.7517868280410767},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6001867651939392},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.5777066349983215},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.571579098701477},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.5663850903511047},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5606861114501953},{"id":"https://openalex.org/C145081991","wikidata":"https://www.wikidata.org/wiki/Q2576388","display_name":"Corpus albicans","level":3,"score":0.525965690612793},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5143195390701294},{"id":"https://openalex.org/C2780651595","wikidata":"https://www.wikidata.org/wiki/Q411478","display_name":"Fluconazole","level":3,"score":0.46849876642227173},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4451194107532501},{"id":"https://openalex.org/C2780670043","wikidata":"https://www.wikidata.org/wiki/Q139137","display_name":"Candida glabrata","level":3,"score":0.4113992750644684},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.25106143951416016},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13428503274917603},{"id":"https://openalex.org/C2779548794","wikidata":"https://www.wikidata.org/wiki/Q578726","display_name":"Antifungal","level":2,"score":0.13144540786743164},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4049/jimmunol.204.supp.59.1","doi":"https://doi.org/10.4049/jimmunol.204.supp.59.1","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.204.supp.59.1","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.6200000047683716,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3027571557","https://openalex.org/W2773355763","https://openalex.org/W2231462075","https://openalex.org/W2808393899","https://openalex.org/W1589692813","https://openalex.org/W1498823518","https://openalex.org/W4403989522","https://openalex.org/W2155184327","https://openalex.org/W2559323921","https://openalex.org/W1977187404"],"abstract_inverted_index":{"Abstract":[0],"Candida":[1,76],"albicans":[2,173],"is":[3,18,45,50,94,150,188],"a":[4,30,46],"commensal":[5],"organism":[6],"that":[7,49,149],"causes":[8],"life-threatening":[9],"or":[10,132],"life-altering":[11],"opportunistic":[12],"infections.":[13],"Treatment":[14],"of":[15,23,32,67,79,90,100,113,116,167],"these":[16],"infections":[17],"limited":[19],"by":[20,180],"the":[21,33,65,73,88,110,193,203],"paucity":[22],"anti-fungal":[24,154],"drug":[25,42],"classes.":[26],"Antimicrobial":[27],"peptides":[28],"are":[29,159],"component":[31],"immune":[34,204],"response":[35,205],"to":[36,152,171,206],"fungi":[37],"and":[38,54,72,139,145,183,210],"promising":[39],"agents":[40],"for":[41,162,213],"development.":[43],"CCL28":[44,80,93,119,141,163,170,191,200],"CC":[47],"chemokine":[48],"abundant":[51],"in":[52,56,68,74,81,124,175,190,202],"saliva":[53],"has":[55,211],"vitro":[57,69],"antimicrobial":[58,70],"activity.":[59,92,165],"In":[60,109],"this":[61],"study,":[62],"we":[63],"examine":[64],"spectrum":[66],"activity":[71,148],"vivo":[75],"killing":[77],"capacity":[78],"oropharyngeal":[82],"candidiasis":[83],"(OPC),":[84],"as":[85,87,178,215],"well":[86],"mechanism":[89],"anti-Candida":[91,164,217],"effective":[95,105],"against":[96,106],"multiple":[97],"clinical":[98,153],"strains":[99],"C.":[101,107,172],"albicans,":[102],"but":[103],"less":[104],"glabrata.":[108],"mouse":[111],"model":[112],"OPC,":[114],"application":[115],"wild":[117,168],"type":[118,169],"reduces":[120],"oral":[121],"fungal":[122,208],"burden":[123],"severely":[125],"immunodeficient":[126],"mice":[127],"without":[128,220],"causing":[129],"excessive":[130],"inflammation":[131],"altering":[133],"tissue":[134],"neutrophil":[135],"recruitment.":[136],"Both":[137],"structured":[138],"unstructured":[140],"proteins":[142],"show":[143],"rapid":[144],"sustained":[146],"fungicidal":[147],"superior":[151],"agents.":[155],"Polyamine":[156],"protein":[157],"transporters":[158],"not":[160],"required":[161],"Application":[166],"results":[174,198],"membrane":[176],"disruption":[177,187],"measured":[179],"solute":[181],"movement":[182],"enzyme":[184],"leakage.":[185],"Membrane":[186],"reduced":[189],"lacking":[192],"functional":[194],"C-terminal":[195],"tail.":[196],"Our":[197],"indicate":[199],"functions":[201],"disrupt":[207],"membranes":[209],"potential":[212],"development":[214],"an":[216],"therapeutic":[218],"agent":[219],"inflammatory":[221],"side":[222],"effects.":[223]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2023-01-06T00:00:00"}
