{"id":"https://openalex.org/W4313383138","doi":"https://doi.org/10.4049/jimmunol.204.supp.169.15","title":"Combination immunotherapy of \u03b1PD-1 and extended half-life IL-2 clears established GL261 gliomas in an MHC class I independent fashion","display_name":"Combination immunotherapy of \u03b1PD-1 and extended half-life IL-2 clears established GL261 gliomas in an MHC class I independent fashion","publication_year":2020,"publication_date":"2020-05-01","ids":{"openalex":"https://openalex.org/W4313383138","doi":"https://doi.org/10.4049/jimmunol.204.supp.169.15"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.204.supp.169.15","doi":"https://doi.org/10.4049/jimmunol.204.supp.169.15","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.204.supp.169.15","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032538191","display_name":"Zachariah Peter Tritz","orcid":"https://orcid.org/0000-0002-5836-7839","observed_orcids":["https://orcid.org/0000-0002-5836-7839","https://orcid.org/0000-0003-0124-4376"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zachariah Peter Tritz","raw_affiliation_strings":["Mayo Clinic Graduate School of Biomedical Sciences","1Mayo Clinic Graduate School of Biomedical Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic Graduate School of Biomedical Sciences","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"1Mayo Clinic Graduate School of Biomedical Sciences","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026507675","display_name":"Kathy Ayasoufi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathy Ayasoufi","raw_affiliation_strings":["Mayo Clinic Department of Immunology","2Mayo Clinic Department of Immunology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic Department of Immunology","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"2Mayo Clinic Department of Immunology","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076599272","display_name":"Courtney Sarah Malo","orcid":"https://orcid.org/0000-0001-9674-3826","observed_orcids":["https://orcid.org/0000-0001-9674-3826"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Courtney Malo","raw_affiliation_strings":["Mayo Clinic Graduate School of Biomedical Sciences","1Mayo Clinic Graduate School of Biomedical Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic Graduate School of Biomedical Sciences","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"1Mayo Clinic Graduate School of Biomedical Sciences","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022053658","display_name":"Benjamin T. Himes","orcid":"https://orcid.org/0000-0001-5420-068X","observed_orcids":["https://orcid.org/0000-0001-5420-068X"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin Himes","raw_affiliation_strings":["Mayo Clinic Graduate School of Biomedical Sciences","1Mayo Clinic Graduate School of Biomedical Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic Graduate School of Biomedical Sciences","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"1Mayo Clinic Graduate School of Biomedical Sciences","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112905643","display_name":"Roman H. Khadka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roman Khadka","raw_affiliation_strings":["Mayo Clinic Graduate School of Biomedical Sciences","1Mayo Clinic Graduate School of Biomedical Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic Graduate School of Biomedical Sciences","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"1Mayo Clinic Graduate School of Biomedical Sciences","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002497763","display_name":"Lila T. Yokanovich","orcid":"https://orcid.org/0000-0002-3823-4051","observed_orcids":["https://orcid.org/0000-0002-3823-4051"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lila Yokanovich","raw_affiliation_strings":["Mayo Clinic Graduate School of Biomedical Sciences","1Mayo Clinic Graduate School of Biomedical Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic Graduate School of Biomedical Sciences","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"1Mayo Clinic Graduate School of Biomedical Sciences","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090612293","display_name":"Emma N. Goddery","orcid":"https://orcid.org/0000-0001-6632-8226","observed_orcids":["https://orcid.org/0000-0001-6632-8226"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emma Goddery","raw_affiliation_strings":["Mayo Clinic Graduate School of Biomedical Sciences","1Mayo Clinic Graduate School of Biomedical Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic Graduate School of Biomedical Sciences","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"1Mayo Clinic Graduate School of Biomedical Sciences","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024074311","display_name":"Cori E. Fain","orcid":"https://orcid.org/0000-0002-8323-6419","observed_orcids":["https://orcid.org/0000-0002-8323-6419"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cori Fain","raw_affiliation_strings":["Mayo Clinic Graduate School of Biomedical Sciences","1Mayo Clinic Graduate School of Biomedical Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic Graduate School of Biomedical Sciences","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"1Mayo Clinic Graduate School of Biomedical Sciences","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110933814","display_name":"Michael Hansen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Hansen","raw_affiliation_strings":["Mayo Clinic Department of Immunology","2Mayo Clinic Department of Immunology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic Department of Immunology","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"2Mayo Clinic Department of Immunology","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101706801","display_name":"Fang Jin","orcid":"https://orcid.org/0000-0002-6606-5232","observed_orcids":["https://orcid.org/0000-0002-6606-5232","https://orcid.org/0000-0003-0774-788X"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fang Jin","raw_affiliation_strings":["Mayo Clinic Department of Immunology","2Mayo Clinic Department of Immunology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic Department of Immunology","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"2Mayo Clinic Department of Immunology","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010999533","display_name":"Chensu Wang","orcid":"https://orcid.org/0000-0001-6996-149X","observed_orcids":["https://orcid.org/0000-0001-6996-149X"]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chensu Wang","raw_affiliation_strings":["Massachusets Institute of Technology","3Massachusets Institute of Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusets Institute of Technology","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"3Massachusets Institute of Technology","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087926553","display_name":"Darrell J. Irvine","orcid":"https://orcid.org/0000-0002-8637-1405","observed_orcids":["https://orcid.org/0000-0002-8637-1405"]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Darrell J Irvine","raw_affiliation_strings":["Massachusets Institute of Technology","3Massachusets Institute of Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusets Institute of Technology","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"3Massachusets Institute of Technology","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111326412","display_name":"Karl Dane Wittrup","orcid":"https://orcid.org/0000-0003-2398-5896","observed_orcids":["https://orcid.org/0000-0003-2398-5896"]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K Dane Wittrup","raw_affiliation_strings":["Massachusets Institute of Technology","3Massachusets Institute of Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusets Institute of Technology","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"3Massachusets Institute of Technology","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042333597","display_name":"Ian F. Parney","orcid":"https://orcid.org/0000-0002-9702-8047","observed_orcids":["https://orcid.org/0000-0002-9702-8047"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ian F Parney","raw_affiliation_strings":["Mayo Clinic , Rochester, Minnesota","4Mayo Clinic, Rochester, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic , Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"4Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":null,"display_name":"Aaron J Johnson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aaron J Johnson","raw_affiliation_strings":["Mayo Clinic Department of Immunology","Mayo Clinic Department of Molecular Medicine","Mayo Clinic Department of Neurology","2Mayo Clinic Department of Immunology","5Mayo Clinic Department of Molecular Medicine","6Mayo Clinic Department of Neurology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic Department of Immunology","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Mayo Clinic Department of Molecular Medicine","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Mayo Clinic Department of Neurology","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"2Mayo Clinic Department of Immunology","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"5Mayo Clinic Department of Molecular Medicine","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"6Mayo Clinic Department of Neurology","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"204","issue":"1_Supplement","first_page":"169.15","last_page":"169.15"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9369999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9369999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.06069999933242798,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9409999847412109},{"id":"https://openalex.org/keywords/gl261-glioma","display_name":"GL261 glioma","score":0.8690000176429749},{"id":"https://openalex.org/keywords/interleukin-2","display_name":"interleukin-2","score":0.6200000047683716},{"id":"https://openalex.org/keywords/combination-immunotherapy","display_name":"combination immunotherapy","score":0.9549999833106995},{"id":"https://openalex.org/keywords/tumor-immunology","display_name":"tumor immunology","score":0.6100000143051147},{"id":"https://openalex.org/keywords/immunological-memory","display_name":"immunological memory","score":0.8159999847412109},{"id":"https://openalex.org/keywords/murine-glioma-model","display_name":"murine glioma model","score":0.6510000228881836}],"concepts":[{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.7338064908981323},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.622773289680481},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.5792481899261475},{"id":"https://openalex.org/C170627219","wikidata":"https://www.wikidata.org/wiki/Q13218497","display_name":"MHC class I","level":4,"score":0.5623398423194885},{"id":"https://openalex.org/C83464605","wikidata":"https://www.wikidata.org/wiki/Q575296","display_name":"Antigen presentation","level":4,"score":0.491044282913208},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4766460359096527},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.470103919506073},{"id":"https://openalex.org/C2778468042","wikidata":"https://www.wikidata.org/wiki/Q273976","display_name":"Blockade","level":3,"score":0.4507664144039154},{"id":"https://openalex.org/C2776999253","wikidata":"https://www.wikidata.org/wiki/Q1304270","display_name":"Combination therapy","level":2,"score":0.44924232363700867},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.4427649676799774},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4401973485946655},{"id":"https://openalex.org/C207936829","wikidata":"https://www.wikidata.org/wiki/Q423163","display_name":"Major histocompatibility complex","level":3,"score":0.43035706877708435},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.4272086024284363},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.4192708134651184},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.36700439453125},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.3590456247329712},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.13596460223197937},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.09543552994728088}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4049/jimmunol.204.supp.169.15","doi":"https://doi.org/10.4049/jimmunol.204.supp.169.15","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.204.supp.169.15","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.699999988079071}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4319433783","https://openalex.org/W4313430114","https://openalex.org/W4324323843","https://openalex.org/W3217183611","https://openalex.org/W4388588698","https://openalex.org/W4416139738","https://openalex.org/W4392356766","https://openalex.org/W3198644046","https://openalex.org/W4388589744","https://openalex.org/W2969843369"],"abstract_inverted_index":{"Abstract":[0],"Glioblastoma":[1],"multiforme":[2],"(GBM)":[3],"is":[4,171],"a":[5],"deadly":[6],"CNS":[7],"malignancy":[8],"with":[9,85],"an":[10,86],"average":[11],"survival":[12],"of":[13,34,41,56,64,72,79,162,173,186,194],"~12":[14],"months":[15],"post":[16],"diagnosis":[17],"despite":[18],"aggressive":[19],"treatment.":[20],"Immunotherapy":[21],"approaches":[22],"to":[23,68,112,121,151,157,214],"treat":[24],"GBM":[25,42],"are":[26,137],"being":[27],"developed,":[28],"but":[29,102],"the":[30,35,38,54,62,70,75,114,122,129,141,174],"unique":[31],"immune":[32],"environment":[33],"brain":[36],"and":[37,99,156,212],"immunosuppressive":[39],"features":[40],"have":[43,146],"complicated":[44],"early":[45],"efforts.":[46],"Even":[47],"\u03b1PD-1":[48,73,134,206],"checkpoint":[49,207],"blockade,":[50],"highly":[51,210],"useful":[52],"in":[53,61,106,183],"context":[55],"melanoma,":[57],"has":[58,92],"proved":[59],"ineffective":[60],"treatment":[63],"GBM.":[65],"In":[66],"order":[67],"promote":[69],"efficacy":[71],"against":[74,140],"GL261":[76,142,164,181],"murine":[77],"model":[78,143],"GBM,":[80],"we":[81,145],"supplemented":[82],"this":[83,148,168,202],"therapy":[84,91,170],"engineered":[87],"IL-2":[88,90,120],"cytokine.":[89],"been":[93],"used":[94],"clinically":[95],"for":[96],"metastatic":[97],"melanoma":[98],"renal":[100],"cancer,":[101],"its":[103],"short":[104],"half-life":[105],"circulation":[107],"necessitated":[108],"dangerously":[109],"high":[110],"doses":[111],"keep":[113],"drug":[115],"concentration":[116],"sufficiently":[117],"high.":[118],"Fusing":[119],"mouse":[123],"serum":[124],"albumin":[125],"molecule":[126],"(MSA-IL-2),":[127],"extends":[128],"cytokine\u2019s":[130],"half-life.":[131],"While":[132],"neither":[133],"nor":[135],"MSA-IL-2":[136],"effective":[138],"monotherapies":[139],"tumor,":[144],"found":[147],"combination":[149,169,203],"immunotherapy":[150,204],"provide":[152],"durable":[153],"tumor":[154],"clearance":[155],"create":[158],"immunologic":[159],"memory":[160],"capable":[161],"resisting":[163],"rechallenge.":[165],"Most":[166],"strikingly,":[167],"independent":[172],"CD8":[175],"T":[176],"cell":[177],"function,":[178],"clearing":[179],"established":[180],"tumors":[182],"mice":[184],"incapable":[185],"MHC":[187,195],"class":[188,196],"I":[189,197],"restricted":[190,198],"antigen":[191,199],"presentation.":[192],"Independence":[193],"presentation":[200],"makes":[201],"using":[205],"blockade":[208],"both":[209],"novel":[211],"translatable":[213],"clinical":[215],"use.":[216]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-13T10:08:12.033832","created_date":"2023-01-06T00:00:00"}