{"id":"https://openalex.org/W4313382018","doi":"https://doi.org/10.4049/jimmunol.198.supp.216.6","title":"Glucose metabolism regulates reactive oxygen species and nitric oxide production of macrophages in response to IFN-\u03b3 and Trypanosoma cruzi","display_name":"Glucose metabolism regulates reactive oxygen species and nitric oxide production of macrophages in response to IFN-\u03b3 and Trypanosoma cruzi","publication_year":2017,"publication_date":"2017-05-01","ids":{"openalex":"https://openalex.org/W4313382018","doi":"https://doi.org/10.4049/jimmunol.198.supp.216.6"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.198.supp.216.6","doi":"https://doi.org/10.4049/jimmunol.198.supp.216.6","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.198.supp.216.6","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066453546","display_name":"Sue-jie Koo","orcid":"https://orcid.org/0000-0002-3305-9952","observed_orcids":["https://orcid.org/0000-0002-3305-9952"]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sue Koo","raw_affiliation_strings":["Univ. of Texas Med. Br. , Galveston","1Univ. of Texas Med. Br., Galveston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Texas Med. Br. , Galveston","institution_ids":["https://openalex.org/I55302922"]},{"raw_affiliation_string":"1Univ. of Texas Med. Br., Galveston","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090643968","display_name":"Bartosz Szcz\u0119sny","orcid":"https://orcid.org/0000-0002-6196-3981","observed_orcids":["https://orcid.org/0000-0002-6196-3981"]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bartosz Szczesny","raw_affiliation_strings":["Univ. of Texas Med. Br. , Galveston","1Univ. of Texas Med. Br., Galveston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Texas Med. Br. , Galveston","institution_ids":["https://openalex.org/I55302922"]},{"raw_affiliation_string":"1Univ. of Texas Med. Br., Galveston","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065183058","display_name":"Nisha Jain Garg","orcid":"https://orcid.org/0000-0002-3453-2369","observed_orcids":["https://orcid.org/0000-0002-3453-2369"]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nisha Garg","raw_affiliation_strings":["Univ. of Texas Med. Br. , Galveston","1Univ. of Texas Med. Br., Galveston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Texas Med. Br. , Galveston","institution_ids":["https://openalex.org/I55302922"]},{"raw_affiliation_string":"1Univ. of Texas Med. Br., Galveston","institution_ids":["https://openalex.org/I55302922"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I55302922"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"198","issue":"Supplement_1","first_page":"216.6","last_page":"216.6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10890","display_name":"Trypanosoma species research and implications","score":0.8945000171661377,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10890","display_name":"Trypanosoma species research and implications","score":0.8945000171661377,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.02160000056028366,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.013000000268220901,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trypanosoma-cruzi","display_name":"Trypanosoma cruzi","score":0.8529999852180481},{"id":"https://openalex.org/keywords/chagas-disease","display_name":"Chagas disease","score":0.9350000023841858},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.9509999752044678},{"id":"https://openalex.org/keywords/glucose-metabolism","display_name":"glucose metabolism","score":0.9670000076293945},{"id":"https://openalex.org/keywords/glycolysis","display_name":"glycolysis","score":0.953000009059906},{"id":"https://openalex.org/keywords/mitochondrial-oxidative-phosphorylation","display_name":"mitochondrial oxidative phosphorylation","score":0.8999999761581421},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9750000238418579},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.9819999933242798},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.9190000295639038},{"id":"https://openalex.org/keywords/nadph-oxidase","display_name":"NADPH oxidase","score":0.8769999742507935},{"id":"https://openalex.org/keywords/gp91phox","display_name":"gp91phox","score":0.9819999933242798},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9359999895095825},{"id":"https://openalex.org/keywords/oligomycin","display_name":"oligomycin","score":0.8809999823570251},{"id":"https://openalex.org/keywords/parasitic-infection","display_name":"parasitic infection","score":0.39899998903274536},{"id":"https://openalex.org/keywords/pro-inflammatory-macrophages","display_name":"inflammatory macrophages","score":0.6729999780654907}],"concepts":[{"id":"https://openalex.org/C20251656","wikidata":"https://www.wikidata.org/wiki/Q162643","display_name":"Glycolysis","level":3,"score":0.7089213132858276},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.5936789512634277},{"id":"https://openalex.org/C3409486","wikidata":"https://www.wikidata.org/wiki/Q827489","display_name":"Pentose phosphate pathway","level":4,"score":0.5607133507728577},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.5094740986824036},{"id":"https://openalex.org/C2777625466","wikidata":"https://www.wikidata.org/wiki/Q150162","display_name":"Trypanosoma cruzi","level":3,"score":0.48507967591285706},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.476802796125412},{"id":"https://openalex.org/C2779719074","wikidata":"https://www.wikidata.org/wiki/Q2038057","display_name":"NADPH oxidase","level":3,"score":0.4652451276779175},{"id":"https://openalex.org/C2778175917","wikidata":"https://www.wikidata.org/wiki/Q17125553","display_name":"Mitochondrial ROS","level":3,"score":0.42196768522262573},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.41558361053466797},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34213611483573914},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3366815447807312},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.23670434951782227},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.0},{"id":"https://openalex.org/C71928629","wikidata":"https://www.wikidata.org/wiki/Q804206","display_name":"Parasite hosting","level":2,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4049/jimmunol.198.supp.216.6","doi":"https://doi.org/10.4049/jimmunol.198.supp.216.6","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.198.supp.216.6","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8560000061988831}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2797552543","https://openalex.org/W2527800795","https://openalex.org/W4313356248","https://openalex.org/W2030343555","https://openalex.org/W2321988497","https://openalex.org/W2618881779","https://openalex.org/W6991916809","https://openalex.org/W2116542547","https://openalex.org/W2009662910","https://openalex.org/W7095701561"],"abstract_inverted_index":{"Abstract":[0],"Macrophages":[1],"(m\u03d5)":[2],"act":[3],"as":[4,124,147],"one":[5],"of":[6,20,26,72,95,107,128,137,165,191,203],"the":[7,21,86,90,98,163,180,189,204],"prime":[8],"barriers":[9],"to":[10,16,83,85,112,234],"Trypanosoma":[11],"cruzi":[12,63],"infection":[13,136],"yet":[14],"fail":[15,82],"achieve":[17],"complete":[18],"clearance":[19],"parasite.":[22],"The":[23,200],"phenotypic":[24],"diversity":[25],"m\u03d5":[27,55,110,119,138,216,232,251],"include":[28],"pro-inflammatory":[29,91,150,220],"and":[30,40,77,81,142,145,167,170,193,240,247],"immunomodulatory":[31],"activated":[32],"states":[33],"which":[34],"are":[35],"supported":[36],"by":[37,152,245],"cytosolic":[38],"glycolysis":[39,87,159,226],"mitochondrial":[41,122,248],"oxidative":[42],"phosphorylation":[43],"(OXPHOS),":[44],"respectively,":[45],"for":[46,162],"their":[47],"differential":[48],"functions.":[49],"We":[50,156,174],"previously":[51],"reported":[52],"that":[53,117,158,176,225],"murine":[54],"(RAW264.7":[56],"or":[57,183],"bone":[58],"marrow-derived)":[59],"infected":[60],"with":[61,97],"T.":[62],"Sylvio":[64],"strain":[65],"(SYL)":[66],"produce":[67],"TNF-\u03b1,":[68],"but":[69,196],"low":[70],"levels":[71],"reactive":[73],"oxygen":[74],"species":[75],"(ROS)":[76],"nitric":[78],"oxide":[79],"(NO)":[80],"switch":[84],"observed":[88,148],"in":[89,104,109,149,172,188,214,219,231,250],"LPS/IFNG-induced":[92,168],"m\u03d5.":[93,173,221],"Pre-blockage":[94],"OXPHOS":[96,141],"ATP":[99],"synthase":[100],"inhibitor,":[101],"oligomycin,":[102],"resulted":[103,187],"further":[105,254],"suppression":[106],"NO":[108,129,146,171,194,241],"responding":[111,233],"SYL.":[113],"These":[114,222],"data":[115,223],"suggested":[116],"SYL-infected":[118,215],"may":[120,227],"utilize":[121],"metabolism":[123,249],"an":[125],"initial":[126],"activator":[127],"production.":[130],"Providing":[131],"interferon-\u03b3":[132],"(IFNG)":[133],"during":[134],"SYL":[135],"shut":[139],"down":[140],"produced":[143],"ROS":[144,169,192],"controls":[151],"18":[153],"hours":[154],"posttreatment.":[155],"hypothesized":[157],"was":[160,211],"required":[161],"activation":[164,230],"IFNG/SYL-":[166],"found":[175],"eliminating":[177],"glucose":[178,185,246],"from":[179],"culture":[181],"media":[182],"inhibiting":[184],"uptake":[186],"failure":[190],"production,":[195],"sustained":[197],"TNF-\u03b1":[198],"release.":[199],"protein":[201],"expression":[202],"ROS-producing":[205],"NADPH":[206],"oxidase":[207],"(NOX2)":[208],"subunit,":[209],"gp91phox,":[210],"not":[212],"detected":[213],"although":[217],"abundant":[218],"suggest":[224],"regulate":[228],"NOX2":[229,238],"inflammatory":[235],"stimuli.":[236],"How":[237],"function":[239],"release":[242],"is":[243],"controlled":[244],"will":[252],"be":[253],"discussed.":[255]},"counts_by_year":[],"updated_date":"2026-09-23T09:40:40.371523","created_date":"2023-01-06T00:00:00"}