{"id":"https://openalex.org/W4313381908","doi":"https://doi.org/10.4049/jimmunol.198.supp.199.14","title":"A robust microparticle platform for a STING-targeted adjuvant that enhances both humoral and cellular immunity during vaccination","display_name":"A robust microparticle platform for a STING-targeted adjuvant that enhances both humoral and cellular immunity during vaccination","publication_year":2017,"publication_date":"2017-05-01","ids":{"openalex":"https://openalex.org/W4313381908","doi":"https://doi.org/10.4049/jimmunol.198.supp.199.14"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.198.supp.199.14","doi":"https://doi.org/10.4049/jimmunol.198.supp.199.14","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.198.supp.199.14","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000922413","display_name":"Robert D. Junkins","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert D Junkins","raw_affiliation_strings":["Univ. of North Carolina , Chapel Hill","1Univ. of North Carolina, Chapel Hill"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of North Carolina , Chapel Hill","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"1Univ. of North Carolina, Chapel Hill","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050156906","display_name":"Brandon M. Johnson","orcid":"https://orcid.org/0000-0002-3871-3378","observed_orcids":["https://orcid.org/0000-0002-3871-3378"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brandon M Johnson","raw_affiliation_strings":["Univ. of North Carolina , Chapel Hill","1Univ. of North Carolina, Chapel Hill"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of North Carolina , Chapel Hill","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"1Univ. of North Carolina, Chapel Hill","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028938492","display_name":"Matthew D. Gallovic","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew D Gallovic","raw_affiliation_strings":["Ohio State Univ","Univ. of North Carolina , Chapel Hill","1Univ. of North Carolina, Chapel Hill","2Ohio State Univ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ohio State Univ","institution_ids":["https://openalex.org/I52357470"]},{"raw_affiliation_string":"Univ. of North Carolina , Chapel Hill","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"1Univ. of North Carolina, Chapel Hill","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"2Ohio State Univ","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Michael A Collier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael A Collier","raw_affiliation_strings":["Univ. of North Carolina , Chapel Hill","1Univ. of North Carolina, Chapel Hill"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of North Carolina , Chapel Hill","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"1Univ. of North Carolina, Chapel Hill","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028409171","display_name":"Rebekah Watkins-Schulz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rebekah Watkins-Schulz","raw_affiliation_strings":["Univ. of North Carolina , Chapel Hill","1Univ. of North Carolina, Chapel Hill"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of North Carolina , Chapel Hill","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"1Univ. of North Carolina, Chapel Hill","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065365482","display_name":"Ning Cheng","orcid":"https://orcid.org/0000-0002-1124-9093","observed_orcids":["https://orcid.org/0000-0002-1124-9093"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ning Cheng","raw_affiliation_strings":["Univ. of North Carolina , Chapel Hill","1Univ. of North Carolina, Chapel Hill"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of North Carolina , Chapel Hill","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"1Univ. of North Carolina, Chapel Hill","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008108462","display_name":"Cl\u00e9ment N. David","orcid":"https://orcid.org/0009-0006-9933-6410","observed_orcids":["https://orcid.org/0009-0006-9933-6410"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Clement N David","raw_affiliation_strings":["Univ. of North Carolina , Chapel Hill","1Univ. of North Carolina, Chapel Hill"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of North Carolina , Chapel Hill","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"1Univ. of North Carolina, Chapel Hill","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108279523","display_name":"Charles E. McGee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles E McGee","raw_affiliation_strings":["Duke Univ","3Duke Univ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke Univ","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"3Duke Univ","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087681431","display_name":"Gregory D. Sempowski","orcid":"https://orcid.org/0000-0003-0391-6594","observed_orcids":["https://orcid.org/0000-0003-0391-6594"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregory D Sempowski","raw_affiliation_strings":["Duke Univ","3Duke Univ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke Univ","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"3Duke Univ","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018023536","display_name":"Ivo D. Shterev","orcid":"https://orcid.org/0000-0002-6804-2608","observed_orcids":["https://orcid.org/0000-0002-6804-2608"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ivo Shterev","raw_affiliation_strings":["Duke Univ","3Duke Univ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke Univ","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"3Duke Univ","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005855096","display_name":"Karen P. McKinnon","orcid":"https://orcid.org/0000-0002-1779-5626","observed_orcids":["https://orcid.org/0000-0002-1779-5626"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karen McKinnon","raw_affiliation_strings":["Univ. of North Carolina , Chapel Hill","1Univ. of North Carolina, Chapel Hill"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of North Carolina , Chapel Hill","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"1Univ. of North Carolina, Chapel Hill","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013153851","display_name":"Eric M. Bachelder","orcid":"https://orcid.org/0000-0002-8572-888X","observed_orcids":["https://orcid.org/0000-0002-8572-888X"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric M Bachelder","raw_affiliation_strings":["Univ. of North Carolina , Chapel Hill","1Univ. of North Carolina, Chapel Hill"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of North Carolina , Chapel Hill","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"1Univ. of North Carolina, Chapel Hill","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079566195","display_name":"Kristy M. Ainslie","orcid":"https://orcid.org/0000-0002-1820-8382","observed_orcids":["https://orcid.org/0000-0002-1820-8382"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kristy M Ainslie","raw_affiliation_strings":["Univ. of North Carolina , Chapel Hill","1Univ. of North Carolina, Chapel Hill"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of North Carolina , Chapel Hill","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"1Univ. of North Carolina, Chapel Hill","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021145558","display_name":"Jenny P.\u2010Y. Ting","orcid":"https://orcid.org/0000-0002-3282-419X","observed_orcids":["https://orcid.org/0000-0002-3282-419X"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jenny P-Y Ting","raw_affiliation_strings":["Univ. of North Carolina , Chapel Hill","1Univ. of North Carolina, Chapel Hill"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of North Carolina , Chapel Hill","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"1Univ. of North Carolina, Chapel Hill","institution_ids":["https://openalex.org/I114027177"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"198","issue":"Supplement_1","first_page":"199.14","last_page":"199.14"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.008500000461935997,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13410","display_name":"Immune responses and vaccinations","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sting-agonist","display_name":"STING agonist","score":0.9419999718666077},{"id":"https://openalex.org/keywords/vaccine-adjuvants","display_name":"vaccine adjuvants","score":0.9639999866485596},{"id":"https://openalex.org/keywords/microparticle-delivery","display_name":"microparticle delivery","score":0.7039999961853027},{"id":"https://openalex.org/keywords/acetalated-dextran","display_name":"acetalated dextran","score":0.9399999976158142},{"id":"https://openalex.org/keywords/intracellular-delivery","display_name":"intracellular delivery","score":0.8550000190734863},{"id":"https://openalex.org/keywords/antigen-presenting-cells","display_name":"antigen-presenting cells","score":0.8939999938011169},{"id":"https://openalex.org/keywords/type-i-interferon","display_name":"type I interferon","score":0.8090000152587891},{"id":"https://openalex.org/keywords/humoral-immunity","display_name":"humoral immunity","score":0.9670000076293945},{"id":"https://openalex.org/keywords/cell-mediated-immunity","display_name":"cell-mediated immunity","score":0.9100000262260437},{"id":"https://openalex.org/keywords/th1-response","display_name":"Th1 response","score":0.871999979019165},{"id":"https://openalex.org/keywords/germinal-center-b-cells","display_name":"germinal center B cells","score":0.9509999752044678},{"id":"https://openalex.org/keywords/memory-t-cells","display_name":"memory T cells","score":0.9649999737739563},{"id":"https://openalex.org/keywords/influenza-vaccination","display_name":"influenza vaccination","score":0.6869999766349792}],"concepts":[{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.8279675841331482},{"id":"https://openalex.org/C2779300339","wikidata":"https://www.wikidata.org/wiki/Q7617409","display_name":"Sting","level":2,"score":0.820101261138916},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.6237907409667969},{"id":"https://openalex.org/C2776548049","wikidata":"https://www.wikidata.org/wiki/Q1142875","display_name":"Humoral immunity","level":3,"score":0.5312703847885132},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5072800517082214},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.4982187747955322},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4795489013195038},{"id":"https://openalex.org/C2777349159","wikidata":"https://www.wikidata.org/wiki/Q18055374","display_name":"Stimulator of interferon genes","level":4,"score":0.47083142399787903},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.46658045053482056},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3984105587005615},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36467239260673523},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3415675163269043},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.2739378809928894},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10625037550926208},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.08523502945899963},{"id":"https://openalex.org/C146978453","wikidata":"https://www.wikidata.org/wiki/Q3798668","display_name":"Aerospace engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4049/jimmunol.198.supp.199.14","doi":"https://doi.org/10.4049/jimmunol.198.supp.199.14","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.198.supp.199.14","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.8199999928474426,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3126978432","https://openalex.org/W3166330342","https://openalex.org/W3126746996","https://openalex.org/W2074505789","https://openalex.org/W4390616119","https://openalex.org/W2623097481","https://openalex.org/W1976325516","https://openalex.org/W4286504551","https://openalex.org/W4360862793","https://openalex.org/W3123341980"],"abstract_inverted_index":{"Abstract":[0],"Most":[1],"FDA-approved":[2],"adjuvants":[3],"for":[4,91,99,131],"infectious":[5,94],"agents":[6],"boost":[7],"humoral":[8,231],"but":[9,77],"not":[10],"cellular":[11,233],"immunity,":[12],"and":[13,159,184,199,205,226,232],"have":[14,59],"poorly-understood":[15],"mechanisms.":[16],"Stimulator":[17],"of":[18,46,65,103,112,151,230],"interferon":[19,177],"genes":[20],"(STING)":[21],"is":[22,38],"an":[23],"exciting":[24],"adjuvant":[25,110,229],"target":[26,128],"due":[27],"to":[28,88,138,167,180,190],"its":[29,47],"role":[30],"in":[31,55,118,147,164,182,186,193],"anti-viral":[32],"immunity;":[33],"however,":[34],"a":[35,50,56,73,113,214,224],"major":[36],"hindrance":[37],"STING\u2019s":[39],"cytosolic":[40],"localization":[41],"which":[42,127],"requires":[43],"intracellular":[44,101,132],"delivery":[45,102,141],"agonists.":[48],"As":[49],"result,":[51],"STING":[52,66,115,152,171,221],"agonists":[53,67],"administered":[54],"soluble":[57,168],"form":[58],"elicited":[60,160],"suboptimal":[61],"immune":[62],"responses.":[63],"Delivery":[64],"via":[68],"particle":[69,140],"platforms":[70,98],"has":[71,78],"proven":[72],"more":[74],"successful":[75],"strategy,":[76],"only":[79],"been":[80],"assessed":[81],"at":[82,149],"doses":[83,150],"that":[84],"are":[85,105],"likely":[86],"cost-prohibitive":[87],"clinical":[89],"translation":[90],"vaccines":[92],"against":[93,213],"diseases.":[95],"Hence,":[96],"alternative":[97],"the":[100,109,170],"STING-agonists":[104],"needed.":[106],"We":[107],"evaluated":[108],"activity":[111],"potent":[114],"agonist,":[116,169],"encapsulated":[117],"acid-sensitive":[119],"acetalated":[120],"dextran":[121],"(Ace-":[122],"DEX)":[123],"polymeric":[124],"microparticles":[125],"(MPs)":[126],"antigen-presenting":[129],"cells":[130,204],"release.":[133],"This":[134],"formulation":[135],"was":[136],"superior":[137],"all":[139],"systems":[142],"tested,":[143],"achieved":[144],"protective":[145],"immunity":[146],"vivo":[148],"agonist":[153,172,222],"50-fold":[154,185],"lower":[155],"than":[156],"previous":[157],"reports,":[158],"no":[161],"observable":[162],"toxicity":[163],"animals.":[165],"Compared":[166],"Ace-DEX":[173,219],"MPs":[174],"enhanced":[175,196],"type-I":[176],"responses":[178],"up":[179,189],"1000-fold":[181],"vitro":[183],"vivo,":[187],"caused":[188],"104-fold":[191],"increases":[192],"antibody":[194],"titers,":[195],"Th1-associated":[197],"responses,":[198],"expanded":[200],"germinal":[201],"center":[202],"B":[203],"memory":[206],"T":[207],"cells.":[208],"It":[209],"also":[210],"provided":[211],"protection":[212],"lethal":[215],"influenza":[216],"challenge.":[217],"Thus,":[218],"MP-encapsulated":[220],"represents":[223],"novel":[225],"feasible":[227],"vaccine":[228],"immunity.":[234]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2}],"updated_date":"2026-10-17T09:40:24.721904","created_date":"2025-10-10T00:00:00"}
