{"id":"https://openalex.org/W4313380609","doi":"https://doi.org/10.4049/jimmunol.198.supp.155.1","title":"Natural nano particle MIR2911 suppresses tumor growth by targeting TGF\u03b2 pathway.","display_name":"Natural nano particle MIR2911 suppresses tumor growth by targeting TGF\u03b2 pathway.","publication_year":2017,"publication_date":"2017-05-01","ids":{"openalex":"https://openalex.org/W4313380609","doi":"https://doi.org/10.4049/jimmunol.198.supp.155.1"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.198.supp.155.1","doi":"https://doi.org/10.4049/jimmunol.198.supp.155.1","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.198.supp.155.1","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Zhen Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhen Zhou","raw_affiliation_strings":["Nanjing Univ. ,","1Nanjing Univ., China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nanjing Univ. ,","institution_ids":["https://openalex.org/I881766915"]},{"raw_affiliation_string":"1Nanjing Univ., China","institution_ids":["https://openalex.org/I881766915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101938134","display_name":"Lintao Wang","orcid":"https://orcid.org/0000-0003-2794-7387","observed_orcids":["https://orcid.org/0000-0003-2794-7387"]},"institutions":[{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lintao Wang","raw_affiliation_strings":["Nanjing Univ. ,","1Nanjing Univ., China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nanjing Univ. ,","institution_ids":["https://openalex.org/I881766915"]},{"raw_affiliation_string":"1Nanjing Univ., China","institution_ids":["https://openalex.org/I881766915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082076770","display_name":"Ke Zen","orcid":"https://orcid.org/0000-0002-5166-2974","observed_orcids":["https://orcid.org/0000-0002-5166-2974"]},"institutions":[{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ke Zen","raw_affiliation_strings":["Nanjing Univ. ,","1Nanjing Univ., China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nanjing Univ. ,","institution_ids":["https://openalex.org/I881766915"]},{"raw_affiliation_string":"1Nanjing Univ., China","institution_ids":["https://openalex.org/I881766915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I881766915"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"198","issue":"Supplement_1","first_page":"155.1","last_page":"155.1"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.8446999788284302,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.8446999788284302,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.1054999977350235,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.008299999870359898,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.800000011920929},{"id":"https://openalex.org/keywords/natural-nanoparticles","display_name":"natural nanoparticles","score":0.7910000085830688},{"id":"https://openalex.org/keywords/tgf-beta-signaling","display_name":"TGF-beta signaling","score":0.7749999761581421},{"id":"https://openalex.org/keywords/tumor-suppression","display_name":"tumor suppression","score":0.7289999723434448},{"id":"https://openalex.org/keywords/lonicera","display_name":"honeysuckle","score":0.9660000205039978},{"id":"https://openalex.org/keywords/mirna-stability","display_name":"miRNA stability","score":0.7149999737739563},{"id":"https://openalex.org/keywords/cancer-therapy","display_name":"cancer therapy","score":0.4860000014305115},{"id":"https://openalex.org/keywords/antiviral-microrna","display_name":"antiviral microRNA","score":0.5}],"concepts":[{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.6318725347518921},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5360972881317139},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.5168328881263733},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4672527015209198},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.28653037548065186},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.25520479679107666},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1256805956363678}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4049/jimmunol.198.supp.155.1","doi":"https://doi.org/10.4049/jimmunol.198.supp.155.1","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.198.supp.155.1","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3161006270","https://openalex.org/W6920818704","https://openalex.org/W7118174595","https://openalex.org/W7152605825","https://openalex.org/W1560761903","https://openalex.org/W7095521780","https://openalex.org/W2004588189","https://openalex.org/W3175916428","https://openalex.org/W3008524219","https://openalex.org/W2011243140"],"abstract_inverted_index":{"Abstract":[0],"Malignant":[1],"tumor":[2,125,153],"is":[3,25,90],"one":[4],"of":[5,12,35,43,48,101,165,168],"the":[6,10,33,39,102,145,158,163,166],"major":[7],"diseases":[8],"threatening":[9],"health":[11],"human":[13,17],"beings.":[14],"In":[15],"many":[16,80,94],"cancers,":[18],"transforming":[19],"growth":[20],"factor":[21],"beta":[22],"(TGF\u03b2)":[23],"expression":[24,67],"increased.":[26],"Further":[27],"researches":[28],"also":[29,129],"indicate":[30],"that,":[31],"in":[32],"development":[34,42],"tumors,":[36],"TGF\u03b2":[37,135],"promotes":[38],"formation":[40],"and":[41,69,78,116,136],"tumors":[44],"through":[45,75],"a":[46,61,152],"variety":[47],"mechanisms.":[49],"Our":[50,85],"research":[51],"group":[52],"previously":[53],"found":[54,87],"that":[55,88,107,131],"traditional":[56],"Chinese":[57],"medicine":[58],"honeysuckle":[59],"encodes":[60],"special":[62],"miRNA,":[63],"MIR2911,":[64],"with":[65,113],"high":[66],"level":[68],"stability.":[70],"MIR2911":[71,89,109,132,150],"can":[72,121,133],"be":[73],"absorbed":[74],"GI":[76],"tract":[77],"inhibit":[79,137],"influenza":[81],"virus":[82],"subtypes":[83],"replication.":[84],"study":[86],"more":[91],"stable":[92],"than":[93],"other":[95,115],"miRNAs.":[96],"With":[97],"up":[98],"to":[99,143,161],"85%":[100],"GC":[103],"content,":[104],"we":[105],"hypothesized":[106],"several":[108],"moleculars":[110],"could":[111],"combine":[112],"each":[114],"form":[117],"natural":[118,146],"nanoparticles,":[119],"which":[120],"easily":[122],"enter":[123],"into":[124],"cells.":[126],"Bioinformatics":[127],"analysis":[128],"showed":[130],"target":[134],"its":[138],"expression.":[139],"This":[140],"project":[141],"intends":[142],"use":[144],"nanoparticles":[147],"formed":[148],"by":[149,156],"as":[151],"therapeutic":[154],"drug,":[155],"inhibiting":[157],"TGF":[159],"pathway,":[160],"achieve":[162],"purpose":[164],"treatment":[167],"tumor.":[169]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2023-01-06T00:00:00"}