{"id":"https://openalex.org/W4313376391","doi":"https://doi.org/10.4049/jimmunol.91.6.819","title":"Phylogeny of the Immune Response","display_name":"Phylogeny of the Immune Response","publication_year":1963,"publication_date":"1963-12-01","ids":{"openalex":"https://openalex.org/W4313376391","doi":"https://doi.org/10.4049/jimmunol.91.6.819","mag":"1579501550","pmid":"https://pubmed.ncbi.nlm.nih.gov/14106306"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.91.6.819","doi":"https://doi.org/10.4049/jimmunol.91.6.819","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.91.6.819","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110101301","display_name":"Howard M. Grey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146328","display_name":"Scripps Clinic","ror":"https://ror.org/05kwjwj05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1311914864","https://openalex.org/I4210146328"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Howard M Grey","raw_affiliation_strings":["Division of Experimental Pathology, Scripps Clinic and Research Foundation , La Jolla, California","Division of Experimental Pathology, Scripps Clinic and Research Foundation From the , La Jolla, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Experimental Pathology, Scripps Clinic and Research Foundation , La Jolla, California","institution_ids":["https://openalex.org/I4210146328"]},{"raw_affiliation_string":"Division of Experimental Pathology, Scripps Clinic and Research Foundation From the , La Jolla, California","institution_ids":["https://openalex.org/I4210146328"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5110101301"],"corresponding_institution_ids":["https://openalex.org/I4210146328"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":4.7961,"has_fulltext":false,"cited_by_count":85,"citation_normalized_percentile":{"value":0.95084485,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"91","issue":"6","first_page":"819","last_page":"825"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.2433999925851822,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.2433999925851822,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.2287999987602234,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.16019999980926514,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hemocyanin","display_name":"hemocyanin","score":0.7919999957084656},{"id":"https://openalex.org/keywords/antibody-response","display_name":"antibody response","score":0.4860000014305115},{"id":"https://openalex.org/keywords/2-mercaptoethanol","display_name":"2-mercaptoethanol","score":0.9010000228881836},{"id":"https://openalex.org/keywords/secondary-immune-response","display_name":"secondary immune response","score":0.9319999814033508},{"id":"https://openalex.org/keywords/primary-antibody-response","display_name":"primary antibody response","score":0.621999979019165},{"id":"https://openalex.org/keywords/precipitation-reaction","display_name":"precipitation reaction","score":0.6309999823570251},{"id":"https://openalex.org/keywords/immune-system-evolution","display_name":"immune system evolution","score":0.46700000762939453}],"concepts":[{"id":"https://openalex.org/C133229898","wikidata":"https://www.wikidata.org/wiki/Q7239484","display_name":"Precipitin","level":3,"score":0.8782134056091309},{"id":"https://openalex.org/C2776727803","wikidata":"https://www.wikidata.org/wiki/Q1496686","display_name":"Keyhole limpet hemocyanin","level":3,"score":0.7704253196716309},{"id":"https://openalex.org/C2779915011","wikidata":"https://www.wikidata.org/wiki/Q407688","display_name":"Hemocyanin","level":3,"score":0.7349929213523865},{"id":"https://openalex.org/C91523082","wikidata":"https://www.wikidata.org/wiki/Q420496","display_name":"Antiserum","level":3,"score":0.6990646123886108},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.6839132308959961},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.592980146408081},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5828847885131836},{"id":"https://openalex.org/C3018913218","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody response","level":3,"score":0.5613674521446228},{"id":"https://openalex.org/C2777124643","wikidata":"https://www.wikidata.org/wiki/Q17076044","display_name":"Limpet","level":3,"score":0.5596842169761658},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5414450764656067},{"id":"https://openalex.org/C2780801004","wikidata":"https://www.wikidata.org/wiki/Q1415366","display_name":"Immunization","level":3,"score":0.477303147315979},{"id":"https://openalex.org/C109766332","wikidata":"https://www.wikidata.org/wiki/Q3532550","display_name":"Turtle (robot)","level":2,"score":0.4432591497898102},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.39222952723503113},{"id":"https://openalex.org/C90856448","wikidata":"https://www.wikidata.org/wiki/Q431","display_name":"Zoology","level":1,"score":0.2654724717140198},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.15644150972366333},{"id":"https://openalex.org/C2776249982","wikidata":"https://www.wikidata.org/wiki/Q25326","display_name":"Mollusca","level":2,"score":0.05341893434524536}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000917","descriptor_name":"Antibody Formation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002498","descriptor_name":"Centrifugation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007122","descriptor_name":"Immunoelectrophoresis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007136","descriptor_name":"Immunoglobulins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012104","descriptor_name":"Reptiles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012106","descriptor_name":"Research","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014426","descriptor_name":"Turtles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.4049/jimmunol.91.6.819","doi":"https://doi.org/10.4049/jimmunol.91.6.819","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.91.6.819","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:14106306","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14106306","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Journal Article"},{"id":"mag:1579501550","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14106306","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1579501550","https://openalex.org/W28059909","https://openalex.org/W2154518253","https://openalex.org/W2388984509","https://openalex.org/W2325796566","https://openalex.org/W2055907754","https://openalex.org/W2348744677","https://openalex.org/W198698108","https://openalex.org/W4313339274","https://openalex.org/W2029840983"],"abstract_inverted_index":{"Summary":[0],"The":[1,22,26],"immune":[2],"response":[3,45,84,104],"of":[4,15,18,34,70,97,113],"turtles":[5],"to":[6,32,100],"giant":[7],"keyhole":[8],"limpet":[9],"hemocyanin":[10],"was":[11],"studied":[12],"by":[13,20,58,80,111],"means":[14],"the":[16,35,41,51,71,95,114],"precipitation":[17],"I*-hemocyanin":[19],"antiserum.":[21],"pertinent":[23],"findings":[24],"were:":[25],"18":[27],"S":[28],"protein":[29,39],"constitutes":[30],"13":[31],"26%":[33],"total":[36],"normal":[37],"serum":[38],"in":[40,105],"turtle.In":[42],"an":[43],"antibody":[44,48,64,74,90],"rapidly":[46,72],"sedimenting":[47,60,63,73],"predominates":[49],"for":[50],"first":[52],"month":[53],"and":[54,91],"is":[55,76,108],"gradually":[56],"replaced":[57],"slowly":[59,62],"antibody.The":[61],"activity":[65,75],"as":[66,68],"well":[67],"that":[69,106],"almost":[77],"entirely":[78],"destroyed":[79],"2-mercaptoethanol":[81],"treatment.No":[82],"anamnestic":[83],"occurred.The":[85],"precipitin":[86],"reaction":[87],"between":[88],"turtle":[89],"antigen":[92],"remains,":[93],"throughout":[94],"course":[96],"immunization,":[98],"similar":[99],"a":[101],"mammalian":[102],"primary":[103],"it":[107],"greatly":[109],"effected":[110],"dilution":[112],"test":[115],"system.":[116]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-01-06T00:00:00"}
