{"id":"https://openalex.org/W4313376294","doi":"https://doi.org/10.4049/jimmunol.160.10.4662","title":"Cutting Edge: The B Cell Surface Protein CD72 Recruits the Tyrosine Phosphatase SHP-1 upon Tyrosine Phosphorylation","display_name":"Cutting Edge: The B Cell Surface Protein CD72 Recruits the Tyrosine Phosphatase SHP-1 upon Tyrosine Phosphorylation","publication_year":1998,"publication_date":"1998-05-01","ids":{"openalex":"https://openalex.org/W4313376294","doi":"https://doi.org/10.4049/jimmunol.160.10.4662","mag":"1644328688","pmid":"https://pubmed.ncbi.nlm.nih.gov/9590210"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.160.10.4662","doi":"https://doi.org/10.4049/jimmunol.160.10.4662","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.160.10.4662","pdf_url":"https://journals.aai.org/jimmunol/article-pdf/160/10/4662/1081314/im109804662o.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://journals.aai.org/jimmunol/article-pdf/160/10/4662/1081314/im109804662o.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075624801","display_name":"Takahiro Adachi","orcid":"https://orcid.org/0000-0002-3711-8577","observed_orcids":["https://orcid.org/0000-0002-3711-8577"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Takahiro Adachi","raw_affiliation_strings":["Department of Immunology, Medical Research Institute, Tokyo Medical and Dental University , Bunkyo-ku, Tokyo ,","*Department of Immunology, Medical Research Institute, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Medical Research Institute, Tokyo Medical and Dental University , Bunkyo-ku, Tokyo ,","institution_ids":["https://openalex.org/I125602781"]},{"raw_affiliation_string":"*Department of Immunology, Medical Research Institute, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan;","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008485301","display_name":"Heinrich Flaswinkel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Heinrich Flaswinkel","raw_affiliation_strings":["Department of Molecular Immunology, Biology III, Freiburg University , Freiburg ,","\u2020Department of Molecular Immunology, Biology III, Freiburg University, Freiburg, Germany; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Immunology, Biology III, Freiburg University , Freiburg ,","institution_ids":["https://openalex.org/I161046081"]},{"raw_affiliation_string":"\u2020Department of Molecular Immunology, Biology III, Freiburg University, Freiburg, Germany; and","institution_ids":["https://openalex.org/I161046081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004797929","display_name":"Hidetaka Yakura","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hidetaka Yakura","raw_affiliation_strings":["Tokyo Metropolitan Institute for Neuroscience , Fuchu, Tokyo ,","\u2021Tokyo Metropolitan Institute for Neuroscience, Fuchu, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tokyo Metropolitan Institute for Neuroscience , Fuchu, Tokyo ,","institution_ids":[]},{"raw_affiliation_string":"\u2021Tokyo Metropolitan Institute for Neuroscience, Fuchu, Tokyo, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013470603","display_name":"Michael G. Reth","orcid":"https://orcid.org/0000-0002-1025-7198","observed_orcids":["https://orcid.org/0000-0002-1025-7198"]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Michael Reth","raw_affiliation_strings":["Department of Molecular Immunology, Biology III, Freiburg University , Freiburg ,","\u2020Department of Molecular Immunology, Biology III, Freiburg University, Freiburg, Germany; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Immunology, Biology III, Freiburg University , Freiburg ,","institution_ids":["https://openalex.org/I161046081"]},{"raw_affiliation_string":"\u2020Department of Molecular Immunology, Biology III, Freiburg University, Freiburg, Germany; and","institution_ids":["https://openalex.org/I161046081"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078122217","display_name":"Takeshi Tsubata","orcid":"https://orcid.org/0000-0003-0760-1258","observed_orcids":["https://orcid.org/0000-0003-0760-1258"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Takeshi Tsubata","raw_affiliation_strings":["Department of Immunology, Medical Research Institute, Tokyo Medical and Dental University , Bunkyo-ku, Tokyo ,","*Department of Immunology, Medical Research Institute, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Medical Research Institute, Tokyo Medical and Dental University , Bunkyo-ku, Tokyo ,","institution_ids":["https://openalex.org/I125602781"]},{"raw_affiliation_string":"*Department of Immunology, Medical Research Institute, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan;","institution_ids":["https://openalex.org/I125602781"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5075624801","https://openalex.org/A5078122217"],"corresponding_institution_ids":["https://openalex.org/I125602781"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":5.1769,"has_fulltext":true,"cited_by_count":168,"citation_normalized_percentile":{"value":0.9667054,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"160","issue":"10","first_page":"4662","last_page":"4665"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd72","display_name":"CD72","score":1.0},{"id":"https://openalex.org/keywords/shp-1","display_name":"SHP-1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/protein-tyrosine-phosphatase","display_name":"protein tyrosine phosphatase","score":0.7540000081062317},{"id":"https://openalex.org/keywords/immunoreceptor-tyrosine-based-inhibition-motif","display_name":"immunoreceptor tyrosine-based inhibition motif","score":0.906000018119812},{"id":"https://openalex.org/keywords/b-cell-receptor-signaling","display_name":"B cell receptor signaling","score":0.7419999837875366},{"id":"https://openalex.org/keywords/tyrosine-phosphorylation","display_name":"tyrosine phosphorylation","score":0.8330000042915344},{"id":"https://openalex.org/keywords/b-cell-activation","display_name":"B cell activation","score":0.49000000953674316},{"id":"https://openalex.org/keywords/wehi-231-cells","display_name":"WEHI-231 cells","score":0.8149999976158142}],"concepts":[{"id":"https://openalex.org/C85528070","wikidata":"https://www.wikidata.org/wiki/Q643602","display_name":"Protein tyrosine phosphatase","level":3,"score":0.9019155502319336},{"id":"https://openalex.org/C2777553839","wikidata":"https://www.wikidata.org/wiki/Q14330986","display_name":"Tyrosine phosphorylation","level":3,"score":0.8215756416320801},{"id":"https://openalex.org/C197153747","wikidata":"https://www.wikidata.org/wiki/Q24780316","display_name":"SH2 domain","level":4,"score":0.7797794342041016},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.6993875503540039},{"id":"https://openalex.org/C2776165026","wikidata":"https://www.wikidata.org/wiki/Q188017","display_name":"Tyrosine","level":2,"score":0.6894264817237854},{"id":"https://openalex.org/C29907709","wikidata":"https://www.wikidata.org/wiki/Q6005558","display_name":"Immunoreceptor tyrosine-based activation motif","level":5,"score":0.5645650625228882},{"id":"https://openalex.org/C101544691","wikidata":"https://www.wikidata.org/wiki/Q420511","display_name":"Receptor tyrosine kinase","level":3,"score":0.5372647047042847},{"id":"https://openalex.org/C108636557","wikidata":"https://www.wikidata.org/wiki/Q21109354","display_name":"Proto-oncogene tyrosine-protein kinase Src","level":3,"score":0.5182600021362305},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4965282082557678},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43508070707321167},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32423752546310425},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.31738537549972534}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000944","descriptor_name":"Antigens, Differentiation, B-Lymphocyte","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011947","descriptor_name":"Receptors, Antigen, B-Cell","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014443","descriptor_name":"Tyrosine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017027","descriptor_name":"Protein Tyrosine Phosphatases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053824","descriptor_name":"Protein Tyrosine Phosphatase, Non-Receptor Type 6","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054592","descriptor_name":"Protein Tyrosine Phosphatase, Non-Receptor Type 11","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.4049/jimmunol.160.10.4662","doi":"https://doi.org/10.4049/jimmunol.160.10.4662","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.160.10.4662","pdf_url":"https://journals.aai.org/jimmunol/article-pdf/160/10/4662/1081314/im109804662o.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:9590210","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9590210","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Journal Article"},{"id":"mag:1644328688","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9590210","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"doi:10.4049/jimmunol.160.10.4662","doi":"https://doi.org/10.4049/jimmunol.160.10.4662","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.160.10.4662","pdf_url":"https://journals.aai.org/jimmunol/article-pdf/160/10/4662/1081314/im109804662o.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310760","display_name":"Uehara Memorial Foundation","ror":"https://ror.org/00gc20a07"},{"id":"https://openalex.org/F4320324799","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31"},{"id":"https://openalex.org/F4320334789","display_name":"Japan Science and Technology Agency","ror":"https://ror.org/00097mb19"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4313376294.pdf","grobid_xml":"https://content.openalex.org/works/W4313376294.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W123148090","https://openalex.org/W1514183485","https://openalex.org/W1548757245","https://openalex.org/W1606124321","https://openalex.org/W1855385293","https://openalex.org/W1969162154","https://openalex.org/W1976805459","https://openalex.org/W1977573846","https://openalex.org/W2000061036","https://openalex.org/W2003044215","https://openalex.org/W2018826402","https://openalex.org/W2030793757","https://openalex.org/W2053142169","https://openalex.org/W2054513471","https://openalex.org/W2055741560","https://openalex.org/W2063825367","https://openalex.org/W2066997038","https://openalex.org/W2067324236","https://openalex.org/W2069545269","https://openalex.org/W2073410553","https://openalex.org/W2074791128","https://openalex.org/W2101073455","https://openalex.org/W2110711414","https://openalex.org/W2119663838","https://openalex.org/W2125886784","https://openalex.org/W2135792631","https://openalex.org/W2136266077","https://openalex.org/W2152218437","https://openalex.org/W2166262166","https://openalex.org/W4250688128"],"related_works":["https://openalex.org/W1644328688","https://openalex.org/W1646540353","https://openalex.org/W21341336","https://openalex.org/W1964203957","https://openalex.org/W1999317776","https://openalex.org/W2009162022","https://openalex.org/W2144954864","https://openalex.org/W2047243876","https://openalex.org/W2082595994","https://openalex.org/W3161898928"],"abstract_inverted_index":{"Activation":[0],"signals":[1],"of":[2,31,40,59,69,73,103],"lymphocytes":[3],"are":[4],"negatively":[5],"regulated":[6],"by":[7,93],"the":[8,12,37,41],"membrane":[9],"molecules":[10],"carrying":[11],"immunoreceptor":[13],"tyrosine-based":[14],"inhibition":[15],"motif":[16],"(ITIM).":[17],"Upon":[18],"tyrosine":[19,55,67,90],"phosphorylation,":[20],"ITIMs":[21],"recruit":[22],"SH2-containing":[23],"phosphatases":[24],"such":[25],"as":[26],"SHP-1,":[27],"resulting":[28],"in":[29,50,77],"down-modulation":[30],"cell":[32,61,79],"activation.":[33],"We":[34],"showed":[35],"that":[36,85,97],"cytoplasmic":[38],"domain":[39],"CD72":[42,70,74,86,98],"molecule":[43],"carries":[44],"an":[45],"ITIM":[46],"and":[47,71],"is":[48,99],"associated":[49],"vitro":[51],"with":[52,75],"SHP-1":[53,76,88],"upon":[54,89],"phosphorylation.":[56],"Moreover,":[57],"cross-linking":[58],"B":[60,78],"Ag":[62],"receptor":[63],"(BCR)":[64],"enhances":[65],"both":[66],"phosphorylation":[68,91],"association":[72],"line":[80],"WEHI-231.":[81],"These":[82],"results":[83],"indicate":[84],"recruits":[87],"induced":[92],"BCR":[94,104],"signaling,":[95],"suggesting":[96],"a":[100],"negative":[101],"regulator":[102],"signaling.":[105]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-01-06T00:00:00"}