{"id":"https://openalex.org/W4313372","doi":"https://doi.org/10.1007/978-3-642-75853-9_17","title":"Tumor Infiltrating Lymphocytes in Human Renal Cell Carcinoma: Adoptive Immunotherapy and Characterization of Interleukin-2 Expanded Tumor-Infiltrating Lymphocytes","display_name":"Tumor Infiltrating Lymphocytes in Human Renal Cell Carcinoma: Adoptive Immunotherapy and Characterization of Interleukin-2 Expanded Tumor-Infiltrating Lymphocytes","publication_year":1991,"publication_date":"1991-01-01","ids":{"openalex":"https://openalex.org/W4313372","doi":"https://doi.org/10.1007/978-3-642-75853-9_17","mag":"4313372"},"language":"en","primary_location":{"id":"doi:10.1007/978-3-642-75853-9_17","doi":"https://doi.org/10.1007/978-3-642-75853-9_17","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-3-642-75853-9_17","pdf_url":null,"source":{"id":"https://openalex.org/S4306463937","display_name":"Springer eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunotherapy of Renal Cell Carcinoma","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W2413756873","display_name":"Immunotherapy of Renal Cell Carcinoma"},"type":"book-chapter","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066748171","display_name":"James Harold Finke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]}],"countries":["NL","US"],"is_corresponding":false,"raw_author_name":"J. Finke","raw_affiliation_strings":["One Clinic Center, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH, 44195, USA","Director Chairman,\n        Department of Urology, University Hospital Nijmegen, P. O. Box 9101, 6500 HB, Nijmegen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"One Clinic Center, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH, 44195, USA","institution_ids":["https://openalex.org/I1316902750"]},{"raw_affiliation_string":"Director Chairman,\n        Department of Urology, University Hospital Nijmegen, P. O. Box 9101, 6500 HB, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I145872427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111895501","display_name":"Siva Murthy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]}],"countries":["NL","US"],"is_corresponding":false,"raw_author_name":"S. Murthy","raw_affiliation_strings":["One Clinic Center, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH, 44195, USA","Director Chairman,\n        Department of Urology, University Hospital Nijmegen, P. O. Box 9101, 6500 HB, Nijmegen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"One Clinic Center, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH, 44195, USA","institution_ids":["https://openalex.org/I1316902750"]},{"raw_affiliation_string":"Director Chairman,\n        Department of Urology, University Hospital Nijmegen, P. O. Box 9101, 6500 HB, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I145872427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047049999","display_name":"Jeannine P. Alexander","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]}],"countries":["NL","US"],"is_corresponding":false,"raw_author_name":"J. Alexander","raw_affiliation_strings":["One Clinic Center, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH, 44195, USA","Director Chairman,\n        Department of Urology, University Hospital Nijmegen, P. O. Box 9101, 6500 HB, Nijmegen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"One Clinic Center, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH, 44195, USA","institution_ids":["https://openalex.org/I1316902750"]},{"raw_affiliation_string":"Director Chairman,\n        Department of Urology, University Hospital Nijmegen, P. O. Box 9101, 6500 HB, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I145872427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005282856","display_name":"Patricia A. Rayman","orcid":"https://orcid.org/0000-0003-2206-370X","observed_orcids":["https://orcid.org/0000-0003-2206-370X"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]}],"countries":["NL","US"],"is_corresponding":false,"raw_author_name":"P. Rayman","raw_affiliation_strings":["One Clinic Center, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH, 44195, USA","Director Chairman,\n        Department of Urology, University Hospital Nijmegen, P. O. Box 9101, 6500 HB, Nijmegen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"One Clinic Center, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH, 44195, USA","institution_ids":["https://openalex.org/I1316902750"]},{"raw_affiliation_string":"Director Chairman,\n        Department of Urology, University Hospital Nijmegen, P. O. Box 9101, 6500 HB, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I145872427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111501441","display_name":"R Tubbs","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Tubbs","raw_affiliation_strings":["One Clinic Center, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH, 44195, USA","Director, Clinical Research,\n        Cleveland Clinic Cancer Center, Cleveland Clinic Foundation, 9500 Euclid Avenue, 44106, Cleveland, Ohio, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"One Clinic Center, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH, 44195, USA","institution_ids":["https://openalex.org/I1316902750"]},{"raw_affiliation_string":"Director, Clinical Research,\n        Cleveland Clinic Cancer Center, Cleveland Clinic Foundation, 9500 Euclid Avenue, 44106, Cleveland, Ohio, USA","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108484847","display_name":"J. Edson Pontes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. E. Pontes","raw_affiliation_strings":["One Clinic Center, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH, 44195, USA","Professor and Chairman,\n        Department of Urology, Wayne State University, 4160 John R., Suite 1017, 48201, Detroit, Michigan, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"One Clinic Center, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH, 44195, USA","institution_ids":["https://openalex.org/I1316902750"]},{"raw_affiliation_string":"Professor and Chairman,\n        Department of Urology, Wayne State University, 4160 John R., Suite 1017, 48201, Detroit, Michigan, USA","institution_ids":["https://openalex.org/I185443292"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068176658","display_name":"James S. Sergi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Sergi","raw_affiliation_strings":["One Clinic Center, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH, 44195, USA","Professor and Chairman,\n        Department of Urology, Wayne State University, 4160 John R., Suite 1017, 48201, Detroit, Michigan, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"One Clinic Center, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH, 44195, USA","institution_ids":["https://openalex.org/I1316902750"]},{"raw_affiliation_string":"Professor and Chairman,\n        Department of Urology, Wayne State University, 4160 John R., Suite 1017, 48201, Detroit, Michigan, USA","institution_ids":["https://openalex.org/I185443292"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112418138","display_name":"Ronald M. Bukowski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. M. Bukowski","raw_affiliation_strings":["One Clinic Center, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH, 44195, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"One Clinic Center, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH, 44195, USA","institution_ids":["https://openalex.org/I1316902750"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.0783,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.88050314,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"119","last_page":"130"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.635699987411499,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.635699987411499,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.13369999825954437,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.06759999692440033,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tumor-infiltrating-lymphocytes","display_name":"tumor-infiltrating lymphocytes","score":0.9959999918937683},{"id":"https://openalex.org/keywords/renal-cell-carcinoma","display_name":"renal cell carcinoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/adoptive-immunotherapy","display_name":"adoptive immunotherapy","score":0.9900000095367432},{"id":"https://openalex.org/keywords/cytotoxic-t-lymphocytes","display_name":"cytotoxic T lymphocytes","score":0.8339999914169312},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.8519999980926514},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.5809999704360962}],"concepts":[{"id":"https://openalex.org/C2778326572","wikidata":"https://www.wikidata.org/wiki/Q7852668","display_name":"Tumor-infiltrating lymphocytes","level":4,"score":0.6513451337814331},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.6465528011322021},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.5577742457389832},{"id":"https://openalex.org/C90375314","wikidata":"https://www.wikidata.org/wiki/Q3537484","display_name":"Adoptive cell transfer","level":4,"score":0.5316793322563171},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5289635062217712},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.48318424820899963},{"id":"https://openalex.org/C2777371288","wikidata":"https://www.wikidata.org/wiki/Q410130","display_name":"Interleukin 2","level":3,"score":0.4439064562320709},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.44320148229599},{"id":"https://openalex.org/C28651165","wikidata":"https://www.wikidata.org/wiki/Q4259786","display_name":"Lymphokine-activated killer cell","level":5,"score":0.4315972924232483},{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.413994163274765},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4026489853858948},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.36960458755493164},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36204004287719727},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.35487592220306396},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33337628841400146},{"id":"https://openalex.org/C129374314","wikidata":"https://www.wikidata.org/wiki/Q909381","display_name":"Interleukin 21","level":4,"score":0.3107491433620453},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0986977219581604},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-3-642-75853-9_17","doi":"https://doi.org/10.1007/978-3-642-75853-9_17","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-3-642-75853-9_17","pdf_url":null,"source":{"id":"https://openalex.org/S4306463937","display_name":"Springer eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunotherapy of Renal Cell Carcinoma","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W57960152","https://openalex.org/W185938529","https://openalex.org/W205401375","https://openalex.org/W230810425","https://openalex.org/W1529401007","https://openalex.org/W1542095657","https://openalex.org/W1542501019","https://openalex.org/W1555013390","https://openalex.org/W1568059997","https://openalex.org/W1877478601","https://openalex.org/W1890985457","https://openalex.org/W1951776719","https://openalex.org/W1985222144","https://openalex.org/W2016520959","https://openalex.org/W2035890003","https://openalex.org/W2053716084","https://openalex.org/W2085395583","https://openalex.org/W2087262264","https://openalex.org/W2089828715","https://openalex.org/W2109762059","https://openalex.org/W2120137683","https://openalex.org/W2140330161","https://openalex.org/W2159673453","https://openalex.org/W2335365056","https://openalex.org/W2415425008"],"related_works":["https://openalex.org/W1990601937","https://openalex.org/W2120137683","https://openalex.org/W2323345521","https://openalex.org/W2144536272","https://openalex.org/W2158488906","https://openalex.org/W2002072541","https://openalex.org/W2140330161","https://openalex.org/W2403272940","https://openalex.org/W2006488490","https://openalex.org/W2008581311"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}
