{"id":"https://openalex.org/W4313368745","doi":"https://doi.org/10.4049/jimmunol.204.supp.65.9","title":"Development of allergic airway immunity depends on MARCH1-mediated ubiquitination of MHCII and CD86 in dendritic cells","display_name":"Development of allergic airway immunity depends on MARCH1-mediated ubiquitination of MHCII and CD86 in dendritic cells","publication_year":2020,"publication_date":"2020-05-01","ids":{"openalex":"https://openalex.org/W4313368745","doi":"https://doi.org/10.4049/jimmunol.204.supp.65.9"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.204.supp.65.9","doi":"https://doi.org/10.4049/jimmunol.204.supp.65.9","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.204.supp.65.9","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084954247","display_name":"Carlos A. Castellanos","orcid":"https://orcid.org/0000-0003-3615-2009","observed_orcids":["https://orcid.org/0000-0003-3615-2009"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carlos A Castellanos","raw_affiliation_strings":["1University of California, San Francisco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of California, San Francisco","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044340296","display_name":"Xin Ren","orcid":"https://orcid.org/0000-0003-1945-796X","observed_orcids":["https://orcid.org/0000-0003-1945-796X"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xin Ren","raw_affiliation_strings":["1University of California, San Francisco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of California, San Francisco","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080860043","display_name":"Hong-Erh Liang","orcid":"https://orcid.org/0000-0003-0620-7224","observed_orcids":["https://orcid.org/0000-0003-0620-7224"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hong-Erh Liang","raw_affiliation_strings":["1University of California, San Francisco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of California, San Francisco","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004486300","display_name":"Brian J. Laidlaw","orcid":"https://orcid.org/0000-0001-5707-9256","observed_orcids":["https://orcid.org/0000-0001-5707-9256"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian J Laidlaw","raw_affiliation_strings":["1University of California, San Francisco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of California, San Francisco","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074787270","display_name":"Andrea J. Barczak","orcid":"https://orcid.org/0000-0003-3901-0997","observed_orcids":["https://orcid.org/0000-0003-3901-0997"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrea Barczak","raw_affiliation_strings":["1University of California, San Francisco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of California, San Francisco","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041478128","display_name":"Joshua D. Rudolph","orcid":"https://orcid.org/0000-0002-5006-8316","observed_orcids":["https://orcid.org/0000-0002-5006-8316"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua Rudolph","raw_affiliation_strings":["1University of California, San Francisco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of California, San Francisco","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000362354","display_name":"Walter L. Eckalbar","orcid":"https://orcid.org/0000-0003-2520-7852","observed_orcids":["https://orcid.org/0000-0003-2520-7852"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Walter L Eckalbar","raw_affiliation_strings":["1University of California, San Francisco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of California, San Francisco","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030063085","display_name":"Xiaozhu Huang","orcid":"https://orcid.org/0000-0003-1165-0749","observed_orcids":["https://orcid.org/0000-0003-1165-0749"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaozhu Huang","raw_affiliation_strings":["1University of California, San Francisco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of California, San Francisco","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047055495","display_name":"Jason G. Cyster","orcid":"https://orcid.org/0000-0002-4735-9745","observed_orcids":["https://orcid.org/0000-0002-4735-9745","https://orcid.org/0000-0003-2345-629X"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason G Cyster","raw_affiliation_strings":["2Howard Hughes Medical Institute, University of California, San Francisco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Howard Hughes Medical Institute, University of California, San Francisco","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066993086","display_name":"Richard M. Locksley","orcid":"https://orcid.org/0000-0002-5468-6867","observed_orcids":["https://orcid.org/0000-0002-5468-6867"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard M Locksley","raw_affiliation_strings":["2Howard Hughes Medical Institute, University of California, San Francisco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Howard Hughes Medical Institute, University of California, San Francisco","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010599370","display_name":"David J. Erle","orcid":"https://orcid.org/0000-0002-2171-0648","observed_orcids":["https://orcid.org/0000-0002-2171-0648"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David J Erle","raw_affiliation_strings":["1University of California, San Francisco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of California, San Francisco","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088766275","display_name":"Satoshi Ishido","orcid":"https://orcid.org/0000-0001-5893-3354","observed_orcids":["https://orcid.org/0000-0001-5893-3354"]},"institutions":[{"id":"https://openalex.org/I137459256","display_name":"Hyogo Medical University","ror":"https://ror.org/001yc7927","country_code":"JP","type":"education","lineage":["https://openalex.org/I137459256"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Satoshi Ishido","raw_affiliation_strings":["3Hyogo College of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Hyogo College of Medicine","institution_ids":["https://openalex.org/I137459256"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102888689","display_name":"Jeoung\u2010Sook Shin","orcid":"https://orcid.org/0000-0002-0711-8234","observed_orcids":["https://orcid.org/0000-0002-0711-8234"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeoung-Sook Shin","raw_affiliation_strings":["1University of California, San Francisco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of California, San Francisco","institution_ids":["https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"204","issue":"1_Supplement","first_page":"65.9","last_page":"65.9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.38749998807907104,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.38749998807907104,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":0.2493000030517578,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.1914999932050705,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/march1","display_name":"MARCH1","score":0.9539999961853027},{"id":"https://openalex.org/keywords/ubiquitination","display_name":"ubiquitination","score":0.7599999904632568},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.9309999942779541},{"id":"https://openalex.org/keywords/mhc-class-ii","display_name":"MHC class II","score":0.875},{"id":"https://openalex.org/keywords/cd86","display_name":"CD86","score":1.0},{"id":"https://openalex.org/keywords/allergic-airway-inflammation","display_name":"allergic airway inflammation","score":0.8640000224113464},{"id":"https://openalex.org/keywords/th2-differentiation","display_name":"Th2 differentiation","score":0.7559999823570251},{"id":"https://openalex.org/keywords/il-4","display_name":"IL-4","score":0.9190000295639038},{"id":"https://openalex.org/keywords/house-dust-mite-allergens","display_name":"house dust mite allergens","score":0.8740000128746033},{"id":"https://openalex.org/keywords/cd11b-dendritic-cells","display_name":"CD11b+ dendritic cells","score":0.8330000042915344},{"id":"https://openalex.org/keywords/dendritic-cell-migration","display_name":"dendritic cell migration","score":0.7599999904632568},{"id":"https://openalex.org/keywords/eosinophilia","display_name":"eosinophilia","score":0.6430000066757202}],"concepts":[{"id":"https://openalex.org/C2781101188","wikidata":"https://www.wikidata.org/wiki/Q5009846","display_name":"CD86","level":4,"score":0.7107004523277283},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.6551526784896851},{"id":"https://openalex.org/C134459356","wikidata":"https://www.wikidata.org/wiki/Q4274835","display_name":"Ubiquitin ligase","level":4,"score":0.6131442785263062},{"id":"https://openalex.org/C81444415","wikidata":"https://www.wikidata.org/wiki/Q7243535","display_name":"Priming (agriculture)","level":3,"score":0.53729248046875},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.486771821975708},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.46862295269966125},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.45269519090652466},{"id":"https://openalex.org/C2779919695","wikidata":"https://www.wikidata.org/wiki/Q4201963","display_name":"CD11c","level":4,"score":0.43452876806259155},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3805698752403259},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.333511084318161},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3293479084968567},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06557360291481018},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.057940781116485596},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.0},{"id":"https://openalex.org/C100701293","wikidata":"https://www.wikidata.org/wiki/Q193838","display_name":"Germination","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4049/jimmunol.204.supp.65.9","doi":"https://doi.org/10.4049/jimmunol.204.supp.65.9","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.204.supp.65.9","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9074000120162964,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7005908763","https://openalex.org/W2106476266","https://openalex.org/W4313383899","https://openalex.org/W2103153413","https://openalex.org/W2143151869","https://openalex.org/W2782104471","https://openalex.org/W2032528769","https://openalex.org/W1547577928","https://openalex.org/W3112606349","https://openalex.org/W4313383837"],"abstract_inverted_index":{"Abstract":[0],"Dendritic":[1],"cells":[2,23,87,96,187],"(DCs)":[3],"play":[4],"an":[5],"essential":[6],"role":[7,110],"in":[8,51,58,102,113,178],"the":[9,37,52,94,103,122,128,164,202],"development":[10],"of":[11,26,54,83,91,105,111,116,127,147,152,170,181,191,209],"type":[12,30],"2":[13,31],"allergic":[14],"immunity":[15],"by":[16,144],"presenting":[17],"allergens":[18,162],"to":[19,63,73,159,163,195,198,201],"cognate":[20],"na\u00efve":[21,213],"T":[22,32,86,95,215],"inducing":[24],"production":[25,90,104,208],"IL-4":[27,210],"thus":[28],"priming":[29,115,143],"helper":[33],"(Th2)":[34],"cells.":[35,118,216],"However,":[36],"molecular":[38],"mechanisms":[39],"underlying":[40],"this":[41],"function":[42],"are":[43],"poorly":[44],"understood.":[45],"We":[46],"found":[47],"that":[48,138],"mice":[49,79,120],"deficient":[50],"expression":[53],"MARCH1":[55,112,129,139],"ubiquitin":[56,123],"ligase":[57],"DCs":[59,158],"were":[60],"completely":[61],"resistant":[62],"developing":[64],"Th2":[65,117,141],"cell":[66,142],"inflammation":[67],"and":[68,88,132,149,193,206],"eosinophilia":[69],"upon":[70],"airway":[71],"exposure":[72],"house":[74],"dust":[75],"mite":[76],"allergens.":[77],"These":[78],"exhibited":[80],"normal":[81,89],"expansion":[82],"allergen-specific":[84,212],"CD4+":[85,214],"IFN-\u03b3":[92],"from":[93,211],"but":[97],"demonstrated":[98],"a":[99,108],"significant":[100],"defect":[101],"IL-4,":[106],"suggesting":[107],"specific":[109],"DC":[114],"Remarkably,":[119],"lacking":[121],"acceptor":[124],"amino":[125],"acids":[126],"substrates,":[130],"MHCII":[131,148,153,175,192],"CD86,":[133],"phenocopied":[134],"MARCH1-deficient":[135],"mice,":[136],"indicating":[137],"promotes":[140],"mediating":[145],"ubiquitination":[146,169,190],"CD86.":[150],"Ubiquitination":[151],"was":[154,176],"important":[155],"for":[156],"CD11b+":[157],"transport":[160],"respiratory":[161],"mediastinal":[165],"lymph":[166,204],"node":[167,205],"whereas":[168],"CD86":[171,194],"as":[172,174],"well":[173],"involved":[177],"transcriptional":[179],"reprograming":[180],"these":[182],"DCs.":[183],"In":[184],"conclusion,":[185],"dendritic":[186],"depend":[188],"on":[189],"condition":[196],"themselves":[197],"effectively":[199],"migrate":[200],"draining":[203],"induce":[207]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-01-06T00:00:00"}