{"id":"https://openalex.org/W4313368591","doi":"https://doi.org/10.4049/jimmunol.204.supp.93.21","title":"TARGETING METABOLIC REPROGRAMMING OF RESPIRATORY SYNCYTIAL VIRUS INFECTION","display_name":"TARGETING METABOLIC REPROGRAMMING OF RESPIRATORY SYNCYTIAL VIRUS INFECTION","publication_year":2020,"publication_date":"2020-05-01","ids":{"openalex":"https://openalex.org/W4313368591","doi":"https://doi.org/10.4049/jimmunol.204.supp.93.21"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.204.supp.93.21","doi":"https://doi.org/10.4049/jimmunol.204.supp.93.21","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.204.supp.93.21","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013774807","display_name":"Azadeh Bahadoran","orcid":"https://orcid.org/0000-0002-3803-9491","observed_orcids":["https://orcid.org/0000-0002-3803-9491"]},"institutions":[{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Azadeh Bahadoran","raw_affiliation_strings":["1The University of Tennessee Health Science Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The University of Tennessee Health Science Center","institution_ids":["https://openalex.org/I160606119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033019425","display_name":"Lavanya Bezavada","orcid":"https://orcid.org/0000-0001-8434-3323","observed_orcids":["https://orcid.org/0000-0001-8434-3323"]},"institutions":[{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lavanya Bezavada","raw_affiliation_strings":["1The University of Tennessee Health Science Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The University of Tennessee Health Science Center","institution_ids":["https://openalex.org/I160606119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076211874","display_name":"Svetlana Rezinciuc","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Svetlana Rezinciuc","raw_affiliation_strings":["1The University of Tennessee Health Science Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The University of Tennessee Health Science Center","institution_ids":["https://openalex.org/I160606119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036771694","display_name":"John P. DeVincenzo","orcid":"https://orcid.org/0000-0003-2655-344X","observed_orcids":["https://orcid.org/0000-0003-2655-344X"]},"institutions":[{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Devincenzo","raw_affiliation_strings":["1The University of Tennessee Health Science Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The University of Tennessee Health Science Center","institution_ids":["https://openalex.org/I160606119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033187365","display_name":"Stephania A. Cormier","orcid":"https://orcid.org/0000-0002-6050-6172","observed_orcids":["https://orcid.org/0000-0002-6050-6172"]},"institutions":[{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephania Cormier","raw_affiliation_strings":["2Louisiana State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Louisiana State University","institution_ids":["https://openalex.org/I121820613"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053781567","display_name":"Heather S. Smallwood","orcid":"https://orcid.org/0000-0001-5711-5771","observed_orcids":["https://orcid.org/0000-0001-5711-5771","https://orcid.org/0000-0001-8278-8118"]},"institutions":[{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heather Smallwood","raw_affiliation_strings":["1The University of Tennessee Health Science Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The University of Tennessee Health Science Center","institution_ids":["https://openalex.org/I160606119"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"204","issue":"1_Supplement","first_page":"93.21","last_page":"93.21"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11243","display_name":"Respiratory viral infections research","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11243","display_name":"Respiratory viral infections research","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11135","display_name":"Virology and Viral Diseases","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11688","display_name":"Microbial infections and disease research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/respiratory-syncytial-virus","display_name":"respiratory syncytial virus","score":0.9950000047683716},{"id":"https://openalex.org/keywords/host-metabolic-reprogramming","display_name":"host metabolic reprogramming","score":0.871999979019165},{"id":"https://openalex.org/keywords/glycolysis","display_name":"glycolysis","score":0.7049999833106995},{"id":"https://openalex.org/keywords/mitochondrial-respiration","display_name":"mitochondrial respiration","score":0.9890000224113464},{"id":"https://openalex.org/keywords/pediatric-rsv-infection","display_name":"pediatric RSV infection","score":0.6510000228881836},{"id":"https://openalex.org/keywords/nasopharyngeal-aspirates","display_name":"nasopharyngeal aspirates","score":0.8939999938011169},{"id":"https://openalex.org/keywords/epithelial-cells","display_name":"epithelial cells","score":0.8019999861717224},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.9909999966621399},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.9980000257492065},{"id":"https://openalex.org/keywords/co-culture","display_name":"co-culture","score":0.5479999780654907},{"id":"https://openalex.org/keywords/proton-leak","display_name":"proton leak","score":0.5189999938011169},{"id":"https://openalex.org/keywords/oxygen-consumption","display_name":"oxygen consumption","score":0.6119999885559082},{"id":"https://openalex.org/keywords/glucose-uptake","display_name":"glucose uptake","score":0.5220000147819519},{"id":"https://openalex.org/keywords/lower-respiratory-tract-infection","display_name":"lower respiratory tract infection","score":0.6100000143051147}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6193797588348389},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.6175150871276855},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.5779173970222473},{"id":"https://openalex.org/C66517615","wikidata":"https://www.wikidata.org/wiki/Q912751","display_name":"Cellular respiration","level":3,"score":0.4864208698272705},{"id":"https://openalex.org/C2991704936","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Cell metabolism","level":3,"score":0.4761880934238434},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.47450965642929077},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.41874730587005615},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.416686087846756},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4139358699321747},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.39395707845687866},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3902972340583801},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.3798159062862396},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.12106946110725403},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.0},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4049/jimmunol.204.supp.93.21","doi":"https://doi.org/10.4049/jimmunol.204.supp.93.21","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.204.supp.93.21","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.75,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3043229697","https://openalex.org/W4410362639","https://openalex.org/W3207058060","https://openalex.org/W3013330105","https://openalex.org/W3030539489","https://openalex.org/W4361294834","https://openalex.org/W4320730098","https://openalex.org/W3207241795","https://openalex.org/W7219363962","https://openalex.org/W2030347934"],"abstract_inverted_index":{"Abstract":[0],"Respiratory":[1],"syncytial":[2],"virus":[3],"(RSV)":[4],"causes":[5],"severe":[6],"respiratory":[7,39,187,202],"disease":[8],"and":[9,29,71,97,127,140,162,178,186,217],"infects":[10],"virtually":[11],"most":[12],"children":[13],"by":[14],"2":[15],"years":[16],"of":[17,24,26,65,112,138,237],"age.":[18],"It":[19],"is":[20],"the":[21,43,81,135,198,219,223],"leading":[22],"cause":[23],"hospitalization":[25],"infants":[27],"worldwide":[28],"remerges":[30],"later":[31],"in":[32,42,51,55,80,109,160,165,189,195,197,208,211,222],"life":[33],"to":[34,57,144,230],"be":[35],"a":[36,62,157],"serious":[37],"lower":[38],"tract":[40],"illness":[41],"elderly.":[44],"Recently,":[45],"significant":[46],"emphasis":[47],"focused":[48],"on":[49],"changes":[50,108,221],"host":[52,224],"cellular":[53,239],"metabolism":[54,196],"response":[56],"viral":[58],"infection.":[59],"We":[60,83,155],"performed":[61],"retrospective":[63],"study":[64],"pediatric":[66,92,190],"patients":[67,214],"infected":[68,91,199,213],"with":[69,76,142],"RSV":[70,90,105,143,171,212,226],"found":[72,156],"this":[73],"infection":[74,106,172,227],"correlated":[75],"increased":[77],"glucose":[78],"uptake":[79],"lungs.":[82,215],"characterized":[84],"cells":[85,120,123,166,203],"freshly":[86],"isolated":[87,167],"from":[88,168],"naturally":[89],"patients\u2019":[93,169,191],"nasopharyngeal":[94],"aspirates":[95],"(NPA)":[96],"quantified":[98],"their":[99,147],"bioenergetics.":[100],"Next,":[101],"we":[102,132],"will":[103,133],"determine":[104,145],"induced":[107],"metabolic":[110,220,240],"responses":[111],"different":[113],"cell":[114,129],"types":[115],"including":[116],"primary":[117],"human":[118],"epithelial":[119],"(NHBE),":[121],"dendritic":[122],"(DCs),":[124],"macrophages":[125],"(MOs)":[126],"A549":[128],"line.":[130],"Additionally,":[131],"characterize":[134],"infect":[136],"co-cultures":[137],"NHBE":[139,153],"DCs/MOs":[141],"if":[146],"crosstalk":[148],"can":[149],"help":[150],"regulate":[151],"aberrant":[152],"metabolism.":[154],"dramatic":[158],"increase":[159],"glycolysis":[161],"mitochondria":[163],"respiration":[164],"NPA.":[170,192],"increases":[173,194],"basal":[174],"respiration,":[175],"ATP":[176],"production,":[177],"proton":[179],"leak":[180],"while":[181],"reducing":[182],"mitochondrial":[183],"oxygen":[184],"consumption":[185],"capacity":[188],"Significant":[193],"patient\u2019s":[200],"upper":[201],"ex":[204],"vivo":[205],"support":[206],"our":[207],"situ":[209],"findings":[210],"Understanding":[216],"defining":[218],"during":[225],"may":[228],"lead":[229],"novel":[231],"therapeutic":[232],"approaches":[233],"through":[234],"targeted":[235],"inhibition":[236],"specific":[238],"pathways.":[241]},"counts_by_year":[],"updated_date":"2026-09-24T07:57:37.273135","created_date":"2023-01-06T00:00:00"}
