{"id":"https://openalex.org/W4313359869","doi":"https://doi.org/10.4049/jimmunol.200.supp.123.3","title":"A B Cell Lymphoma-Associated LncRNA Modulates BCR-Mediated Calcium Signaling","display_name":"A B Cell Lymphoma-Associated LncRNA Modulates BCR-Mediated Calcium Signaling","publication_year":2018,"publication_date":"2018-05-01","ids":{"openalex":"https://openalex.org/W4313359869","doi":"https://doi.org/10.4049/jimmunol.200.supp.123.3"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.200.supp.123.3","doi":"https://doi.org/10.4049/jimmunol.200.supp.123.3","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.200.supp.123.3","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047326660","display_name":"Jacqueline E. Payton","orcid":"https://orcid.org/0000-0001-8832-3661","observed_orcids":["https://orcid.org/0000-0001-8832-3661"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jacqueline Payton","raw_affiliation_strings":["Washington University School of Medicine","1Washington University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University School of Medicine","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"1Washington University School of Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035497662","display_name":"Sarah Pyfrom","orcid":"https://orcid.org/0000-0002-3781-6463","observed_orcids":["https://orcid.org/0000-0002-3781-6463"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah Pyfrom","raw_affiliation_strings":["Washington University School of Medicine","1Washington University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University School of Medicine","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"1Washington University School of Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101439625","display_name":"Hong Luo","orcid":"https://orcid.org/0009-0006-3463-3238","observed_orcids":["https://orcid.org/0009-0006-3463-3238"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hong Luo","raw_affiliation_strings":["Washington University School of Medicine","1Washington University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University School of Medicine","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"1Washington University School of Medicine","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076454649","display_name":"Eugene M. Oltz","orcid":"https://orcid.org/0000-0002-2513-7156","observed_orcids":["https://orcid.org/0000-0002-2513-7156"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eugene M Oltz","raw_affiliation_strings":["Washington University School of Medicine","1Washington University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University School of Medicine","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"1Washington University School of Medicine","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I204465549"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"200","issue":"Supplement_1","first_page":"123.3","last_page":"123.3"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.02070000022649765,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/long-non-coding-rna","display_name":"long non-coding RNA","score":0.9850000143051147},{"id":"https://openalex.org/keywords/b-cell-lymphoma","display_name":"B-cell lymphoma","score":0.878000020980835},{"id":"https://openalex.org/keywords/non-hodgkin-lymphoma","display_name":"non-Hodgkin lymphoma","score":0.9879999756813049},{"id":"https://openalex.org/keywords/b-cell-receptor-signaling","display_name":"B cell receptor signaling","score":0.8880000114440918},{"id":"https://openalex.org/keywords/calcium-signaling","display_name":"calcium signaling","score":0.996999979019165},{"id":"https://openalex.org/keywords/plcgamma2","display_name":"PLC\u03b32","score":0.9829999804496765},{"id":"https://openalex.org/keywords/phospholipase-c","display_name":"phospholipase C","score":0.8460000157356262},{"id":"https://openalex.org/keywords/orai-channels","display_name":"Orai channels","score":0.9779999852180481},{"id":"https://openalex.org/keywords/pld1","display_name":"phospholipase D1","score":0.8920000195503235},{"id":"https://openalex.org/keywords/dicer1","display_name":"DICER1","score":0.9929999709129333},{"id":"https://openalex.org/keywords/dhx9","display_name":"DHX9","score":1.0},{"id":"https://openalex.org/keywords/protein-rna-interactions","display_name":"RNA-protein interactions","score":0.6790000200271606},{"id":"https://openalex.org/keywords/lymphomagenesis","display_name":"lymphomagenesis","score":0.7900000214576721}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6298292875289917},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.45624321699142456},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4343661665916443},{"id":"https://openalex.org/C43907098","wikidata":"https://www.wikidata.org/wiki/Q903924","display_name":"breakpoint cluster region","level":3,"score":0.41263970732688904},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3398599326610565},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.247379332780838},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18556323647499084}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4049/jimmunol.200.supp.123.3","doi":"https://doi.org/10.4049/jimmunol.200.supp.123.3","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.200.supp.123.3","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3036889400","https://openalex.org/W2797136163","https://openalex.org/W7123372920","https://openalex.org/W2578419642","https://openalex.org/W2115370041","https://openalex.org/W2586660573","https://openalex.org/W3135276324","https://openalex.org/W2320846965","https://openalex.org/W4313359541","https://openalex.org/W2463910465"],"abstract_inverted_index":{"Abstract":[0],"Long":[1],"non-coding":[2],"RNAs":[3],"(lncRNA)":[4],"act":[5],"as":[6,146],"transcriptional":[7,62],"regulators,":[8],"scaffolds,":[9],"and":[10,35,49,114,123,141,170,190,209],"signaling":[11,93,100,228,234],"modulators,":[12],"but":[13,53],"their":[14],"role":[15],"in":[16,29,58,107,117,163],"normal":[17,36],"or":[18,73],"malignant":[19],"lymphocytes":[20],"is":[21,45,56,83],"unknown.":[22],"We":[23,97,178],"identified":[24],"lncRNAs":[25],"with":[26,149,231],"altered":[27],"expression":[28],">100":[30],"human":[31],"Non-Hodgkin":[32],"Lymphoma":[33],"(NHL)":[34],"B":[37,150],"cell":[38,112,151],"samples.":[39],"One":[40],"of":[41,47,64,75,104,155,196,213],"these":[42,174,220],"lncRNA":[43],"genes":[44],"upstream":[46],"PLCG2":[48,65,80,82],"parallels":[50],"its":[51],"expression,":[52],"the":[54,59,105,121,211],"transcript":[55],"localized":[57],"cytoplasm,":[60],"making":[61],"regulation":[63],"unlikely.":[66],"As":[67],"expected,":[68],"knock-out":[69],"(KO),":[70],"knock-down":[71],"(KD),":[72],"over-expression":[74],"lncRNA-PLCG2":[76,109,130,145,197,214,224],"did":[77],"not":[78],"affect":[79],"levels.":[81],"a":[84,236],"B-cell":[85],"specific":[86],"phospholipase":[87],"C":[88],"enzyme":[89],"that":[90,223,240],"stimulates":[91],"Ca2+":[92,99,118,227],"after":[94],"BCR":[95,106,232],"activation.":[96],"assessed":[98],"via":[101,229],"IgM":[102],"stimulation":[103],"multiple":[108],"KO/KD":[110],"NHL":[111],"lines":[113],"observed":[115],"defects":[116],"efflux":[119],"from":[120],"ER":[122],"influx":[124],"through":[125],"Orai":[126],"channels.":[127],"To":[128],"identify":[129],"interacting":[131],"proteins,":[132,235],"we":[133,172],"performed":[134,180],"RNA":[135],"pull-down":[136],"experiments":[137],"using":[138,185],"sense":[139],"(S)":[140],"anti-sense":[142],"(AS,":[143],"control)":[144],"bait":[147],"incubated":[148],"lysates.":[152],"Mass":[153],"spectrometry":[154],"eluted":[156],"proteins":[157,160],"showed":[158,193],"several":[159],"significantly":[161],"enriched":[162],"S":[164],"versus":[165],"AS,":[166],"including":[167],"PLD1,":[168,188],"DICER1":[169],"DHX9;":[171],"confirmed":[173],"by":[175],"Western":[176],"blot.":[177],"next":[179],"RNA-binding":[181],"protein":[182],"Immunoprecipitation":[183],"(RIP)":[184],"antibodies":[186],"for":[187],"DHX9":[189],"DICER1,":[191],"which":[192],"2\u201310-fold":[194],"enrichment":[195],"compared":[198],"to":[199],"IgG":[200],"isotype":[201],"control.":[202],"Ongoing":[203],"studies":[204],"are":[205],"mapping":[206],"lncRNA-PLCG2-protein":[207],"interactions":[208],"evaluating":[210],"impact":[212],"on":[215],"PLD1":[216],"activity.":[217],"Taken":[218],"together,":[219],"results":[221],"suggest":[222],"modulates":[225],"BCR-mediated":[226],"interaction":[230],"downstream":[233],"previously":[237],"unrecognized":[238],"mechanism":[239],"may":[241],"promote":[242],"lymphomagenesis.":[243]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2023-01-06T00:00:00"}