{"id":"https://openalex.org/W4313359759","doi":"https://doi.org/10.4049/jimmunol.200.supp.117.43","title":"A blood-based transcriptional signature in a novel murine tuberculosis model predicts risk of human tuberculosis progression.","display_name":"A blood-based transcriptional signature in a novel murine tuberculosis model predicts risk of human tuberculosis progression.","publication_year":2018,"publication_date":"2018-05-01","ids":{"openalex":"https://openalex.org/W4313359759","doi":"https://doi.org/10.4049/jimmunol.200.supp.117.43"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.200.supp.117.43","doi":"https://doi.org/10.4049/jimmunol.200.supp.117.43","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.200.supp.117.43","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056039945","display_name":"Courtney Ray Plumlee","orcid":"https://orcid.org/0000-0001-7142-4394","observed_orcids":["https://orcid.org/0000-0001-7142-4394"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Courtney R Plumlee","raw_affiliation_strings":["Center for Infectious Disease Research","1Center for Infectious Disease Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Infectious Disease Research","institution_ids":[]},{"raw_affiliation_string":"1Center for Infectious Disease Research","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073128032","display_name":"Benjamin Henry Gern","orcid":"https://orcid.org/0000-0002-0142-5970","observed_orcids":["https://orcid.org/0000-0002-0142-5970"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Benjamin H Gern","raw_affiliation_strings":["Center for Infectious Disease Research","1Center for Infectious Disease Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Infectious Disease Research","institution_ids":[]},{"raw_affiliation_string":"1Center for Infectious Disease Research","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028613036","display_name":"Fergal J. Duffy","orcid":"https://orcid.org/0000-0002-4675-0937","observed_orcids":["https://orcid.org/0000-0002-4675-0937"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fergal J Duffy","raw_affiliation_strings":["Center for Infectious Disease Research","1Center for Infectious Disease Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Infectious Disease Research","institution_ids":[]},{"raw_affiliation_string":"1Center for Infectious Disease Research","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061152059","display_name":"Jared L. Delahaye","orcid":"https://orcid.org/0000-0002-6506-2208","observed_orcids":["https://orcid.org/0000-0002-6506-2208"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jared Delahaye","raw_affiliation_strings":["Center for Infectious Disease Research","Univ. of Washington","1Center for Infectious Disease Research","2Univ. of Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Infectious Disease Research","institution_ids":[]},{"raw_affiliation_string":"Univ. of Washington","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"1Center for Infectious Disease Research","institution_ids":[]},{"raw_affiliation_string":"2Univ. of Washington","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009101426","display_name":"Tige R. Rustad","orcid":"https://orcid.org/0000-0003-2996-2943","observed_orcids":["https://orcid.org/0000-0003-2996-2943"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tige R Rustad","raw_affiliation_strings":["Center for Infectious Disease Research","1Center for Infectious Disease Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Infectious Disease Research","institution_ids":[]},{"raw_affiliation_string":"1Center for Infectious Disease Research","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003978275","display_name":"John D. Aitchison","orcid":"https://orcid.org/0000-0002-9153-6497","observed_orcids":["https://orcid.org/0000-0002-9153-6497","https://orcid.org/0000-0001-5226-7709"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John D Aitchison","raw_affiliation_strings":["Center for Infectious Disease Research","1Center for Infectious Disease Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Infectious Disease Research","institution_ids":[]},{"raw_affiliation_string":"1Center for Infectious Disease Research","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088822597","display_name":"David R. Sherman","orcid":"https://orcid.org/0000-0003-2185-944X","observed_orcids":["https://orcid.org/0000-0003-2185-944X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David R Sherman","raw_affiliation_strings":["Center for Infectious Disease Research","1Center for Infectious Disease Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Infectious Disease Research","institution_ids":[]},{"raw_affiliation_string":"1Center for Infectious Disease Research","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054463329","display_name":"Daniel E. Zak","orcid":"https://orcid.org/0000-0002-1404-400X","observed_orcids":["https://orcid.org/0000-0002-1404-400X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniel E Zak","raw_affiliation_strings":["Center for Infectious Disease Research","1Center for Infectious Disease Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Infectious Disease Research","institution_ids":[]},{"raw_affiliation_string":"1Center for Infectious Disease Research","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085564578","display_name":"Michael Y. Gerner","orcid":"https://orcid.org/0000-0001-5406-8308","observed_orcids":["https://orcid.org/0000-0001-5406-8308"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Y Gerner","raw_affiliation_strings":["Univ. of Washington","2Univ. of Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Washington","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"2Univ. of Washington","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075715453","display_name":"Kevin B. Urdahl","orcid":"https://orcid.org/0000-0003-0088-1066","observed_orcids":["https://orcid.org/0000-0003-0088-1066"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin B Urdahl","raw_affiliation_strings":["Center for Infectious Disease Research","Univ. of Washington","1Center for Infectious Disease Research","2Univ. of Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Infectious Disease Research","institution_ids":[]},{"raw_affiliation_string":"Univ. of Washington","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"1Center for Infectious Disease Research","institution_ids":[]},{"raw_affiliation_string":"2Univ. of Washington","institution_ids":["https://openalex.org/I201448701"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"200","issue":"Supplement_1","first_page":"117.43","last_page":"117.43"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13410","display_name":"Immune responses and vaccinations","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11381","display_name":"Infectious Diseases and Tuberculosis","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tuberculosis","display_name":"tuberculosis","score":0.9139999747276306},{"id":"https://openalex.org/keywords/mycobacterium-tuberculosis","display_name":"Mycobacterium tuberculosis","score":0.9909999966621399},{"id":"https://openalex.org/keywords/disease-progression-prediction","display_name":"disease progression prediction","score":0.7009999752044678},{"id":"https://openalex.org/keywords/murine-tuberculosis-model","display_name":"murine tuberculosis model","score":0.9020000100135803},{"id":"https://openalex.org/keywords/granuloma","display_name":"granuloma","score":0.8920000195503235},{"id":"https://openalex.org/keywords/early-intervention","display_name":"early intervention","score":0.5049999952316284},{"id":"https://openalex.org/keywords/host-immune-response","display_name":"host immune response","score":0.38199999928474426}],"concepts":[{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.8386167883872986},{"id":"https://openalex.org/C2777975735","wikidata":"https://www.wikidata.org/wiki/Q130971","display_name":"Mycobacterium tuberculosis","level":3,"score":0.6763537526130676},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6371439099311829},{"id":"https://openalex.org/C2779696439","wikidata":"https://www.wikidata.org/wiki/Q7512811","display_name":"Signature (topology)","level":2,"score":0.6336795091629028},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5624189376831055},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.5366384983062744},{"id":"https://openalex.org/C2779733811","wikidata":"https://www.wikidata.org/wiki/Q5531562","display_name":"Gene signature","level":4,"score":0.49301454424858093},{"id":"https://openalex.org/C2988867146","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Human disease","level":3,"score":0.4741211235523224},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.4461781978607178},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43531420826911926},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4350455701351166},{"id":"https://openalex.org/C63363279","wikidata":"https://www.wikidata.org/wiki/Q5133848","display_name":"Clinical significance","level":2,"score":0.43350785970687866},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3436206579208374},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.22902709245681763},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.20107942819595337},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16398143768310547},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.08629584312438965},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.08431577682495117},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4049/jimmunol.200.supp.117.43","doi":"https://doi.org/10.4049/jimmunol.200.supp.117.43","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.200.supp.117.43","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3113230718","https://openalex.org/W3135557082","https://openalex.org/W3011251145","https://openalex.org/W2784182290","https://openalex.org/W4254063982","https://openalex.org/W4324020989","https://openalex.org/W4396678064","https://openalex.org/W2310773425","https://openalex.org/W2551900838","https://openalex.org/W3212622641"],"abstract_inverted_index":{"Abstract":[0],"Tuberculosis":[1],"(TB)":[2],"is":[3,198],"a":[4,12,27,96,114,133,144,184,242],"highly":[5],"heterogeneous":[6],"human":[7,124,176,219],"disease":[8,58],"that":[9,31,90,99,119,129,164,171,188],"develops":[10],"in":[11,35,212,241],"subset":[13],"of":[14,38,74,123,140,147,229],"individuals":[15,34,61],"who":[16,62],"inhale":[17],"Mycobacterium":[18],"tuberculosis":[19],"(Mtb).":[20],"Using":[21],"advanced":[22],"machine-learning":[23],"algorithms,":[24],"we":[25,112,181],"discovered":[26],"blood":[28,185],"transcriptional":[29,186],"signature":[30,53,187,197,207],"identifies":[32],"Mtb-exposed":[33],"the":[36,82,87,110,215,227,230],"process":[37],"progressing":[39],"to":[40,44,71,103,106,157,218,225,234,238],"active":[41],"TB":[42,57,92,117,210,239],"up":[43],"18":[45],"months":[46],"before":[47],"they":[48],"exhibit":[49,143,167],"clinical":[50],"symptoms.":[51],"This":[52,221],"may":[54],"help":[55],"prevent":[56],"by":[59],"identifying":[60],"could":[63],"benefit":[64],"from":[65,153],"early":[66],"intervention.":[67],"However,":[68],"it":[69],"fails":[70],"identify":[72],"~30%":[73],"progressors":[75],"and":[76,191],"does":[77],"not":[78],"reveal":[79],"insights":[80],"into":[81],"diverse":[83],"outcome-governing":[84],"pathways":[85,108],"within":[86,109,160],"infected":[88,131],"lung":[89],"underlie":[91],"progression.":[93],"To":[94],"develop":[95],"tractable":[97,231],"system":[98,233],"enables":[100,223],"blood-based":[101],"signatures":[102],"be":[104],"linked":[105],"mechanistic":[107],"lung,":[111],"pioneered":[113],"novel":[115],"murine":[116],"model":[118],"recapitulates":[120],"key":[121],"aspects":[122],"Mtb":[125,142,166,177],"infection.":[126],"We":[127],"find":[128],"mice":[130],"with":[132,149,175],"physiologic,":[134],"ultra-low":[135],"dose":[136],"(i.e.,":[137],"1\u20133":[138],"CFUs)":[139],"aerosolized":[141],"broad":[145],"range":[146],"outcomes,":[148],"bacterial":[150],"burdens":[151],"ranging":[152],"less":[154],"than":[155],"10":[156],"~106":[158],"CFUs":[159],"individual":[161],"lungs.":[162],"Mice":[163],"contain":[165],"well-circumscribed":[168],"granulomatous":[169],"structures":[170],"share":[172],"many":[173],"features":[174],"granulomas.":[178],"In":[179],"addition,":[180],"have":[182],"identified":[183,205],"distinguishes":[189],"\"controller\"":[190],"\"progressor\"":[192],"mice.":[193],"Remarkably,":[194],"this":[195],"mouse-derived":[196],"equally":[199],"as":[200,202],"effective":[201],"our":[203],"previously":[204],"human-derived":[206],"at":[208],"predicting":[209],"risk":[211],"humans,":[213],"confirming":[214],"model\u2019s":[216],"relevance":[217],"disease.":[220],"finding":[222],"us":[224],"use":[226],"tools":[228],"mouse":[232],"address":[235],"questions":[236],"central":[237],"pathogenesis":[240],"clinically":[243],"relevant":[244],"model.":[245]},"counts_by_year":[{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-13T10:08:12.033832","created_date":"2023-01-06T00:00:00"}
