{"id":"https://openalex.org/W4313359559","doi":"https://doi.org/10.4049/jimmunol.200.supp.52.17","title":"Mycobacterium tuberculosis stimulates neutrophil infiltration into the lungs through activation of S100A proteins in an early secreted antigenic target of 6-kDa dependent manner","display_name":"Mycobacterium tuberculosis stimulates neutrophil infiltration into the lungs through activation of S100A proteins in an early secreted antigenic target of 6-kDa dependent manner","publication_year":2018,"publication_date":"2018-05-01","ids":{"openalex":"https://openalex.org/W4313359559","doi":"https://doi.org/10.4049/jimmunol.200.supp.52.17"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.200.supp.52.17","doi":"https://doi.org/10.4049/jimmunol.200.supp.52.17","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.200.supp.52.17","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060272372","display_name":"Bock\u2010Gie Jung","orcid":"https://orcid.org/0000-0002-1923-2878","observed_orcids":["https://orcid.org/0000-0002-1923-2878"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bock-Gie Jung","raw_affiliation_strings":["University of Texas","1University of Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas","institution_ids":[]},{"raw_affiliation_string":"1University of Texas","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086530366","display_name":"Biodun A. Adeniyi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Biodun A Adeniyi","raw_affiliation_strings":["University of Texas","1University of Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas","institution_ids":[]},{"raw_affiliation_string":"1University of Texas","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077176756","display_name":"Buka Samten","orcid":"https://orcid.org/0000-0002-3608-4790","observed_orcids":["https://orcid.org/0000-0002-3608-4790"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Buka Samten","raw_affiliation_strings":["University of Texas","1University of Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas","institution_ids":[]},{"raw_affiliation_string":"1University of Texas","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"200","issue":"Supplement_1","first_page":"52.17","last_page":"52.17"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13410","display_name":"Immune responses and vaccinations","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11316","display_name":"Mycobacterium research and diagnosis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mycobacterium-tuberculosis","display_name":"Mycobacterium tuberculosis","score":0.996999979019165},{"id":"https://openalex.org/keywords/esat-6","display_name":"ESAT-6","score":0.8040000200271606},{"id":"https://openalex.org/keywords/cfp-10","display_name":"CFP-10","score":0.968999981880188},{"id":"https://openalex.org/keywords/s100a9","display_name":"S100A9","score":0.8989999890327454},{"id":"https://openalex.org/keywords/neutrophil-infiltration","display_name":"neutrophil infiltration","score":0.921999990940094},{"id":"https://openalex.org/keywords/pulmonary-inflammation","display_name":"lung inflammation","score":0.6150000095367432},{"id":"https://openalex.org/keywords/esx-1-secretion-system","display_name":"ESX-1 secretion system","score":0.9829999804496765},{"id":"https://openalex.org/keywords/tuberculosis-pathogenesis","display_name":"tuberculosis pathogenesis","score":0.7990000247955322},{"id":"https://openalex.org/keywords/intranasal-infection","display_name":"intranasal infection","score":0.7639999985694885}],"concepts":[{"id":"https://openalex.org/C2781064340","wikidata":"https://www.wikidata.org/wiki/Q22228705","display_name":"ESAT-6","level":4,"score":0.854534924030304},{"id":"https://openalex.org/C153400128","wikidata":"https://www.wikidata.org/wiki/Q3150731","display_name":"Infiltration (HVAC)","level":2,"score":0.667386531829834},{"id":"https://openalex.org/C2777975735","wikidata":"https://www.wikidata.org/wiki/Q130971","display_name":"Mycobacterium tuberculosis","level":3,"score":0.6017228960990906},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.5761610269546509},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5269744396209717},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.4922250807285309},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4458930790424347},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.43769651651382446},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.4264233112335205},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41688960790634155},{"id":"https://openalex.org/C2776307749","wikidata":"https://www.wikidata.org/wiki/Q18031354","display_name":"S100A9","level":3,"score":0.4154775142669678},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.37231510877609253},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.3575659990310669},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.34523653984069824},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24397215247154236},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.19338318705558777},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4049/jimmunol.200.supp.52.17","doi":"https://doi.org/10.4049/jimmunol.200.supp.52.17","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.200.supp.52.17","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9922999739646912,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4313383163","https://openalex.org/W2010146052","https://openalex.org/W2014623764","https://openalex.org/W3010372469","https://openalex.org/W7097606066","https://openalex.org/W2991134127","https://openalex.org/W2141361194","https://openalex.org/W2986148007","https://openalex.org/W4388190129","https://openalex.org/W3159919420"],"abstract_inverted_index":{"Abstract":[0],"Health":[1],"Science":[2],"Center":[3],"at":[4,99,104,118,152,159],"Tyler":[5],"Neutrophils":[6],"infiltrate":[7],"the":[8,17,23,27,144,181],"lungs":[9,145,238],"in":[10,32,204,236,251,255],"active":[11],"tuberculosis":[12,67],"(TB)":[13],"and":[14,26,47,82,86,92,102,155,190,199,220],"contribute":[15],"to":[16,157,231],"exacerbation":[18],"of":[19,29,38,43,65,128,143,166,180,202,228],"TB":[20,33,256],"pathology.":[21],"However,":[22],"contributing":[24],"factors":[25],"mechanisms":[28],"neutrophil":[30,89,97,116,141,253],"infiltration":[31,98,117,142],"are":[34],"unclear.":[35],"As":[36],"secretion":[37,59,201],"early":[39,147],"secreted":[40],"antigenic":[41],"target":[42],"6":[44],"kDa":[45],"(ESAT-6)":[46],"its":[48,78],"molecular":[49],"partner":[50],"culture":[51],"filtrate":[52],"protein":[53,200],"10":[54],"kD":[55],"(CFP10)":[56],"by":[57,186],"ESX-1":[58],"system":[60],"is":[61],"essential":[62],"for":[63],"pathogenesis":[64],"Mycobacterium":[66],"(Mtb),":[68],"we":[69],"infected":[70],"C57BL/6":[71],"mice":[72,175],"intranasally":[73],"with":[74,124,217],"Mtb":[75],"strains":[76],"H37Rv,":[77],"esat-6":[79,83,93,110,221,233],"deletion":[80,111,234],"mutant,":[81],"complemented":[84,94,222],"strain":[85,95,223],"evaluated":[87],"lung":[88,168,214,252],"infiltration.":[90],"H37Rv":[91,219],"induced":[96,113,140,212,224],"day":[100,105],"7":[101],"peaked":[103,151],"14":[106],"post":[107,162],"infection.":[108,241,257],"Whereas":[109],"mutant":[112,235],"significantly":[114,183,225],"less":[115],"both":[119],"time":[120],"points.":[121],"In":[122],"line":[123],"this,":[125,218],"intranasal":[126,240],"delivery":[127],"recombinant":[129],"ESAT-6":[130,171,194,211],"but":[131],"not":[132],"CFP10":[133,173],"or":[134,172],"Hank\u2019s":[135],"balanced":[136],"salt":[137],"solution":[138],"(vehicle)":[139],"as":[146,148,178],"2":[149],"hours,":[150,154],"24":[153],"started":[156],"decline":[158],"72":[160],"hours":[161],"treatment.":[163],"RNA-sequencing":[164],"analysis":[165,208],"total":[167],"RNA":[169],"from":[170],"treated":[174],"identified":[176],"S100A9":[177,203,229,246],"one":[179],"most":[182],"upregulated":[184],"genes":[185],"ESAT-6.":[187],"Real-time":[188],"PCR":[189],"ELISA":[191],"validated":[192],"that":[193,210,244],"stimulated":[195],"increased":[196],"gene":[197],"expression":[198],"mouse":[205,237],"lungs.":[206],"Immunohistochemistry":[207],"revealed":[209],"neutrophilic":[213],"inflammation.":[215],"Consistent":[216],"higher":[226],"levels":[227],"compared":[230],"their":[232],"after":[239],"We":[242],"conclude":[243],"ESAT-6-induced":[245],"plays":[247],"a":[248],"critical":[249],"role":[250],"infiltrations":[254]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2023-01-06T00:00:00"}