{"id":"https://openalex.org/W4313359486","doi":"https://doi.org/10.4049/jimmunol.200.supp.49.17","title":"Preoperative exercise therapy protects the liver from ischemia-reperfusion injury","display_name":"Preoperative exercise therapy protects the liver from ischemia-reperfusion injury","publication_year":2018,"publication_date":"2018-05-01","ids":{"openalex":"https://openalex.org/W4313359486","doi":"https://doi.org/10.4049/jimmunol.200.supp.49.17"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.200.supp.49.17","doi":"https://doi.org/10.4049/jimmunol.200.supp.49.17","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.200.supp.49.17","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101612634","display_name":"Hongji Zhang","orcid":"https://orcid.org/0000-0002-7704-4365","observed_orcids":["https://orcid.org/0000-0002-7704-4365"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Hongji Zhang","raw_affiliation_strings":["Union Hospital, Huazhong University of Science and Technology , Wuhan, PR","Univ. of Pittsburgh Med. Ctr","1Univ. of Pittsburgh Med. Ctr","2Union Hospital, Huazhong University of Science and Technology, Wuhan, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Union Hospital, Huazhong University of Science and Technology , Wuhan, PR","institution_ids":["https://openalex.org/I47720641"]},{"raw_affiliation_string":"Univ. of Pittsburgh Med. Ctr","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210134769"]},{"raw_affiliation_string":"1Univ. of Pittsburgh Med. Ctr","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210134769"]},{"raw_affiliation_string":"2Union Hospital, Huazhong University of Science and Technology, Wuhan, PR China","institution_ids":["https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051708739","display_name":"Jinghua Ren","orcid":"https://orcid.org/0000-0002-6931-0766","observed_orcids":["https://orcid.org/0000-0002-6931-0766"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Jinghua Ren","raw_affiliation_strings":["Union Hospital, Huazhong University of Science and Technology , Wuhan, PR","Univ. of Pittsburgh Med. Ctr","1Univ. of Pittsburgh Med. Ctr","2Union Hospital, Huazhong University of Science and Technology, Wuhan, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Union Hospital, Huazhong University of Science and Technology , Wuhan, PR","institution_ids":["https://openalex.org/I47720641"]},{"raw_affiliation_string":"Univ. of Pittsburgh Med. Ctr","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210134769"]},{"raw_affiliation_string":"1Univ. of Pittsburgh Med. Ctr","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210134769"]},{"raw_affiliation_string":"2Union Hospital, Huazhong University of Science and Technology, Wuhan, PR China","institution_ids":["https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022456133","display_name":"Hamza O. Yazdani","orcid":"https://orcid.org/0000-0002-3437-0339","observed_orcids":["https://orcid.org/0000-0002-3437-0339"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hamza O Yazdani","raw_affiliation_strings":["Univ. of Pittsburgh Med. Ctr","1Univ. of Pittsburgh Med. Ctr"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Pittsburgh Med. Ctr","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210134769"]},{"raw_affiliation_string":"1Univ. of Pittsburgh Med. Ctr","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210134769"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038140786","display_name":"Dirk J. van der Windt","orcid":"https://orcid.org/0000-0001-8839-577X","observed_orcids":["https://orcid.org/0000-0001-8839-577X"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dirk Van Der Windt","raw_affiliation_strings":["Univ. of Pittsburgh Med. Ctr","1Univ. of Pittsburgh Med. Ctr"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Pittsburgh Med. Ctr","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210134769"]},{"raw_affiliation_string":"1Univ. of Pittsburgh Med. Ctr","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210134769"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112155927","display_name":"Jinxiang Zhang","orcid":"https://orcid.org/0000-0002-5447-272X","observed_orcids":["https://orcid.org/0000-0002-5447-272X"]},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinxiang Zhang","raw_affiliation_strings":["Union Hospital, Huazhong University of Science and Technology , Wuhan, PR","2Union Hospital, Huazhong University of Science and Technology, Wuhan, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Union Hospital, Huazhong University of Science and Technology , Wuhan, PR","institution_ids":["https://openalex.org/I47720641"]},{"raw_affiliation_string":"2Union Hospital, Huazhong University of Science and Technology, Wuhan, PR China","institution_ids":["https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053733739","display_name":"Allan Tsung","orcid":"https://orcid.org/0000-0002-3916-8965","observed_orcids":["https://orcid.org/0000-0002-3916-8965"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Allan Tsung","raw_affiliation_strings":["Univ. of Pittsburgh Med. Ctr","1Univ. of Pittsburgh Med. Ctr"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Pittsburgh Med. Ctr","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210134769"]},{"raw_affiliation_string":"1Univ. of Pittsburgh Med. Ctr","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210134769"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008254848","display_name":"Hai Huang","orcid":"https://orcid.org/0000-0002-2013-073X","observed_orcids":["https://orcid.org/0000-0002-2013-073X","https://orcid.org/0000-0001-7430-0119"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Hai Huang","raw_affiliation_strings":["Union Hospital, Huazhong University of Science and Technology , Wuhan, PR","Univ. of Pittsburgh Med. Ctr","1Univ. of Pittsburgh Med. Ctr","2Union Hospital, Huazhong University of Science and Technology, Wuhan, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Union Hospital, Huazhong University of Science and Technology , Wuhan, PR","institution_ids":["https://openalex.org/I47720641"]},{"raw_affiliation_string":"Univ. of Pittsburgh Med. Ctr","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210134769"]},{"raw_affiliation_string":"1Univ. of Pittsburgh Med. Ctr","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210134769"]},{"raw_affiliation_string":"2Union Hospital, Huazhong University of Science and Technology, Wuhan, PR China","institution_ids":["https://openalex.org/I47720641"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"200","issue":"Supplement_1","first_page":"49.17","last_page":"49.17"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10999","display_name":"Organ Transplantation Techniques and Outcomes","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10999","display_name":"Organ Transplantation Techniques and Outcomes","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11585","display_name":"Exercise and Physiological Responses","score":0.005900000222027302,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/preoperative-exercise","display_name":"preoperative exercise","score":0.8870000243186951},{"id":"https://openalex.org/keywords/aerobic-exercise","display_name":"aerobic exercise","score":0.8539999723434448},{"id":"https://openalex.org/keywords/hepatic-ischemia-reperfusion-injury","display_name":"hepatic ischemia-reperfusion injury","score":0.9279999732971191},{"id":"https://openalex.org/keywords/liver-transplantation","display_name":"liver transplantation","score":0.7179999947547913},{"id":"https://openalex.org/keywords/sterile-inflammation","display_name":"sterile inflammation","score":0.8930000066757202},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.8730000257492065},{"id":"https://openalex.org/keywords/neutrophil-infiltration","display_name":"neutrophil infiltration","score":0.9929999709129333},{"id":"https://openalex.org/keywords/hepatocyte-apoptosis","display_name":"hepatocyte apoptosis","score":0.7919999957084656},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9879999756813049},{"id":"https://openalex.org/keywords/serum-alt","display_name":"serum ALT","score":0.4860000014305115},{"id":"https://openalex.org/keywords/liver-surgery","display_name":"liver surgery","score":0.30799999833106995},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.8650000095367432}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.827427327632904},{"id":"https://openalex.org/C2776637226","wikidata":"https://www.wikidata.org/wiki/Q6658207","display_name":"Liver injury","level":2,"score":0.5481874346733093},{"id":"https://openalex.org/C2780114680","wikidata":"https://www.wikidata.org/wiki/Q1413991","display_name":"Reperfusion injury","level":3,"score":0.5168560147285461},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.5100196003913879},{"id":"https://openalex.org/C2777318727","wikidata":"https://www.wikidata.org/wiki/Q409464","display_name":"Lactate dehydrogenase","level":3,"score":0.5052130818367004},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4852016270160675},{"id":"https://openalex.org/C2779609443","wikidata":"https://www.wikidata.org/wiki/Q1368191","display_name":"Liver transplantation","level":3,"score":0.478385329246521},{"id":"https://openalex.org/C103038586","wikidata":"https://www.wikidata.org/wiki/Q1152037","display_name":"Aerobic exercise","level":2,"score":0.4383012354373932},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.37432825565338135},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3681407868862152},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.2943122386932373},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4049/jimmunol.200.supp.49.17","doi":"https://doi.org/10.4049/jimmunol.200.supp.49.17","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.200.supp.49.17","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4313368751","https://openalex.org/W4312566024","https://openalex.org/W3170247258","https://openalex.org/W3166013813","https://openalex.org/W4402663796","https://openalex.org/W4401832174","https://openalex.org/W3086559420","https://openalex.org/W7131324127","https://openalex.org/W4385685903","https://openalex.org/W2319476914"],"abstract_inverted_index":{"Abstract":[0],"Introduction":[1],"Surgical":[2],"stress":[3],"such":[4],"as":[5,67],"hepatic":[6,195],"ischemia/reperfusion":[7],"(I/R)":[8],"injury":[9],"results":[10],"in":[11,122,161,186,210,215],"an":[12],"increased":[13,173],"risk":[14],"of":[15,36,70,110,125,149,224,232,244],"postoperative":[16],"morbidity":[17],"and":[18,39,198],"mortality,":[19],"including":[20],"liver":[21,76,117,170,233,249,253],"transplantation.":[22],"Preoperative":[23],"exercise":[24,62,88,95,133,163,187,216,226],"therapy":[25,63,227],"has":[26,64],"been":[27],"shown":[28],"to":[29,53],"enhance":[30],"physical":[31],"capacity":[32],"at":[33,107,127],"the":[34,47,131,147,162,166,201,229],"moment":[35],"hospital":[37],"admission":[38],"may":[40],"facilitate":[41],"better":[42],"recovery":[43],"after":[44,75,130,169,189],"surgery.":[45,254],"However,":[46],"mechanisms":[48],"behind":[49],"this":[50],"protection":[51],"remain":[52],"be":[54],"elucidated.":[55],"Here":[56],"we":[57],"hypothesize":[58],"that":[59,251],"preoperative":[60,225],"aerobic":[61],"protective":[65],"effects":[66,223],"a":[68,99,108,142,192,238],"result":[69],"inhibiting":[71],"sterile":[72],"inflammatory":[73],"processes":[74],"I/R":[77,119,234],"injury.":[78],"Methods":[79],"Eight-week-old":[80],"male":[81],"C57BL/6":[82],"mice":[83,126,140,152,164,168,188],"were":[84,153,178,212],"randomly":[85],"divided":[86],"into":[87],"(n=15)":[89,92],"or":[90,246],"sedentary":[91,151,167],"groups.":[93],"The":[94,155],"group":[96],"ran":[97],"on":[98,228],"motorized":[100],"treadmill":[101],"for":[102,112,240],"60":[103],"min/day,":[104],"5":[105],"days/week":[106],"speed":[109],"12.5m/min":[111],"4":[113,137],"weeks.":[114],"70%":[115],"partial":[116],"warm":[118],"was":[120,158,184],"performed":[121],"both":[123],"groups":[124],"72":[128],"hours":[129],"final":[132],"session.":[134],"Results":[135],"After":[136],"weeks,60%":[138],"exercised":[139],"showed":[141],"3%\u20136%":[143],"weight":[144,148],"loss":[145],"whereas":[146,180],"all":[150,213],"increased.":[154],"sALT":[156],"levels":[157],"significantly":[159],"reduced":[160],"than":[165],"I/R.":[171],"Significantly":[172],"Natural":[174],"Killer":[175],"(NK)":[176],"cells":[177],"observed,":[179],"less":[181],"neutrophil":[182],"infiltration":[183],"seen":[185],"I/R,":[190],"suggesting":[191],"link":[193],"between":[194],"immune":[196],"modulation":[197],"exercise.":[199],"Moreover,":[200],"lactate":[202],"dehydrogenase":[203],"(LDH),":[204],"apoptosis,":[205],"reactive":[206],"oxygen":[207],"species":[208],"(ROS)":[209],"hepatocyte":[211],"decreased":[214],"mice.":[217],"Conclusions":[218],"These":[219],"data":[220],"show":[221],"beneficial":[222],"experimental":[230],"model":[231],"injury,":[235],"which":[236],"offer":[237],"rationale":[239],"encouraging":[241],"predisposed":[242],"patients":[243],"HCC":[245],"other":[247],"end-stage":[248],"diseases":[250],"need":[252]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2023-01-06T00:00:00"}
