{"id":"https://openalex.org/W4313359459","doi":"https://doi.org/10.4049/jimmunol.200.supp.108.12","title":"Role of Astrocyte Activation in Experimental Cerebral Malaria","display_name":"Role of Astrocyte Activation in Experimental Cerebral Malaria","publication_year":2018,"publication_date":"2018-05-01","ids":{"openalex":"https://openalex.org/W4313359459","doi":"https://doi.org/10.4049/jimmunol.200.supp.108.12"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.200.supp.108.12","doi":"https://doi.org/10.4049/jimmunol.200.supp.108.12","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.200.supp.108.12","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-2","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038067393","display_name":"Arnulfo Tu\u00f1on-Ortiz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arnulfo B N Tunon-Ortiz","raw_affiliation_strings":["University of Utah","1University of Utah"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Utah","institution_ids":["https://openalex.org/I223532165"]},{"raw_affiliation_string":"1University of Utah","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073086005","display_name":"Thayer King","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thayer P King","raw_affiliation_strings":["Emory University","University of Utah","1University of Utah","2Emory University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emory University","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"University of Utah","institution_ids":["https://openalex.org/I223532165"]},{"raw_affiliation_string":"1University of Utah","institution_ids":["https://openalex.org/I223532165"]},{"raw_affiliation_string":"2Emory University","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063526155","display_name":"Patrice Nsangou Mimche","orcid":"https://orcid.org/0000-0002-3761-7237","observed_orcids":["https://orcid.org/0000-0002-3761-7237"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrice N Mimche","raw_affiliation_strings":["University of Utah","1University of Utah"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Utah","institution_ids":["https://openalex.org/I223532165"]},{"raw_affiliation_string":"1University of Utah","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030344106","display_name":"Tracey J. Lamb","orcid":"https://orcid.org/0000-0003-0620-3944","observed_orcids":["https://orcid.org/0000-0003-0620-3944"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tracey J Lamb","raw_affiliation_strings":["University of Utah","1University of Utah"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Utah","institution_ids":["https://openalex.org/I223532165"]},{"raw_affiliation_string":"1University of Utah","institution_ids":["https://openalex.org/I223532165"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"200","issue":"Supplement_1","first_page":"108.12","last_page":"108.12"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.7041000127792358,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.7041000127792358,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.27810001373291016,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cerebral-malaria","display_name":"cerebral malaria","score":0.7990000247955322},{"id":"https://openalex.org/keywords/astrocyte-activation","display_name":"astrocyte activation","score":0.9620000123977661},{"id":"https://openalex.org/keywords/blood-brain-barrier-disruption","display_name":"blood-brain barrier disruption","score":0.9480000138282776},{"id":"https://openalex.org/keywords/plasmodium-berghei-anka","display_name":"Plasmodium berghei ANKA","score":0.9079999923706055},{"id":"https://openalex.org/keywords/epha2","display_name":"EphA2","score":0.8569999933242798},{"id":"https://openalex.org/keywords/receptor-tyrosine-kinases","display_name":"receptor tyrosine kinase","score":0.8830000162124634},{"id":"https://openalex.org/keywords/plasmodium-falciparum","display_name":"Plasmodium falciparum","score":0.9070000052452087},{"id":"https://openalex.org/keywords/endothelial-activation","display_name":"endothelial activation","score":0.7979999780654907},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.8600000143051147},{"id":"https://openalex.org/keywords/cerebellum","display_name":"cerebellum","score":0.8169999718666077},{"id":"https://openalex.org/keywords/frontal-cortex","display_name":"frontal cortex","score":0.8899999856948853},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.6669999957084656}],"concepts":[{"id":"https://openalex.org/C2908793570","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Cerebral Malaria","level":4,"score":0.9520943760871887},{"id":"https://openalex.org/C2777237215","wikidata":"https://www.wikidata.org/wiki/Q65021","display_name":"Plasmodium berghei","level":3,"score":0.9016387462615967},{"id":"https://openalex.org/C2777542381","wikidata":"https://www.wikidata.org/wiki/Q502961","display_name":"Astrocyte","level":3,"score":0.7388923168182373},{"id":"https://openalex.org/C2778402981","wikidata":"https://www.wikidata.org/wiki/Q221694","display_name":"Blood\u2013brain barrier","level":3,"score":0.623509407043457},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.5999459624290466},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5475996732711792},{"id":"https://openalex.org/C2781041448","wikidata":"https://www.wikidata.org/wiki/Q75839","display_name":"Cerebral cortex","level":2,"score":0.5256855487823486},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.46723610162734985},{"id":"https://openalex.org/C2775867548","wikidata":"https://www.wikidata.org/wiki/Q1897162","display_name":"Parasitemia","level":4,"score":0.43691834807395935},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.43271806836128235},{"id":"https://openalex.org/C2778371730","wikidata":"https://www.wikidata.org/wiki/Q311383","display_name":"Plasmodium falciparum","level":3,"score":0.42670905590057373},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.2824038863182068},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.24266543984413147}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4049/jimmunol.200.supp.108.12","doi":"https://doi.org/10.4049/jimmunol.200.supp.108.12","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.200.supp.108.12","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-2","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9789000153541565,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.8500000238418579,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2135210895","https://openalex.org/W2117123380","https://openalex.org/W2115504773","https://openalex.org/W2896800161","https://openalex.org/W4307427571","https://openalex.org/W2143829191","https://openalex.org/W2751451015","https://openalex.org/W2608011702","https://openalex.org/W2007404775","https://openalex.org/W2096624589"],"abstract_inverted_index":{"Abstract":[0],"Cerebral":[1],"malaria":[2,48,99,148,177],"(CM)":[3],"is":[4,53,56,80,145],"a":[5,13,50,131,141,151],"severe":[6],"complication":[7],"of":[8,39,64,75,96,116,136,169],"Plasmodium":[9,120],"falciparum":[10],"(Pf)":[11],"with":[12,119,134],"high":[14],"lethality":[15],"rate.":[16],"Key":[17],"features":[18],"at":[19,127],"the":[20,73,76,87,93,111,137],"cellular":[21],"and":[22,37,113,149],"molecular":[23],"level":[24],"are":[25,69,124],"endothelial":[26],"cell":[27],"(EC)":[28],"activation,":[29],"blood-brain":[30],"barrier":[31],"(BBB)":[32],"dysfunction,":[33],"pro-inflammatory":[34],"cytokine":[35],"signaling,":[36],"sequestration":[38],"infected":[40,118],"red":[41],"blood":[42],"cells":[43,70],"(iRBCs).":[44],"While":[45],"research":[46],"on":[47,163],"as":[49],"peripheral":[51],"infection":[52],"extensive,":[54],"there":[55],"still":[57],"much":[58],"left":[59],"to":[60,106],"investigate":[61],"in":[62,85,110,147,154,160,165,175],"terms":[63],"its":[65],"neuropathological":[66],"progression.":[67],"Astrocytes":[68],"that":[71,108],"maintain":[72],"stability":[74],"BBB,":[77],"yet":[78],"nothing":[79],"known":[81],"about":[82],"their":[83],"role":[84,153],"maintaining":[86],"BBB":[88,155,173],"during":[89],"cerebral":[90,98,176],"malaria.":[91],"In":[92],"mouse":[94],"model":[95],"experimental":[97],"(ECM),":[100],"we":[101],"have":[102],"used":[103],"flow":[104],"cytometry":[105],"determine":[107],"astrocytes":[109,164],"cerebellum":[112],"frontal":[114],"cortex":[115],"mice":[117],"berghei":[121],"ANKA":[122],"(PbA)":[123],"both":[125],"activated":[126],"6":[128],"days":[129],"PI,":[130],"time-point":[132],"correlated":[133],"breakdown":[135],"BBB.":[138],"Furthermore,":[139],"EphA2,":[140],"receptor":[142],"tyrosine":[143],"kinase,":[144],"upregulated":[146],"plays":[150],"critical":[152],"disruption.":[156],"We":[157],"show":[158],"increases":[159],"EphA2":[161],"densities":[162],"ECM.":[166],"The":[167],"implications":[168],"these":[170],"data":[171],"for":[172],"disruption":[174],"will":[178],"be":[179],"discussed.":[180]},"counts_by_year":[],"updated_date":"2026-09-25T08:18:29.962427","created_date":"2025-10-10T00:00:00"}