{"id":"https://openalex.org/W4313358968","doi":"https://doi.org/10.4049/jimmunol.202.supp.181.23","title":"IL-27-dependent STAT1 activation is enhanced in CD4 T cells from HIV infected patients","display_name":"IL-27-dependent STAT1 activation is enhanced in CD4 T cells from HIV infected patients","publication_year":2019,"publication_date":"2019-05-01","ids":{"openalex":"https://openalex.org/W4313358968","doi":"https://doi.org/10.4049/jimmunol.202.supp.181.23"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.202.supp.181.23","doi":"https://doi.org/10.4049/jimmunol.202.supp.181.23","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.202.supp.181.23","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089795750","display_name":"Jie Cheng","orcid":"https://orcid.org/0000-0002-8835-3171","observed_orcids":["https://orcid.org/0000-0002-8835-3171","https://orcid.org/0009-0008-2031-6236"]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jie Cheng","raw_affiliation_strings":["Department of Microbiology and Immunology, Georgetown University School of Medicine","1Department of Microbiology and Immunology, Georgetown University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Georgetown University School of Medicine","institution_ids":["https://openalex.org/I184565670"]},{"raw_affiliation_string":"1Department of Microbiology and Immunology, Georgetown University School of Medicine","institution_ids":["https://openalex.org/I184565670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104343537","display_name":"Jai Kumar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jai Kumar","raw_affiliation_strings":["Division of Infectious Diseases and Travel Medicine, Georgetown University School of Medicine","2Division of Infectious Diseases and Travel Medicine, Georgetown University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases and Travel Medicine, Georgetown University School of Medicine","institution_ids":["https://openalex.org/I184565670"]},{"raw_affiliation_string":"2Division of Infectious Diseases and Travel Medicine, Georgetown University School of Medicine","institution_ids":["https://openalex.org/I184565670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083402039","display_name":"Princy N. Kumar","orcid":"https://orcid.org/0000-0002-5994-2727","observed_orcids":["https://orcid.org/0000-0002-5994-2727"]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Princy Kumar","raw_affiliation_strings":["Division of Infectious Diseases and Travel Medicine, Georgetown University School of Medicine","2Division of Infectious Diseases and Travel Medicine, Georgetown University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases and Travel Medicine, Georgetown University School of Medicine","institution_ids":["https://openalex.org/I184565670"]},{"raw_affiliation_string":"2Division of Infectious Diseases and Travel Medicine, Georgetown University School of Medicine","institution_ids":["https://openalex.org/I184565670"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049234296","display_name":"Marta Cat\u00e1lfamo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marta Catalfamo","raw_affiliation_strings":["Department of Microbiology and Immunology, Georgetown University School of Medicine","1Department of Microbiology and Immunology, Georgetown University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Georgetown University School of Medicine","institution_ids":["https://openalex.org/I184565670"]},{"raw_affiliation_string":"1Department of Microbiology and Immunology, Georgetown University School of Medicine","institution_ids":["https://openalex.org/I184565670"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I184565670"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"202","issue":"1_Supplement","first_page":"181.23","last_page":"181.23"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.8086000084877014,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.8086000084877014,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.18160000443458557,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stat1-activation","display_name":"STAT1 activation","score":0.9929999709129333},{"id":"https://openalex.org/keywords/stat3","display_name":"STAT3","score":0.8650000095367432},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.9070000052452087},{"id":"https://openalex.org/keywords/hiv-infection","display_name":"HIV infection","score":0.906000018119812},{"id":"https://openalex.org/keywords/interleukin-7","display_name":"IL-7","score":0.9169999957084656},{"id":"https://openalex.org/keywords/interleukin-2","display_name":"interleukin-2","score":0.9509999752044678},{"id":"https://openalex.org/keywords/il-15","display_name":"IL-15","score":1.0},{"id":"https://openalex.org/keywords/jak-stat-signaling","display_name":"JAK/STAT signaling","score":0.8659999966621399},{"id":"https://openalex.org/keywords/cd4-t-cell-homeostasis","display_name":"CD4+ T cell homeostasis","score":0.8169999718666077},{"id":"https://openalex.org/keywords/immune-activation","display_name":"immune activation","score":0.6600000262260437},{"id":"https://openalex.org/keywords/type-i-interferon","display_name":"type I interferon","score":0.6110000014305115},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.7300000190734863}],"concepts":[{"id":"https://openalex.org/C2777003663","wikidata":"https://www.wikidata.org/wiki/Q14912030","display_name":"STAT1","level":3,"score":0.634575366973877},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.5902734994888306},{"id":"https://openalex.org/C171958077","wikidata":"https://www.wikidata.org/wiki/Q419333","display_name":"STAT protein","level":4,"score":0.5749852061271667},{"id":"https://openalex.org/C2778923194","wikidata":"https://www.wikidata.org/wiki/Q14912019","display_name":"STAT3","level":3,"score":0.5583867430686951},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.5443659424781799},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5244432091712952},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5184664130210876},{"id":"https://openalex.org/C79484868","wikidata":"https://www.wikidata.org/wiki/Q5971673","display_name":"IL-2 receptor","level":4,"score":0.4655986726284027},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.45220375061035156},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.43796926736831665},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.4293835759162903},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.33354389667510986},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3083209991455078},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4049/jimmunol.202.supp.181.23","doi":"https://doi.org/10.4049/jimmunol.202.supp.181.23","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.202.supp.181.23","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1974097834","https://openalex.org/W1600413402","https://openalex.org/W2417160039","https://openalex.org/W2115493739","https://openalex.org/W4313354824","https://openalex.org/W4319433498","https://openalex.org/W2924129825","https://openalex.org/W4200114276","https://openalex.org/W2149851148","https://openalex.org/W2323147012"],"abstract_inverted_index":{"Abstract":[0],"In":[1,274],"patients":[2,236],"with":[3,252],"HIV":[4,117,157,234,278],"infection,":[5,279],"reconstitution":[6],"of":[7,15,66,72,97,110,114,144,198,277],"the":[8,37,48,67,94,111,128,149,162,275,280],"CD4":[9,27,38,98,203,230,287],"T":[10,28,39,50,99,154,180,206,231,261,288],"cell":[11,29,40,51,289],"pool":[12,41,52],"after":[13],"initiation":[14],"combination":[16],"antiretroviral":[17],"therapy":[18],"(cART)":[19],"is":[20,42,54],"a":[21,108,238],"slow":[22],"process":[23],"and":[24,62,70,76,80,91,121,130,137,173,193,200,204,208,214,243,269,291],"depends":[25],"on":[26,170,176],"counts":[30],"prior":[31],"to":[32,47,83,87,93,151,190,210,227],"therapy.":[33],"This":[34,254],"suggests":[35],"that":[36,60,106,141,187,225,266],"under":[43],"homeostatic":[44],"pressure":[45],"compared":[46,226],"CD8":[49,205,260],"which":[53],"expanded.":[55],"We":[56,159,185,222],"have":[57,167],"previously":[58],"shown":[59,105],"lymphopenia":[61],"IL-7":[63,268],"increase":[64],"expression":[65,146,172,197,242],"Signal":[68],"Transducer":[69],"Activator":[71],"Transcriptions":[73],"1,":[74],"2":[75,79],"3":[77],"(STAT1,":[78],"3)":[81],"leading":[82],"an":[84,168,211],"enhanced":[85,212,245,281],"response":[86,150],"Type":[88],"I":[89],"IFNs":[90],"contributing":[92],"immune":[95],"activation":[96,216,247,284,290],"cells.":[100,124,262],"A":[101],"recent":[102],"report":[103],"has":[104],"IL-27,":[107],"member":[109],"IL-12":[112],"family":[113],"cytokines,":[115],"inhibits":[116],"replication":[118],"in":[119,153,179,188,202,219,249,259],"monocytes":[120],"monocyte-derived":[122],"dendritic":[123],"IL-27":[125,134,152,177,218,272],"signals":[126],"through":[127],"JAK/STAT":[129],"MAPK":[131],"pathways.":[132],"Since":[133],"activates":[135],"STAT1":[136,199,213,241,246,283],"STAT3,":[138],"we":[139],"hypothesized":[140],"IL-7-dependent":[142],"modulation":[143],"STATs":[145,171],"can":[147],"influence":[148],"cells":[155,181,207,232],"from":[156,182,233],"patients.":[158],"tested":[160],"whether":[161],"\u03b3c-cytokines":[163],"IL-2,":[164,267],"IL-7,":[165,191],"IL-15":[166,194,270],"effect":[169,255],"their":[174],"impact":[175,286],"signaling":[178],"healthy":[183,228],"controls.":[184],"found":[186,224],"addition":[189],"IL-2":[192],"significantly":[195,239],"increased":[196,240],"STAT3":[201,215],"led":[209],"upon":[217,248],"vitro":[220,250],"stimulation.":[221],"also":[223],"controls,":[229],"infected":[235],"had":[237],"showed":[244],"stimulation":[251],"IL-27.":[253],"was":[256],"not":[257],"observed":[258],"These":[263],"data":[264],"suggest":[265],"modulate":[271],"signaling.":[273],"context":[276],"IL-27-dependent":[282],"may":[285],"function.":[292]},"counts_by_year":[],"updated_date":"2026-09-24T07:57:37.273135","created_date":"2023-01-06T00:00:00"}