{"id":"https://openalex.org/W4313353318","doi":"https://doi.org/10.4049/jimmunol.188.supp.53.10","title":"Specialized proresolution mediators enhance human B cell differentiation to antibody secreting cells (53.10)","display_name":"Specialized proresolution mediators enhance human B cell differentiation to antibody secreting cells (53.10)","publication_year":2012,"publication_date":"2012-05-01","ids":{"openalex":"https://openalex.org/W4313353318","doi":"https://doi.org/10.4049/jimmunol.188.supp.53.10"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.188.supp.53.10","doi":"https://doi.org/10.4049/jimmunol.188.supp.53.10","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.188.supp.53.10","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083203540","display_name":"Sesquile Ramon","orcid":"https://orcid.org/0000-0003-4897-7788","observed_orcids":["https://orcid.org/0000-0003-4897-7788"]},"institutions":[{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sesquile Ramon","raw_affiliation_strings":["Microbiology and Immunology, University of Rochester Med. Center , Rochester, NY","1Microbiology and Immunology, University of Rochester Med. Center, Rochester, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microbiology and Immunology, University of Rochester Med. Center , Rochester, NY","institution_ids":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"raw_affiliation_string":"1Microbiology and Immunology, University of Rochester Med. Center, Rochester, NY","institution_ids":["https://openalex.org/I28792581","https://openalex.org/I5388228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029525374","display_name":"Charles Nicholas Serhan","orcid":"https://orcid.org/0000-0003-4627-8545","observed_orcids":["https://orcid.org/0000-0003-4627-8545"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles Serhan","raw_affiliation_strings":["Anesthesiology, Brigham and Women's Hosp. , Boston, MA","2Anesthesiology, Brigham and Women's Hosp., Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anesthesiology, Brigham and Women's Hosp. , Boston, MA","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"2Anesthesiology, Brigham and Women's Hosp., Boston, MA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064982745","display_name":"Richard P. Phipps","orcid":"https://orcid.org/0000-0002-6428-1388","observed_orcids":["https://orcid.org/0000-0002-6428-1388"]},"institutions":[{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard Phipps","raw_affiliation_strings":["Microbiology and Immunology, University of Rochester Med. Center , Rochester, NY","1Microbiology and Immunology, University of Rochester Med. Center, Rochester, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microbiology and Immunology, University of Rochester Med. Center , Rochester, NY","institution_ids":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"raw_affiliation_string":"1Microbiology and Immunology, University of Rochester Med. Center, Rochester, NY","institution_ids":["https://openalex.org/I28792581","https://openalex.org/I5388228"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"188","issue":"1_Supplement","first_page":"53.10","last_page":"53.10"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/b-cell-differentiation","display_name":"B cell differentiation","score":0.9330000281333923},{"id":"https://openalex.org/keywords/antibody-secreting-cells","display_name":"antibody-secreting cells","score":0.953000009059906},{"id":"https://openalex.org/keywords/resolvin-d1","display_name":"resolvin D1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/protectin-d1","display_name":"protectin D1","score":0.9419999718666077},{"id":"https://openalex.org/keywords/lipoxins","display_name":"lipoxins","score":0.699999988079071},{"id":"https://openalex.org/keywords/resolvins","display_name":"resolvins","score":0.9649999737739563},{"id":"https://openalex.org/keywords/maresins","display_name":"maresins","score":0.7950000166893005},{"id":"https://openalex.org/keywords/blimp-1","display_name":"Blimp-1","score":0.7760000228881836},{"id":"https://openalex.org/keywords/xbp1","display_name":"XBP1","score":0.949999988079071},{"id":"https://openalex.org/keywords/pax-5","display_name":"Pax-5","score":0.9940000176429749},{"id":"https://openalex.org/keywords/plasma-cell-differentiation","display_name":"plasma cell differentiation","score":0.6990000009536743},{"id":"https://openalex.org/keywords/resolution-of-inflammation","display_name":"inflammation resolution","score":0.8650000095367432},{"id":"https://openalex.org/keywords/adjuvants","display_name":"adjuvants","score":0.7369999885559082},{"id":"https://openalex.org/keywords/anti-inflammatory-therapy","display_name":"anti-inflammatory therapy","score":0.7559999823570251}],"concepts":[{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.6798372864723206},{"id":"https://openalex.org/C180899940","wikidata":"https://www.wikidata.org/wiki/Q117982","display_name":"Lipid signaling","level":3,"score":0.6096230745315552},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5971099138259888},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5932908058166504},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.517716646194458},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.511216402053833},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4901807904243469},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.4477366507053375},{"id":"https://openalex.org/C2778453870","wikidata":"https://www.wikidata.org/wiki/Q188930","display_name":"B cell","level":3,"score":0.41627490520477295},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3296378254890442}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4049/jimmunol.188.supp.53.10","doi":"https://doi.org/10.4049/jimmunol.188.supp.53.10","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.188.supp.53.10","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2113364393","https://openalex.org/W2306942050","https://openalex.org/W4322095691","https://openalex.org/W2517461385","https://openalex.org/W4281676746","https://openalex.org/W965728056","https://openalex.org/W3082774434","https://openalex.org/W7037511275","https://openalex.org/W2810931297","https://openalex.org/W2070057682"],"abstract_inverted_index":{"Abstract":[0],"The":[1,115,162],"resolution":[2],"of":[3,25,36,54,60,64,71,105,125,133,154,176,182,194],"inflammation":[4,26,183],"is":[5],"an":[6,122],"active":[7],"and":[8,43,69,113,139,141,159,168,184,198,201],"dynamic":[9],"process":[10,24],"critical":[11],"in":[12,164],"maintaining":[13],"homeostasis.":[14],"Newly":[15],"identified":[16],"lipid-derived":[17],"mediators":[18,31],"are":[19,81,119,160],"key":[20],"players":[21],"during":[22,178],"the":[23,55,87,103,131,134,155,173,179,191],"resolution.":[27],"These":[28,187],"specialized":[29],"proresolution":[30],"(SPM)":[32],"constitute":[33],"separate":[34],"classes":[35],"compounds,":[37],"which":[38],"include":[39],"lipoxins,":[40],"resolvins,":[41],"protectins":[42],"maresins,":[44],"all":[45],"derived":[46],"from":[47],"essential":[48],"fatty":[49],"acids.":[50],"SPM":[51,89,129,156,177,195],"regulate":[52,130],"aspects":[53],"immune":[56],"response,":[57],"including":[58],"inhibition":[59],"neutrophil":[61],"infiltration,":[62],"reduction":[63],"T":[65],"cell":[66,144,151,166],"cytokine":[67],"production":[68,170],"stimulation":[70],"macrophage":[72],"phagocytic":[73],"activity.":[74],"However,":[75],"their":[76],"effects":[77],"on":[78],"B":[79,108,143],"lymphocytes":[80],"unknown.":[82],"Our":[83],"study":[84],"shows":[85],"that":[86],"novel":[88],"17-hydroxydosahexaenoic":[90],"acid":[91],"(17-HDHA),":[92],"resolvin":[93],"D1":[94,99],"(RvD1)":[95],"but":[96],"not":[97],"protectin":[98],"(PD1),":[100],"strongly":[101],"increase":[102,163],"ability":[104],"normal":[106],"human":[107],"cells":[109],"to":[110,121],"produce":[111],"IgM":[112],"IgG.":[114],"increased":[116,123],"antibody":[117,149,169],"levels":[118],"due":[120],"number":[124],"antibody-secreting":[126],"cells.":[127],"Furthermore,":[128],"expression":[132],"transcription":[135],"factors":[136],"Blimp-1,":[137],"Xbp-1":[138],"Pax-5,":[140],"promote":[142],"differentiation":[145,167],"towards":[146],"a":[147],"CD27+CD38+":[148],"secreting":[150],"phenotype.":[152],"None":[153],"affect":[157],"proliferation":[158],"non-toxic.":[161],"plasma":[165],"coincides":[171],"with":[172],"known":[174],"involvement":[175],"late":[180],"stages":[181],"pathogen":[185],"clearance.":[186],"new":[188],"findings":[189],"highlight":[190],"potential":[192],"applications":[193],"as":[196],"endogenous":[197],"non-toxic":[199],"adjuvants":[200],"anti-inflammatory":[202],"therapeutic":[203],"molecules.":[204]},"counts_by_year":[],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2023-01-06T00:00:00"}