{"id":"https://openalex.org/W4313349770","doi":"https://doi.org/10.4049/jimmunol.184.supp.143.16","title":"Oligoclonality and innate-like features in the TCR repertoire of type II NKT cells reactive to a \u03b2-linked self-glycolipid (143.16)","display_name":"Oligoclonality and innate-like features in the TCR repertoire of type II NKT cells reactive to a \u03b2-linked self-glycolipid (143.16)","publication_year":2010,"publication_date":"2010-04-01","ids":{"openalex":"https://openalex.org/W4313349770","doi":"https://doi.org/10.4049/jimmunol.184.supp.143.16"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.184.supp.143.16","doi":"https://doi.org/10.4049/jimmunol.184.supp.143.16","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.184.supp.143.16","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008923363","display_name":"Philomena Arrenberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40399489","display_name":"Torrey Pines Institute For Molecular Studies","ror":"https://ror.org/01grq2104","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I40399489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Philomena Arrenberg","raw_affiliation_strings":["Torrey Pines Institute for Molecular Studies , San Diego, CA","1Torrey Pines Institute for Molecular Studies, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Torrey Pines Institute for Molecular Studies , San Diego, CA","institution_ids":["https://openalex.org/I40399489"]},{"raw_affiliation_string":"1Torrey Pines Institute for Molecular Studies, San Diego, CA","institution_ids":["https://openalex.org/I40399489"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113307007","display_name":"Ramesh Chandra Halder","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40399489","display_name":"Torrey Pines Institute For Molecular Studies","ror":"https://ror.org/01grq2104","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I40399489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ramesh Halder","raw_affiliation_strings":["Torrey Pines Institute for Molecular Studies , San Diego, CA","1Torrey Pines Institute for Molecular Studies, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Torrey Pines Institute for Molecular Studies , San Diego, CA","institution_ids":["https://openalex.org/I40399489"]},{"raw_affiliation_string":"1Torrey Pines Institute for Molecular Studies, San Diego, CA","institution_ids":["https://openalex.org/I40399489"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025440962","display_name":"Yang David Dai","orcid":"https://orcid.org/0000-0002-7638-849X","observed_orcids":["https://orcid.org/0000-0002-7638-849X"]},"institutions":[{"id":"https://openalex.org/I40399489","display_name":"Torrey Pines Institute For Molecular Studies","ror":"https://ror.org/01grq2104","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I40399489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yang Dai","raw_affiliation_strings":["Torrey Pines Institute for Molecular Studies , San Diego, CA","1Torrey Pines Institute for Molecular Studies, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Torrey Pines Institute for Molecular Studies , San Diego, CA","institution_ids":["https://openalex.org/I40399489"]},{"raw_affiliation_string":"1Torrey Pines Institute for Molecular Studies, San Diego, CA","institution_ids":["https://openalex.org/I40399489"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019987457","display_name":"Igor Maricic","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40399489","display_name":"Torrey Pines Institute For Molecular Studies","ror":"https://ror.org/01grq2104","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I40399489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Igor Maricic","raw_affiliation_strings":["Torrey Pines Institute for Molecular Studies , San Diego, CA","1Torrey Pines Institute for Molecular Studies, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Torrey Pines Institute for Molecular Studies , San Diego, CA","institution_ids":["https://openalex.org/I40399489"]},{"raw_affiliation_string":"1Torrey Pines Institute for Molecular Studies, San Diego, CA","institution_ids":["https://openalex.org/I40399489"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072512711","display_name":"Vipin Kumar","orcid":"https://orcid.org/0000-0002-2838-2472","observed_orcids":["https://orcid.org/0000-0002-2838-2472"]},"institutions":[{"id":"https://openalex.org/I40399489","display_name":"Torrey Pines Institute For Molecular Studies","ror":"https://ror.org/01grq2104","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I40399489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vipin Kumar","raw_affiliation_strings":["Torrey Pines Institute for Molecular Studies , San Diego, CA","1Torrey Pines Institute for Molecular Studies, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Torrey Pines Institute for Molecular Studies , San Diego, CA","institution_ids":["https://openalex.org/I40399489"]},{"raw_affiliation_string":"1Torrey Pines Institute for Molecular Studies, San Diego, CA","institution_ids":["https://openalex.org/I40399489"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I40399489"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"184","issue":"Supplement_1","first_page":"143.16","last_page":"143.16"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-ii-nkt-cells","display_name":"type II NKT cells","score":0.996999979019165},{"id":"https://openalex.org/keywords/cd1d-restricted-t-cells","display_name":"CD1d-restricted T cells","score":0.8339999914169312},{"id":"https://openalex.org/keywords/sulfatide","display_name":"sulfatide","score":0.9150000214576721},{"id":"https://openalex.org/keywords/tcr-repertoire","display_name":"T cell receptor repertoire","score":0.8500000238418579},{"id":"https://openalex.org/keywords/tcr-gene-usage","display_name":"TCR gene usage","score":0.6290000081062317},{"id":"https://openalex.org/keywords/cdr3-length","display_name":"CDR3 length","score":0.6899999976158142},{"id":"https://openalex.org/keywords/innate-like-t-cells","display_name":"innate-like T cells","score":0.6690000295639038},{"id":"https://openalex.org/keywords/oligoclonality","display_name":"oligoclonality","score":0.7020000219345093},{"id":"https://openalex.org/keywords/cd1d-tetramer","display_name":"CD1d tetramer","score":0.625},{"id":"https://openalex.org/keywords/autoimmunity","display_name":"autoimmunity","score":0.7160000205039978},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.8560000061988831},{"id":"https://openalex.org/keywords/invariant-nkt-cells","display_name":"invariant NKT cells","score":0.5820000171661377}],"concepts":[{"id":"https://openalex.org/C2778607024","wikidata":"https://www.wikidata.org/wiki/Q4216825","display_name":"CD1D","level":5,"score":0.8163036108016968},{"id":"https://openalex.org/C19317047","wikidata":"https://www.wikidata.org/wiki/Q412037","display_name":"T-cell receptor","level":4,"score":0.7821478247642517},{"id":"https://openalex.org/C139563560","wikidata":"https://www.wikidata.org/wiki/Q224930","display_name":"Natural killer T cell","level":4,"score":0.6736434698104858},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6722001433372498},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.48301446437835693},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.4792197346687317},{"id":"https://openalex.org/C22222904","wikidata":"https://www.wikidata.org/wiki/Q422882","display_name":"Glycolipid","level":2,"score":0.44250521063804626},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.42962589859962463},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.37415289878845215},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3486670255661011},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3460562229156494},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2982841730117798},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.24402841925621033},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2224915325641632}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4049/jimmunol.184.supp.143.16","doi":"https://doi.org/10.4049/jimmunol.184.supp.143.16","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.184.supp.143.16","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1987471913","https://openalex.org/W7100576184","https://openalex.org/W2013089842","https://openalex.org/W2464224402","https://openalex.org/W1586480373","https://openalex.org/W791235142","https://openalex.org/W2323847384","https://openalex.org/W2243106965","https://openalex.org/W1524552658","https://openalex.org/W122494755"],"abstract_inverted_index":{"Abstract":[0],"CD1d-restricted":[1,203],"type":[2,11,43,144,147,169],"II":[3,44,148,170],"NKT":[4,13,45,149,171],"cells":[5,14,172,205],"are":[6,16,140],"distinct":[7],"from":[8,211],"the":[9,23,38,63,71,137,158,183,197],"invariant":[10],"I":[12,145],"and":[15,32,55,73,85,97,101,122,146,152,215,219],"poorly":[17],"characterized.":[18],"A":[19],"major":[20],"subset":[21,47],"recognizes":[22],"\u03b2-linked":[24,200],"self-glycolipid":[25],"sulfatide,":[26],"playing":[27],"a":[28],"role":[29],"in":[30,48,136,206],"autoimmunity":[31],"anti-tumor":[33],"immunity.":[34],"Here,":[35],"we":[36,66],"analyzed":[37],"TCR":[39,52,64,90,120,177],"repertoire":[40],"of":[41,58,70,81,106,118,167,182,186,199],"this":[42],"cell":[46],"mouse,":[49],"using":[50],"flowcytometry,":[51],"gene":[53,75,99,179],"sequencing":[54],"spectratyping":[56],"analysis":[57],"sorted":[59],"sulfatide/CD1d-tetramer+":[60],"cells.":[61,190],"For":[62],"\u03b2-chain,":[65],"found":[67],"predominant":[68],"usage":[69,180],"V\u03b28.1/V\u03b23.1":[72],"J\u03b22.7":[74],"segments":[76,100],"with":[77],"few":[78],"dominant":[79],"clonotypes":[80],"restricted":[82],"CDR3":[83,116],"lengths":[84,111],"conserved":[86,113,141],"acidic":[87],"residues.":[88,115],"The":[89],"\u03b1-chain":[91],"was":[92],"predominantly":[93],"encoded":[94,125],"by":[95,126,202,209],"V\u03b11/V\u03b13":[96],"J\u03b17/J\u03b19":[98],"showed":[102],"defined":[103],"CDR3\u03b1":[104],"regions":[105,117,154],"8":[107],"or":[108,129],"9":[109],"a.a.":[110],"comprising":[112],"basic":[114],"both":[119],"\u03b1-":[121],"\u03b2-chains":[123],"were":[124],"germline":[127],"sequences":[128],"N-additions.":[130],"Though":[131],"potential":[132],"CD1d-binding":[133],"tyrosine":[134],"residues":[135],"CDR2\u03b2":[138],"region":[139],"between":[142,157],"most":[143],"TCRs,":[150],"CDR1\u03b1":[151],"3\u03b1":[153],"differ":[155],"significantly":[156],"two":[159],"subsets.":[160],"Collectively,":[161],"these":[162],"findings":[163],"emphasize":[164],"innate-like":[165],"features":[166],"sulfatide-reactive":[168],"as":[173,175],"well":[174],"oligoclonal":[176],"V\u03b1-J\u03b1/V\u03b2-J\u03b2":[178],"characteristic":[181],"antigen-specific":[184],"responses":[185],"conventional":[187],"MHC-restricted":[188],"T":[189,204],"These":[191],"data":[192],"provide":[193],"important":[194],"clues":[195],"to":[196],"recognition":[198],"glycolipids":[201],"general.":[207],"(Supported":[208],"grants":[210],"NIH,":[212],"JDRF,":[213],"MSNRC":[214],"DNRG":[216],"(to":[217,221],"VK)":[218],"DFG":[220],"PA).)":[222]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2023-01-06T00:00:00"}