{"id":"https://openalex.org/W4313348355","doi":"https://doi.org/10.1101/2022.12.29.522099","title":"Ketamine modulates a norepinephrine-astroglial circuit to persistently suppress futility-induced passivity","display_name":"Ketamine modulates a norepinephrine-astroglial circuit to persistently suppress futility-induced passivity","publication_year":2022,"publication_date":"2022-12-29","ids":{"openalex":"https://openalex.org/W4313348355","doi":"https://doi.org/10.1101/2022.12.29.522099"},"language":"en","primary_location":{"id":"doi:10.1101/2022.12.29.522099","doi":"https://doi.org/10.1101/2022.12.29.522099","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2022.12.29.522099","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2022/12/29/2022.12.29.522099.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2022/12/29/2022.12.29.522099.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035785911","display_name":"Marc Duque","orcid":"https://orcid.org/0000-0003-2999-4283","observed_orcids":["https://orcid.org/0000-0003-2999-4283"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Marc Duque","raw_affiliation_strings":["Department of Molecular and Cellular Biology, Harvard University; Cambridge, MA 02138, USA","Graduate Program in Neuroscience, Harvard Medical School; Boston, MA 02115, USA","Boston, MA 0115, USA","Cambridge, MA 0238, USA","Department of Molecular and Cellular Biology, Harvard University","Graduate Program in Neuroscience, Harvard Medical School"],"raw_orcid":"https://orcid.org/0000-0003-2999-4283","affiliations":[{"raw_affiliation_string":"Department of Molecular and Cellular Biology, Harvard University; Cambridge, MA 02138, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Graduate Program in Neuroscience, Harvard Medical School; Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Boston, MA 0115, USA","institution_ids":[]},{"raw_affiliation_string":"Cambridge, MA 0238, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Molecular and Cellular Biology, Harvard University","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Graduate Program in Neuroscience, Harvard Medical School","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081265465","display_name":"Alex Chen","orcid":"https://orcid.org/0000-0003-3950-4460","observed_orcids":["https://orcid.org/0000-0003-3950-4460"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I195573530","display_name":"Janelia Research Campus","ror":"https://ror.org/013sk6x84","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410","https://openalex.org/I195573530"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Alex B. Chen","raw_affiliation_strings":["Department of Molecular and Cellular Biology, Harvard University; Cambridge, MA 02138, USA","Graduate Program in Neuroscience, Harvard Medical School; Boston, MA 02115, USA","Janelia Research Campus, Howard Hughes Medical Institute; Ashburn, VA 20147, USA","Ashburn, VA 20147, USA","Boston, MA 0115, USA","Cambridge, MA 0238, USA","Department of Molecular and Cellular Biology, Harvard University","Graduate Program in Neuroscience, Harvard Medical School","Janelia Research Campus, Howard Hughes Medical Institute"],"raw_orcid":"https://orcid.org/0000-0003-3950-4460","affiliations":[{"raw_affiliation_string":"Department of Molecular and Cellular Biology, Harvard University; Cambridge, MA 02138, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Graduate Program in Neuroscience, Harvard Medical School; Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Janelia Research Campus, Howard Hughes Medical Institute; Ashburn, VA 20147, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I195573530"]},{"raw_affiliation_string":"Ashburn, VA 20147, USA","institution_ids":[]},{"raw_affiliation_string":"Boston, MA 0115, USA","institution_ids":[]},{"raw_affiliation_string":"Cambridge, MA 0238, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Molecular and Cellular Biology, Harvard University","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Graduate Program in Neuroscience, Harvard Medical School","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Janelia Research Campus, Howard Hughes Medical Institute","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I195573530"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044519575","display_name":"Eric T. Hsu","orcid":"https://orcid.org/0000-0002-3232-6131","observed_orcids":["https://orcid.org/0000-0002-3232-6131"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eric Hsu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3232-6131","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087968625","display_name":"Sujatha Narayan","orcid":"https://orcid.org/0000-0002-3741-1319","observed_orcids":["https://orcid.org/0000-0002-3741-1319"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I195573530","display_name":"Janelia Research Campus","ror":"https://ror.org/013sk6x84","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410","https://openalex.org/I195573530"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sujatha Narayan","raw_affiliation_strings":["Janelia Research Campus, Howard Hughes Medical Institute; Ashburn, VA 20147, USA","Ashburn, VA 20147, USA","Janelia Research Campus, Howard Hughes Medical Institute"],"raw_orcid":"https://orcid.org/0000-0002-3741-1319","affiliations":[{"raw_affiliation_string":"Janelia Research Campus, Howard Hughes Medical Institute; Ashburn, VA 20147, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I195573530"]},{"raw_affiliation_string":"Ashburn, VA 20147, USA","institution_ids":[]},{"raw_affiliation_string":"Janelia Research Campus, Howard Hughes Medical Institute","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I195573530"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5098059539","display_name":"Altyn Rymbek","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Altyn Rymbek","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004325700","display_name":"Shahinoor Begum","orcid":"https://orcid.org/0009-0003-3472-4605","observed_orcids":["https://orcid.org/0009-0003-3472-4605"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shahinoor Begum","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072237751","display_name":"Gesine Saher","orcid":"https://orcid.org/0000-0003-3507-9604","observed_orcids":["https://orcid.org/0000-0003-3507-9604"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gesine Saher","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3507-9604","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067931881","display_name":"Adam E. Cohen","orcid":"https://orcid.org/0000-0002-8699-2404","observed_orcids":["https://orcid.org/0000-0002-8699-2404"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Adam Ezra Cohen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051474045","display_name":"David E. Olson","orcid":"https://orcid.org/0000-0002-4517-0543","observed_orcids":["https://orcid.org/0000-0002-4517-0543"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David E. Olson","raw_affiliation_strings":["Center for Neuroscience, University of California, Davis; Davis, CA 95618, USA","Department of Biochemistry and Molecular Medicine, School of Medicine, University of California, Davis; Sacramento, CA 95817, USA","Department of Chemistry, University of California, Davis; Davis, CA 95616, USA","Institute for Psychedelics and Neurotherapeutics, University of California, Davis, Davis, CA 95616, USA","Center for Neuroscience, University of California, Davis","Davis, CA 9518, USA","Davis, CA 95616, USA","Department of Biochemistry and Molecular Medicine, School of Medicine, University of California, Davis","Department of Chemistry, University of California, Davis","Sacramento, CA 9817, USA"],"raw_orcid":"https://orcid.org/0000-0002-4517-0543","affiliations":[{"raw_affiliation_string":"Center for Neuroscience, University of California, Davis; Davis, CA 95618, USA","institution_ids":["https://openalex.org/I84218800"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Medicine, School of Medicine, University of California, Davis; Sacramento, CA 95817, USA","institution_ids":["https://openalex.org/I84218800"]},{"raw_affiliation_string":"Department of Chemistry, University of California, Davis; Davis, CA 95616, USA","institution_ids":["https://openalex.org/I84218800"]},{"raw_affiliation_string":"Institute for Psychedelics and Neurotherapeutics, University of California, Davis, Davis, CA 95616, USA","institution_ids":["https://openalex.org/I84218800"]},{"raw_affiliation_string":"Center for Neuroscience, University of California, Davis","institution_ids":["https://openalex.org/I84218800"]},{"raw_affiliation_string":"Davis, CA 9518, USA","institution_ids":[]},{"raw_affiliation_string":"Davis, CA 95616, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Medicine, School of Medicine, University of California, Davis","institution_ids":["https://openalex.org/I84218800"]},{"raw_affiliation_string":"Department of Chemistry, University of California, Davis","institution_ids":["https://openalex.org/I84218800"]},{"raw_affiliation_string":"Sacramento, CA 9817, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063329234","display_name":"David A. Prober","orcid":"https://orcid.org/0000-0002-7371-4675","observed_orcids":["https://orcid.org/0000-0002-7371-4675"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David A Prober","raw_affiliation_strings":["Center for Neuroscience, University of California, Davis","Davis, CA 9518, USA","Davis, CA 95616, USA","Department of Biochemistry and Molecular Medicine, School of Medicine, University of California, Davis","Department of Chemistry, University of California, Davis","Institute for Psychedelics and Neurotherapeutics, University of California, Davis, Davis, CA 95616, USA","Sacramento, CA 9817, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Neuroscience, University of California, Davis","institution_ids":["https://openalex.org/I84218800"]},{"raw_affiliation_string":"Davis, CA 9518, USA","institution_ids":[]},{"raw_affiliation_string":"Davis, CA 95616, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Medicine, School of Medicine, University of California, Davis","institution_ids":["https://openalex.org/I84218800"]},{"raw_affiliation_string":"Department of Chemistry, University of California, Davis","institution_ids":["https://openalex.org/I84218800"]},{"raw_affiliation_string":"Institute for Psychedelics and Neurotherapeutics, University of California, Davis, Davis, CA 95616, USA","institution_ids":["https://openalex.org/I84218800"]},{"raw_affiliation_string":"Sacramento, CA 9817, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045821378","display_name":"Dwight E. Bergles","orcid":"https://orcid.org/0000-0002-7133-7378","observed_orcids":["https://orcid.org/0000-0002-7133-7378"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dwight E Bergles","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7133-7378","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053276209","display_name":"Mark C. Fishman","orcid":"https://orcid.org/0000-0003-0033-541X","observed_orcids":["https://orcid.org/0000-0003-0033-541X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark C Fishman","raw_affiliation_strings":["Department of Stem Cell and Regenerative Biology, Harvard University; Cambridge, MA 02138, USA","Cambridge, MA 0213, USA","Department of Stem Cell and Regenerative Biology, Harvard University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Stem Cell and Regenerative Biology, Harvard University; Cambridge, MA 02138, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Cambridge, MA 0213, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Stem Cell and Regenerative Biology, Harvard University","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082119295","display_name":"Florian Engert","orcid":"https://orcid.org/0000-0001-8169-2990","observed_orcids":["https://orcid.org/0000-0001-8169-2990"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Florian Engert","raw_affiliation_strings":["Department of Molecular and Cellular Biology, Harvard University; Cambridge, MA 02138, USA","Cambridge, MA 0238, USA","Department of Molecular and Cellular Biology, Harvard University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cellular Biology, Harvard University; Cambridge, MA 02138, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Cambridge, MA 0238, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Molecular and Cellular Biology, Harvard University","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050933701","display_name":"Misha B. Ahrens","orcid":"https://orcid.org/0000-0002-3457-4462","observed_orcids":["https://orcid.org/0000-0002-3457-4462"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I195573530","display_name":"Janelia Research Campus","ror":"https://ror.org/013sk6x84","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410","https://openalex.org/I195573530"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Misha B Ahrens","raw_affiliation_strings":["Janelia Research Campus, Howard Hughes Medical Institute; Ashburn, VA 20147, USA","Ashburn, VA 20147, USA","Janelia Research Campus, Howard Hughes Medical Institute"],"raw_orcid":"https://orcid.org/0000-0002-3457-4462","affiliations":[{"raw_affiliation_string":"Janelia Research Campus, Howard Hughes Medical Institute; Ashburn, VA 20147, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I195573530"]},{"raw_affiliation_string":"Ashburn, VA 20147, USA","institution_ids":[]},{"raw_affiliation_string":"Janelia Research Campus, Howard Hughes Medical Institute","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I195573530"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5035785911","https://openalex.org/A5081265465"],"corresponding_institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I136199984","https://openalex.org/I195573530"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.8711000084877014,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.8711000084877014,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.10220000147819519,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.011900000274181366,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ketamine","display_name":"ketamine","score":1.0},{"id":"https://openalex.org/keywords/astroglia","display_name":"astroglia","score":0.7590000033378601},{"id":"https://openalex.org/keywords/norepinephrine","display_name":"norepinephrine","score":0.9330000281333923},{"id":"https://openalex.org/keywords/learned-helplessness","display_name":"learned helplessness","score":0.8209999799728394},{"id":"https://openalex.org/keywords/passivity","display_name":"passivity","score":0.8090000152587891},{"id":"https://openalex.org/keywords/alpha1-adrenergic-receptors","display_name":"alpha1-adrenoceptors","score":0.9359999895095825},{"id":"https://openalex.org/keywords/noradrenergic-neurons","display_name":"noradrenergic neurons","score":0.9440000057220459},{"id":"https://openalex.org/keywords/zebrafish-larvae","display_name":"zebrafish larvae","score":0.8849999904632568},{"id":"https://openalex.org/keywords/antidepressant-mechanism-of-action","display_name":"antidepressant mechanism","score":0.5839999914169312},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.44999998807907104}],"concepts":[{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7925810813903809},{"id":"https://openalex.org/C2776032975","wikidata":"https://www.wikidata.org/wiki/Q5018833","display_name":"Calcium imaging","level":3,"score":0.6370563507080078},{"id":"https://openalex.org/C2780795376","wikidata":"https://www.wikidata.org/wiki/Q243547","display_name":"Ketamine","level":2,"score":0.5321202874183655},{"id":"https://openalex.org/C2776878037","wikidata":"https://www.wikidata.org/wiki/Q169444","display_name":"Zebrafish","level":3,"score":0.5304483771324158},{"id":"https://openalex.org/C2780648746","wikidata":"https://www.wikidata.org/wiki/Q28208871","display_name":"Glutamatergic","level":4,"score":0.5062105059623718},{"id":"https://openalex.org/C67018056","wikidata":"https://www.wikidata.org/wiki/Q414896","display_name":"NMDA receptor","level":3,"score":0.47829753160476685},{"id":"https://openalex.org/C74254510","wikidata":"https://www.wikidata.org/wiki/Q7240508","display_name":"Premovement neuronal activity","level":2,"score":0.4676589071750641},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.465189129114151},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.4525446593761444},{"id":"https://openalex.org/C181080969","wikidata":"https://www.wikidata.org/wiki/Q60097","display_name":"Calcium in biology","level":3,"score":0.43709596991539},{"id":"https://openalex.org/C2777542381","wikidata":"https://www.wikidata.org/wiki/Q502961","display_name":"Astrocyte","level":3,"score":0.42222797870635986},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35177043080329895},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3475499153137207},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.3415378928184509},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2669103741645813},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.25793296098709106},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.21763744950294495},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18817386031150818},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1101/2022.12.29.522099","doi":"https://doi.org/10.1101/2022.12.29.522099","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2022.12.29.522099","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2022/12/29/2022.12.29.522099.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1101/2022.12.29.522099","doi":"https://doi.org/10.1101/2022.12.29.522099","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2022.12.29.522099","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2022/12/29/2022.12.29.522099.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9074000120162964}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3372546951","display_name":null,"funder_award_id":"IIS-1912293","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4793704816","display_name":"CRCNS US-German Research Proposal: Neural Computations Underlying Mechanical -Flow Sensing in Zebrafish","funder_award_id":"1912293","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G4973792023","display_name":"Graduate Research Fellowship Program (GRFP)","funder_award_id":"1745303","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G5867770422","display_name":null,"funder_award_id":"DGE1745303","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000074102","display_name":null,"funder_award_id":"1R01NS124017","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000872143","display_name":"The Heart and the Mind: An Integrative Approach to Brain-Body Interactions in the Zebrafish","funder_award_id":"U19NS104653","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4313348355.pdf","grobid_xml":"https://content.openalex.org/works/W4313348355.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W1532702661","https://openalex.org/W1592147371","https://openalex.org/W1981097208","https://openalex.org/W2005594217","https://openalex.org/W2019751519","https://openalex.org/W2023081218","https://openalex.org/W2033919519","https://openalex.org/W2034265209","https://openalex.org/W2042404539","https://openalex.org/W2044389563","https://openalex.org/W2051685988","https://openalex.org/W2057062357","https://openalex.org/W2059150405","https://openalex.org/W2086305648","https://openalex.org/W2089351762","https://openalex.org/W2105728643","https://openalex.org/W2117124138","https://openalex.org/W2119531941","https://openalex.org/W2121610933","https://openalex.org/W2123476505","https://openalex.org/W2137296158","https://openalex.org/W2189977459","https://openalex.org/W2197078876","https://openalex.org/W2291957660","https://openalex.org/W2310204605","https://openalex.org/W2310949909","https://openalex.org/W2346390990","https://openalex.org/W2418769740","https://openalex.org/W2471673808","https://openalex.org/W2741959390","https://openalex.org/W2785770559","https://openalex.org/W2787343838","https://openalex.org/W2789034326","https://openalex.org/W2808301300","https://openalex.org/W2902980710","https://openalex.org/W2940723333","https://openalex.org/W2941652504","https://openalex.org/W2950418175","https://openalex.org/W2953308498","https://openalex.org/W2991987583","https://openalex.org/W3010499243","https://openalex.org/W3013839449","https://openalex.org/W3086773311","https://openalex.org/W3096208965","https://openalex.org/W3112535936","https://openalex.org/W3114833400","https://openalex.org/W3127186731","https://openalex.org/W3132500005","https://openalex.org/W3157088173","https://openalex.org/W3183790491","https://openalex.org/W3203310594","https://openalex.org/W3205085416","https://openalex.org/W4247665917","https://openalex.org/W4283692276","https://openalex.org/W4297497355"],"related_works":["https://openalex.org/W4405496609","https://openalex.org/W4409627088","https://openalex.org/W2917233765","https://openalex.org/W2571926868","https://openalex.org/W2887303718","https://openalex.org/W3169276507","https://openalex.org/W3038046194","https://openalex.org/W1995094023","https://openalex.org/W4410456134","https://openalex.org/W4390014584"],"abstract_inverted_index":{"Mood-altering":[0],"compounds":[1],"hold":[2],"promise":[3],"for":[4,68,87],"the":[5,100],"treatment":[6],"of":[7,89,93,102,115],"many":[8,69],"psychiatric":[9],"disorders,":[10],"such":[11],"as":[12],"depression,":[13],"but":[14],"connecting":[15],"their":[16],"molecular,":[17],"circuit,":[18],"and":[19,84,96,147],"behavioral":[20,116,136],"effects":[21,31,137],"has":[22],"been":[23],"challenging.":[24],"Here":[25],"we":[26],"find":[27],"that,":[28],"analogous":[29],"to":[30,50,108],"in":[32,43,57,66,119],"rodent":[33],"learned":[34],"helplessness":[35],"models,":[36],"ketamine":[37,62,124,133],"pre-exposure":[38],"persistently":[39,139],"suppresses":[40],"futility-induced":[41],"passivity":[42,110],"larval":[44],"zebrafish.":[45],"While":[46],"antidepressants":[47],"are":[48,106],"thought":[49],"primarily":[51],"act":[52],"on":[53,80],"neurons,":[54],"brain-wide":[55],"imaging":[56],"behaving":[58],"zebrafish":[59],"showed":[60],"that":[61,99,123,132],"elevates":[63,125],"intracellular":[64],"calcium":[65,74,104,127],"astroglia":[67,97],"minutes,":[70],"followed":[71],"by":[72,111,138],"persistent":[73],"downregulation":[75],"post-washout.":[76],"Calcium":[77],"elevation":[78,105],"depends":[79],"astroglial":[81,126],"\u03b11-adrenergic":[82],"receptors":[83],"is":[85],"required":[86],"suppression":[88],"passivity.":[90],"Chemo-/optogenetic":[91],"perturbations":[92],"noradrenergic":[94],"neurons":[95,146],"demonstrate":[98],"aftereffects":[101],"glial":[103],"sufficient":[107],"suppress":[109],"inhibiting":[112],"neuronal-astroglial":[113],"integration":[114],"futility.":[117],"Imaging":[118],"mouse":[120],"cortex":[121],"reveals":[122],"through":[128],"conserved":[129],"pathways,":[130],"suggesting":[131],"exerts":[134],"its":[135],"modulating":[140],"evolutionarily":[141],"ancient":[142],"neuromodulatory":[143],"systems":[144],"spanning":[145],"astroglia.":[148]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2023-01-06T00:00:00"}