{"id":"https://openalex.org/W4313348125","doi":"https://doi.org/10.4049/jimmunol.120.3.939","title":"Aging and the Immune Response","display_name":"Aging and the Immune Response","publication_year":1978,"publication_date":"1978-03-01","ids":{"openalex":"https://openalex.org/W4313348125","doi":"https://doi.org/10.4049/jimmunol.120.3.939","mag":"1771798376","pmid":"https://pubmed.ncbi.nlm.nih.gov/632593"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.120.3.939","doi":"https://doi.org/10.4049/jimmunol.120.3.939","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.120.3.939","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108522072","display_name":"Ian Gardner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ian D Gardner","raw_affiliation_strings":["Division Infectious Diseases, Department of Medicine, Stanford University Medical School , Stanford, California 94305","Division of Allergy, Immunology and Infectious Diseases, Palo Alto Medical Research Foundation , Palo Alto, California 94301","Division Infectious Diseases, Department of Medicine, Stanford University Medical School From the , Palo Alto, California 94301 and the , Stanford, California 94305","From the Division of Allergy, Immunology and Infectious Diseases, Palo Alto Medical Research Foundation, Palo Alto, California 94301 and the Division Infectious Diseases, Department of Medicine, Stanford University Medical School, Stanford, California 94305"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division Infectious Diseases, Department of Medicine, Stanford University Medical School , Stanford, California 94305","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Division of Allergy, Immunology and Infectious Diseases, Palo Alto Medical Research Foundation , Palo Alto, California 94301","institution_ids":[]},{"raw_affiliation_string":"Division Infectious Diseases, Department of Medicine, Stanford University Medical School From the , Palo Alto, California 94301 and the , Stanford, California 94305","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"From the Division of Allergy, Immunology and Infectious Diseases, Palo Alto Medical Research Foundation, Palo Alto, California 94301 and the Division Infectious Diseases, Department of Medicine, Stanford University Medical School, Stanford, California 94305","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109840575","display_name":"Jack S. Remington","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jack S Remington","raw_affiliation_strings":["Division Infectious Diseases, Department of Medicine, Stanford University Medical School , Stanford, California 94305","Division of Allergy, Immunology and Infectious Diseases, Palo Alto Medical Research Foundation , Palo Alto, California 94301","Division Infectious Diseases, Department of Medicine, Stanford University Medical School From the , Palo Alto, California 94301 and the , Stanford, California 94305","From the Division of Allergy, Immunology and Infectious Diseases, Palo Alto Medical Research Foundation, Palo Alto, California 94301 and the Division Infectious Diseases, Department of Medicine, Stanford University Medical School, Stanford, California 94305"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division Infectious Diseases, Department of Medicine, Stanford University Medical School , Stanford, California 94305","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Division of Allergy, Immunology and Infectious Diseases, Palo Alto Medical Research Foundation , Palo Alto, California 94301","institution_ids":[]},{"raw_affiliation_string":"Division Infectious Diseases, Department of Medicine, Stanford University Medical School From the , Palo Alto, California 94301 and the , Stanford, California 94305","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"From the Division of Allergy, Immunology and Infectious Diseases, Palo Alto Medical Research Foundation, Palo Alto, California 94301 and the Division Infectious Diseases, Department of Medicine, Stanford University Medical School, Stanford, California 94305","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":5.0299,"has_fulltext":false,"cited_by_count":124,"citation_normalized_percentile":{"value":0.95746432,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"120","issue":"3","first_page":"939","last_page":"943"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11155","display_name":"Toxoplasma gondii Research Studies","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11155","display_name":"Toxoplasma gondii Research Studies","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13410","display_name":"Immune responses and vaccinations","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.8560000061988831},{"id":"https://openalex.org/keywords/immune-response","display_name":"immune response","score":0.7319999933242798},{"id":"https://openalex.org/keywords/toxoplasma-gondii","display_name":"Toxoplasma gondii","score":0.9890000224113464},{"id":"https://openalex.org/keywords/antibody-response","display_name":"antibody response","score":0.7580000162124634},{"id":"https://openalex.org/keywords/humoral-immunity","display_name":"humoral immunity","score":0.921999990940094},{"id":"https://openalex.org/keywords/tissue-cysts","display_name":"tissue cysts","score":0.7950000166893005},{"id":"https://openalex.org/keywords/latent-infection","display_name":"latent infection","score":0.8700000047683716},{"id":"https://openalex.org/keywords/chronic-infection","display_name":"chronic infection","score":0.9330000281333923},{"id":"https://openalex.org/keywords/age-related-immunosenescence","display_name":"age-related immunosenescence","score":0.8389999866485596},{"id":"https://openalex.org/keywords/intracellular-parasites","display_name":"intracellular parasites","score":0.6190000176429749},{"id":"https://openalex.org/keywords/infection-susceptibility","display_name":"infection susceptibility","score":0.6700000166893005}],"concepts":[{"id":"https://openalex.org/C2778128430","wikidata":"https://www.wikidata.org/wiki/Q131003","display_name":"Toxoplasma gondii","level":3,"score":0.8816296458244324},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.7898008823394775},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6772438883781433},{"id":"https://openalex.org/C3019392825","wikidata":"https://www.wikidata.org/wiki/Q383126","display_name":"Chronic infection","level":3,"score":0.6028541326522827},{"id":"https://openalex.org/C71928629","wikidata":"https://www.wikidata.org/wiki/Q804206","display_name":"Parasite hosting","level":2,"score":0.5805938243865967},{"id":"https://openalex.org/C2780597408","wikidata":"https://www.wikidata.org/wiki/Q193211","display_name":"Cyst","level":2,"score":0.5680016875267029},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5284507274627686},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4598658084869385},{"id":"https://openalex.org/C2779056147","wikidata":"https://www.wikidata.org/wiki/Q1660191","display_name":"Immunosenescence","level":3,"score":0.44800761342048645},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4428941607475281},{"id":"https://openalex.org/C2778062946","wikidata":"https://www.wikidata.org/wiki/Q154878","display_name":"Toxoplasmosis","level":2,"score":0.42174461483955383},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.17659908533096313},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16353806853294373},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000917","descriptor_name":"Antibody Formation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003560","descriptor_name":"Cysts","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004396","descriptor_name":"Coloring Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014124","descriptor_name":"Toxoplasmosis, Animal","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.4049/jimmunol.120.3.939","doi":"https://doi.org/10.4049/jimmunol.120.3.939","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.120.3.939","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:632593","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/632593","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Journal Article"},{"id":"pmh:oai:mouseion.jax.org:ssbb1978-2558","doi":null,"is_oa":false,"landing_page_url":"https://mouseion.jax.org/ssbb1978/1559","pdf_url":null,"source":{"id":"https://openalex.org/S4377196421","display_name":"The Mouseion at the JAXlibrary (Jackson Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210115256","host_organization_name":"Jackson Laboratory","host_organization_lineage":["https://openalex.org/I4210115256"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Subject Strain Bibliography 1978","raw_type":"text"},{"id":"mag:1771798376","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/632593","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1771798376","https://openalex.org/W1551233524","https://openalex.org/W4301163105","https://openalex.org/W1934652287","https://openalex.org/W2580792903","https://openalex.org/W2091233992","https://openalex.org/W1553231704","https://openalex.org/W2075161650","https://openalex.org/W7117652004","https://openalex.org/W2115694713"],"abstract_inverted_index":{"Studies":[0],"were":[1],"performed":[2],"to":[3,49,136,149,162],"determine":[4],"the":[5,10,24,43,56,59,69,77,82,94,97,114,145,157],"effect":[6],"of":[7,23,45,58,68,71,76,84,96,101,106,118,129,132,156],"aging":[8],"on":[9],"antibody":[11],"response":[12,48,148],"and":[13,62],"cyst":[14,164],"formations":[15],"after":[16,90],"infection":[17,61,91,151],"with":[18,31,93,125],"a":[19,39,74],"relatively":[20],"avirulent":[21],"strain":[22],"intracellular":[25],"parasite":[26],"Toxoplasma":[27,72],"gondii.":[28],"When":[29],"compared":[30],"young":[32,122],"mice":[33,37,98,110,135],"(4":[34],"months),":[35],"aged":[36],"showed":[38],"significant":[40],"decrease":[41,52,143],"in":[42,108,144,159],"magnitude":[44],"humoral":[46],"immune":[47,147],"infection.":[50,66,102],"This":[51],"was":[53],"observed":[54],"at":[55,99],"peak":[57],"acute":[60],"also":[63],"during":[64],"chronic":[65],"Evaluation":[67],"presence":[70],"cysts,":[73],"measure":[75],"latent":[78],"infection,":[79],"revealed":[80],"that":[81,140],"numbers":[83,105,165],"tissue":[85],"cysts":[86,107],"present":[87],"11":[88],"weeks":[89],"increased":[92,130,154,163],"age":[95],"time":[100],"The":[103],"larger":[104],"older":[109,134],"which":[111],"had":[112],"received":[113],"same":[115],"inoculum":[116],"size":[117],"T.":[119,137],"gondii":[120],"as":[121],"mice,":[123],"together":[124],"our":[126],"previous":[127],"observations":[128],"susceptibility":[131],"these":[133],"gondii,":[138],"suggest":[139],"an":[141,153],"age-related":[142],"early":[146],"this":[150],"allows":[152],"multiplication":[155],"organism":[158],"vivo,":[160],"leading":[161],"or":[166],"death.":[167]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2023-01-06T00:00:00"}
