{"id":"https://openalex.org/W4313347828","doi":"https://doi.org/10.4049/jimmunol.162.9.5063","title":"An Essential Role for NF-\u03baB in IL-18-Induced IFN-\u03b3 Expression in KG-1 Cells","display_name":"An Essential Role for NF-\u03baB in IL-18-Induced IFN-\u03b3 Expression in KG-1 Cells","publication_year":1999,"publication_date":"1999-05-01","ids":{"openalex":"https://openalex.org/W4313347828","doi":"https://doi.org/10.4049/jimmunol.162.9.5063","mag":"1537817561","pmid":"https://pubmed.ncbi.nlm.nih.gov/10227974"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.162.9.5063","doi":"https://doi.org/10.4049/jimmunol.162.9.5063","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.162.9.5063","pdf_url":"https://journals.aai.org/jimmunol/article-pdf/162/9/5063/1103027/5063.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://journals.aai.org/jimmunol/article-pdf/162/9/5063/1103027/5063.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108725627","display_name":"Hirotada Kojima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104993","display_name":"Hayashibara (Japan)","ror":"https://ror.org/01rvpy991","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210104993"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hirotada Kojima","raw_affiliation_strings":["Fujisaki Institute, Hayashibara Biochemical Laboratories Inc. , Fujisaki, Okayama ,","Fujisaki Institute, Hayashibara Biochemical Laboratories Inc., Fujisaki, Okayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fujisaki Institute, Hayashibara Biochemical Laboratories Inc. , Fujisaki, Okayama ,","institution_ids":["https://openalex.org/I4210104993"]},{"raw_affiliation_string":"Fujisaki Institute, Hayashibara Biochemical Laboratories Inc., Fujisaki, Okayama, Japan","institution_ids":["https://openalex.org/I4210104993"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yasushi Aizawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104993","display_name":"Hayashibara (Japan)","ror":"https://ror.org/01rvpy991","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210104993"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasushi Aizawa","raw_affiliation_strings":["Fujisaki Institute, Hayashibara Biochemical Laboratories Inc. , Fujisaki, Okayama ,","Fujisaki Institute, Hayashibara Biochemical Laboratories Inc., Fujisaki, Okayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fujisaki Institute, Hayashibara Biochemical Laboratories Inc. , Fujisaki, Okayama ,","institution_ids":["https://openalex.org/I4210104993"]},{"raw_affiliation_string":"Fujisaki Institute, Hayashibara Biochemical Laboratories Inc., Fujisaki, Okayama, Japan","institution_ids":["https://openalex.org/I4210104993"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069410225","display_name":"Yoshiaki Yanai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104993","display_name":"Hayashibara (Japan)","ror":"https://ror.org/01rvpy991","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210104993"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshiaki Yanai","raw_affiliation_strings":["Fujisaki Institute, Hayashibara Biochemical Laboratories Inc. , Fujisaki, Okayama ,","Fujisaki Institute, Hayashibara Biochemical Laboratories Inc., Fujisaki, Okayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fujisaki Institute, Hayashibara Biochemical Laboratories Inc. , Fujisaki, Okayama ,","institution_ids":["https://openalex.org/I4210104993"]},{"raw_affiliation_string":"Fujisaki Institute, Hayashibara Biochemical Laboratories Inc., Fujisaki, Okayama, Japan","institution_ids":["https://openalex.org/I4210104993"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040772073","display_name":"Katsue Nagaoka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104993","display_name":"Hayashibara (Japan)","ror":"https://ror.org/01rvpy991","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210104993"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Katsue Nagaoka","raw_affiliation_strings":["Fujisaki Institute, Hayashibara Biochemical Laboratories Inc. , Fujisaki, Okayama ,","Fujisaki Institute, Hayashibara Biochemical Laboratories Inc., Fujisaki, Okayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fujisaki Institute, Hayashibara Biochemical Laboratories Inc. , Fujisaki, Okayama ,","institution_ids":["https://openalex.org/I4210104993"]},{"raw_affiliation_string":"Fujisaki Institute, Hayashibara Biochemical Laboratories Inc., Fujisaki, Okayama, Japan","institution_ids":["https://openalex.org/I4210104993"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101592326","display_name":"Makoto Takeuchi","orcid":"https://orcid.org/0000-0003-2856-0264","observed_orcids":["https://orcid.org/0000-0003-2856-0264"]},"institutions":[{"id":"https://openalex.org/I4210104993","display_name":"Hayashibara (Japan)","ror":"https://ror.org/01rvpy991","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210104993"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Makoto Takeuchi","raw_affiliation_strings":["Fujisaki Institute, Hayashibara Biochemical Laboratories Inc. , Fujisaki, Okayama ,","Fujisaki Institute, Hayashibara Biochemical Laboratories Inc., Fujisaki, Okayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fujisaki Institute, Hayashibara Biochemical Laboratories Inc. , Fujisaki, Okayama ,","institution_ids":["https://openalex.org/I4210104993"]},{"raw_affiliation_string":"Fujisaki Institute, Hayashibara Biochemical Laboratories Inc., Fujisaki, Okayama, Japan","institution_ids":["https://openalex.org/I4210104993"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112505889","display_name":"Tsunetaka Ohta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104993","display_name":"Hayashibara (Japan)","ror":"https://ror.org/01rvpy991","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210104993"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tsunetaka Ohta","raw_affiliation_strings":["Fujisaki Institute, Hayashibara Biochemical Laboratories Inc. , Fujisaki, Okayama ,","Fujisaki Institute, Hayashibara Biochemical Laboratories Inc., Fujisaki, Okayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fujisaki Institute, Hayashibara Biochemical Laboratories Inc. , Fujisaki, Okayama ,","institution_ids":["https://openalex.org/I4210104993"]},{"raw_affiliation_string":"Fujisaki Institute, Hayashibara Biochemical Laboratories Inc., Fujisaki, Okayama, Japan","institution_ids":["https://openalex.org/I4210104993"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113546236","display_name":"Hakuo Ikegami","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104993","display_name":"Hayashibara (Japan)","ror":"https://ror.org/01rvpy991","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210104993"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hakuo Ikegami","raw_affiliation_strings":["Fujisaki Institute, Hayashibara Biochemical Laboratories Inc. , Fujisaki, Okayama ,","Fujisaki Institute, Hayashibara Biochemical Laboratories Inc., Fujisaki, Okayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fujisaki Institute, Hayashibara Biochemical Laboratories Inc. , Fujisaki, Okayama ,","institution_ids":["https://openalex.org/I4210104993"]},{"raw_affiliation_string":"Fujisaki Institute, Hayashibara Biochemical Laboratories Inc., Fujisaki, Okayama, Japan","institution_ids":["https://openalex.org/I4210104993"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111662812","display_name":"Masao Ikeda","orcid":"https://orcid.org/0009-0009-8990-2708","observed_orcids":["https://orcid.org/0009-0009-8990-2708"]},"institutions":[{"id":"https://openalex.org/I4210104993","display_name":"Hayashibara (Japan)","ror":"https://ror.org/01rvpy991","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210104993"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masao Ikeda","raw_affiliation_strings":["Fujisaki Institute, Hayashibara Biochemical Laboratories Inc. , Fujisaki, Okayama ,","Fujisaki Institute, Hayashibara Biochemical Laboratories Inc., Fujisaki, Okayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fujisaki Institute, Hayashibara Biochemical Laboratories Inc. , Fujisaki, Okayama ,","institution_ids":["https://openalex.org/I4210104993"]},{"raw_affiliation_string":"Fujisaki Institute, Hayashibara Biochemical Laboratories Inc., Fujisaki, Okayama, Japan","institution_ids":["https://openalex.org/I4210104993"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103372479","display_name":"Masashi Kurimoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104993","display_name":"Hayashibara (Japan)","ror":"https://ror.org/01rvpy991","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210104993"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masashi Kurimoto","raw_affiliation_strings":["Fujisaki Institute, Hayashibara Biochemical Laboratories Inc. , Fujisaki, Okayama ,","Fujisaki Institute, Hayashibara Biochemical Laboratories Inc., Fujisaki, Okayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fujisaki Institute, Hayashibara Biochemical Laboratories Inc. , Fujisaki, Okayama ,","institution_ids":["https://openalex.org/I4210104993"]},{"raw_affiliation_string":"Fujisaki Institute, Hayashibara Biochemical Laboratories Inc., Fujisaki, Okayama, Japan","institution_ids":["https://openalex.org/I4210104993"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210104993"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":3.3992,"has_fulltext":true,"cited_by_count":107,"citation_normalized_percentile":{"value":0.93330913,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"162","issue":"9","first_page":"5063","last_page":"5069"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12620","display_name":"Signaling Pathways in Disease","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/il-18","display_name":"IL-18","score":0.8880000114440918},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.8450000286102295},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.9900000095367432},{"id":"https://openalex.org/keywords/kg-1-cells","display_name":"KG-1 cells","score":0.8510000109672546},{"id":"https://openalex.org/keywords/ikappabalpha-degradation","display_name":"I\u03baB\u03b1 degradation","score":0.8149999976158142},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.6970000267028809},{"id":"https://openalex.org/keywords/nf-kappab-binding-site","display_name":"NF-kappaB binding site","score":0.7960000038146973},{"id":"https://openalex.org/keywords/myelomonocytic-cells","display_name":"myelomonocytic cells","score":0.8169999718666077},{"id":"https://openalex.org/keywords/cytokine-induction","display_name":"cytokine induction","score":0.7540000081062317}],"concepts":[{"id":"https://openalex.org/C161733203","wikidata":"https://www.wikidata.org/wiki/Q911828","display_name":"Reporter gene","level":4,"score":0.6676650047302246},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.6387236714363098},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.543157696723938},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5429889559745789},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.541750967502594},{"id":"https://openalex.org/C2777730290","wikidata":"https://www.wikidata.org/wiki/Q411114","display_name":"NF-\u03baB","level":3,"score":0.5413105487823486},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.540073573589325},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.5392334461212158},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.537043035030365},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5074052214622498},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.49092891812324524},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4440152049064636},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4415053427219391},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.4399181604385376},{"id":"https://openalex.org/C27153228","wikidata":"https://www.wikidata.org/wiki/Q3787274","display_name":"Transcriptional regulation","level":4,"score":0.4375315308570862},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3013596534729004},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.196664959192276},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14413827657699585},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000072000","descriptor_name":"NF-KappaB Inhibitor alpha","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002461","descriptor_name":"Cell Line, Transformed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003513","descriptor_name":"Cycloheximide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D012045","descriptor_name":"Regulatory Sequences, Nucleic Acid","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D020382","descriptor_name":"Interleukin-18","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D020382","descriptor_name":"Interleukin-18","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D020672","descriptor_name":"I-kappa B Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.4049/jimmunol.162.9.5063","doi":"https://doi.org/10.4049/jimmunol.162.9.5063","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.162.9.5063","pdf_url":"https://journals.aai.org/jimmunol/article-pdf/162/9/5063/1103027/5063.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:10227974","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10227974","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Journal Article"},{"id":"mag:1537817561","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10227974","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"doi:10.4049/jimmunol.162.9.5063","doi":"https://doi.org/10.4049/jimmunol.162.9.5063","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.162.9.5063","pdf_url":"https://journals.aai.org/jimmunol/article-pdf/162/9/5063/1103027/5063.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320323453","display_name":"Hyogo College of Medicine","ror":"https://ror.org/001yc7927"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4313347828.pdf","grobid_xml":"https://content.openalex.org/works/W4313347828.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W95988660","https://openalex.org/W140877157","https://openalex.org/W1487549623","https://openalex.org/W1492606093","https://openalex.org/W1514942862","https://openalex.org/W1515994079","https://openalex.org/W1522816379","https://openalex.org/W1573683888","https://openalex.org/W1600694014","https://openalex.org/W1727750278","https://openalex.org/W1811517392","https://openalex.org/W1866793215","https://openalex.org/W1964377967","https://openalex.org/W1975602003","https://openalex.org/W1978963848","https://openalex.org/W1979520552","https://openalex.org/W1980768491","https://openalex.org/W1985162445","https://openalex.org/W1986663284","https://openalex.org/W1987869706","https://openalex.org/W1988563171","https://openalex.org/W1988820544","https://openalex.org/W1991137313","https://openalex.org/W1995127434","https://openalex.org/W1995507251","https://openalex.org/W1997509253","https://openalex.org/W2011641869","https://openalex.org/W2023803780","https://openalex.org/W2041828716","https://openalex.org/W2045348184","https://openalex.org/W2053128835","https://openalex.org/W2056831005","https://openalex.org/W2060913542","https://openalex.org/W2061994720","https://openalex.org/W2062346175","https://openalex.org/W2067394439","https://openalex.org/W2067680656","https://openalex.org/W2070597700","https://openalex.org/W2084648778","https://openalex.org/W2101257770","https://openalex.org/W2120872281","https://openalex.org/W2124576546","https://openalex.org/W2134692276","https://openalex.org/W2140707292","https://openalex.org/W2159979956","https://openalex.org/W2161575486","https://openalex.org/W2166781237","https://openalex.org/W2171831396","https://openalex.org/W2410810869","https://openalex.org/W4313308240","https://openalex.org/W4313342465"],"related_works":["https://openalex.org/W1537817561","https://openalex.org/W2080884904","https://openalex.org/W2067394439","https://openalex.org/W2381633829","https://openalex.org/W1529375690","https://openalex.org/W2108219708","https://openalex.org/W1900281246","https://openalex.org/W2003103801","https://openalex.org/W7098695070","https://openalex.org/W2091237142"],"abstract_inverted_index":{"IL-18":[0,43],"is":[1,89],"a":[2,18,45,108],"multifunctional":[3],"cytokine":[4,15],"playing":[5],"various":[6],"regulatory":[7,75],"roles":[8],"in":[9,44,149],"the":[10,25,35,39,52,72,87,96,112,137,141,145,150],"immune":[11],"system":[12],"including":[13],"induced":[14,100],"production.":[16],"As":[17],"part":[19],"of":[20,28,38,54,71,81,95,107,111,120,132,144,152],"our":[21],"ongoing":[22],"studies":[23],"on":[24],"molecular":[26],"mechanisms":[27],"IL-18-induced":[29,93],"IFN-gamma":[30,40,73,97,153],"production,":[31],"we":[32,57],"have":[33,58],"examined":[34],"transcriptional":[36],"regulation":[37,151],"gene":[41,74,83,98,154],"by":[42,101,156],"human":[46],"myelomonocytic":[47],"cell":[48],"line,":[49],"KG-1.":[50],"On":[51],"basis":[53],"DNA/protein":[55],"binding,":[56],"determined":[59],"an":[60,118],"IL-18-inducible":[61],"NF-kappa":[62,127,146],"B":[63,115,124,128,147],"binding":[64],"site":[65],"located":[66],"at":[67],"-786":[68],"to":[69,139],"-776":[70],"region":[76],"(designated":[77],"KBBsite).":[78],"Transient":[79],"transfection":[80],"promoter-reporter":[82],"constructs":[84],"revealed":[85],"that":[86],"KBBsite":[88],"required":[90],"for":[91],"full":[92],"activation":[94],"transcription":[99],"IL-18.":[102,157],"In":[103],"addition,":[104],"stable":[105],"transformants":[106],"dominant-negative":[109],"form":[110],"I":[113,122],"kappa":[114,123],"alpha":[116,125],"showed":[117],"inhibition":[119],"IL-18-dependent":[121],"degradation,":[126],"activation,":[129],"and":[130],"expression":[131,155],"IFN-gamma.":[133],"These":[134],"results":[135],"are":[136],"first":[138],"show":[140],"actual":[142],"significance":[143],"pathway":[148]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2023-01-06T00:00:00"}
