{"id":"https://openalex.org/W4313347683","doi":"https://doi.org/10.4049/jimmunol.163.3.1521","title":"Regulation of Cytokines, Cytokine Inhibitors, and Acute-Phase Proteins Following Anti-TNF-\u03b1 Therapy in Rheumatoid Arthritis","display_name":"Regulation of Cytokines, Cytokine Inhibitors, and Acute-Phase Proteins Following Anti-TNF-\u03b1 Therapy in Rheumatoid Arthritis","publication_year":1999,"publication_date":"1999-08-01","ids":{"openalex":"https://openalex.org/W4313347683","doi":"https://doi.org/10.4049/jimmunol.163.3.1521","mag":"2101951838","pmid":"https://pubmed.ncbi.nlm.nih.gov/10415055"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.163.3.1521","doi":"https://doi.org/10.4049/jimmunol.163.3.1521","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.163.3.1521","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110954321","display_name":"Peter J Charles","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802369498","display_name":"Charing Cross Hospital","ror":"https://ror.org/02gcp3110","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I153355300","https://openalex.org/I2802369498"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Peter Charles","raw_affiliation_strings":["Department of Rheumatology, Charing Cross Hospital , London ,","*Department of Rheumatology, Charing Cross Hospital, London, United Kingdom;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, Charing Cross Hospital , London ,","institution_ids":["https://openalex.org/I2802369498"]},{"raw_affiliation_string":"*Department of Rheumatology, Charing Cross Hospital, London, United Kingdom;","institution_ids":["https://openalex.org/I2802369498"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109831417","display_name":"Michael J. Elliott","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405264228","display_name":"Kennedy Institute of Rheumatology","ror":"https://ror.org/01ahsqc77","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149","https://openalex.org/I4405264228"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Michael J Elliott","raw_affiliation_strings":["The Kennedy Institute of Rheumatology , London ,","\u2020The Kennedy Institute of Rheumatology, London, United Kingdom;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Kennedy Institute of Rheumatology , London ,","institution_ids":["https://openalex.org/I4405264228"]},{"raw_affiliation_string":"\u2020The Kennedy Institute of Rheumatology, London, United Kingdom;","institution_ids":["https://openalex.org/I4405264228"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Diana Davis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405264228","display_name":"Kennedy Institute of Rheumatology","ror":"https://ror.org/01ahsqc77","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149","https://openalex.org/I4405264228"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Diana Davis","raw_affiliation_strings":["The Kennedy Institute of Rheumatology , London ,","\u2020The Kennedy Institute of Rheumatology, London, United Kingdom;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Kennedy Institute of Rheumatology , London ,","institution_ids":["https://openalex.org/I4405264228"]},{"raw_affiliation_string":"\u2020The Kennedy Institute of Rheumatology, London, United Kingdom;","institution_ids":["https://openalex.org/I4405264228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113999894","display_name":"A. R. Potter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405264228","display_name":"Kennedy Institute of Rheumatology","ror":"https://ror.org/01ahsqc77","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149","https://openalex.org/I4405264228"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alison Potter","raw_affiliation_strings":["The Kennedy Institute of Rheumatology , London ,","\u2020The Kennedy Institute of Rheumatology, London, United Kingdom;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Kennedy Institute of Rheumatology , London ,","institution_ids":["https://openalex.org/I4405264228"]},{"raw_affiliation_string":"\u2020The Kennedy Institute of Rheumatology, London, United Kingdom;","institution_ids":["https://openalex.org/I4405264228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111538700","display_name":"Joachim Robert Kalden","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088053","display_name":"Universit\u00e4tsklinikum Erlangen","ror":"https://ror.org/0030f2a11","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210088053"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Joachim R Kalden","raw_affiliation_strings":["Institute of Clinical Immunology and Rheumatology , Erlangen ,","\u2021Institute of Clinical Immunology and Rheumatology, Erlangen, Germany;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Clinical Immunology and Rheumatology , Erlangen ,","institution_ids":["https://openalex.org/I4210088053"]},{"raw_affiliation_string":"\u2021Institute of Clinical Immunology and Rheumatology, Erlangen, Germany;","institution_ids":["https://openalex.org/I4210088053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110079095","display_name":"Christian Antoni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088053","display_name":"Universit\u00e4tsklinikum Erlangen","ror":"https://ror.org/0030f2a11","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210088053"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christian Antoni","raw_affiliation_strings":["Institute of Clinical Immunology and Rheumatology , Erlangen ,","\u2021Institute of Clinical Immunology and Rheumatology, Erlangen, Germany;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Clinical Immunology and Rheumatology , Erlangen ,","institution_ids":["https://openalex.org/I4210088053"]},{"raw_affiliation_string":"\u2021Institute of Clinical Immunology and Rheumatology, Erlangen, Germany;","institution_ids":["https://openalex.org/I4210088053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110445652","display_name":"Ferdinand C. Breedveld","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Ferdinand C Breedveld","raw_affiliation_strings":["Department of Rheumatology, University Hospital , Leiden ,","\u00a7Department of Rheumatology, University Hospital, Leiden, The Netherlands;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, University Hospital , Leiden ,","institution_ids":["https://openalex.org/I2800006345"]},{"raw_affiliation_string":"\u00a7Department of Rheumatology, University Hospital, Leiden, The Netherlands;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090753435","display_name":"Josef S Smolen","orcid":"https://orcid.org/0000-0002-4302-8877","observed_orcids":["https://orcid.org/0000-0002-4302-8877"]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Josef S Smolen","raw_affiliation_strings":["University Klinik fur Innere Medizin III , Vienna ,","\u00b6University Klinik fur Innere Medizin III, Vienna, Austria; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Klinik fur Innere Medizin III , Vienna ,","institution_ids":["https://openalex.org/I76134821"]},{"raw_affiliation_string":"\u00b6University Klinik fur Innere Medizin III, Vienna, Austria; and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103535881","display_name":"Gabriele Eberl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088053","display_name":"Universit\u00e4tsklinikum Erlangen","ror":"https://ror.org/0030f2a11","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210088053"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Gabriele Eberl","raw_affiliation_strings":["Institute of Clinical Immunology and Rheumatology , Erlangen ,","\u2021Institute of Clinical Immunology and Rheumatology, Erlangen, Germany;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Clinical Immunology and Rheumatology , Erlangen ,","institution_ids":["https://openalex.org/I4210088053"]},{"raw_affiliation_string":"\u2021Institute of Clinical Immunology and Rheumatology, Erlangen, Germany;","institution_ids":["https://openalex.org/I4210088053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087576743","display_name":"Kimberly L. DeWoody","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kim deWoody","raw_affiliation_strings":["\u2225Centocor, Malvern, PA 19335"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u2225Centocor, Malvern, PA 19335","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057580992","display_name":"Marc Feldmann","orcid":"https://orcid.org/0000-0003-0800-7840","observed_orcids":["https://orcid.org/0000-0003-0800-7840"]},"institutions":[{"id":"https://openalex.org/I4405264228","display_name":"Kennedy Institute of Rheumatology","ror":"https://ror.org/01ahsqc77","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149","https://openalex.org/I4405264228"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Marc Feldmann","raw_affiliation_strings":["The Kennedy Institute of Rheumatology , London ,","\u2020The Kennedy Institute of Rheumatology, London, United Kingdom;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Kennedy Institute of Rheumatology , London ,","institution_ids":["https://openalex.org/I4405264228"]},{"raw_affiliation_string":"\u2020The Kennedy Institute of Rheumatology, London, United Kingdom;","institution_ids":["https://openalex.org/I4405264228"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111772241","display_name":"Ravinder Nath Maini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405264228","display_name":"Kennedy Institute of Rheumatology","ror":"https://ror.org/01ahsqc77","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149","https://openalex.org/I4405264228"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ravinder N Maini","raw_affiliation_strings":["The Kennedy Institute of Rheumatology , London ,","\u2020The Kennedy Institute of Rheumatology, London, United Kingdom;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Kennedy Institute of Rheumatology , London ,","institution_ids":["https://openalex.org/I4405264228"]},{"raw_affiliation_string":"\u2020The Kennedy Institute of Rheumatology, London, United Kingdom;","institution_ids":["https://openalex.org/I4405264228"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":15.1758,"has_fulltext":false,"cited_by_count":570,"citation_normalized_percentile":{"value":0.99563975,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"163","issue":"3","first_page":"1521","last_page":"1528"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.9940000176429749},{"id":"https://openalex.org/keywords/anti-tnf-therapy","display_name":"anti-TNF therapy","score":0.9710000157356262},{"id":"https://openalex.org/keywords/chimeric-monoclonal-antibody","display_name":"chimeric monoclonal antibody","score":0.8529999852180481},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.777999997138977},{"id":"https://openalex.org/keywords/cytokine-inhibitors","display_name":"cytokine inhibitors","score":0.9750000238418579},{"id":"https://openalex.org/keywords/acute-phase-proteins","display_name":"acute phase proteins","score":0.9829999804496765},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.878000020980835},{"id":"https://openalex.org/keywords/soluble-tnf-receptors","display_name":"soluble TNF receptors","score":0.8700000047683716},{"id":"https://openalex.org/keywords/interleukin-1-receptor-antagonist","display_name":"interleukin-1 receptor antagonist","score":0.949999988079071},{"id":"https://openalex.org/keywords/serum-amyloid-a","display_name":"serum amyloid A","score":0.9710000157356262},{"id":"https://openalex.org/keywords/haptoglobin","display_name":"haptoglobin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/fibrinogen","display_name":"fibrinogen","score":1.0},{"id":"https://openalex.org/keywords/diurnal-variation","display_name":"diurnal variation","score":0.9380000233650208},{"id":"https://openalex.org/keywords/cytokine-cascade","display_name":"cytokine cascade","score":0.800000011920929},{"id":"https://openalex.org/keywords/atherosclerosis-risk","display_name":"atherosclerosis risk","score":0.8899999856948853}],"concepts":[{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.7650039196014404},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.7387283444404602},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6656593680381775},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.6562289595603943},{"id":"https://openalex.org/C206396517","wikidata":"https://www.wikidata.org/wiki/Q422025","display_name":"Haptoglobin","level":2,"score":0.6498698592185974},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.6379867792129517},{"id":"https://openalex.org/C57194454","wikidata":"https://www.wikidata.org/wiki/Q424211","display_name":"Acute-phase protein","level":3,"score":0.6379410028457642},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5281681418418884},{"id":"https://openalex.org/C2779036427","wikidata":"https://www.wikidata.org/wiki/Q381899","display_name":"Fibrinogen","level":2,"score":0.5186690092086792},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5155027508735657},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4562793970108032},{"id":"https://openalex.org/C55359608","wikidata":"https://www.wikidata.org/wiki/Q3113038","display_name":"Serum amyloid A","level":3,"score":0.45365893840789795},{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.4221537709236145},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4137255847454071},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36030328273773193},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3300575613975525},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14114224910736084},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000069285","descriptor_name":"Infliximab","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000093242","descriptor_name":"Interleukin-6 Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000209","descriptor_name":"Acute-Phase Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D000209","descriptor_name":"Acute-Phase Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007375","descriptor_name":"Interleukin-1","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D007375","descriptor_name":"Interleukin-1","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008137","descriptor_name":"Longitudinal Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012795","descriptor_name":"Sialoglycoproteins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D018124","descriptor_name":"Receptors, Tumor Necrosis Factor","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D018124","descriptor_name":"Receptors, Tumor Necrosis Factor","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D018501","descriptor_name":"Antirheumatic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018501","descriptor_name":"Antirheumatic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D053590","descriptor_name":"Interleukin 1 Receptor Antagonist Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.4049/jimmunol.163.3.1521","doi":"https://doi.org/10.4049/jimmunol.163.3.1521","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.163.3.1521","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:10415055","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10415055","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Clinical Trial"},{"id":"mag:2101951838","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10415055","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":54,"referenced_works":["https://openalex.org/W63864630","https://openalex.org/W132781887","https://openalex.org/W169058504","https://openalex.org/W192772623","https://openalex.org/W1521359488","https://openalex.org/W1528765374","https://openalex.org/W1892298186","https://openalex.org/W1968376159","https://openalex.org/W1971685694","https://openalex.org/W1973123086","https://openalex.org/W1983693149","https://openalex.org/W1988375787","https://openalex.org/W1989497089","https://openalex.org/W1995344305","https://openalex.org/W1996794055","https://openalex.org/W2006831045","https://openalex.org/W2019737992","https://openalex.org/W2026342001","https://openalex.org/W2031172875","https://openalex.org/W2031670584","https://openalex.org/W2036452124","https://openalex.org/W2039186692","https://openalex.org/W2039499980","https://openalex.org/W2043287930","https://openalex.org/W2045590518","https://openalex.org/W2051355303","https://openalex.org/W2056813079","https://openalex.org/W2058267243","https://openalex.org/W2067761476","https://openalex.org/W2076621710","https://openalex.org/W2084386397","https://openalex.org/W2085096893","https://openalex.org/W2085853581","https://openalex.org/W2086238123","https://openalex.org/W2093446277","https://openalex.org/W2096491169","https://openalex.org/W2101840353","https://openalex.org/W2113504065","https://openalex.org/W2129202470","https://openalex.org/W2133602875","https://openalex.org/W2139162201","https://openalex.org/W2142180500","https://openalex.org/W2142273705","https://openalex.org/W2143037496","https://openalex.org/W2146922459","https://openalex.org/W2152348310","https://openalex.org/W2154746915","https://openalex.org/W2206659032","https://openalex.org/W2315575691","https://openalex.org/W2326254434","https://openalex.org/W2399818948","https://openalex.org/W2464144985","https://openalex.org/W2736164330","https://openalex.org/W4211003773"],"related_works":["https://openalex.org/W2101951838","https://openalex.org/W75787204","https://openalex.org/W2134714663","https://openalex.org/W2091651459","https://openalex.org/W2103708944","https://openalex.org/W2516202125","https://openalex.org/W2079082223","https://openalex.org/W2166830441","https://openalex.org/W2468300504","https://openalex.org/W2103854548"],"abstract_inverted_index":{"Treatment":[0],"with":[1,80],"a":[2,45,54,84,167],"chimeric":[3],"mAb":[4],"to":[5,10,101],"TNF-alpha":[6],"has":[7],"been":[8,31],"shown":[9],"suppress":[11],"inflammation":[12],"and":[13,60,88,130,149,155],"improve":[14],"patient":[15],"well-being":[16],"in":[17,38,49,66,104,141,175],"rheumatoid":[18],"arthritis":[19],"(RA),":[20],"but":[21],"the":[22,50,67,81,89,102],"mechanisms":[23],"of":[24,26,41,53,56,70,72,83,91,123,162],"action":[25],"such":[27,111,126],"treatment":[28],"have":[29],"not":[30],"fully":[32],"explored.":[33],"Here":[34],"we":[35],"show":[36],"that":[37],"vivo":[39],"administration":[40],"anti-TNF-alpha":[42,96],"Ab,":[43],"using":[44],"longitudinal":[46],"analysis,":[47],"results":[48,77],"rapid":[51],"down-regulation":[52],"spectrum":[55],"cytokines,":[57],"cytokine":[58,86,124],"inhibitors,":[59],"acute-phase":[61,142],"proteins.":[62],"Marked":[63],"diurnal":[64],"variation":[65],"serum":[68,146,151],"levels":[69,117,122],"some":[71],"these":[73],"were":[74,78,133],"detected.":[75],"These":[76],"consistent":[79],"concept":[82],"cytokine-dependent":[85],"cascade,":[87],"degree":[90],"clinical":[92],"benefit":[93],"noted":[94],"after":[95,145],"therapy":[97],"is":[98,166,173],"probably":[99],"due":[100],"reduction":[103,159],"many":[105],"proinflammatory":[106],"mediators":[107],"apart":[108],"from":[109],"TNF-alpha,":[110],"as":[112,127,135,164],"IL-6,":[113],"which":[114,172],"reached":[115],"normal":[116],"within":[118],"24":[119],"h.":[120],"Serum":[121],"inhibitors":[125],"soluble":[128],"p75":[129],"p55":[131],"TNFR":[132],"reduced":[134],"was":[136],"IL-1":[137],"receptor":[138],"antagonist.":[139],"Reductions":[140],"proteins":[143],"occurred":[144],"IL-6":[147],"fell":[148],"included":[150],"amyloid":[152],"A,":[153],"haptoglobin,":[154],"fibrinogen.":[156],"The":[157],"latter":[158],"could":[160],"be":[161],"importance,":[163],"it":[165],"risk":[168],"factor":[169],"for":[170],"atherosclerosis,":[171],"augmented":[174],"RA":[176],"patients.":[177]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":20},{"year":2021,"cited_by_count":22},{"year":2020,"cited_by_count":23},{"year":2019,"cited_by_count":16},{"year":2018,"cited_by_count":18},{"year":2017,"cited_by_count":19},{"year":2016,"cited_by_count":23},{"year":2015,"cited_by_count":17},{"year":2014,"cited_by_count":15},{"year":2013,"cited_by_count":20},{"year":2012,"cited_by_count":19}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2023-01-06T00:00:00"}