{"id":"https://openalex.org/W4313335879","doi":"https://doi.org/10.4049/jimmunol.163.3.1110","title":"Cutting Edge: Extracellular Signal-Regulated Kinase Activates Syk: A New Potential Feedback Regulation of Fc\u03b5 Receptor Signaling","display_name":"Cutting Edge: Extracellular Signal-Regulated Kinase Activates Syk: A New Potential Feedback Regulation of Fc\u03b5 Receptor Signaling","publication_year":1999,"publication_date":"1999-08-01","ids":{"openalex":"https://openalex.org/W4313335879","doi":"https://doi.org/10.4049/jimmunol.163.3.1110","mag":"2132196948","pmid":"https://pubmed.ncbi.nlm.nih.gov/10415002"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.163.3.1110","doi":"https://doi.org/10.4049/jimmunol.163.3.1110","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.163.3.1110","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050134236","display_name":"Rong Xu","orcid":"https://orcid.org/0000-0003-3127-4795","observed_orcids":["https://orcid.org/0000-0003-3127-4795"]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Rong Xu","raw_affiliation_strings":["Immunology, The Weizmann Institute of Science , Rehovot ,","*Immunology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunology, The Weizmann Institute of Science , Rehovot ,","institution_ids":["https://openalex.org/I53964585"]},{"raw_affiliation_string":"*Immunology and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079331236","display_name":"Rony Seger","orcid":"https://orcid.org/0000-0001-9363-8852","observed_orcids":["https://orcid.org/0000-0001-9363-8852"]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Rony Seger","raw_affiliation_strings":["Biological Regulation, The Weizmann Institute of Science , Rehovot ,","\u2020Biological Regulation, The Weizmann Institute of Science, Rehovot, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biological Regulation, The Weizmann Institute of Science , Rehovot ,","institution_ids":["https://openalex.org/I53964585"]},{"raw_affiliation_string":"\u2020Biological Regulation, The Weizmann Institute of Science, Rehovot, Israel","institution_ids":["https://openalex.org/I53964585"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021244474","display_name":"Israel Pecht","orcid":"https://orcid.org/0000-0002-1883-9547","observed_orcids":["https://orcid.org/0000-0002-1883-9547"]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Israel Pecht","raw_affiliation_strings":["Immunology, The Weizmann Institute of Science , Rehovot ,","*Immunology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunology, The Weizmann Institute of Science , Rehovot ,","institution_ids":["https://openalex.org/I53964585"]},{"raw_affiliation_string":"*Immunology and","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I53964585"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":0.8727,"has_fulltext":false,"cited_by_count":40,"citation_normalized_percentile":{"value":0.72366585,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"163","issue":"3","first_page":"1110","last_page":"1114"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/syk","display_name":"Syk","score":0.8690000176429749},{"id":"https://openalex.org/keywords/erk1","display_name":"ERK1","score":0.9229999780654907},{"id":"https://openalex.org/keywords/fcepsilonri-signaling","display_name":"Fc\u03b5RI signaling","score":0.8519999980926514},{"id":"https://openalex.org/keywords/mast-cells","display_name":"mast cells","score":0.8100000023841858},{"id":"https://openalex.org/keywords/positive-feedback-regulation","display_name":"positive feedback regulation","score":0.8209999799728394},{"id":"https://openalex.org/keywords/serine-phosphorylation","display_name":"serine phosphorylation","score":0.7289999723434448},{"id":"https://openalex.org/keywords/mek-inhibitors","display_name":"MEK inhibitors","score":0.7860000133514404},{"id":"https://openalex.org/keywords/degranulation","display_name":"degranulation","score":0.8180000185966492},{"id":"https://openalex.org/keywords/rbl-2h3-cells","display_name":"RBL-2H3 cells","score":0.8410000205039978}],"concepts":[{"id":"https://openalex.org/C35174551","wikidata":"https://www.wikidata.org/wiki/Q7660502","display_name":"Syk","level":4,"score":0.8693497776985168},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6009565591812134},{"id":"https://openalex.org/C90934575","wikidata":"https://www.wikidata.org/wiki/Q6593810","display_name":"Mitogen-activated protein kinase kinase","level":4,"score":0.5658767819404602},{"id":"https://openalex.org/C124160383","wikidata":"https://www.wikidata.org/wiki/Q14914383","display_name":"ASK1","level":5,"score":0.5595822334289551},{"id":"https://openalex.org/C159479382","wikidata":"https://www.wikidata.org/wiki/Q18030801","display_name":"MAP2K7","level":5,"score":0.5359234809875488},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.49846935272216797},{"id":"https://openalex.org/C137361374","wikidata":"https://www.wikidata.org/wiki/Q6714442","display_name":"MAP kinase kinase kinase","level":4,"score":0.4851601719856262},{"id":"https://openalex.org/C59143045","wikidata":"https://www.wikidata.org/wiki/Q15314942","display_name":"Cyclin-dependent kinase 9","level":5,"score":0.4817057251930237},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.4686673879623413},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.46660539507865906},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.42371371388435364},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4236315190792084},{"id":"https://openalex.org/C82495950","wikidata":"https://www.wikidata.org/wiki/Q14911732","display_name":"Cyclin-dependent kinase 2","level":4,"score":0.4009701609611511},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39841192960739136},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3909299075603485}],"mesh":[{"descriptor_ui":"D000072377","descriptor_name":"Syk Kinase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000941","descriptor_name":"Antigens","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004792","descriptor_name":"Enzyme Precursors","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D004792","descriptor_name":"Enzyme Precursors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004792","descriptor_name":"Enzyme Precursors","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D004792","descriptor_name":"Enzyme Precursors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005246","descriptor_name":"Feedback","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013347","descriptor_name":"Subcellular Fractions","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014443","descriptor_name":"Tyrosine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015471","descriptor_name":"Leukemia, Basophilic, Acute","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015550","descriptor_name":"Cell Degranulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015550","descriptor_name":"Cell Degranulation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D017455","descriptor_name":"Receptors, IgE","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017871","descriptor_name":"Calcium-Calmodulin-Dependent Protein Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D017871","descriptor_name":"Calcium-Calmodulin-Dependent Protein Kinases","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D017871","descriptor_name":"Calcium-Calmodulin-Dependent Protein Kinases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D020928","descriptor_name":"Mitogen-Activated Protein Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048052","descriptor_name":"Mitogen-Activated Protein Kinase 3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048728","descriptor_name":"MAP Kinase Kinase Kinase 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.4049/jimmunol.163.3.1110","doi":"https://doi.org/10.4049/jimmunol.163.3.1110","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.163.3.1110","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:10415002","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10415002","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Journal Article"},{"id":"mag:2132196948","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10415002","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W271097414","https://openalex.org/W1505084152","https://openalex.org/W1529522766","https://openalex.org/W1572526443","https://openalex.org/W1886292263","https://openalex.org/W1965265661","https://openalex.org/W1967960352","https://openalex.org/W1971915141","https://openalex.org/W1974555059","https://openalex.org/W1980090694","https://openalex.org/W1980776953","https://openalex.org/W1988222207","https://openalex.org/W2002258688","https://openalex.org/W2036431526","https://openalex.org/W2037111992","https://openalex.org/W2060101293","https://openalex.org/W2061452540","https://openalex.org/W2086262311","https://openalex.org/W2154901790","https://openalex.org/W2158093352","https://openalex.org/W2399303500"],"related_works":["https://openalex.org/W2132196948","https://openalex.org/W2065702591","https://openalex.org/W1978568961","https://openalex.org/W2081170890","https://openalex.org/W2951383966","https://openalex.org/W2158093352","https://openalex.org/W1558813342","https://openalex.org/W2103901094","https://openalex.org/W2012902336","https://openalex.org/W2399303500"],"abstract_inverted_index":{"The":[0],"protein":[1,22,71,74,141,145],"tyrosine":[2,146],"kinase":[3,23,26,75,77],"Syk":[4,18,59,90,111],"is":[5,148],"an":[6],"essential":[7],"element":[8],"in":[9,36,64,65,114],"several":[10],"cascades":[11],"coupling":[12,117],"Ag":[13],"receptors":[14],"to":[15,31,124],"cell":[16,49],"responses.":[17],"and":[19,39,56,91,144],"the":[20,69,82,86,98,101,115,118,125,132],"mitogen-activated":[21,70],"extracellular":[24],"signal-regulated":[25,73],"1":[27,120],"(ERK1)":[28],"were":[29],"found":[30],"form":[32],"a":[33,106,135],"tight":[34],"complex":[35],"both":[37],"resting":[38],"Ag-stimulated":[40],"rat":[41],"mucosal-type":[42],"mast":[43,129],"cells":[44],"(rat":[45],"basophilic":[46],"leukemia":[47],"2H3":[48],"line":[50],"RBL-2H3).":[51],"A":[52],"direct":[53],"serine":[54],"phosphorylation":[55,84],"activation":[57,93],"of":[58,85,89,100,110,128,134,138],"by":[60,112],"ERK":[61,113],"was":[62],"observed":[63],"vitro":[66],"experiments.":[67],"Moreover":[68],"kinase/extracellular":[72],"(ERK)":[76],"(MEK)":[78],"inhibitors":[79],"markedly":[80],"decreased":[81],"Ag-induced":[83],"tyrosyl":[87],"residues":[88],"its":[92],"as":[94,96],"well":[95],"suppressed":[97],"degranulation":[99],"cells.":[102],"These":[103],"results":[104],"suggest":[105],"positive":[107],"feedback":[108],"regulation":[109],"cascade":[116],"type":[119,137],"Fc":[121],"epsilon":[122],"receptor":[123],"secretory":[126],"response":[127],"cells;":[130],"hence,":[131],"existence":[133],"novel":[136],"cross-talk":[139],"between":[140],"serine/threonine":[142],"kinases":[143,147],"suggested.":[149]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2023-01-06T00:00:00"}
