{"id":"https://openalex.org/W4313335871","doi":"https://doi.org/10.4049/jimmunol.163.3.1435","title":"TNF-\u03b1 Suppresses IFN-\u03b3-Induced MHC Class II Expression in HT1080 Cells by Destabilizing Class II trans -Activator mRNA","display_name":"TNF-\u03b1 Suppresses IFN-\u03b3-Induced MHC Class II Expression in HT1080 Cells by Destabilizing Class II trans -Activator mRNA","publication_year":1999,"publication_date":"1999-08-01","ids":{"openalex":"https://openalex.org/W4313335871","doi":"https://doi.org/10.4049/jimmunol.163.3.1435","mag":"2123327385","pmid":"https://pubmed.ncbi.nlm.nih.gov/10415044"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.163.3.1435","doi":"https://doi.org/10.4049/jimmunol.163.3.1435","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.163.3.1435","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101079363","display_name":"Yulong Han","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I4405287411","display_name":"Cleveland Clinic Research","ror":"https://ror.org/053229s83","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yulong Han","raw_affiliation_strings":["Department of Neuroscience, The Lerner Research Institute, Cleveland Clinic Foundation , Cleveland, OH 44195","*Department of Neuroscience, The Lerner Research Institute, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, The Lerner Research Institute, Cleveland Clinic Foundation , Cleveland, OH 44195","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]},{"raw_affiliation_string":"*Department of Neuroscience, The Lerner Research Institute, and","institution_ids":["https://openalex.org/I4405287411"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005706548","display_name":"Z-H. Lucy Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I4405287411","display_name":"Cleveland Clinic Research","ror":"https://ror.org/053229s83","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Z-H Lucy Zhou","raw_affiliation_strings":["Department of Neuroscience, The Lerner Research Institute, Cleveland Clinic Foundation , Cleveland, OH 44195","*Department of Neuroscience, The Lerner Research Institute, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, The Lerner Research Institute, Cleveland Clinic Foundation , Cleveland, OH 44195","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]},{"raw_affiliation_string":"*Department of Neuroscience, The Lerner Research Institute, and","institution_ids":["https://openalex.org/I4405287411"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034732141","display_name":"Richard M. Ransohoff","orcid":"https://orcid.org/0000-0003-0175-6910","observed_orcids":["https://orcid.org/0000-0003-0175-6910"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I4405287411","display_name":"Cleveland Clinic Research","ror":"https://ror.org/053229s83","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard M Ransohoff","raw_affiliation_strings":["Department of Neuroscience, The Lerner Research Institute, Cleveland Clinic Foundation , Cleveland, OH 44195","\u2020Mellen Center for Multiple Sclerosis Treatment and Research, Department of Neurology, Cleveland Clinic Foundation, Cleveland, OH 44195","*Department of Neuroscience, The Lerner Research Institute, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, The Lerner Research Institute, Cleveland Clinic Foundation , Cleveland, OH 44195","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]},{"raw_affiliation_string":"\u2020Mellen Center for Multiple Sclerosis Treatment and Research, Department of Neurology, Cleveland Clinic Foundation, Cleveland, OH 44195","institution_ids":["https://openalex.org/I1316902750"]},{"raw_affiliation_string":"*Department of Neuroscience, The Lerner Research Institute, and","institution_ids":["https://openalex.org/I4405287411"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5101079363"],"corresponding_institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":0.873,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.70087743,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"163","issue":"3","first_page":"1435","last_page":"1440"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.2709999978542328,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.2709999978542328,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.1835000067949295,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.1460999995470047,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9919999837875366},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.9829999804496765},{"id":"https://openalex.org/keywords/mhc-class-ii-expression","display_name":"MHC class II expression","score":0.9800000190734863},{"id":"https://openalex.org/keywords/mrna-destabilization","display_name":"mRNA destabilization","score":0.8130000233650208},{"id":"https://openalex.org/keywords/ht1080-cells","display_name":"HT1080 cells","score":0.859000027179718},{"id":"https://openalex.org/keywords/fibrosarcoma","display_name":"fibrosarcoma","score":0.9070000052452087},{"id":"https://openalex.org/keywords/tetracycline-regulated-expression","display_name":"tetracycline-regulated expression","score":0.6579999923706055},{"id":"https://openalex.org/keywords/transforming-growth-factor-beta","display_name":"TGF-beta","score":0.7279999852180481},{"id":"https://openalex.org/keywords/interferon-beta","display_name":"interferon-beta","score":0.9049999713897705},{"id":"https://openalex.org/keywords/immune-regulation","display_name":"immune regulation","score":0.36899998784065247}],"concepts":[{"id":"https://openalex.org/C2775890610","wikidata":"https://www.wikidata.org/wiki/Q14914108","display_name":"CIITA","level":5,"score":0.9886110424995422},{"id":"https://openalex.org/C2778814158","wikidata":"https://www.wikidata.org/wiki/Q959350","display_name":"MHC class II","level":4,"score":0.6966538429260254},{"id":"https://openalex.org/C119997001","wikidata":"https://www.wikidata.org/wiki/Q21113110","display_name":"CD74","level":5,"score":0.6224302053451538},{"id":"https://openalex.org/C170627219","wikidata":"https://www.wikidata.org/wiki/Q13218497","display_name":"MHC class I","level":4,"score":0.6110270619392395},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.578380286693573},{"id":"https://openalex.org/C2777751087","wikidata":"https://www.wikidata.org/wiki/Q5636047","display_name":"HT1080","level":3,"score":0.5255122184753418},{"id":"https://openalex.org/C108249834","wikidata":"https://www.wikidata.org/wiki/Q3922363","display_name":"Antigen processing","level":5,"score":0.4956592321395874},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.46933498978614807},{"id":"https://openalex.org/C197695756","wikidata":"https://www.wikidata.org/wiki/Q1750372","display_name":"MHC restriction","level":5,"score":0.45759090781211853},{"id":"https://openalex.org/C207936829","wikidata":"https://www.wikidata.org/wiki/Q423163","display_name":"Major histocompatibility complex","level":3,"score":0.4512665271759033},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.41822463274002075},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.38985636830329895},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2866206765174866},{"id":"https://openalex.org/C2776495794","wikidata":"https://www.wikidata.org/wiki/Q1362453","display_name":"Fibrosarcoma","level":2,"score":0.27586600184440613},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08390495181083679}],"mesh":[{"descriptor_ui":"D000949","descriptor_name":"Histocompatibility Antigens Class II","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D000949","descriptor_name":"Histocompatibility Antigens Class II","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000949","descriptor_name":"Histocompatibility Antigens Class II","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005354","descriptor_name":"Fibrosarcoma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007108","descriptor_name":"Immune Tolerance","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013752","descriptor_name":"Tetracycline","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.4049/jimmunol.163.3.1435","doi":"https://doi.org/10.4049/jimmunol.163.3.1435","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.163.3.1435","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:10415044","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10415044","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Journal Article"},{"id":"mag:2123327385","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10415044","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7246000170707703}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5062867232","display_name":"Integrated EGFR function in cytokine-driven inflammation and cancer","funder_award_id":"P01CA062220","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6890051928","display_name":"Chemokines in CNS inflammation","funder_award_id":"R01NS032151","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W1504458230","https://openalex.org/W1508586454","https://openalex.org/W1509790685","https://openalex.org/W1514071621","https://openalex.org/W1534209628","https://openalex.org/W1593714022","https://openalex.org/W1653126782","https://openalex.org/W1663655858","https://openalex.org/W1666597578","https://openalex.org/W1674446916","https://openalex.org/W1800101419","https://openalex.org/W1839926879","https://openalex.org/W1847235528","https://openalex.org/W1958125414","https://openalex.org/W1974684256","https://openalex.org/W1978434092","https://openalex.org/W1979517563","https://openalex.org/W1981483909","https://openalex.org/W1995744312","https://openalex.org/W1996202980","https://openalex.org/W1997879748","https://openalex.org/W2008215408","https://openalex.org/W2012987505","https://openalex.org/W2016492849","https://openalex.org/W2020482800","https://openalex.org/W2029007974","https://openalex.org/W2037753737","https://openalex.org/W2041772815","https://openalex.org/W2044974676","https://openalex.org/W2048154652","https://openalex.org/W2049170267","https://openalex.org/W2060320549","https://openalex.org/W2069152375","https://openalex.org/W2084480440","https://openalex.org/W2085437232","https://openalex.org/W2091953393","https://openalex.org/W2098677328","https://openalex.org/W2101213402","https://openalex.org/W2104820327","https://openalex.org/W2105191579","https://openalex.org/W2111537010","https://openalex.org/W2112260561","https://openalex.org/W2122312331","https://openalex.org/W2126283955","https://openalex.org/W2128885656","https://openalex.org/W2135009852","https://openalex.org/W2140278516","https://openalex.org/W2152892875","https://openalex.org/W2154684602","https://openalex.org/W2410929775"],"related_works":["https://openalex.org/W2123327385","https://openalex.org/W2111537010","https://openalex.org/W1958125414","https://openalex.org/W2171530333","https://openalex.org/W2085347754","https://openalex.org/W2140278516","https://openalex.org/W2069152375","https://openalex.org/W4313331533","https://openalex.org/W1924755146","https://openalex.org/W2067683521"],"abstract_inverted_index":{"Precise":[0],"regulation":[1],"of":[2,14,55,122],"MHC":[3,32,49,58,83,133,149,170],"class":[4,33,50,59,84,134,150,171],"II":[5,19,34,51,60,85,135,151,172],"gene":[6],"expression":[7,61,86,100,136,152,173],"is":[8,37,164,174],"crucial":[9],"for":[10,28],"development":[11],"and":[12,30,46,66,98,148],"function":[13],"the":[15,120,165],"immune":[16],"system.":[17],"Class":[18],"trans-activator":[20],"(CIITA)":[21],"has":[22],"been":[23],"shown":[24],"to":[25,131,159],"be":[26],"required":[27],"constitutive":[29],"IFN-gamma-induced":[31,76,146],"transcription.":[35],"TNF-alpha":[36,56,74,92,126,144],"commonly":[38],"coexpressed":[39],"with":[40,141],"IFN-gamma":[41,114],"during":[42],"immune-mediated":[43],"inflammatory":[44],"responses":[45],"modulates":[47],"IFN-gamma-stimulated":[48],"expression.":[52],"The":[53],"effect":[54],"on":[57,63],"depends":[62],"cell":[64],"type":[65],"cellular":[67],"differentiation":[68],"state.":[69],"We":[70],"show":[71],"here":[72],"that":[73,125,156],"suppresses":[75],"CIITA":[77,95,109,147,178],"mRNA":[78,96],"accumulation,":[79],"resulting":[80],"in":[81,87,101,119,137,153,168],"decreased":[82],"human":[88],"fibrosarcoma":[89],"HT1080":[90,138],"cells.":[91,139],"also":[93],"inhibits":[94],"accumulation":[97],"protein":[99],"a":[102,128],"tetracycline-regulated":[103],"system":[104],"without":[105],"affecting":[106],"promoter":[107],"activity.":[108],"mRNA,":[110],"regulated":[111],"by":[112,176],"either":[113],"or":[115,161],"tetracycline,":[116],"was":[117],"destabilized":[118],"presence":[121],"TNF-alpha,":[123],"suggesting":[124],"utilizes":[127],"distinct":[129],"mechanism":[130],"suppress":[132],"Consistent":[140],"this":[142],"interpretation,":[143],"blocked":[145],"mutant":[154],"cells":[155],"are":[157],"unresponsive":[158],"TGF-beta":[160],"IFN-beta.":[162],"This":[163],"first":[166],"instance":[167],"which":[169],"inhibited":[175],"destabilizing":[177],"mRNA.":[179]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2023-01-06T00:00:00"}