{"id":"https://openalex.org/W4313333804","doi":"https://doi.org/10.4049/jimmunol.161.6.2873","title":"\u03b1-Melanocyte-Stimulating Hormone Inhibits the Nuclear Transcription Factor NF-\u03baB Activation Induced by Various Inflammatory Agents","display_name":"\u03b1-Melanocyte-Stimulating Hormone Inhibits the Nuclear Transcription Factor NF-\u03baB Activation Induced by Various Inflammatory Agents","publication_year":1998,"publication_date":"1998-09-01","ids":{"openalex":"https://openalex.org/W4313333804","doi":"https://doi.org/10.4049/jimmunol.161.6.2873","mag":"2151407154","pmid":"https://pubmed.ncbi.nlm.nih.gov/9743348"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.161.6.2873","doi":"https://doi.org/10.4049/jimmunol.161.6.2873","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.161.6.2873","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031631094","display_name":"Sunil K. Manna","orcid":"https://orcid.org/0000-0002-0149-209X","observed_orcids":["https://orcid.org/0000-0002-0149-209X"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sunil K Manna","raw_affiliation_strings":["Cytokine Research Laboratory, Department of Molecular Oncology, University of Texas M. D. Anderson Cancer Center, Houston, TX 77030"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cytokine Research Laboratory, Department of Molecular Oncology, University of Texas M. D. Anderson Cancer Center, Houston, TX 77030","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048675624","display_name":"Bharat Bhushan Aggarwal","orcid":"https://orcid.org/0000-0003-3534-2898","observed_orcids":["https://orcid.org/0000-0003-3534-2898"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bharat B Aggarwal","raw_affiliation_strings":["Cytokine Research Laboratory, Department of Molecular Oncology, University of Texas M. D. Anderson Cancer Center, Houston, TX 77030"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cytokine Research Laboratory, Department of Molecular Oncology, University of Texas M. D. Anderson Cancer Center, Houston, TX 77030","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1343551460"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":5.5961,"has_fulltext":false,"cited_by_count":254,"citation_normalized_percentile":{"value":0.96954128,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"161","issue":"6","first_page":"2873","last_page":"2880"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.004399999976158142,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alpha-msh","display_name":"alpha-melanocyte-stimulating hormone","score":0.9990000128746033},{"id":"https://openalex.org/keywords/nf-kappab-activation","display_name":"NF-\u03baB activation","score":0.9549999833106995},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.8930000066757202},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8090000152587891},{"id":"https://openalex.org/keywords/ikappabalpha-degradation","display_name":"I\u03baB\u03b1 degradation","score":0.9350000023841858},{"id":"https://openalex.org/keywords/nf-kappab-p65-nuclear-translocation","display_name":"p65 nuclear translocation","score":0.921999990940094},{"id":"https://openalex.org/keywords/camp-signaling","display_name":"cAMP signaling","score":0.9110000133514404},{"id":"https://openalex.org/keywords/protein-kinase-a","display_name":"protein kinase A","score":0.9750000238418579},{"id":"https://openalex.org/keywords/lps","display_name":"LPS","score":0.6100000143051147},{"id":"https://openalex.org/keywords/okadaic-acid","display_name":"okadaic acid","score":0.9890000224113464},{"id":"https://openalex.org/keywords/ceramide","display_name":"ceramide","score":0.9940000176429749},{"id":"https://openalex.org/keywords/activator-protein-1","display_name":"activator protein-1","score":0.7210000157356262},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.34299999475479126}],"concepts":[{"id":"https://openalex.org/C2777730290","wikidata":"https://www.wikidata.org/wiki/Q411114","display_name":"NF-\u03baB","level":3,"score":0.5669251680374146},{"id":"https://openalex.org/C2779730028","wikidata":"https://www.wikidata.org/wiki/Q15325101","display_name":"I\u03baB\u03b1","level":4,"score":0.5376618504524231},{"id":"https://openalex.org/C2780989459","wikidata":"https://www.wikidata.org/wiki/Q423981","display_name":"Melanocyte-stimulating hormone","level":3,"score":0.5104423761367798},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5061835646629333},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4887394905090332},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.4830544590950012},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.4775177538394928},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47185608744621277},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.45157235860824585},{"id":"https://openalex.org/C123298856","wikidata":"https://www.wikidata.org/wiki/Q15317427","display_name":"NFKB1","level":4,"score":0.4449392259120941},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4409295320510864},{"id":"https://openalex.org/C183978625","wikidata":"https://www.wikidata.org/wiki/Q903596","display_name":"Electrophoretic mobility shift assay","level":4,"score":0.4347497820854187},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.39036715030670166},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3658692240715027},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3605600595474243},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3365786671638489},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.24144643545150757},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19458502531051636},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15427914261817932},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08513709902763367}],"mesh":[{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000521","descriptor_name":"alpha-MSH","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002518","descriptor_name":"Ceramides","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D002518","descriptor_name":"Ceramides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015500","descriptor_name":"Chloramphenicol O-Acetyltransferase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015500","descriptor_name":"Chloramphenicol O-Acetyltransferase","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017930","descriptor_name":"Genes, Reporter","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018808","descriptor_name":"Transcription Factor AP-1","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D018808","descriptor_name":"Transcription Factor AP-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019169","descriptor_name":"Jurkat Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019319","descriptor_name":"Okadaic Acid","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D019319","descriptor_name":"Okadaic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051996","descriptor_name":"Transcription Factor RelA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052002","descriptor_name":"NF-kappa B p50 Subunit","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.4049/jimmunol.161.6.2873","doi":"https://doi.org/10.4049/jimmunol.161.6.2873","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.161.6.2873","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:9743348","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9743348","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Journal Article"},{"id":"mag:2151407154","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9743348","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W62571714","https://openalex.org/W128911665","https://openalex.org/W1502098090","https://openalex.org/W1508967452","https://openalex.org/W1566308385","https://openalex.org/W1568518323","https://openalex.org/W1581590867","https://openalex.org/W1608075847","https://openalex.org/W1634459475","https://openalex.org/W1637808652","https://openalex.org/W1868478050","https://openalex.org/W1925917964","https://openalex.org/W1969419107","https://openalex.org/W1973223056","https://openalex.org/W1974190789","https://openalex.org/W1979310972","https://openalex.org/W1979901481","https://openalex.org/W1983668987","https://openalex.org/W1993847641","https://openalex.org/W1999048321","https://openalex.org/W1999855196","https://openalex.org/W2006470470","https://openalex.org/W2011509827","https://openalex.org/W2012740861","https://openalex.org/W2015690288","https://openalex.org/W2016730049","https://openalex.org/W2026467468","https://openalex.org/W2042658226","https://openalex.org/W2043342443","https://openalex.org/W2043725635","https://openalex.org/W2052466501","https://openalex.org/W2052893447","https://openalex.org/W2072659035","https://openalex.org/W2088493593","https://openalex.org/W2091695331","https://openalex.org/W2121252248","https://openalex.org/W2123327793","https://openalex.org/W2128635872","https://openalex.org/W2133764756","https://openalex.org/W2141100586","https://openalex.org/W2142541950","https://openalex.org/W2144634347","https://openalex.org/W2146913070","https://openalex.org/W2168889062"],"related_works":["https://openalex.org/W2151407154","https://openalex.org/W2373677333","https://openalex.org/W2041928527","https://openalex.org/W2063743408","https://openalex.org/W2018999902","https://openalex.org/W2165592417","https://openalex.org/W2061253122","https://openalex.org/W1965248549","https://openalex.org/W2051588649","https://openalex.org/W1999201639"],"abstract_inverted_index":{"Alpha-melanocyte-stimulating":[0],"hormone":[1],"(alpha-MSH)":[2],"is":[3,24],"a":[4,21,51,71],"tridecapeptide":[5],"found":[6],"mainly":[7],"in":[8,70],"the":[9,39,44,94,97,114,128],"brain,":[10],"pituitary,":[11],"and":[12,73,87,124,168,204],"circulation.":[13],"It":[14,76],"inhibits":[15],"most":[16,28],"forms":[17],"of":[18,30,34,41,46,54,96,113,117,127,131,141,153,161,165,169,179],"inflammation":[19,31],"by":[20,50,83,102,148,200],"mechanism":[22,207],"that":[23,62,110,194,205],"not":[25],"known.":[26],"As":[27],"types":[29],"require":[32],"activation":[33,45,69,81,95],"NF-kappa":[35,67,79,118,132,142,187,197],"B,":[36,119],"we":[37],"investigated":[38],"effect":[40,90,152],"alpha-MSH":[42,63,154,195],"on":[43],"this":[47,206],"transcription":[48,98],"factor":[49,99],"wide":[52],"variety":[53],"inflammatory":[55,202],"stimuli.":[56],"Electrophoretic":[57],"mobility":[58],"shift":[59],"assay":[60],"showed":[61],"completely":[64],"abolished":[65],"TNF-mediated":[66],"B":[68,80,122,133,188,198],"dose-":[72],"time-dependent":[74],"manner.":[75],"also":[77,135],"suppressed":[78,185],"induced":[82,147],"LPS,":[84],"okadaic":[85],"acid,":[86],"ceramide.":[88],"The":[89,150],"was":[91,104],"specific,":[92],"as":[93,163],"activating":[100],"protein-1":[101],"TNF":[103],"unaffected.":[105],"Western":[106],"blot":[107],"analysis":[108],"revealed":[109],"TNF-dependent":[111],"degradation":[112],"inhibitory":[115,151,175],"subunit":[116,130],"I":[120],"kappa":[121],"alpha,":[123],"nuclear":[125],"translocation":[126],"p65":[129],"were":[134],"inhibited.":[136],"This":[137],"correlated":[138],"with":[139],"suppression":[140],"B-dependent":[143],"reporter":[144],"gene":[145],"expression":[146],"TNF.":[149],"appeared":[155],"to":[156,210],"be":[157],"mediated":[158],"through":[159],"generation":[160],"cAMP,":[162,182],"inhibitors":[164],"adenylate":[166],"cyclase":[167],"protein":[170],"kinase":[171],"A":[172],"reversed":[173],"its":[174,211],"effect.":[176],"Similarly,":[177],"addition":[178],"membrane-permeable":[180],"dibutyryl":[181],"like":[183],"alpha-MSH,":[184],"TNF-induced":[186],"activation.":[189],"Overall,":[190],"our":[191],"results":[192],"suggest":[193],"suppresses":[196],"activated":[199],"various":[201],"agents":[203],"probably":[208],"contributes":[209],"anti-inflammatory":[212],"effects.":[213]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2023-01-06T00:00:00"}