{"id":"https://openalex.org/W4313333786","doi":"https://doi.org/10.4049/jimmunol.161.6.3010","title":"Two Distinct Phospholipases C of Listeria monocytogenes Induce Ceramide Generation, Nuclear Factor-\u03baB Activation, and E-Selectin Expression in Human Endothelial Cells","display_name":"Two Distinct Phospholipases C of Listeria monocytogenes Induce Ceramide Generation, Nuclear Factor-\u03baB Activation, and E-Selectin Expression in Human Endothelial Cells","publication_year":1998,"publication_date":"1998-09-01","ids":{"openalex":"https://openalex.org/W4313333786","doi":"https://doi.org/10.4049/jimmunol.161.6.3010","mag":"2150919382","pmid":"https://pubmed.ncbi.nlm.nih.gov/9743365"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.161.6.3010","doi":"https://doi.org/10.4049/jimmunol.161.6.3010","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.161.6.3010","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Nicole Schwarzer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200763008","display_name":"Justus-Liebig-Universit\u00e4t Gie\u00dfen","ror":"https://ror.org/033eqas34","country_code":"DE","type":"education","lineage":["https://openalex.org/I200763008"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Nicole Schwarzer","raw_affiliation_strings":["Department of Internal Medicine, Justus-Liebig University , Giessen ,","*Department of Internal Medicine and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Justus-Liebig University , Giessen ,","institution_ids":["https://openalex.org/I200763008"]},{"raw_affiliation_string":"*Department of Internal Medicine and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057888475","display_name":"Ralph N\u00f6st","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200763008","display_name":"Justus-Liebig-Universit\u00e4t Gie\u00dfen","ror":"https://ror.org/033eqas34","country_code":"DE","type":"education","lineage":["https://openalex.org/I200763008"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ralph No\u0308st","raw_affiliation_strings":["Department of Internal Medicine, Justus-Liebig University , Giessen ,","*Department of Internal Medicine and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Justus-Liebig University , Giessen ,","institution_ids":["https://openalex.org/I200763008"]},{"raw_affiliation_string":"*Department of Internal Medicine and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054872321","display_name":"Joachim Seybold","orcid":"https://orcid.org/0000-0003-1444-8976","observed_orcids":["https://orcid.org/0000-0003-1444-8976"]},"institutions":[{"id":"https://openalex.org/I200763008","display_name":"Justus-Liebig-Universit\u00e4t Gie\u00dfen","ror":"https://ror.org/033eqas34","country_code":"DE","type":"education","lineage":["https://openalex.org/I200763008"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Joachim Seybold","raw_affiliation_strings":["Department of Internal Medicine, Justus-Liebig University , Giessen ,","*Department of Internal Medicine and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Justus-Liebig University , Giessen ,","institution_ids":["https://openalex.org/I200763008"]},{"raw_affiliation_string":"*Department of Internal Medicine and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076984957","display_name":"Shreemanta K. Parida","orcid":"https://orcid.org/0000-0003-2129-6691","observed_orcids":["https://orcid.org/0000-0003-2129-6691"]},"institutions":[{"id":"https://openalex.org/I200763008","display_name":"Justus-Liebig-Universit\u00e4t Gie\u00dfen","ror":"https://ror.org/033eqas34","country_code":"DE","type":"education","lineage":["https://openalex.org/I200763008"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Shreemanta K Parida","raw_affiliation_strings":["Institute of Medical Microbiology, Justus-Liebig University , Giessen ,","\u2020Institute of Medical Microbiology, Justus-Liebig University, Giessen, Germany; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Medical Microbiology, Justus-Liebig University , Giessen ,","institution_ids":["https://openalex.org/I200763008"]},{"raw_affiliation_string":"\u2020Institute of Medical Microbiology, Justus-Liebig University, Giessen, Germany; and","institution_ids":["https://openalex.org/I200763008"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087930729","display_name":"Oliver Fuhrmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200763008","display_name":"Justus-Liebig-Universit\u00e4t Gie\u00dfen","ror":"https://ror.org/033eqas34","country_code":"DE","type":"education","lineage":["https://openalex.org/I200763008"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Oliver Fuhrmann","raw_affiliation_strings":["Department of Internal Medicine, Justus-Liebig University , Giessen ,","*Department of Internal Medicine and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Justus-Liebig University , Giessen ,","institution_ids":["https://openalex.org/I200763008"]},{"raw_affiliation_string":"*Department of Internal Medicine and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066509179","display_name":"Matthias Kr\u00fcll","orcid":"https://orcid.org/0000-0001-7034-2119","observed_orcids":["https://orcid.org/0000-0001-7034-2119"]},"institutions":[{"id":"https://openalex.org/I200763008","display_name":"Justus-Liebig-Universit\u00e4t Gie\u00dfen","ror":"https://ror.org/033eqas34","country_code":"DE","type":"education","lineage":["https://openalex.org/I200763008"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Matthias Kru\u0308ll","raw_affiliation_strings":["Department of Internal Medicine, Justus-Liebig University , Giessen ,","*Department of Internal Medicine and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Justus-Liebig University , Giessen ,","institution_ids":["https://openalex.org/I200763008"]},{"raw_affiliation_string":"*Department of Internal Medicine and","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Reinhold Schmidt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200763008","display_name":"Justus-Liebig-Universit\u00e4t Gie\u00dfen","ror":"https://ror.org/033eqas34","country_code":"DE","type":"education","lineage":["https://openalex.org/I200763008"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Reinhold Schmidt","raw_affiliation_strings":["Department of Internal Medicine, Justus-Liebig University , Giessen ,","*Department of Internal Medicine and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Justus-Liebig University , Giessen ,","institution_ids":["https://openalex.org/I200763008"]},{"raw_affiliation_string":"*Department of Internal Medicine and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068506060","display_name":"Robert Charles Newton","orcid":"https://orcid.org/0000-0002-4919-8498","observed_orcids":["https://orcid.org/0000-0002-4919-8498"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Robert Newton","raw_affiliation_strings":["Imperial College School of Medicine, National Heart and Lung Institute, Department of Thoracic Medicine , London ,","\u2021Imperial College School of Medicine, National Heart and Lung Institute, Department of Thoracic Medicine, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imperial College School of Medicine, National Heart and Lung Institute, Department of Thoracic Medicine , London ,","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"\u2021Imperial College School of Medicine, National Heart and Lung Institute, Department of Thoracic Medicine, London, United Kingdom","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017328820","display_name":"Stefan Hippenstiel","orcid":"https://orcid.org/0000-0002-5146-1064","observed_orcids":["https://orcid.org/0000-0002-5146-1064"]},"institutions":[{"id":"https://openalex.org/I200763008","display_name":"Justus-Liebig-Universit\u00e4t Gie\u00dfen","ror":"https://ror.org/033eqas34","country_code":"DE","type":"education","lineage":["https://openalex.org/I200763008"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Stefan Hippenstiel","raw_affiliation_strings":["Department of Internal Medicine, Justus-Liebig University , Giessen ,","*Department of Internal Medicine and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Justus-Liebig University , Giessen ,","institution_ids":["https://openalex.org/I200763008"]},{"raw_affiliation_string":"*Department of Internal Medicine and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072629255","display_name":"Eugen Domann","orcid":"https://orcid.org/0000-0003-4089-1023","observed_orcids":["https://orcid.org/0000-0003-4089-1023"]},"institutions":[{"id":"https://openalex.org/I200763008","display_name":"Justus-Liebig-Universit\u00e4t Gie\u00dfen","ror":"https://ror.org/033eqas34","country_code":"DE","type":"education","lineage":["https://openalex.org/I200763008"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Eugen Domann","raw_affiliation_strings":["Institute of Medical Microbiology, Justus-Liebig University , Giessen ,","\u2020Institute of Medical Microbiology, Justus-Liebig University, Giessen, Germany; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Medical Microbiology, Justus-Liebig University , Giessen ,","institution_ids":["https://openalex.org/I200763008"]},{"raw_affiliation_string":"\u2020Institute of Medical Microbiology, Justus-Liebig University, Giessen, Germany; and","institution_ids":["https://openalex.org/I200763008"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061655044","display_name":"Trinad Chakraborty","orcid":"https://orcid.org/0000-0002-1452-4759","observed_orcids":["https://orcid.org/0000-0002-1452-4759","https://orcid.org/0009-0003-4875-3036"]},"institutions":[{"id":"https://openalex.org/I200763008","display_name":"Justus-Liebig-Universit\u00e4t Gie\u00dfen","ror":"https://ror.org/033eqas34","country_code":"DE","type":"education","lineage":["https://openalex.org/I200763008"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Trinad Chakraborty","raw_affiliation_strings":["Institute of Medical Microbiology, Justus-Liebig University , Giessen ,","\u2020Institute of Medical Microbiology, Justus-Liebig University, Giessen, Germany; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Medical Microbiology, Justus-Liebig University , Giessen ,","institution_ids":["https://openalex.org/I200763008"]},{"raw_affiliation_string":"\u2020Institute of Medical Microbiology, Justus-Liebig University, Giessen, Germany; and","institution_ids":["https://openalex.org/I200763008"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040973193","display_name":"Norbert Suttorp","orcid":"https://orcid.org/0000-0002-3958-1151","observed_orcids":["https://orcid.org/0000-0002-3958-1151"]},"institutions":[{"id":"https://openalex.org/I200763008","display_name":"Justus-Liebig-Universit\u00e4t Gie\u00dfen","ror":"https://ror.org/033eqas34","country_code":"DE","type":"education","lineage":["https://openalex.org/I200763008"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Norbert Suttorp","raw_affiliation_strings":["Department of Internal Medicine, Justus-Liebig University , Giessen ,","*Department of Internal Medicine and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Justus-Liebig University , Giessen ,","institution_ids":["https://openalex.org/I200763008"]},{"raw_affiliation_string":"*Department of Internal Medicine and","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":7.8122,"has_fulltext":false,"cited_by_count":50,"citation_normalized_percentile":{"value":0.97828562,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"161","issue":"6","first_page":"3010","last_page":"3018"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10900","display_name":"Listeria monocytogenes in Food Safety","score":0.7451000213623047,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10900","display_name":"Listeria monocytogenes in Food Safety","score":0.7451000213623047,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.057100001722574234,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10873","display_name":"Bacterial Infections and Vaccines","score":0.026900000870227814,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/listeria-monocytogenes","display_name":"Listeria monocytogenes","score":1.0},{"id":"https://openalex.org/keywords/phospholipase-c","display_name":"phospholipase C","score":0.9399999976158142},{"id":"https://openalex.org/keywords/phosphatidylcholine-specific-phospholipase-c","display_name":"phosphatidylcholine-specific phospholipase C","score":0.847000002861023},{"id":"https://openalex.org/keywords/phosphatidylinositol-specific-phospholipase-c","display_name":"phosphatidylinositol-specific phospholipase C","score":0.9990000128746033},{"id":"https://openalex.org/keywords/ceramide-generation","display_name":"ceramide generation","score":0.7509999871253967},{"id":"https://openalex.org/keywords/nf-kappab-activation","display_name":"NF-\u03baB activation","score":0.9390000104904175},{"id":"https://openalex.org/keywords/neutrophil-adhesion","display_name":"neutrophil adhesion","score":0.8149999976158142},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.753000020980835},{"id":"https://openalex.org/keywords/sphingomyelinase","display_name":"sphingomyelinase","score":0.875},{"id":"https://openalex.org/keywords/virulence-factors","display_name":"virulence factors","score":0.7620000243186951}],"concepts":[{"id":"https://openalex.org/C2781350384","wikidata":"https://www.wikidata.org/wiki/Q292015","display_name":"Listeria monocytogenes","level":3,"score":0.8631340265274048},{"id":"https://openalex.org/C2777851122","wikidata":"https://www.wikidata.org/wiki/Q424213","display_name":"Ceramide","level":3,"score":0.7331571578979492},{"id":"https://openalex.org/C2778597717","wikidata":"https://www.wikidata.org/wiki/Q420248","display_name":"Phospholipase C","level":3,"score":0.5683004856109619},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5205094218254089},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.481145977973938},{"id":"https://openalex.org/C12927208","wikidata":"https://www.wikidata.org/wiki/Q210430","display_name":"Phospholipase","level":3,"score":0.4661219120025635},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.44966474175453186},{"id":"https://openalex.org/C61322309","wikidata":"https://www.wikidata.org/wiki/Q423143","display_name":"Sphingomyelin","level":3,"score":0.4262077808380127},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.40728989243507385},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.4060344099998474},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3977378308773041},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2473360300064087},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.1484212875366211},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.07820072770118713},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.07662558555603027},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06786918640136719},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.0},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002518","descriptor_name":"Ceramides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002518","descriptor_name":"Ceramides","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008088","descriptor_name":"Listeriosis","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008088","descriptor_name":"Listeriosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008088","descriptor_name":"Listeriosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008089","descriptor_name":"Listeria monocytogenes","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D010738","descriptor_name":"Type C Phospholipases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D014471","descriptor_name":"Umbilical Veins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015290","descriptor_name":"Second Messenger Systems","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019040","descriptor_name":"E-Selectin","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D019040","descriptor_name":"E-Selectin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D043265","descriptor_name":"Phosphatidylinositol Diacylglycerol-Lyase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054801","descriptor_name":"Phosphoinositide Phospholipase C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.4049/jimmunol.161.6.3010","doi":"https://doi.org/10.4049/jimmunol.161.6.3010","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.161.6.3010","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:9743365","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9743365","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.319.1469","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.319.1469","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.jimmunol.org/content/161/6/3010.full.pdf","raw_type":"text"},{"id":"mag:2150919382","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9743365","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":77,"referenced_works":["https://openalex.org/W141774154","https://openalex.org/W155617828","https://openalex.org/W1490556833","https://openalex.org/W1491611834","https://openalex.org/W1505016159","https://openalex.org/W1510071762","https://openalex.org/W1510982093","https://openalex.org/W1513643699","https://openalex.org/W1515398907","https://openalex.org/W1608075847","https://openalex.org/W1631426208","https://openalex.org/W1657392119","https://openalex.org/W1666876313","https://openalex.org/W1795330227","https://openalex.org/W1821737407","https://openalex.org/W1890757015","https://openalex.org/W1903870221","https://openalex.org/W1910948703","https://openalex.org/W1914692347","https://openalex.org/W1937850854","https://openalex.org/W1955860125","https://openalex.org/W1970040115","https://openalex.org/W1970458460","https://openalex.org/W1978710334","https://openalex.org/W1979520552","https://openalex.org/W1983668987","https://openalex.org/W2003709444","https://openalex.org/W2006014863","https://openalex.org/W2007599029","https://openalex.org/W2008936283","https://openalex.org/W2010168640","https://openalex.org/W2014006617","https://openalex.org/W2016018338","https://openalex.org/W2020535062","https://openalex.org/W2028652974","https://openalex.org/W2029276835","https://openalex.org/W2032371793","https://openalex.org/W2036770241","https://openalex.org/W2041576624","https://openalex.org/W2048655464","https://openalex.org/W2054487299","https://openalex.org/W2057408703","https://openalex.org/W2064554088","https://openalex.org/W2070005836","https://openalex.org/W2077156149","https://openalex.org/W2092330976","https://openalex.org/W2095019663","https://openalex.org/W2095214726","https://openalex.org/W2101944658","https://openalex.org/W2116136184","https://openalex.org/W2118438470","https://openalex.org/W2122857784","https://openalex.org/W2125419801","https://openalex.org/W2127953000","https://openalex.org/W2130487625","https://openalex.org/W2134137910","https://openalex.org/W2134812217","https://openalex.org/W2138216096","https://openalex.org/W2139319526","https://openalex.org/W2139535814","https://openalex.org/W2143210915","https://openalex.org/W2146391433","https://openalex.org/W2147395065","https://openalex.org/W2149098147","https://openalex.org/W2152311269","https://openalex.org/W2156013229","https://openalex.org/W2156115231","https://openalex.org/W2157603347","https://openalex.org/W2158708535","https://openalex.org/W2160217307","https://openalex.org/W2245100229","https://openalex.org/W2267988210","https://openalex.org/W2338218840","https://openalex.org/W2342113215","https://openalex.org/W2343854559","https://openalex.org/W2433345218","https://openalex.org/W2766276685"],"related_works":["https://openalex.org/W2150919382","https://openalex.org/W7099466484","https://openalex.org/W1666876313","https://openalex.org/W1910948703","https://openalex.org/W2108517025","https://openalex.org/W2140216056","https://openalex.org/W2043976709","https://openalex.org/W1955860125","https://openalex.org/W2048655464","https://openalex.org/W2116136184"],"abstract_inverted_index":{"Infection":[0,88],"of":[1,14,24,50,89,112,128,200,231,249],"endothelial":[2,28,40,90,154,239],"cells":[3,91,240],"by":[4,174],"Listeria":[5,86],"monocytogenes":[6,21,56,195,233],"is":[7],"an":[8,243],"essential":[9],"step":[10],"in":[11,151,203,246],"the":[12,43,48,60,82,247],"pathogenesis":[13,248],"listeriosis.":[15,251],"We":[16],"recently":[17],"reported":[18],"that":[19,132,185,197,202],"L.":[20,55,152,194,232],"induces":[22],"up-regulation":[23],"E-selectin":[25,52,113,223],"and":[26,31,68,75,115,122,145,187,225],"other":[27],"adhesion":[29,36,123,237],"molecules":[30],"subsequent":[32],"polymorphonuclear":[33],"leukocyte":[34],"(PMN)":[35],"into":[37],"cultured":[38],"human":[39],"cells.":[41],"In":[42],"present":[44],"study,":[45],"we":[46],"characterized":[47],"mechanisms":[49],"enhanced":[51,226],"expression":[53],"using":[54],"wild":[57,108],"type":[58],"(EGD),":[59],"isogenic":[61],"in-frame":[62],"deletion":[63],"mutants":[64],"for":[65,100,138,161,193],"phosphatidylcholine":[66],"(PC)-":[67],"phosphatidylinositol":[69],"(PI)-specific":[70],"phospholipases":[71,135],"EGD":[72,76,93,97,107],"delta":[73,77,94,98],"plcA":[74,95],"plcB,":[78],"as":[79,81,104,117,119,207],"well":[80,118],"nonvirulent":[83],"control":[84,211],"strain":[85],"innocua.":[87],"with":[92,106],"or":[96,163,178],"plcB":[99],"6":[101],"h":[102],"induced,":[103],"compared":[105],"type,":[109],"intermediate":[110,159],"levels":[111,160],"mRNA":[114],"protein":[116],"PMN":[120,227,236],"rolling":[121],"at":[124],"a":[125,139],"shear":[126],"rate":[127],"1":[129],"dyne/cm2,":[130],"indicating":[131],"both":[133],"bacterial":[134,179],"are":[136,189],"required":[137],"maximal":[140],"effect.":[141],"Similarly,":[142],"ceramide":[143],"content":[144],"NF-kappa":[146,219],"B":[147,220],"activity":[148],"were":[149],"increased":[150,222],"monocytogenes-exposed":[153],"cells,":[155],"but":[156],"only":[157],"to":[158,210,217,234,238],"PC-":[162],"PI-phospholipase":[164],"C":[165],"(PLC)-deficient":[166],"listerial":[167],"mutants.":[168],"Phospholipase":[169],"effects":[170],"could":[171],"be":[172,242],"mimicked":[173],"exogenously":[175],"added":[176],"ceramides":[177,201],"sphingomyelinase.":[180],"The":[181,229],"data":[182],"presented":[183],"indicate":[184],"PI-PLC":[186],"PC-PLC":[188],"important":[190,244],"virulence":[191],"factors":[192],"infections":[196],"induce":[198],"accumulation":[199],"turn":[204],"may":[205,241],"act":[206],"second":[208],"messengers":[209],"host":[212],"cell":[213],"signal-transduction":[214],"pathways":[215],"leading":[216],"persistent":[218],"activation,":[221],"expression,":[224],"rolling/adhesion.":[228],"ability":[230],"stimulate":[235],"mechanism":[245],"severe":[250]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2023-01-06T00:00:00"}