{"id":"https://openalex.org/W4313313508","doi":"https://doi.org/10.4049/jimmunol.121.6.2399","title":"The Mouse Mutant \u201cMotheaten\u201d","display_name":"The Mouse Mutant \u201cMotheaten\u201d","publication_year":1978,"publication_date":"1978-12-01","ids":{"openalex":"https://openalex.org/W4313313508","doi":"https://doi.org/10.4049/jimmunol.121.6.2399"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.121.6.2399","doi":"https://doi.org/10.4049/jimmunol.121.6.2399","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.121.6.2399","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108398761","display_name":"Charles L. Sidman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles L Sidman","raw_affiliation_strings":["Department of Pathology, Harvard Medical School , Boston, Massachusetts 02115","Jackson Laboratory , Bar Harbor, Maine 04609","From the Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115 and The Jackson Laboratory, Bar Harbor, Maine 04609","Jackson Laboratory From the , Boston, Massachusetts 02115 and The , Bar Harbor, Maine 04609"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Harvard Medical School , Boston, Massachusetts 02115","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Jackson Laboratory , Bar Harbor, Maine 04609","institution_ids":["https://openalex.org/I4210115256"]},{"raw_affiliation_string":"From the Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115 and The Jackson Laboratory, Bar Harbor, Maine 04609","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210115256"]},{"raw_affiliation_string":"Jackson Laboratory From the , Boston, Massachusetts 02115 and The , Bar Harbor, Maine 04609","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036394378","display_name":"Leonard D. Shultz","orcid":"https://orcid.org/0000-0002-4868-1031","observed_orcids":["https://orcid.org/0000-0002-4868-1031"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leonard D Shultz","raw_affiliation_strings":["Department of Pathology, Harvard Medical School , Boston, Massachusetts 02115","Jackson Laboratory , Bar Harbor, Maine 04609","From the Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115 and The Jackson Laboratory, Bar Harbor, Maine 04609","Jackson Laboratory From the , Boston, Massachusetts 02115 and The , Bar Harbor, Maine 04609"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Harvard Medical School , Boston, Massachusetts 02115","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Jackson Laboratory , Bar Harbor, Maine 04609","institution_ids":["https://openalex.org/I4210115256"]},{"raw_affiliation_string":"From the Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115 and The Jackson Laboratory, Bar Harbor, Maine 04609","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210115256"]},{"raw_affiliation_string":"Jackson Laboratory From the , Boston, Massachusetts 02115 and The , Bar Harbor, Maine 04609","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079811330","display_name":"Emil R. Unanue","orcid":"https://orcid.org/0000-0001-8629-0018","observed_orcids":["https://orcid.org/0000-0001-8629-0018"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emil R Unanue","raw_affiliation_strings":["Department of Pathology, Harvard Medical School , Boston, Massachusetts 02115","Jackson Laboratory , Bar Harbor, Maine 04609","From the Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115 and The Jackson Laboratory, Bar Harbor, Maine 04609","Jackson Laboratory From the , Boston, Massachusetts 02115 and The , Bar Harbor, Maine 04609"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Harvard Medical School , Boston, Massachusetts 02115","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Jackson Laboratory , Bar Harbor, Maine 04609","institution_ids":["https://openalex.org/I4210115256"]},{"raw_affiliation_string":"From the Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115 and The Jackson Laboratory, Bar Harbor, Maine 04609","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210115256"]},{"raw_affiliation_string":"Jackson Laboratory From the , Boston, Massachusetts 02115 and The , Bar Harbor, Maine 04609","institution_ids":["https://openalex.org/I4210115256"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":0.6839,"has_fulltext":false,"cited_by_count":38,"citation_normalized_percentile":{"value":0.68643641,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"121","issue":"6","first_page":"2399","last_page":"2404"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9208999872207642,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9208999872207642,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11725","display_name":"Immunodeficiency and Autoimmune Disorders","score":0.07660000026226044,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/severe-combined-immunodeficiency","display_name":"severe combined immunodeficiency","score":0.875},{"id":"https://openalex.org/keywords/b-lymphocyte-deficiency","display_name":"B lymphocyte deficiency","score":0.7099999785423279},{"id":"https://openalex.org/keywords/t-cell-dysfunction","display_name":"T cell dysfunction","score":0.8199999928474426},{"id":"https://openalex.org/keywords/thymus-independent-antigens","display_name":"thymus-independent antigens","score":0.8270000219345093},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.6679999828338623},{"id":"https://openalex.org/keywords/cytotoxic-t-lymphocytes","display_name":"cytotoxic T lymphocytes","score":0.7310000061988831},{"id":"https://openalex.org/keywords/autoimmunity","display_name":"autoimmunity","score":0.6759999990463257},{"id":"https://openalex.org/keywords/t-cell-mitogen-response","display_name":"T-cell mitogen response","score":0.5170000195503235}],"concepts":[{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.691681444644928},{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.6489594578742981},{"id":"https://openalex.org/C2777422395","wikidata":"https://www.wikidata.org/wiki/Q3149136","display_name":"Immunocompetence","level":3,"score":0.6380163431167603},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5619969367980957},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5606290102005005},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.5451050400733948},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.5241656303405762},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.5158390402793884},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4686319828033447},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.46642738580703735},{"id":"https://openalex.org/C2777607303","wikidata":"https://www.wikidata.org/wiki/Q641307","display_name":"Immunodeficiency","level":3,"score":0.44604599475860596},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.43691906332969666},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4366741180419922},{"id":"https://openalex.org/C2778453870","wikidata":"https://www.wikidata.org/wiki/Q188930","display_name":"B cell","level":3,"score":0.4321509301662445},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3758268356323242},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3423565626144409},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.217494934797287},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.15523135662078857},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1543513536453247},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13476458191871643}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4049/jimmunol.121.6.2399","doi":"https://doi.org/10.4049/jimmunol.121.6.2399","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.121.6.2399","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1532912284","https://openalex.org/W1930712675","https://openalex.org/W2084238769","https://openalex.org/W1705381357","https://openalex.org/W1852634555","https://openalex.org/W1594841873","https://openalex.org/W2062898707","https://openalex.org/W1566284962","https://openalex.org/W1597199485","https://openalex.org/W4313310218"],"abstract_inverted_index":{"Abstract":[0],"Motheaten":[1,69],"mice":[2,70],"have":[3],"normal":[4,77],"levels":[5,11],"of":[6,12,75,114,132,141],"T":[7,38,54,118],"lymphocytes":[8],"but":[9,96],"reduced":[10],"B":[13,16,27,78,116],"lymphocytes.":[14],"Those":[15],"cells":[17,65,73,123],"that":[18,128],"are":[19,124],"present":[20],"show":[21],"an":[22,153],"impaired":[23],"proliferative":[24,51],"response":[25,34],"to":[26,35,53,61,81,90,138,152],"cell":[28,33,55,79,86],"mitogens":[29],"and":[30,57,117,150],"no":[31],"plaque-forming":[32],"thymus-independent":[36,82],"antigens.":[37,83],"lymphocyte":[39],"function":[40],"is":[41,87,97,136],"also":[42],"defective":[43],"in":[44],"motheaten":[45,106,134],"mice,":[46],"as":[47,156],"assayed":[48],"by":[49,58,100],"the":[50,59,105,129,133,139,144],"responses":[52,80],"mitogens,":[56],"capacity":[60],"develop":[62],"cytotoxic":[63],"killer":[64],"against":[66],"allogeneic":[67],"cells.":[68],"possess":[71],"spleen":[72],"capable":[74],"suppressing":[76],"This":[84],"suppressor":[85],"not":[88],"sensitive":[89],"anti-Thy-1":[91],"antibody":[92],"plus":[93],"complement":[94],"treatment":[95],"partially":[98],"removed":[99],"adherence":[101],"on":[102],"plastic.":[103],"Overall,":[104],"mouse":[107],"suffers":[108],"a":[109],"functional":[110],"severe":[111],"combined":[112],"immunodeficiency":[113],"both":[115],"cells,":[119],"even":[120],"though":[121],"these":[122],"present.":[125],"We":[126],"postulate":[127],"inescapable":[130],"lethality":[131],"defect":[135],"due":[137],"lack":[140],"immunocompetence":[142],"during":[143],"critical":[145],"developmental":[146],"period":[147],"before":[148],"adulthood":[149],"perhaps":[151],"autoaggressive":[154],"component":[155],"well.":[157]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-07T09:51:55.459714","created_date":"2023-01-06T00:00:00"}
