{"id":"https://openalex.org/W4313310686","doi":"https://doi.org/10.4049/jimmunol.119.5.1821","title":"Studies on the Cytolytic Activity of Human Lymphocytes","display_name":"Studies on the Cytolytic Activity of Human Lymphocytes","publication_year":1977,"publication_date":"1977-11-01","ids":{"openalex":"https://openalex.org/W4313310686","doi":"https://doi.org/10.4049/jimmunol.119.5.1821","mag":"1559385839","pmid":"https://pubmed.ncbi.nlm.nih.gov/410884"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.119.5.1821","doi":"https://doi.org/10.4049/jimmunol.119.5.1821","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.119.5.1821","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"H Kirk Ziegler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H Kirk Ziegler","raw_affiliation_strings":["Department of Medicine of The Johns Hopkins University School of Medicine and the O'Neill Memorial Research Laboratories of the Good Samaritan Hospital , Baltimore, Maryland","Department of Medicine of The Johns Hopkins University School of Medicine and the O'Neill Memorial Research Laboratories of the Good Samaritan Hospital From the , Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine of The Johns Hopkins University School of Medicine and the O'Neill Memorial Research Laboratories of the Good Samaritan Hospital , Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Department of Medicine of The Johns Hopkins University School of Medicine and the O'Neill Memorial Research Laboratories of the Good Samaritan Hospital From the , Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047952976","display_name":"Carl A. Geyer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carl Geyer","raw_affiliation_strings":["Department of Medicine of The Johns Hopkins University School of Medicine and the O'Neill Memorial Research Laboratories of the Good Samaritan Hospital , Baltimore, Maryland","Department of Medicine of The Johns Hopkins University School of Medicine and the O'Neill Memorial Research Laboratories of the Good Samaritan Hospital From the , Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine of The Johns Hopkins University School of Medicine and the O'Neill Memorial Research Laboratories of the Good Samaritan Hospital , Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Department of Medicine of The Johns Hopkins University School of Medicine and the O'Neill Memorial Research Laboratories of the Good Samaritan Hospital From the , Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008102030","display_name":"Christopher S. Henney","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher S Henney","raw_affiliation_strings":["Department of Medicine of The Johns Hopkins University School of Medicine and the O'Neill Memorial Research Laboratories of the Good Samaritan Hospital , Baltimore, Maryland","Department of Medicine of The Johns Hopkins University School of Medicine and the O'Neill Memorial Research Laboratories of the Good Samaritan Hospital From the , Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine of The Johns Hopkins University School of Medicine and the O'Neill Memorial Research Laboratories of the Good Samaritan Hospital , Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Department of Medicine of The Johns Hopkins University School of Medicine and the O'Neill Memorial Research Laboratories of the Good Samaritan Hospital From the , Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I145311948"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":1.9219,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.85036186,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"119","issue":"5","first_page":"1821","last_page":"1829"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.9682999849319458,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.9682999849319458,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.0210999995470047,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.009399999864399433,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/k-cells","display_name":"K cells","score":0.7059999704360962},{"id":"https://openalex.org/keywords/cytotoxic-t-lymphocytes","display_name":"cytotoxic T lymphocytes","score":0.7509999871253967},{"id":"https://openalex.org/keywords/fc-receptors","display_name":"Fc receptors","score":0.8019999861717224},{"id":"https://openalex.org/keywords/igg-fc","display_name":"IgG Fc","score":0.7680000066757202},{"id":"https://openalex.org/keywords/protein-a","display_name":"protein A","score":0.972000002861023},{"id":"https://openalex.org/keywords/cytochalasin-b","display_name":"cytochalasin B","score":0.9850000143051147},{"id":"https://openalex.org/keywords/camp","display_name":"cyclic AMP","score":0.753000020980835},{"id":"https://openalex.org/keywords/immune-complexes","display_name":"immune complexes","score":0.7400000095367432},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"cell adhesion","score":0.6389999985694885},{"id":"https://openalex.org/keywords/antibody-coating","display_name":"antibody coating","score":0.4269999861717224},{"id":"https://openalex.org/keywords/lymphocyte-activation","display_name":"lymphocyte activation","score":0.3540000021457672}],"concepts":[{"id":"https://openalex.org/C73588182","wikidata":"https://www.wikidata.org/wiki/Q2663023","display_name":"Cytolysis","level":4,"score":0.8690453171730042},{"id":"https://openalex.org/C182615771","wikidata":"https://www.wikidata.org/wiki/Q1369386","display_name":"Lytic cycle","level":3,"score":0.7759674191474915},{"id":"https://openalex.org/C57409179","wikidata":"https://www.wikidata.org/wiki/Q1218293","display_name":"Lysis","level":2,"score":0.7332453727722168},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.6254356503486633},{"id":"https://openalex.org/C2779012151","wikidata":"https://www.wikidata.org/wiki/Q26998028","display_name":"Cytochalasin B","level":3,"score":0.6086265444755554},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5807424187660217},{"id":"https://openalex.org/C74884574","wikidata":"https://www.wikidata.org/wiki/Q171407","display_name":"Divalent","level":2,"score":0.5482221245765686},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5226314067840576},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.44558489322662354},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42513880133628845},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4085002541542053},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.36564335227012634},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3362380564212799},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.2968561053276062},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.1804981827735901},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.15964055061340332},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000920","descriptor_name":"Antibody-Dependent Cell Cytotoxicity","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000936","descriptor_name":"Antigen-Antibody Complex","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001667","descriptor_name":"Binding, Competitive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003080","descriptor_name":"Cold Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003571","descriptor_name":"Cytochalasin B","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003601","descriptor_name":"Cytotoxicity Tests, Immunologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004492","descriptor_name":"Edetic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007141","descriptor_name":"Immunoglobulin Fc Fragments","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.4049/jimmunol.119.5.1821","doi":"https://doi.org/10.4049/jimmunol.119.5.1821","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.119.5.1821","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:410884","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/410884","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Journal Article"},{"id":"mag:1559385839","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/410884","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1559385839","https://openalex.org/W4313311544","https://openalex.org/W1497945345","https://openalex.org/W1791244243","https://openalex.org/W2061698140","https://openalex.org/W1915551097","https://openalex.org/W1964686209","https://openalex.org/W7099945955","https://openalex.org/W4313311499","https://openalex.org/W2216360019"],"abstract_inverted_index":{"Abstract":[0],"The":[1],"binding":[2,54,83,109,213],"of":[3,21,31,44,55,65,75,101,127,134,147,154,169,191,201],"human":[4,181],"K":[5,32,56,66,81,107,144,202,216],"cells":[6,38,57,149],"to":[7,12],"antibody-coated":[8],"cell":[9,33,50,82,108,218],"monolayers":[10],"and":[11,103,116,139,173,220],"immobilized":[13],"immune":[14],"complexes":[15],"was":[16,58,70,84,110,122,158],"studied":[17],"under":[18],"a":[19,92,93,198,212,221],"variety":[20],"experimental":[22],"conditions.":[23],"Binding":[24],"could":[25,183],"be":[26,185],"demonstrated":[27],"by":[28,60,86,113,117,124,131,161,171,174,187],"the":[29,36,42,48,76,98,125,132,143,163,189],"depletion":[30],"activity":[34,46,69],"in":[35,47,62,180],"nonadherent":[37],"as":[39,41],"well":[40],"augmentation":[43],"lytic":[45,68,222],"adherent":[49],"fraction.":[51],"A":[52,89],"selective":[53],"shown":[59],"experiments":[61],"which":[63,224],"\u03c490%":[64],"cell-mediated":[67,145,203],"depleted":[71],"while":[72],"only":[73],"10%":[74],"total":[77],"lymphocytes":[78,182],"were":[79],"bound.":[80],"inhibited":[85,112,142],"staphylococcal":[87],"protein":[88],"(SPA)":[90],"indicating":[91],"dependence":[94],"on":[95],"interactions":[96],"between":[97],"Fc":[99,105],"portion":[100],"IgG":[102],"homologous":[104],"receptors.":[106],"partially":[111],"cytochalasin":[114,140],"B":[115,141],"low":[118,152],"temperature":[119],"(0\u00b0C)":[120],"but":[121],"unaffected":[123],"absence":[126],"divalent":[128],"cations":[129],"or":[130],"presence":[133],"cAMP-\u201cactive\u201d":[135],"drugs.":[136],"Both":[137],"SPA":[138],"lysis":[146],"target":[148,192],"coated":[150],"with":[151,209],"amounts":[153],"antibody.":[155,194],"This":[156],"inhibition":[157,168],"reversed,":[159],"however,":[160],"increasing":[162,188],"antibody":[164],"\u201ccoat\u201d.":[165],"In":[166],"contrast,":[167],"cytolysis":[170,204],"EDTA":[172],"drugs":[175],"that":[176],"raised":[177],"cAMP":[178],"levels":[179],"not":[184],"reversed":[186],"amount":[190],"cell-associated":[193],"These":[195],"findings":[196],"allow":[197],"clear":[199],"dissection":[200],"into":[205],"two":[206],"independent":[207],"events,":[208],"distinctive":[210],"requirements:":[211],"phase":[214,223],"involving":[215],"cell-target":[217],"interaction":[219],"follows":[225],"such":[226],"accomodation.":[227]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-01-06T00:00:00"}
